Current Amyloid Beta News and Events

Current Amyloid Beta News and Events, Amyloid Beta News Articles.
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Aging-US: Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex
''The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β'' (2021-01-25)

First observation of the early link between proteins linked to Alzheimer's disease
Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development. (2021-01-25)

The liver processes coconut oil differently than rapeseed oil
Coconut oil has increasingly found its way into German kitchens in recent years, although its alleged health benefits are controversial. Scientists at the University of Bonn have now been able to show how it is metabolized in the liver. Their findings could also have implications for the treatment of certain diarrheal diseases. The results are published in the journal Molecular Metabolism. (2021-01-25)

A new study shows the relationship between surgery and Alzheimer's disease
Amsterdam, January 21, 2021 - A new study published in the Journal of Alzheimer's Disease carried out by researchers at the Marqués de Valdecilla-IDIVAL University Hospital, in collaboration with researchers at the University of Bonn Medical Center, proposes that major surgery is a promoter or accelerator of Alzheimer's disease (AD). The first author of the publication was Carmen Lage and the principal investigator Pascual Sánchez-Juan. (2021-01-21)

Automated imaging reveals where TAU protein originates in the brain in Alzheimer's disease
Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals. (2021-01-20)

University of Kentucky researchers link low blood amylin level to reduced progression of Alzheimer's
The team's work shows that early pathological processes in the brains of individuals who are genetically predisposed to develop Alzheimer's disease are modulated by a pancreatic hormone called amylin. This study is the first to show that the brains of patients with familial AD accumulate amyloid-forming amylin secreted by the pancreas. (2021-01-20)

CRISPR technology to cure sickle cell disease at UIC
The first cases treated with gene-editing technology were recently published in an article co-authored by Dr. Damiano Rondelli, the Michael Reese Professor of Hematology at the UIC College of Medicine. The article reports two patients have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020. (2021-01-20)

NAD+ can restore age-related muscle deterioration
Scientists at EPFL have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function. (2021-01-19)

Basis for the essential cellular powerhouses
Researchers have solved the operating mode of the barrel pore protein assembly in the mitochondrial outer membrane (2021-01-15)

MicroRNA may serve as therapeutic targets for traumatic brain injury
WRAIR scientists have shown that traumatic brain injury causes coordinated microRNA dysregulation followed by increased amounts of the beta-site amyloid cleaving enzyme, or BACE1, and loss of amyloid precursor protein. BACE-1 cleaves APP to generate amyloid beta peptides, a hallmark of neurodegenerative disease pathology and brain cells loss, which are the focus of several clinical trials for Alzheimer's disease. Future research will characterize the direct role of miRNAs and their relationship to BACE1 within TBI. (2021-01-14)

Following the hops of disordered proteins could lead to future treatments of Alzheimer's disease
Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds. (2021-01-14)

Toadlet peptide transforms into a deadly weapon against bacteria
Researchers at the Technion - Israel Institute of Technology and the European Molecular Biology Laboratory in Hamburg have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infections (2021-01-14)

Mount Sinai researchers identify and characterize 3 molecular subtypes of Alzheimer's
Critical step toward developing precision medicine treatments (2021-01-07)

Protein that can be toxic in the heart and nerves may help prevent Alzheimer's
A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer's disease, a new study led by a UT Southwestern researcher shows. The findings, published recently in the Journal of Biological Chemistry, could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure. (2021-01-07)

A prognostic Alzheimer's disease blood test in the symptom-free stage
Using a blood test, a German-Dutch research team has predicted the risk of Alzheimer's disease in people who were clinically diagnosed as not having Alzheimer's disease but who perceived themselves as cognitively impaired (Subjective Cognitive Declined, SCD). The researchers analyzed blood samples from an SCD cohort supervised at the Alzheimer Center Amsterdam. Using a test developed in Bochum, they identified all 22 subjects at study entry who developed Alzheimer's dementia, thus the clinical symptoms, within six years. (2021-01-06)

Modern microbes provide window into ancient ocean
Roughly two billion years ago, microorganisms called cyanobacteria fundamentally transformed the globe. Researchers are now stepping back to that pivotal moment in Earth's history. (2021-01-06)

New drug combination could improve glucose and weight control in diabetes
Scientists have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood glucose control and weight loss in mice, according to a study published today in eLife. (2020-12-22)

Alzheimer's disease: regulating copper in the brain stops memory loss among mice
Alzheimer's disease is characterized by the presence of amyloid plaques1 in the patient's brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that regulates the circulation of copper in the brain. (2020-12-17)

Carrots are healthy, but active enzyme unlocks full benefits
Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin. (2020-12-11)

Beta-blockers display anti-inflammatory effects in advanced liver disease
Beta-blockers are used to prevent internal bleeding in patients with liver cirrhosis and portal hypertension. Researchers from MedUni Vienna have now shown that Beta-blockers also have beneficial effects on systemic inflammation and this translates into improved clinical outcomes. (2020-12-10)

Genetic differences important in Alzheimer's diagnosis
The two used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet in Sweden have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs. (2020-12-10)

Researchers identify an action mechanism for a drug against Alzheimer' disease
A study conducted on mice published in the journalGeroscience has identified the action mechanism of a promising compound against Alzheimer's disease, developed by the team of Medical Chemistry and Pharmacology at the University of Barcelona. The new drug belongs to a family of molecules that, when bound to imidazole I2 receptors, these cause a reduction in neuroinflammation and an improvement in cognition and other markers of the progression of this disease, the most prevalent among dementias. (2020-12-09)

