Current Angiogenesis News and Events | Page 2

Current Angiogenesis News and Events, Angiogenesis News Articles.
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'Hopeful technology' could change detection, diagnosis of deadly ovarian cancer
Ovarian cancer claims the lives of more than 14,000 women in the U.S. each year, ranking fifth among cancer deaths in women. A multidisciplinary team at Washington University has found an innovative way to use sound and light to diagnose ovarian tumors, which may lead to a promising new diagnostic imaging technique to improve current standard of care. (2018-11-14)

Biomaterial could keep tooth alive after root canal (video)
A root canal ranks high on most people's list of dreaded dental procedures, and it results in a dead tooth susceptible to further decay. Now scientists have developed a peptide hydrogel designed to regenerate dental pulp after a root canal, preserving the tooth. The researchers will present their results today at the 256th National Meeting & Exposition of the American Chemical Society. (2018-08-22)

Texas A&M team develops new way to grow blood vessels
Formation of new blood vessels, a process also known as angiogenesis, is one of the major clinical challenges in wound healing and tissue implants. To address this issue, researchers from Texas A&M University have developed a clay-based platform to deliver therapeutic proteins to the body to assist with the formation of blood vessels. (2018-08-17)

A molecular switch may serve as new target point for cancer and diabetes therapies
If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal Molecular Cell. (2018-08-15)

New targets found to reduce blood vessel damage in diabetes
In diabetes, both the tightly woven endothelial cells that line our blood vessels and the powerhouses that drive those cells start to come apart as early steps in the destruction of our vasculature. (2018-07-09)

Researchers find a promising new approach for treating liver cirrhosis
In a study in The American Journal of Pathology, investigators report that treatment with aleglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma (PPARα/γ) agonist, reduced inflammation, vasoconstriction, angiogenesis, mucosal disruption, and tumor necrosis factor (TNF)-α overproduction in cirrhotic rats with PH. This suggests a promising new approach for treating liver cirrhosis. (2018-06-18)

Reviving the protector: new tactic against medulloblastoma
Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (2018-06-11)

UEA research could help fine-tune cancer treatment
Cancer therapies that cut off blood supply to a tumour could be more effective in combination with existing chemotherapeutic drugs -- according to new research from the University of East Anglia. New research published today in the journal EMBO Reports reveals that tumour growth is better-reduced in mice when the expression of a particular protein called Beta3-integrin is targeted in combination with drugs that are already used in cancer patients. (2018-05-25)

Biomarker helps identify 'window of opportunity' for cancer chemotherapy timing
Angiogenesis, the formation of new blood vessels, is essential for tumor growth. A new study reported in The American Journal of Pathology describes a vascular stabilization biomarker that can visualize blood vessel activity, thus optimizing the timing of anticancer therapies including anti-angiogenics. (2018-04-09)

The microenvironment of diabetic retinopathy supports lymphatic neovascularization
'We asked whether proliferative diabetic retinopathy involves the growth of new lymphatic vessels in addition to blood vessels -- and, indeed, we found expression of lymphatic markers in the PDR tissues.' The new study, conducted at the University of Helsinki, Finland, was published in the Journal of Pathology. (2018-03-29)

Sulfur amino acid restriction diet triggers new blood vessel formation in mice
Putting mice on a diet containing low amounts of the essential amino acid methionine triggered the formation of new blood vessels in skeletal muscle, according to a new study from Harvard T.H. Chan School of Public Health. The finding adds insight to previous research showing that a methionine-restricted diet extends lifespan and healthspan, suggesting that improved vascular function may contribute to these benefits. (2018-03-22)

80% cut in liver metastasis by restricting the blood vessels supplying it
The International Journal of Cancer has just published the results of an experimental therapy tested on mice. The research, led by the Signaling Lab research group of the UPV/EHU's Faculty of Medicine and Pharmacy and the Department of Pharmacology, Pharmacy and Pharmaceutical Technology of the University of Santiago de Compostela, achieved an 80% reduction in liver metastasis brought about by colon cancer. (2018-03-16)

