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Targeted drug helps leukemia patients who do not benefit from initial therapy
A new study has found that patients with chronic myeloid leukemia who have not responded to interferon treatments experience long-term benefits when they switch to the targeted drug imatinib. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study indicates that imatinib is the treatment of choice for these patients. (2012-02-27)

Sandia seeks better neural control of prosthetics for amputees
Sandia National Laboratories researchers, using off-the-shelf equipment in a chemistry lab, have been working on ways to improve amputees' control over prosthetics with direct help from their own nervous systems. (2012-02-21)

Tohoku grim reminder of potential for Pacific Northwest megaquake
The March 11, 2011 Tohoku earthquake is a grim reminder of the potential for another strong-motion mega-earthquake along the Pacific Northwest coast, geophysicist John Anderson of the University of Nevada, Reno told members of the American Association for the Advancement of Science in a lecture at their annual conference in Vancouver, B.C., Sunday. (2012-02-21)

Telomere failure, telomerase activation drive prostate cancer progression
Genomic instability caused by an erosion of the protective caps on chromosomes, followed by activation of an enzyme that reinforces those caps, allows malignant cells to evade destruction and acquire more deadly characteristics, researchers report in an online now article at the journal Cell. (2012-02-20)

Blocking telomerase kills cancer cells but provokes resistance, progression
Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive and spread, scientists report in the Feb. 17 issue of Cell. (2012-02-20)

Reformulated imatinib eliminates morphine tolerance in lab studies
By reformulating the common cancer drug imatinib (Gleevec), researchers have eliminated morphine tolerance in rats -- an important step toward improving the effectiveness of chronic pain management in patients, according to researchers at the University of Texas MD Anderson Cancer Center. (2012-02-19)

Sandia National Laboratories researchers find energy storage 'solutions' in MetILs
Sandia researchers have developed a new family of liquid salt electrolytes, known as MetILs, that could lead to batteries able to cost-effectively store three times more energy than today's batteries. (2012-02-17)

'Talking dictionaries' document vanishing languages
Digital technology is coming to the rescue of some of the world's most endangered languages. Linguists from National Geographic's Enduring Voices project who are racing to document and revitalize struggling languages are unveiling an effective new tool: Talking dictionaries. (2012-02-17)

Nanoparticles may enhance cancer therapy
A mixture of current drugs and carbon nanoparticles shows potential to enhance treatment for head-and-neck cancers, especially when combined with radiation therapy, according to new research by Rice University and the University of Texas MD Anderson Cancer Center. (2012-02-16)

First EarthScope 'transportable array' seismic station reaches US East Coast
Yulee, Florida. Not a place one usually thinks of as an Earthquake Epicenter. But this swampland not far from the Georgia state line is now home to a state-of-the-art seismic station known as 457A. Here, within a few miles of the Atlantic Ocean, 457A has been installed to record ground motion from earthquakes. Earthquakes do happen on the East Coast of the United States, as the Virginia quake of August, 2011 attests. (2012-02-16)

Study explains high platelets in ovarian cancer patients; survival reduced
Highly elevated platelet levels fuel tumor growth and reduce the survival of ovarian cancer patients, an international team of researchers led by scientists at the University of Texas MD Anderson Cancer center reports in the New England Journal of Medicine. (2012-02-15)

Ethanol mandate not the best option
Many people are willing to pay a premium for ethanol, but not enough to justify the government mandate for the corn-based fuel, a Michigan State University economist argues. (2012-02-13)

Fetal exposure to radiation increases risk of testicular cancer
Male fetuses of mothers that are exposed to radiation during early pregnancy may have an increased chance of developing testicular cancer, according to a study in mice at the University of Texas MD Anderson Cancer Center. The article was published today in PLoS ONE. (2012-02-13)

UT MD Anderson, Texas A&M team up to treat canine lymphoma
A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports. (2012-02-07)

Cardiopulmonary exercise testing may predict post-liver transplantation survival
Researchers from the UK determined that preoperative cardiopulmonary exercise testing is a specific predictor of 90-day survival following liver transplantation. Study results available in the February issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, shows that the CPET measurement -- the anaerobic threshold or fitness level -- significantly predicts mortality in patients post-transplantation. (2012-01-31)

SUMO-snipping protein plays crucial role in T and B cell development
When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at the University of Texas MD Anderson Cancer Center reports today in Molecular Cell. (2012-01-27)

Mutated Kras spins a molecular loop that launches pancreatic cancer
Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating (2012-01-26)

Inflammatory mediator promotes colorectal cancer by stifling protective genes
Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. (2012-01-22)

Study tests new treatments for the winter blues
If winter's long nights and cold weather have you feeling depressed, a new research study could lift your spirits. The study aims to help adult (ages 21-64) men and women with seasonal affective disorder by comparing two new types of light technologies to determine which one works better. (2012-01-19)

'Exergames' may provide cognitive benefit for older adults
Virtual reality-enhanced exercise, or (2012-01-17)

Discovery could help stem smoking-related diseases
Sufferers of smoking-related lung diseases could have their debilitating symptoms reduced following the discovery of a potential new treatment. (2012-01-11)

Team finds a better way to gauge the climate costs of land use changes
Those making land use decisions to reduce the harmful effects of climate change have focused almost exclusively on greenhouse gases -- analyzing, for example, how much carbon dioxide is released when a forest is cleared to grow crops. A new study in Nature Climate Change aims to present a more complete picture -- to incorporate other characteristics of ecosystems that also influence climate. (2012-01-08)

