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Current Amyotrophic Lateral Sclerosis News and Events, Amyotrophic Lateral Sclerosis News Articles.
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Laser-powered nanomotors chart their own course
The University of Tokyo introduced a system of gold nanorods that acts like a tiny light-driven motor, with its direction of motion is determined by the orientation of the motors. This work may lead to smaller and more precise nanomachines. (2020-11-04)

New artificial skin functions like natural skin
Researchers at RIKEN in Japan have developed an improved human-skin equivalent that reproduces a property that controls the structure and physiological function of skin. This artificial skin will enhance in-depth analyses of physiological skin functions, provide solutions to skin problems caused by diseases or ageing, and reduce the need for animal testing. (2020-10-30)

JNIS: brain-computer allows patients with severe paralysis to text, email, bank
Researchers demonstrated the success of a fully implantable wireless medical device, the Stentrode™ brain-computer interface (BCI), designed to allow patients with severe paralysis to resume daily tasks -- including texting, emailing, shopping and banking online -- without the need for open brain surgery. The first-in-human study was published in the (i>Journal of NeuroInterventional Surgery™, the leading international peer-reviewed journal for the clinical field of neurointerventional surgery. (2020-10-28)

Small brain device proves big game changer for severely paralysed patients
A tiny device the size of a small paperclip has been shown to help patients with upper limb paralysis to text, email and even shop online in the first human trial. (2020-10-28)

More than half of American adults with advanced MS report mistreatment by caregivers
Four in 10 people with advanced multiple sclerosis, or MS, are emotionally abused by someone responsible for caring for them, reports a study led by the University of California, Riverside. Further, the study finds one quarter are financially exploited, one in six are neglected, one in nine are battered, and one in 12 are sexually assaulted by a caregiver. (2020-10-27)

Multiple sclerosis as the flip side of immune fitness
About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study led by the University of Zurich has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells which - although they are effective in fighting off pathogens such as Epstein-Barr virus - also attack brain tissue. (2020-10-22)

A wearable sensor to help ALS patients communicate
MIT researchers have designed a skin-like device that can be attached to the face and measure small movements such as a twitch or a smile. With this approach, patients with amyotrophic lateral sclerosis (ALS) could communicate a variety of sentiments with small movements that are measured and interpreted by the device. (2020-10-22)

Why can our brains learn and memorize?
The long-term potentiation (LTP) and long-term depression (LTD) of hippocampal excitatory synapse involved in learning and memory formation in brain have been separately explained, but the molecular mechanism has not been elucidated. The group focused on the competition of exocytosis and endocytosis of AMPA-type glutamate receptors dependent on the number of calcium ions that flow into the postsynaptic neurons, and demonstrated the comprehensive understanding of the LTP and LTD by a large-scale mathematical model simulation. (2020-10-21)

Mayo Clinic: diagnostic, therapeutic advance for rare neurodegenerative disorder
Mayo Clinic researchers, along with national and global collaborators, have developed a potential test for Machado-Joseph disease, or spinocerebellar ataxia type 3 (SCA3) ? a disease that has no cure. They also have clarified the role of a gene target associated with the disease. (2020-10-21)

Coronavirus: Study finds further door opener into the cell
The coronavirus SARS-CoV-2 is known to infect cells via the receptor ACE2. An international research team under German-Finnish coordination has now identified neuropilin-1 as a factor that can facilitate SARS-CoV-2 entry into the cells' interior. Neuropilin-1 is localized in the respiratory and olfactory epithelia. Experts from the German Center for Neurodegenerative Diseases (DZNE), Technical University of Munich, University Medical Center Goettingen, University of Helsinki and other research institutions now published their findings in the journal ''Science''. (2020-10-20)

Anti-inflammatory therapy shows promise in slowing progression of multiple sclerosis
Intranasal administration of an anti-inflammatory drug helped reduce disease progression in a preclinical model of multiple sclerosis, according to recent research out of the University of Alberta. (2020-10-20)

Gut bacteria in multiple sclerosis: Probiotic or commensal, good or bad?
Though evidence suggests that the gut microbiome modulates risk of multiple sclerosis, new findings from the University of Vermont highlight complex interactions between host genetics and environmental factors impact susceptibility to multiple sclerosis. Strategies to prevent or treat multiple sclerosis should take into account host genetics, the pre-existing gut microbiome, and the timing or mode of the intervention. (2020-10-19)