Looking for the origins of schizophrenia
Schizophrenia may be related to neurodevelopment changes, including brain's inability to create the appropriate vascular system, according to new study resulted from a partnership between the D'Or Institute for Research and Education, the University of Chile and the Federal University of Rio de Janeiro (UFRJ). The results broaden the understanding about the causes of this severe and disabling disorder, which affects about 1 percent of the world's population. (2018-02-22)

New immunotherapy combination tolerable, effective in patients with advanced kidney cancer
Combining an anti-angiogenesis agent, which blocks blood vessel formation, with an immunotherapy agent, was found to have promising anti-tumor activity and no unexpected side effects in an early-phase clinical trial in patients with advanced kidney cancer. (2018-02-10)

Cutting off tumor supplies
Preventing tumour vascularization is therefore an interesting anti-tumour therapy that has been explored over the last ten years. But how to be truly effective? By identifying two cytokines, key factors in the recruitment of blood cells essential to the formation of new blood vessels, and above all by deciphering how these factors interact simultaneously with blood vessels, researchers at UNIGE are highlighting an additional way of controlling tumour progression. (2018-02-02)

Blood vessel-on-a-chips show anti-cancer drug effects in human cells
Researchers at the Institute of Industrial Science, the University of Tokyo, and LIMMS/CNRS-IIS a joint French - Japanese research laboratory between the CNRS and the University of Tokyo, report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, recapitulating biochemical events of the human angiogenesis. The chip also confirmed the effects of two FDA-approved anti-angiogenic drugs, demonstrating its applicability to drug discovery. (2018-01-30)

Starving tumors: New target discovered
Actively growing tumors have a high demand for oxygen and nutrients. Therefore, they stimulate the growth of blood vessels. This process is called angiogenesis. If tumor-associated angiogenesis is suppressed, this may limit tumor growth. Scientists from the German Cancer Research Center and the European Center for Angioscience at Heidelberg University have now discovered a new target for anti-angiogenic tumor therapy (2018-01-23)

How a tumor grows can predict response to cancer therapy
Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs. (2017-12-21)

Scientists shed light on a tumor-suppressive protein in metastases
?A new study conducted at the VIB-KU Leuven Center for Cancer Biology in Belgium has labeled the protein Caveolin-1 as a high-potential pursuit in the fight against cancer. Many research projects have already implicated this protein in both tumor-promotive and suppressive functions, but its exact role remained elusive. By examining macrophages at the sites of metastases, the scientists have now described the 'anti-metastatic surveillance' role of Caveolin-1 for the first time. (2017-12-05)

How bone cells promote lung cancer growth
A certain type of cell in the bone marrow can help promote tumor growth in mice with early stage lung cancer, a new study finds. (2017-11-30)

Some cancer therapies may provide a new way to treat high blood pressure
Drugs designed to halt cancer growth may offer a new way to control high blood pressure (hypertension), say Georgetown University Medical Center investigators. The finding could offer a real advance in hypertension treatment because although a number of high blood pressure drugs are now available, they work by different mechanisms that are not suited for all patients. (2017-11-20)

HKBU Chinese medicine scholars develop HKBU Chinese medicine scholars develop
Chinese Medicine scholars at Hong Kong Baptist University (HKBU) have succeeded in developing a novel targeted delivery system for CRISPR/Cas9 to achieve therapeutic genome editing of VEGFA in osteosarcoma (OS). (2017-11-10)

Stem cells from muscle could address diabetes-related circulation problems
Stem cells taken from muscle tissue could promote better blood flow in patients with diabetes who develop peripheral artery disease, a painful complication that can require surgery or lead to amputation. A new study in mice at the University of Illinois found that an injection of the stem cells prompted new blood vessels to grow, improving circulation in the affected tissues and function in the affected limbs. (2017-11-06)

Likely new treatment target identified for diabetic retinopathy
In oxygen-compromising conditions like diabetes, the body grows new blood vessels to help, but the result is often leaky, dysfunctional vessels that make bad matters worse. Now scientists have identified a new target for reducing that dysfunctional blood vessel development in the eye in a common condition called diabetic retinopathy, the leading cause of blindness in working-age adults. (2017-10-10)

Gene identified that may provide potential therapy for cerebral cavernous malformations
Researchers at University of California San Diego School of Medicine, with national collaborators, have identified a series of molecular clues to understanding the formation of cerebral cavernous malformations (CCMs). The study offers the first genome-wide analysis of the transcriptome of brain microvascular endothelial cells after KRIT1 inactivation. Findings were published Sept. 28 in the Journal of Experimental Medicine. (2017-10-09)