2 genes affect anxiety, behavior in mice with too much MeCP2
The anxiety and behavioral issues associated with excess MeCP2 protein result from overexpression of two genes (Crh [corticotropin-releasing hormone] and Oprm 1 [mu-opioid receptor MOR 1]), which may point the way to treating these problems in patients with too much of the protein, said Baylor College of Medicine scientists. (2012-01-08)

Lead-free solder becomes top income-generating technology in Ames Lab and ISU history
Fifteen years ago, an environmentally-friendly solder developed by the US Department of Energy's Ames Laboratory made history as the first cost-effective, broadly usable alternative to tin-lead solder, a toxic but necessary ingredient in a range of consumer electronics. Now lead-free solder, invented by Ames Lab metallurgist Iver Anderson, has made history again: In 2011, it became the top royalty income-generating technology ever produced in the history of both Ames Lab and Iowa State University. (2012-01-05)

Fibroblasts contribute to melanoma tumor growth, say Moffitt Cancer Center researchers
Fibroblasts, cells that play a role in the structural framework of tissues, play an apparent role in melanoma tumor growth. Fibroblasts also contribute to melanoma drug resistance and may also facilitate the (2012-01-05)

Study links quality of mother-toddler relationship to teen obesity
The quality of the emotional relationship between a mother and her young child could affect the potential for that child to be obese during adolescence, a new study suggests. Researchers analyzed national data detailing relationship characteristics between mothers and their children during their toddler years. The lower the quality of the relationship in terms of the child's emotional security and the mother's sensitivity, the higher the risk that a child would be obese at age 15 years, according to the analysis. (2011-12-26)

Previously unconnected molecular networks conspire to promote cancer
An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at the University of Texas MD Anderson Cancer Center reports today in Molecular Cell. (2011-12-22)

Potential concern about drugs in clinical trial
Drugs that enhance levels of small molecules derived naturally in the body from a major component of animal fats are currently in clinical trials for the treatment of high blood pressure and diabetes. Researchers have now generated data in mice that raise new concerns about the use of these drugs in humans. (2011-12-19)

Goddard scientists selected as participating scientists in missions
Scientists at the NASA Goddard Space Flight Center in Greenbelt, Md., have been selected as Participating Scientists in NASA's Mars Science Laboratory (MSL) and Cassini missions. (2011-12-15)

Prognostic model developed for MDS related to prior cancer therapy
A large-scale analysis of patients whose myelodysplastic syndrome is related to earlier cancer treatment overturns the notion that all of them have a poor prognosis, researchers from the University of Texas MD Anderson Cancer Center report at the 53rd Annual Meeting of the American Society of Hematology. (2011-12-13)

AML patients have high response rate with vorinostat added to treatment
Adding a drug that activates genes to frontline combination therapy for acute myeloid leukemia resulted in an 85 percent remission rate after initial treatment, researchers at the University of Texas MD Anderson Cancer Center reported at the 53rd Annual Meeting of the American Society of Hematology. (2011-12-12)

B cell receptor inhibitor causes chronic lymphocytic leukemia remission
A new, targeted approach to treating chronic lymphocytic leukemia has produced durable remissions in a Phase I/II clinical trial for patients with relapsed or resistant disease, investigators report at the 53rd Annual Meeting of the American Society of Hematology. (2011-12-11)

Cellular processing of proteins found in Congolese child birthing tea now revealed
Many plants produce compounds that serve as a defense against predators or pathogens. As recently as the early 1990s, a unique class of proteins previously unknown to science, the cyclotides, was discovered. First noted through African tribal use as a tea given to speed up delivery during childbirth, cyclotides have since been determined to serve as a powerful insecticidal defense in the plants that produce them, and they also have anti-HIV and antimicrobial properties. (2011-12-09)

Pharmacists crucial in plan for terrorist chemical weapons
Terrorist attacks with chemical weapons are a real possibility, according to a study that appears in the Journal of Pharmacy Practice, published by SAGE. Thanks to their extensive knowledge of toxic agents, and how to treat those who have been exposed, pharmacists are an invaluable resource in the event of an actual or potential chemical weapons attack. (2011-12-09)

Combination of everolimus and exemestane improves survival for women with metastatic breast cancer
In an international Phase III randomized study, everolimus, when combined with the hormonal therapy exemestane, has been shown to dramatically improve progression‑free survival, according to research from The University of Texas MD Anderson Cancer Center. (2011-12-07)

Study finds side effects, complications, mastectomy more likely after partial breast irradiation
Accelerated partial breast irradiation brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate of later mastectomy, increased radiation-related toxicities and post-operative complications, compared to traditional whole breast irradiation, according to researchers from the University of Texas MD Anderson Cancer Center. (2011-12-06)

Everolimus prolongs progression-free survival for patients with neuroendocrine tumors
Combination treatment with octreotide shows improved results in tumors associated with carcinoid syndrome. (2011-11-29)

Study shows medical marijuana laws reduce traffic deaths
A new study shows that laws legalizing medical marijuana lead to fewer traffic deaths and less consumption of alcohol. (2011-11-29)

UT MD Anderson creates institute to accelerate cancer drug development
Academic and government leaders announced today the establishment of a major new research institute at the University of Texas MD Anderson Cancer Center that will blend the best attributes of academic and industrial research to identify and validate new cancer targets, convert such scientific knowledge into new cancer drugs, and advance these novel agents into innovative clinical trials. (2011-11-28)

Study explains how heart attack can lead to heart rupture
A new study by University of Iowa researchers pinpoints a single protein as the key player in the biochemical cascade that leads to cardiac rupture. The findings, published Nov. 13 as an advance online publication (AOP) of the journal Nature Medicine, suggest that blocking the action of this protein, known as CaM kinase, may help prevent cardiac rupture and reduce the risk of death. (2011-11-17)

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