Investigational ALS drug prolongs patient survival in clinical trial
An experimental medication that was recently shown to slow the progression of amyotrophic lateral sclerosis has now demonstrated the potential to also prolong patient survival. The findings come from a clinical trial conducted by investigators at the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital and Amylyx Pharmaceuticals, Inc., the company that manufactures the medication. (2020-10-16)

New therapy improves treatment for multiple sclerosis
A new therapy that binds a cytokine to a blood protein shows potential in treating multiple sclerosis, and may even prevent it. (2020-10-12)

New class of highly effective inhibitors protects against neurodegeneration
Heidelberg University neurobiologists have uncovered how a special receptor can lead to cell death. Their fundamental findings on neurodegenerative processes simultaneously led the researchers to a completely new principle for therapeutic agents. In their experiments on mouse models, they discovered a new class of highly effective inhibitors for protecting nerve cells. This novel class of drugs opens up perspectives to combat currently untreatable diseases of the nervous system. (2020-10-08)

Simple sugar possible therapy for repairing myelin in multiple sclerosis
N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study. (2020-10-07)

Study defines risk factors for unemployment in working people with multiple sclerosis
'Risk of unemployment is highest during the first three to five years after diagnosis, so we need to be able to intervene early to prevent job losses, and their subsequent impact. This study points to factors related to risk of unemployment that may be amenable to early intervention. Professionals who provide MS care should be aware of the potential impact of this diagnosis on future employment, and be prepared to intervene before individuals leave the work force.' (2020-10-05)

Are brain-computer interface spellers secure?
Brain-Computer Interfaces (BCIs), which aim to construct a pathway for people to interact with computers directly by thought, have received great attention in recent years. An electroencephalogram-based BCI speller, which allows the user to input text to computer using brain signals, is one of the most popular BCI systems. However, researchers in China show that these BCI spellers can be easily attacked, exposing a critical security concern in EEG-based BCI systems. (2020-10-03)

A RUDN University biologist described how a harmless bacterium turns into a phytopathogen
A researcher from RUDN University suggested that Xanthomonas bacteria that are harmful to plants might have developed from a nonpathogenic related species by receiving virulence genes from other species of bacteria. (2020-10-03)

Medicine for multiple sclerosis patients inhibits coronavirus - at least in a test tube
A drug which has already been approved for the treatment of multiple sclerosis patients effectively inhibits the coronavirus when tested on human lung cells. This is shown by a newly published study from biomedicine researchers at Aarhus University, Denmark. (2020-10-02)

COVID-19: Berlin scientists lay basis for a passive vaccination
Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité -- Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially trigger undesired side effects. They report their findings in the scientific journal ''Cell''. (2020-09-24)

Accuracy of commercial antibody kits for SARS-CoV-2 varies widely
There is wide variation in the performance of commercial kits for detecting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published September 24 in the open-access journal PLOS Pathogens by Jonathan Edgeworth and Blair Merrick of Guy's and St Thomas' NHS Foundation Trust, Suzanne Pickering and Katie Doores of King's College London, and colleagues. (2020-09-24)

Converting lateral scanning into axial focusing to speed up 3D microscopy
In optical microscopy, high-speed volumetric imaging is limited by either the slow axial scanning rate or aberrations introduced by the z-scanning mechanism. To overcome these limitations, scientists at UT Southwestern have introduced a novel optical design that transforms a lateral-scan motion into a scan in the third dimension. Their microscope realized laser focusing at a rate of 12 kHz and allowed observation of fast dynamics inside cells and the beating heart in Zebrafish embryos. (2020-09-23)

Risk gene for Alzheimer's has early effects on the brain
A genetic predisposition to late-onset Alzheimer's disease affects how the brains of young adults cope with certain memory tasks. Researchers from the DZNE and the Ruhr-Universität Bochum report on this in the scientific journal 'Current Biology'. Their findings are based on studies with magnetic resonance imaging in individuals at the age of about 20 years. The scientists suspect that the observed effects could be related to very early disease processes. (2020-09-15)

Embryos taking shape via buckling
The embryo of an animal first looks like a hollow sphere. Invaginations then appear at different stages of development, which will give rise to the body's structures. Although buckling could be the dominant mechanism that triggers invagination, it has never been possible of measuring the tiny forces involved. This gap has finally been filled thanks to a study carried out by scientists from the University of Geneva. (2020-09-14)

World's first major study into MS and pregnancy reveals it delays onset of MS symptoms by more than 3 years
A comprehensive international study, led by Monash researchers, has definitively found that pregnancy can delay the onset of multiple sclerosis (MS) by more than 3 years. (2020-09-14)

