Current Amyotrophic Lateral Sclerosis News and Events

Current Amyotrophic Lateral Sclerosis News and Events, Amyotrophic Lateral Sclerosis News Articles.
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Genetic sequence for parasitic flowering plant Sapria
A team of Harvard-led researchers presented the most complete genome yet assembled of one of the major Rafflesiaceae lineages, Sapria himalayana. (2021-01-22)

Hematopoietic stem cell transplants may provide long-term benefit for people with MS
A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The research is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that in some people their disability improved over 10 years after treatment. (2021-01-20)

The Lancet Public Health: Modelling study estimates impact of 'test to release' strategy to reduce - or replace - quarantine for contacts of COVID-19 cases
Quarantine time after contact with a confirmed COVID-19 case could potentially be reduced to 7 days without raising the risk of onward transmission of the virus by testing people on the seventh day of quarantine with either a PCR or lateral flow antigen (LFA) test, findings from an English modelling study published today in The Lancet Public Health journal suggest. (2021-01-20)

ALS study reveals a unique population
The secrets long hidden in the DNA of patients with amyotrophic lateral sclerosis (ALS) living in Malta have been unlocked, according to a new study in the European Journal of Human Genetics by an international team of researchers led by the University of Malta. (2021-01-19)

COVID-19 has multiple faces
Scientists from the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have found that COVID-19 comprises at least five different variants. These differ in how the immune system responds to the infection. (2021-01-18)

T cells linked to myelin implicated in MS-like disease in monkeys
Scientists have uncovered new clues implicating a type of herpes virus as the cause of a central nervous system disease in monkeys that's similar to multiple sclerosis in people. By linking two specific T cells to the loss of myelin, scientists say the new study opens the possibility of developing an antiviral therapy that could be especially useful for newly diagnosed cases of multiple sclerosis. (2021-01-15)

Research reveals how teeth functioned and evolved in giant mega-sharks
A pioneering study by University of Bristol researchers finds that the evolution of teeth in the giant prehistoric shark Megalodon and its relatives was a by-product of becoming huge, rather than an adaptation to new feeding habits. (2021-01-13)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Study suggests compound protects myelin, nerve fibers
A compound developed at Oregon Health & Science University appears to protect nerve fibers and the fatty sheath, called myelin, that covers nerve cells in the brain and spinal cord. The new research in a mouse model advances earlier work to develop the compound - known as sobetirome - that has already showed promise in stimulating the repair of myelin. (2021-01-13)

Imaging technique proves effective in measuring mitochondrial dysfunction in motor neuron disease (MND)
Non-invasive imaging technique called 31-phosphorus magnetic resonance spectroscopy used to measure mitochondrial function in patients with motor neuron disease (MND) (2021-01-13)

UK government must urgently rethink lateral flow test roll out, warn experts
UK government plans to widen the roll out of the Innova lateral flow test without supporting evidence risks serious harm, warn experts in The BMJ today. (2021-01-12)

School testing plans risk spreading covid-19 more widely, warn experts
As schools prepare to re-open to all pupils in February, experts warn that UK government plans for mass testing risks spreading covid-19 more widely. (2021-01-12)

Gene therapy strategy found effective in mouse model of hereditary disease TSC
Patients with a genetic disorder called tuberous sclerosis complex have noncancerous tumors growing in numerous organs, and their treatment options are limited. A gene therapy strategy effectively treated mice that express one of the mutated genes that cause the disease. (2021-01-08)

Treating an autoimmune disease in mice with an mRNA vaccine
Christina Krienke and colleagues have designed an mRNA vaccine that delayed the onset of and reduced the severity of multiple sclerosis-like disease in mice. (2021-01-07)

People in rural areas less likely to receive specialty care for neurologic conditions
A new study has found that while the prevalence of neurologic conditions like dementia, stroke, Parkinson's disease and multiple sclerosis (MS) is consistent across the U.S., the distribution of neurologists is not, and people in more rural areas may be less likely to receive specialty care for certain neurologic conditions. The study, funded by the American Academy of Neurology, is published in the December 23, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-12-23)

Beyond changing DNA itself, mutagens also cause errors in gene transcription
The discovery that toxic stressors can cause errors in gene transcription opens new avenues of research on diseases such as Alzheimer's and Parkinson's and sheds light on the potential role of the ''transcriptome'' in aging. (2020-12-21)

Scientists develop new land surface model including multiple processes and human activities
Researchers from the Institute of Atmospheric Physics developed a land surface model CAS-LSM that has improved the descriptions of biogeochemical process and urban modules, compared with the earlier version of this model. (2020-12-18)

Protein linked to progressive lung scarring in scleroderma patients
Osteopontin is discovered as the culprit behind systemic sclerosis patients' main cause of death: lung fibrosis. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein. (2020-12-17)

Additional analyses of pridopidine for HD
Positive results from additional analyses of PRIDE-HD and Open-HART trials with pridopidine published in peer-reviewed journal, The Journal of Huntington's Disease. Exploratory additional efficacy data show pridopidine (45 mg bid) to be first drug to exert a significant and clinically meaningful beneficial effect on Total Functional Capacity. Results from Open-HART trial demonstrate potential durability of effect of pridopidine with less TFC decline over 5 years compared to historical placebo group, as well as positive safety and tolerability data. (2020-12-16)

Rapid lateral flow immunoassay developed for fluorescence detection of SARS-CoV-2 RNA
Scientists from the Suzhou Institute of Biomedical Engineering and Technology have developed a novel amplification-free rapid SARS-CoV-2 nucleic acid detection platform based on hybrid capture fluorescence immunoassay (HC-FIA). (2020-12-10)