Healing molecule discovery could reduce limb amputations for diabetes patients
Scientists have discovered new insights into a molecule which is part of the body's tissue repair system, in a finding which could help treat non-healing wounds and injuries, such as diabetic foot. (2017-10-04)

Imaging agents developed to better monitor growth of tumours
UAlberta researchers have created two new imaging agents that could help physicians visualize the formation of tumour-associated blood vessels, keep track of tumour growth and possibly generate new therapies. (2017-10-04)

Study shows new biomarker could predict which pregnant women with type 1 diabetes could develop pre-eclampsia
New research at this year's European Association for the Study of Diabetes Annual Meeting in Lisbon, Portugal, shows that a biomarker -- Leucine-Rich alpha-2-Glycoprotein-1 (LRG1) -- can be used to predict the occurrence of pre-eclampsia in prospective mothers with type 1 diabetes. (2017-09-14)

FDA-approved drug may block resistance to anti-angiogenesis therapy
A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels. (2017-09-13)

New tool for cell-free therapy based on artificial membrane vesicles
Scientists at Kazan Federal University's Institute of Fundamental Medicine and Biology, led by Professor Albert Rizvanov, have shown that artificial membrane vesicles generated by cytochalasin B treatment of human cells retain angiogenic activity. (2017-09-12)

Ramucirumab plus docetaxel improves progression-free survival in urothelial cancer
Ramucirumab plus docetaxel improves progression-free survival in patients with advanced or metastatic urothelial cancer who have progressed on platinum-based chemotherapy, according to late-breaking results from the phase III RANGE trial presented today at the ESMO 2017 Congress in Madrid to be published in The Lancet. (2017-09-10)

How new blood vessels sprout
IBS biologists discovered a key regulator of normal as well as pathological formation of new blood vessels. (2017-08-29)

Researchers identify key compounds to resolve abnormal vascular growth in AMD
A compound of specific bioactive products from a major family of enzymes reduced the severity of age-related macular degeneration (AMD) in a preclinical model, according to a new study led by Massachusetts Eye and Ear researchers. (2017-08-21)

Molecule in human saliva has potential for wound healing
A study published online in The FASEB Journal delves into the mystifying fact that wounds in your mouth heal faster and more efficiently than wounds elsewhere. (2017-08-07)

Genome editing with CRISPR-Cas9 prevents angiogenesis of the retina
A research team from the Schepens Eye Research Institute of Massachusetts Eye and Ear has successfully prevented mice from developing angiogenesis of the retina--the sensory tissue at the back of the eye--using gene-editing techniques with CRISPR-Cas9. (2017-07-24)

How blood vessels slow down and accelerate tumor growth
Scientists from the German Cancer Research Center and Heidelberg University have discovered a new mechanism that causes faster sprouting of blood vessels. Cells of a specific type called pericytes, which are attached to the outside of fine blood vessels, are involved in this process. If a particular protein molecule is switched off, this leads to the formation of significantly more, albeit immature, vessels, the scientists now report. As a result, the tumor gets supplied better and can grow faster. (2017-07-18)

Tracking the mechanisms of artery formation
The Notch signal pathway could be the basis for new therapies for cardiovascular diseases. (2017-07-17)

Immunosuppression underlies resistance to anti-angiogenic therapy
A Massachusetts General Hospital research team has identified a novel mechanism behind resistance to angiogenesis inhibitors -- drugs that fight cancer by suppressing the formation of new blood vessels. (2017-07-14)

Giving birth multiple times has impact on stroke recovery, study shows
New research published in the Proceedings of the National Academy of Sciences shows that while perimenopausal female mice that gave birth multiple times (multiparous) were at higher risk of stroke, they recovered better than mice that had not ever reproduced. (2017-06-27)

Blood vessels and the immune system talk to each other; implications for cancer treatment
Researchers at Baylor College of Medicine and MD Anderson Cancer Center have discovered that tumor blood vessels and the immune system influence each other's functions, and propose that considering these bilateral effects in cancer therapy might improve outcomes. (2017-04-03)

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