Ammonium triggers formation of lateral roots
Despite the importance of changes in root architecture to exploit local nutrient patches, mechanisms integrating external nutrient signals into the root developmental program remain poorly understood. ''Here, we show for the first time that local ammonium supply stimulates the accumulation of auxin in the root vasculature and promotes auxin diffusion and lateral root formation to build a highly branched root system'', says Prof. Nicolaus von Wirén from the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK). (2020-09-11)

Unlocking the mystery of tau for treatment of neurodegenerative diseases
A team of researchers from various collaborating universities and hospitals in Japan has uncovered crucial molecular details regarding the activity of the ''tau'' protein, promising to revolutionize the therapy of tau-induced neurodegenerative diseases. (2020-09-09)

Lumpy proteins stiffen blood vessels of the brain
Deposits of a protein called ''Medin'', which manifest in virtually all older adults, reduce the elasticity of blood vessels during aging and hence may be a risk factor for vascular dementia. Experts from the German Center for Neurodegenerative Diseases and the Hertie Institute for Clinical Brain Research at the University of Tübingen report on this in the scientific journal PNAS. (2020-09-09)

Mysterious cellular droplets come into focus
Researchers are shedding light on a type of membrane-less organelle, known as biological condensates, that play a role in DNA repair and aging. Using the Frontera supercomputer, biophysicists from the University of Illinois, Urbana-Champaign performed coarse-grained molecular dynamics of one particular biomolecular condensate -- fused in sarcoma (FUS). Writing in the Journal of Physical Chemistry Letters, they outlined a phase diagram showing the physical states of the condensate under different conditions of temperature and pressure. (2020-09-09)

Investigational drug stops toxic proteins tied to neurodegenerative diseases
An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic. Results were published in Science Translational Medicine. (2020-09-08)

"Hotspots" of a corona infection in the human body
An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases (DZNE) and Cornell University in the US have investigated cellular factors that could be significant for an infection. To this end, they analysed the activity of 28 specific genes in a wide range of human tissues. Their findings, which provide a map of potentially disease-relevant factors across the human body, are published in the journal ''Cell Reports''. (2020-09-03)

COVID-19 impact survey yields unexpected findings for individuals with progressive MS
Dr. Chiaravalloti: 'People with progressive MS appeared to have adapted more effectively to the lockdown conditions. Knowing their increased risk, they may have been early adopters of safety precautions, which may have provided a sense of control that countered negative emotional reactions. They are also accustomed to living with medical uncertainly and social isolation, two major factors that fueled high levels of psychological discomfort in the general population.' (2020-09-02)

Investigational ALS drug generates promising clinical trial results
An experimental medication slows the progression of ALS (2020-09-02)

Scientists identify promising new ALS drug candidates
Scientists have taken a significant step forward in the search to find effective new drug candidates for the treatment of Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease. (2020-09-01)

Intelligent software tackles plant cell jigsaw puzzle
German researchers, including scientists from the European Molecular Biology Laboratory in Heidelberg (EMBL), developed a machine learning-based algorithm to study the morphogenesis of plants at a cellular level. So far it was impossible to solve this evolving and changing puzzle. (2020-08-31)

Guam study advances research of cycads as an ecotoxin
University of Guam research has revealed that younger cycad seeds pose a greater risk for toxicity when consumed than more mature seeds, bringing the scientific community one step closer to understanding the origins of a neurodegenerative disease prevalent on Guam in World War II and closer to understanding related neurological disorders elsewhere. (2020-08-31)

A novel salvinia-like slippery surface
Inspired by the hydrophobic leaves of Salvinia molesta and the slippery Nepenthes pitcher plants, a Salvinia-like slippery surface (SSS) consisting of protrusions with slippery heads was designed. Compared to a control surface, the SSS exhibits increased stability against pressure and impact, the enhanced lateral mobility of water drops as well as the reduced hydrodynamic drag. (2020-08-28)

"Jumping" DNA regulates human neurons
''Jumping'' sequences of DNA, known as transposable elements, partner up with evolutionarily recent proteins to influence the differentiation and physiological functioning of human neurons. (2020-08-28)

Tag team gut bacteria worsen symptoms of multiple sclerosis
Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that a particular combination of microorganisms in the gut can worsen symptoms in a mouse model of multiple sclerosis. The study published in the scientific journal Nature shows that two specific gut bacteria enhance the activity of immune cells that attack the body's own brain and spinal cord. (2020-08-26)

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