Antiepileptic drug reduces motor neuron excitability in ALS
The antiepileptic drug ezogabine reduced pathologic excitability of cortical and spinal motor neuron cells that are early signs of clinical dysfunction in people with amyotrophic lateral sclerosis (ALS), according to a study conducted by the Neurological Clinical Research Institute of Massachusetts General Hospital (MGH). In addition, the multi-site study involves the first clinical investigation of ALS using a drug identified through an induced pluripotent stem cell model. (2020-12-10)

New biomarker candidate for amyotrophic lateral sclerosis
A research team from the Centre for Protein Diagnostics (Prodi) at Ruhr University Bochum (RUB), in collaboration with scientists from Dresden Technical University, Essen University Hospital and University Hospital Göttingen, has developed a diagnostic tool for the rare neurological disease amyotrophic lateral sclerosis (ALS). The study used the patented immuno-infrared sensor to analyse folding changes of proteins in the cerebrospinal fluid (CSF) of ALS patients after specific binding. (2020-12-09)

Memory deficits resulting from epigenetic changes in Alzheimer's disease can be reversed
Memory loss associated with Alzheimer's disease (AD) may be able to be restored by inhibiting certain enzymes involved in abnormal gene transcription, according to a preclinical study by researchers at the University at Buffalo. (2020-12-09)

Radicals seem to be good for the brain
Scientists of the German Center for Neurodegenerative Diseases (DZNE) report in the journal Cell Stem Cell that reactive oxygen molecules, also known as 'free radicals.' are important for the brain's ability to adapt -- at least in mice. (2020-12-04)

NIH researchers link cases of ALS and FTD to a Huntington's disease-associated mutation
A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease. This large, international project, which included a collaboration between the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), opens a potentially new avenue for diagnosing and treating some individuals with FTD or ALS. (2020-12-04)

Lung tissue from COVID-19 patients and others reveals promising target to treat lung fibrosis
An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease. Experiments in mouse models of lung fibrosis showed that administering blockers of (2020-12-04)

What social distancing does to a brain
Scientists discover a neuropeptide that reflects the current state of a fish's social environment (2020-12-02)

Scientists identify new genetic MND risk factor in junk DNA
Researchers from the University of Sheffield have identified a new genetic risk factor for Motor Neurone Disease (MND). (2020-12-01)

Drug reverses age-related cognitive decline within days
Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer, and even enhance cognition in healthy animals. (2020-12-01)

Multi-center, multi-tracer PET studies harmonized to detect neuroinflammation in ALS
A novel ALS (amyotrophic lateral sclerosis) study has pooled data from multiple sites to effectively visualize neuroinflammation, which is key to developing drugs to treat the disease. Pooling data acquired from different scanners, different neuroinflammation positron emission tomography (PET) markers and different sites enhanced researchers' ability to detect neuroinflammation in ALS patients. This research was published in the November issue of The Journal of Nuclear Medicine. (2020-12-01)

Quantum nanodiamonds may help detect disease earlier
The quantum sensing abilities of nanodiamonds can be used to improve the sensitivity of paper-based diagnostic tests, potentially allowing for earlier detection of diseases such as HIV, according to a study led by UCL researchers in the i-sense McKendry group. (2020-11-25)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Dormant threat: Abnormal proteins unleash latent toxicity in neurodegenerative diseases
Though neurodegenerative diseases are becoming more common in today's aging societies, the exact way in which accumulated abnormal proteins become toxic to neurons is unknown. In a recent study conducted at Daegu Gyeongbuk Institute of Science and Technology, Korea, scientists have discovered a new mechanism of action by which these abnormal proteins actually unlock the normally latent toxicity of native proteins. Their results represent a completely new avenue toward the development of effective therapies. (2020-11-20)

Gut-brain axis influences multiple sclerosis
A Basel-led international research team has discovered a connection between the intestinal flora and sites of inflammation in the central nervous system in multiple sclerosis. A specific class of immune cell plays a central role in this newly identified gut-brain axis. The discovery could pave the way for new treatments for MS that target the intestinal flora. (2020-11-20)

Predicting forces between oddly shaped nanoparticles
Materials scientists at Duke University have devised a simplified method for calculating the forces that cause nanoparticles to self-assemble. With this new model and graphical user interface, researchers will be able to make previously impossible predictions about how nanoparticles with a wide variety of shapes will interact with one another. The new method offers opportunities for rationally designing such particles for a wide range of applications from harnessing solar energy to driving catalytic reactions. (2020-11-19)

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. (2020-11-18)

The long road to dementia
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers from the Hertie Institute for Clinical Brain Research and the German Center for Neurodegenerative Diseases show in the journal Nature Neuroscience that this chain reaction starts much earlier in mice than commonly assumed. (2020-11-17)

Smartphone use offers tool to treat MS, other diseases
Monitoring how patients with multiple sclerosis or other degenerative diseases use their smartphones could provide valuable information to help get them better treatment. In the journal Chaos, researchers used an app to record the keystroke dynamics of a control group and those of subjects in various stages of MS treatment. In doing so, they observed changes in the way people with MS typed that were not seen in subjects who did not have the disease. (2020-11-17)

New ALS guideline establishes national standard for managing neurodegenerative disease
The first Canadian guideline for the care and management of patients with amyotrophic lateral sclerosis (ALS) -- Lou Gehrig's disease -- recommends a patient-focused approach, with attention to holistic and emotional aspects of well-being. The guideline, published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191721, is intended for ALS clinicians, allied health professionals and primary care providers, and contains an easy-to-reference table with comprehensive recommendations. (2020-11-16)

Promising MS drug may worsen disease, research suggests
The drug has not yet made it to human trials for multiple sclerosis, but scientists at the University of Virginia School of Medicine are urging their colleagues to move cautiously. (2020-11-13)

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