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Uncovering secrets of bone marrow cells and how they differentiate
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells -- fat cells, bone-making cells and cartilage-making cells. Respectively, those cells are called adipocytes, osteoblasts and chondrocytes. This non-hematopoietic cell system is distinct from another production line in the bone marrow -- the hematopoietic system -- that makes red blood cells, blood-clotting cells and cells of the immune system. (2019-07-31)

Electricity-conducting bacteria yield secret to tiny batteries, big medical advances
These strange bacteria conduct electricity via a structure never before seen in nature -- a structure scientists can co-opt to miniaturize electronics, create powerful-yet-tiny batteries, build pacemakers without wires and develop a host of other medical advances. (2019-04-04)

Bacterial nanowire mystery solved
Deep in the ocean or underground, where there is no oxygen, Geobacter bacteria 'breathe' by projecting tiny protein filaments called 'nanowires' into the soil, to dispose of excess electrons resulting from the conversion of nutrients to energy. (2019-04-04)

Ultrasound helps predict the success of fistulas in individual dialysis patients
Certain parameters measured by ultrasound helped predict the success of an arteriovenous fistula, the preferred type of hemodialysis vascular access, in individual patients. (2018-10-11)

Discovery gives cystic fibrosis researchers new direction
A multi-disciplinary team of researchers at the Novartis Institutes for BioMedical Research (NIBR) and Harvard Medical School (HMS) started out trying to catalogue all the different cells in the airway and the paths they take to become those cells. In the process, they discovered a completely new type of cell, which they name a pulmonary ionocyte. (2018-08-01)

Scientists create nanomaterials that reconfigure in response to biochemical signals
A newly published paper in Nature Chemistry details how a research team lead by scientists at the Advanced Science Research Center's Nanoscience Initiative are developing self-assembling electronic nanomaterials that can respond to biochemical signals for potential therapeutic use. (2018-04-30)

From one, many
In three landmark studies, Harvard researchers report how they have systematically profiled every cell in developing zebrafish and frog embryos to establish a roadmap revealing how one cell builds an entire organism. The findings represent a catalog of genetic 'recipes' for generating different cell types and provide an unprecedented resource for the study of developmental biology and disease. (2018-04-26)

Communication between lung tumors and bones contributes to tumor progression
Massachusetts General Hospital investigators have identified a way in which a type of lung cancer co-opts a portion of the immune system to increase tumor progression. (2017-11-30)

Sniffing out stem cell fates in the nose
Single-cell RNA sequencing has allowed researchers to identify adult stem cells as they transform into mature cells, but the process becomes complicated when stem cells can transform into several different types of cells. UC Berkeley neuroscientists teamed with statisticians and computer scientists to improve the analysis of their experimental results, and were able to track stem cell fates in the nose as olfactory stem cells differentiated into sensory neurons and support cells. (2017-05-11)

Disproving hypothesis clears path for research for new treatment options for schizophrenia
Researchers reported negative results from the first repeated-dose study of a dopamine-1 receptor (D1R) agonist for treating cognitive and negative symptoms of schizophrenia. Based on earlier preclinical research suggesting that reduced signaling through the D1R might contribute to these symptoms, scientists speculated that administering ultra-low doses of D1R agonists might counteract these symptoms. For over a decade, researchers have sought to reproduce comparable results in clinical studies, with mixed findings and no definitive answers. (2016-03-10)

Beyond average
Two separate research teams have developed high-throughput techniques to quickly, easily and inexpensively give every individual cell in a sample a unique genetic barcode. (2015-05-21)

Messenger RNA-associated protein drives multiple paths in T-cell development
The lab of Kristen Lynch, Ph.D., studies how this splicing occurs in T cells and how it is regulated by multiple proteins. A new study published in the Proceedings of the National Academy of Sciences from her lab describes a cascade of events that may explain changes in gene expression that occur during the development of the human immune system. (2015-04-21)