New and unexplored dimension in the study of protein-protein interactions
Cells accumulate glutamate and related molecules under stress, and so formation of high-order protein assemblies under these conditions has important biological implications. Specifically, this would represent a mechanism by which the presence of stressor compounds in the cell could control DNA replication. (2020-12-09)

Novel form of Alzheimer's protein found in spinal fluid indicates stage of the disease
Researchers at Washington University School of Medicine in St. Louis have found a novel form of the Alzheimer's protein tau in the fluid surrounding the brain and spinal cord. This form of tau -- known as MTBR tau -- indicates what stage of Alzheimer's a person is in and tracks with tangles of tau protein in the brain. (2020-12-07)

Findings about cilia on cells of the vessel wall may be relevant for diabetes treatment
A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for transplantation therapies in diabetes, as formation of functional blood vessels is important for the treatment to be successful. (2020-12-04)

Hidden network of enzymes accounts for loss of brain synapses in Alzheimer's
A new study on Alzheimer's disease by Scripps Research scientists has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for memory and cognition. (2020-12-03)

Discovery of plant amyloids could help create varieties with improved seed quality
A research team, which included scientists from St Petersburg University, has shown for the first time that special amyloid fibrils are found in plants. These fibrils are responsible for the 'conservation' of nutrients in plant seeds. (2020-12-02)

Stress hormones can reawaken sleeping tumor cells, raising risk of cancer recurrence
Stress hormones and immune cells called neutrophils may contribute to the recurrence of tumors years after treatment by awakening dormant cancer cells, suggests a study of mice and data from 80 patients with lung cancer. (2020-12-02)

Forest fires, cars, power plants join list of risk factors for Alzheimer's disease
A new study led by researchers at UC San Francisco has found that among older Americans with cognitive impairment, the greater the air pollution in their neighborhood, the higher the likelihood of amyloid plaques - a hallmark of Alzheimer's disease. The study adds to a body of evidence indicating that pollution from cars, factories, power plants and forest fires joins established dementia risk factors like smoking and diabetes. (2020-11-30)

New tests identify very early changes in Alzheimer's disease before symptoms appear
Researchers at the University of Gothenburg in Sweden, together with their colleagues at the Barcelona Beta Research Centre in Spain, the University Medical Centre in Ljubljana, Slovenia, and the University of Paris, have found new forms of tau protein that become abnormal in the very early stages of Alzheimer's disease before cognitive problems develop. The scientists developed new tools to detect these subtle changes and confirmed their results in human samples. (2020-11-30)

Brain waves guide us in spotlighting surprises
A new study by MIT and Boston University neuroscientists finds that the dynamic interplay of different brain wave frequencies, rather than dedicated circuitry, appears to govern the brain's knack for highlighting what's surprising and downplaying what's predictable. (2020-11-24)

Team uses copper to image Alzheimer's aggregates in the brain
A proof-of-concept study conducted in a mouse model of Alzheimer's disease offers new evidence that copper isotopes can be used to detect the amyloid-beta protein deposits that form in the brains of people living with -- or at risk of developing -- Alzheimer's. (2020-11-24)

Tracing the flow of cerebrospinal fluid
Understanding how the clear, watery substance flows through the brain could yield new insights into health and disease. (2020-11-23)

Early signs of Alzheimer's disease in people with Down's syndrome
Researchers at Karolinska Institutet in Sweden have studied the incidence and regional distribution of Alzheimer's disease biomarkers in the brains of people with Down's syndrome. The results can bring new possibilities for earlier diagnosis and preventive treatment of dementia. The study is published in Molecular Neurodegeneration. (2020-11-22)

Antibiotic resistance surveillance tools in Puerto Rican watersheds after Hurricane Maria
Virginia Tech researchers and international collaborators have further developed an innovative antibiotic resistance surveillance approach by applying DNA sequencing techniques to detect the spread of disease in watersheds impacted by large-scale storms. (2020-11-18)

Diabetes increases neuritic damage around amyloid plaques in Alzheimer's disease
New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer's disease (AD). (2020-11-18)

Antiviral defense from the gut
The study demonstrates how a subset of common gut bacteria renders mice resistant to viral infections. Experiments identify a specific bacterial population sharing a common molecule on their surface that is responsible for triggering natural antiviral immunity The work sets stage for development of preventive treatments that boost resistance to viruses in humans (2020-11-18)

Found: a genetic link to molecular events that precede symptoms in Alzheimer's disease
Tufts researchers find a key mutation causing abnormal transport of BACE1, the enzyme responsible for processing the Alzheimer's disease-linked amyloid protein. Identification of this mutation, which is more common among African Americans with Alzheimer's, may allow early intervention. (2020-11-18)

Tau protein changes in Alzheimer's disease correlate with dementia stage
In new research, Judith Steen, Ph.D. and colleagues at Boston Children's Hospital show for the first time that a pathological form of the tau protein involved in the progression of Alzheimer's disease changes over time due to chemical modifications. Observed in brain tissue from Alzheimer's patients, the modified tau forms correlated with stages of dementia. These discoveries likely mean it will take multiple drugs to target the tau protein effectively. (2020-11-18)

The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers from the Hertie Institute for Clinical Brain Research and the German Center for Neurodegenerative Diseases show in the journal Nature Neuroscience that this chain reaction starts much earlier in mice than commonly assumed. (2020-11-17)

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