Current Alzheimer Disease News and Events

Current Alzheimer Disease News and Events, Alzheimer Disease News Articles.
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Alzheimer Europe sets out recommendations to improve data sharing in dementia research
At an online European Parliament workshop hosted by Deirdre Clune MEP (Ireland), Alzheimer Europe launched a new report ''Data Sharing in Dementia Research'', which reviews recent changes in EU research policy and sets out recommendations to improve data sharing in dementia research. (2021-02-23)

Immune-compromised people with HIV, APOE4 gene may have a compounded risk for Alzheimer's
People living with the human immunodeficiency virus (HIV) who have a history of severe immunosuppression and at least one copy of the Alzheimer's disease-related gene variant APOE4, might see a compounded adverse effect on the circuitry that impacts memory. This could eventually lead to an increased risk for dementia after age 65, according to Georgetown University Medical Center investigators and colleagues. (2021-02-22)

BU researchers identify biochemical process responsible for producing toxic tau
Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. Groups of toxic tau protein, termed tau oligomers, drive disease progression and memory loss in Alzheimer's disease (AD). A new study from Boston University School of Medicine (BUSM) shows how these tau oligomers form, and, correspondingly, how they can be prevented. (2021-02-22)

A 'twisted elevator' could be key to understanding neurological diseases
For the first time, researchers have found one of the most important molecular machines in our cells uses a 'twisting elevator' mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another. (2021-02-17)

Protein linked to Alzheimer's, strokes cleared from brain blood vessels
Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (2021-02-17)

SuperAger brains resist protein tangles that lead to Alzheimer's
A new study showed cognitive SuperAgers have resistance to the development of fibrous tangles in a brain region related to memory and which are known to be markers of Alzheimer's disease. Their resistance appears to help protect their memory. (2021-02-17)

Discovery of biomarker could help predict Alzheimer's years before symptoms emerge
A unique brain protein measured in the blood could be used to diagnose Alzheimer's disease decades before symptoms develop, according to new Edith Cowan University (ECU) research. (2021-02-17)

Differences in walking patterns could predict type of cognitive decline in older adults
Canadian researchers are the first to study how different patterns in the way older adults walk could more accurately diagnose different types of dementia and identify Alzheimer's disease. (2021-02-16)

Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases
In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies. The results also supported the disorder's ties to Parkinson's and Alzheimer diseases. (2021-02-16)

Spanish scientists uncover early links between cardiovascular risk and brain metabolism
Investigators at the CNIC have discovered a link between brain metabolism, cardiovascular risk, and atherosclerosis during middle age, years before symptoms appear (2021-02-15)

People with and without AD have a different threshold for elective revascularisation
The risk of both mortality and rehospitalisation after an elective revascularisation procedure for coronary artery disease is similar for people with and without Alzheimer's disease (AD), but people with AD had worse outcomes after an emergency procedure, according to a new study from the University of Eastern Finland. (2021-02-15)

Spinal fluid of people with Alzheimer's risk gene signals inflammation
People who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes in the fluid around their brain and spinal cord that are detectable years before symptoms arise, according to new research from Duke Health. (2021-02-11)

Prediabetes may be linked to worse brain health
For the study, published in the journal Diabetes, Obesity and Metabolism, researchers analysed data from the UK Biobank of 500,000 people aged 58 years on average, and found that people with higher than normal blood sugar levels were 42% more likely to experience cognitive decline over an average of four years, and were 54% more likely to develop vascular dementia over an average of eight years (although absolute rates of both cognitive decline and dementia were low). (2021-02-11)

Case Western Reserve-led team finds that people with dementia at higher risk for COVID-19
A study led by Case Western Reserve University researchers found that patients with dementia were at a significantly increased risk for COVID-19--and the risk was higher still for African Americans with dementia. (2021-02-09)

AD diagnostics could become more accessible
A team of researchers from the Laboratory of Biophysics at NUST MISIS, Lomonosov Moscow State University and D. Mendeleev University of Chemical Technology of Russia has summarized metal-containing diagnostic agents for positron emission tomography (PET), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT) imaging of Alzheimer's disease (AD). According to the researchers, their use could improve access to diagnostic imaging of AD among the risk groups. (2021-02-09)

Higher blood pressure at night than in daytime may increase Alzheimer's disease risk
Higher blood pressure at night than in daytime may be a risk factor for Alzheimer's disease in older men. This is suggested by a new study from researchers at Uppsala University, now published in the journal Hypertension. (2021-02-08)

Brain protein that causes Alzheimer's also protects against the disease: USask research
Findings from a new study on Alzheimer's disease (AD), led by researchers at the University of Saskatchewan (USask), could eventually help clinicians identify people at highest risk for developing the irreversible, progressive brain disorder and pave the way for treatments that slow or prevent its onset. (2021-02-08)

Research establishes a new method to predict individual risk of cognitive decline
This work shows that direct measures of brain signatures during mental activity are more sensitive and accurate predictors of memory decline than current standard behavioral testing. (2021-02-05)

Innovation from Vienna: Ultrasound in the treatment of brain diseases
Ultrasound is not only used as an imaging technique but targeted pulses of ultrasound can be used as a highly accurate treatment for a range of brain diseases. A review jointly written by MedUni Vienna and the University of Toronto shows that the new treatments are already on the brink of broad clinical application. (2021-02-04)

Imaging of a living brain can help clearly differentiate between two types of dementia
Scientists in Portugal and the United Kingdom were able to confirm that an imaging technique that traces neuronal dopaminergic deficiency in the brain is able to differentiate, in vivo, Alzheimer's disease from the lesser-known dementia with Lewy bodies. This could have important implications for the specific management and treatment of these conditions. (2021-02-04)