The roots of human altruism
Apes hardly ever act selflessly without being solicited by others; humans often do. What has caused this curious divergence, which is arguably the secret to our species' unparalleled success? A team headed by an anthropologist from the University of Zurich now reveals that cooperative care for the young was the evolutionary precondition for the emergence of spontaneous altruistic behavior. (2014-08-27)

American Aging Association Meeting presents latest developments in aging research
The American Aging Association Meeting drew experts from all over the world to present the most advanced scholarship in the field of aging research. (2014-06-04)

Making sense of our senses
According to a new book by Tel Aviv University's professor Thalma Lobel, our senses influence our decisions and behavior more than we can possibly imagine. 'Sensation: The New Science of Physical Intelligence,' published this month by Simon and Schuster, explores over 100 experiments in the modern science of embodied cognition conducted at universities around the world and concludes that sensual physical experiences unconsciously affect our everyday choices, and have profound implications for our lives. (2014-04-14)

Deletion of FAT10 gene reduces body fat, slows down aging in mice
A single gene appears to play a crucial role in coordinating the immune system and metabolism, and deleting the gene in mice reduces body fat and extends lifespan, according to new research by scientists at the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University and Yale University School of Medicine. (2014-03-24)

A digital test for toxic genes
Tel Aviv University researchers have developed a new computer algorithm that predicts which metabolic genes are lethal to cells when overproduced. Their findings could help guide metabolic engineering to produce new chemicals and drugs in more cost-effective ways. (2014-01-29)

A peptide to protect brain function
Prof. Illana Gozes of Tel Aviv University has developed a new peptide, called NAP or Davunetide, that has the capacity to both protect and restore critical cell functions in the brain. Her findings indicate that NAP could be an effective tool in combating effects of neurodegenerative diseases such as Alzheimer's, ALS, and Parkinson's. (2013-06-13)

Fish oil may protect dialysis patients from sudden cardiac death
A study published in Kidney International has found that higher levels of omega-3 fatty acids in the blood of patients just starting hemodialysis were very strongly associated with a lower risk of sudden cardiac death over the first year of their treatment. (2013-02-06)

Do low-carb diets damage the kidneys?
A low-carbohydrate high-protein weight loss diet does not negatively affect healthy obese patients' kidney function or their fluid and electrolyte balance compared with a low-fat diet. Additional studies are needed to evaluate the diet's effects in different types of individuals, such as those with pre-existing kidney disease. (2012-05-31)

A safer alternative to laser eye surgery?
A new type of procedure for correcting short-sightedness could be safer than laser eye surgery, according to a new Cochrane Systematic Review. The study also shows that patients prefer the new procedure, despite there being little difference between the two in terms of improving vision. (2010-05-11)

Decreased muscle strength predicts functional impairments in older adults
Decreased muscle strength is associated with difficulty in performing functional activities such as stooping, crouching or kneeling in older adults, according to an observational study published in the January issue of Physical Therapy, the scientific journal of the American Physical Therapy Association. These researchers found that adults with SCK difficulty had significant decreases in adjusted strength measurements of trunk extensor, knee extensor and ankle flexion muscles. (2010-02-01)

Kidney disease affects response to blood thinner
Patients with reduced kidney function require lower doses of the anticoagulant drug warfarin, and may need closer monitoring to avoid serious bleeding complications, suggests a study in the April 2009 issue of the Journal of the American Society of Nephrology. (2009-02-18)

Appealing the death sentence for brain cells
A Tel Aviv University researcher's drug candidate could provide protection against Alzheimer's disease. (2008-05-29)

New search engine 'revolutionary'
A 26-year-old Australian PhD student has patented a new way of exploring the web that could revolutionise existing search engines. Developed by Ori Allon, the Orion TM search engine is designed to complement searches conducted on services such as Google, Yahoo or MSN Search. It matches keywords with page content and allows users to select from search results for relevance without having to visit a website. (2005-09-06)

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