Genetics study finds ancestral background can affect Alzheimer's disease risk
Genetics contributes to the risk of developing Alzheimer's disease, and the APOE gene is the strongest genetic risk factor, specifically the APOE4 allele. However, it has been known for a while that the risk due to the APOE4 allele differs considerably across populations, with Europeans having a greater risk from the APOE4 allele than Africans and African Americans. (2021-02-03)

Researchers explore link between 'Alzheimer's gene' and COVID-19
A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19. ''Our study provides a causal link between the Alzheimer's disease risk factor ApoE4 and COVID-19 and explains why some (e.g., ApoE4 carriers) but not all COVID-19 patients exhibit neurological manifestations'' said City of Hope's Yanhong Shi, Ph.D., co-corresponding author of the Cell Stem Cell study. (2021-02-03)

Air pollution poses risk to thinking skills in later life, a study says
Exposure to air pollution in childhood is linked to a decline in thinking skills in later life, a study suggests. A greater exposure to air pollution at the very start of life was associated with a detrimental effect on people's cognitive skills up to 60 years later, the research found. (2021-02-02)

Automated imaging detects and tracks brain protein involved in Alzheimer's disease
Applying an automated method to brain images revealed where deposits of tau, a protein implicated in Alzheimer's disease, first emerge in the cerebral cortex. Tau deposits in this tiny region were highly predictive of subsequent tau spread through the brain. (2021-02-02)

Dementia rates higher in men with common genetic disorder haemochromatosis
New research has found that men who have the Western world's most common genetic disorder are more likely to develop dementia, compared to those without the faulty genes. (2021-02-02)

Scientists find promising avenue to restore cognitive function impaired by Alzheimer's disease
A team of neuroscientists has identified a potential means to address the loss of cognitive function due to Alzheimer's disease by targeting protein synthesis in mice. Their findings reveal that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation. (2021-02-02)

Aging-US: Anserine protected against cognitive decline
The Aging-US results suggest that anserine protects elderly persons with MCI from cognitive declines by suppressing MPO-mediated neuroinflammatory responses. (2021-02-02)

An integrated approach for an effective prevention of Alzheimer´s disease
Recent studies demonstrate that styles of life involving interdependent actions of exercise, oriental practices such as QiGong, nutrition, mental and social activity and mindfulness are effective in preventing Alzheimer´s disease and other forms of dementia (2021-02-01)

New discovery for how the brain 'tangles' in Alzheimer's Disease
University of Queensland researchers have discovered a new 'seeding' process in brain cells that could be a cause of dementia and Alzheimer's disease. (2021-02-01)

Obesity may exacerbate the effects of Alzheimer's disease, new study shows
New research from the University of Sheffield has found being overweight is an additional burden on brain health and it may exacerbate Alzheimer's disease. (2021-01-29)

Discovery of early plasma biomarkers for Alzheimer's disease
A Quebec research team has discovered two early plasma markers to detect Alzheimer's disease five years before its onset. The results of this recent study have been published in the prestigious scientific journal Alzheimer's & Dementia: Translational Research & Clinical Interventions (TRCI). (2021-01-28)

First observation of the early link between proteins linked to Alzheimer's disease
Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development. (2021-01-25)

A new study shows the relationship between surgery and Alzheimer's disease
Amsterdam, January 21, 2021 - A new study published in the Journal of Alzheimer's Disease carried out by researchers at the Marqués de Valdecilla-IDIVAL University Hospital, in collaboration with researchers at the University of Bonn Medical Center, proposes that major surgery is a promoter or accelerator of Alzheimer's disease (AD). The first author of the publication was Carmen Lage and the principal investigator Pascual Sánchez-Juan. (2021-01-21)

Abnormal hyperactivation in the brain may be an early sign of Alzheimer's
A research team led by UdeM psychology and neuroscience professor Sylvie Belleville has just targeted an early biomarker of the disease. (2021-01-21)

Automated imaging reveals where TAU protein originates in the brain in Alzheimer's disease
Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals. (2021-01-20)

University of Kentucky researchers link low blood amylin level to reduced progression of Alzheimer's
The team's work shows that early pathological processes in the brains of individuals who are genetically predisposed to develop Alzheimer's disease are modulated by a pancreatic hormone called amylin. This study is the first to show that the brains of patients with familial AD accumulate amyloid-forming amylin secreted by the pancreas. (2021-01-20)

MicroRNA may serve as therapeutic targets for traumatic brain injury
WRAIR scientists have shown that traumatic brain injury causes coordinated microRNA dysregulation followed by increased amounts of the beta-site amyloid cleaving enzyme, or BACE1, and loss of amyloid precursor protein. BACE-1 cleaves APP to generate amyloid beta peptides, a hallmark of neurodegenerative disease pathology and brain cells loss, which are the focus of several clinical trials for Alzheimer's disease. Future research will characterize the direct role of miRNAs and their relationship to BACE1 within TBI. (2021-01-14)

Following the hops of disordered proteins could lead to future treatments of Alzheimer's disease
Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds. (2021-01-14)

New studies support blood test for early detection of Alzheimer's disease
In three recent publications in Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer's disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials. (2021-01-13)

Approximately half of AD dementia cases are mild, one-fifth are severe
What percent of patients with Alzheimer's Disease (AD) currently have severe dementia? Do more people have mild disease? Or are the majority suffering with moderate dementia? A new study using data from the Framingham Heart Study (FHS) sheds light on these trends. (2021-01-13)

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