Current Angiogenesis News and Events | Page 20

Current Angiogenesis News and Events, Angiogenesis News Articles.
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MGH study identifies new inhibitor of tumor angiogenesis and growth
A research team based at the Massachusetts General Hospital has shown that a natural factor called thrombospondin-2 (TSP- 2) inhibits the development of certain tumors in a mouse model by preventing the development of blood vessels, a process called angiogenesis. TSP-2 now joins a growing list of anti-angiogenesis factors being studied and in some instances tested as possible anti-cancer drugs. (1999-12-20)

Scientists find protein can protect new blood vessels from leaking ---promising complement togrowth stimulant VEGF
A protein recently found to increase blood vessel growth now appears to protect vessels from leaking as well, a potential boon to treatments for chronic inflammatory diseases and for new therapies that grow healthy blood vessels in damaged hearts and limb (1999-12-20)

Growing new blood vessels with a timed-release capsule of growth factor is a promising treatment for heart bypass patients, finds NHLBI study
Heart bypass patients treated with a timed-release capsule of a substance that promotes the growth of new blood vessels showed evidence of improved blood supply and heart function, according to a study supported by the National Heart, Lung, and Blood Institute. (1999-11-01)

Time-released capsule delivers 'growth factor' to improve coronary bypass surgery
A type of therapy that helps new blood vessels grow could offer an alternative for heart patients who are not good candidates for bypass surgery. Not only that, but the therapy appears to be safe and free of side effects, according to a study in today's Circulation: Journal of the American Heart Association. (1999-10-31)

MGH researchers identify angiogenesis inhibitor in gallbladder cancer
Researchers at the Massachusetts General Hospital have discovered that a cellular growth factor called TGF-beta-1 has a previously unsuspected role in regulating the growth of blood vessels associated with metastatic gallbladder cancer. (1999-09-28)

New findings point to new target to block angiogenesis
Scientists at the Vanderbilt-Ingram Cancer Center have identified an unexpected participant in the process of blood vessel development. Reported in the Sept. 15 issue of the journal Cancer Research, their findings point to a new target for drugs that inhibit this process. (1999-09-15)

UI researchers discover that aggressive cancer cells may make their own blood vessels
Until now, researchers assumed that tumors attracted blood vessels to provide tumors with nutrition and pathways for tumor cells to spread throughout the body. However, a University of Iowa study shows that highly aggressive cancer cells themselves may generate their own vascular networks independent of angiogenesis. (1999-08-30)

New anti-angiogenic proteins discovered
A team of scientist working at UCLA and Human Genome Sciences discovered two human proteins that inhibit the formation of new blood vessels and have potential for treating cancer through suppression of tumor growth. (1999-08-05)

Simple test predicts ability to grow new blood vessels: Breakthrough in battle against heart disease, diabetes, cancer
The human body is able to grow new blood vessels that compensate for the blocked vessels that cause heart attacks. These new vessels may also feed cancerous tumors and cause blindness in diabetes patients. A study published in the August 3 Circulation describes a simple blood test that can predict a person's ability to grow such vessels. Armed with this, doctors can better decide on appropriate treatment. (1999-08-02)

Protein in eyes may be potential treatment for leading causes of blindness
Northwestern researchers have found that a protein found naturally in the healthy retina halts excessive blood vessel growth in the eye and may one day be used as a treatment for diabetic retinopathy and macular degeneration, the leading causes of blindness in the Western world. (1999-07-09)

High blood pressure drug promotes new blood vessel growth in lab animals, providing potential 'angiogenesis' treatment
A drug used to lower high blood pressure can stimulate the growth of new blood vessels in laboratory animals. (1999-06-14)

Sniffing Out The Promise Of Anti-Angiogenesis Therapy
In a phase II clinical trial, researchers adminstered the anti-angiogenic small peptide IM862 to 35 patients with Kaposi's Sarcoma. The lesions of 13 patients disappeared or shrank. In 17 patients, the disease did not progress for six months or more. Few side effects were observed. (1999-05-17)

UCSF-Harvard Team Reports Encouraging Results In Drug Study Of Mice With Cancer
Researchers report that four drugs thought to disrupt the formation of blood vessels that fuel tumor growth have been shown for the first time to be effective at treating spontaneous tumors at distinct stages of progression in mice. (1999-04-30)

Scientists Discover Important Molecular Link That Allows Cells To Form Blood Vessels
The new finding may lead to the development of more targeted treatments - with fewer side effects - for cancer and other diseases that involve angiogenisis. (1999-04-15)

Inhibiting Growth Of New Blood Vessels Reduces Heart Disease Plaque In Mice
Treatment of mice with substances that halt the growth of blood vessels inhibited the development of artery-clogging deposits known as plaque, as well as the tiny blood vessels that may nourish the plaque, according to a study reported in today's Circulation: Journal of the American Heart Association. (1999-04-05)

Lo-Cal Diet Slows Prostate Cancer In Animals, New Research Finds
A low-calorie diet slows the progress of prostate cancer in animals, new research shows. The slowing of tumor progression occurred whether the calories were reduced by cutting fat, carbohydrates, or the overall diet. (1999-03-19)

Novel Biological Interaction Found To Explain Blood Vessel Growth To Tumors
Duke University Medical Center researchers believe they have answered one of cancer's central enigmas: why some blood vessels are able to grow to, and feed, tumors, while other vessels are not. (1999-03-16)

Growth Factor Contributes To Angiogenesis
A University of Michigan team has found that a natural substance known as vascular endothelial growth factor (VEGF) contributes to angiogenesis not only by stimulating blood vessel growth, but also by prolonging the survival of blood vessel cells. (1999-02-02)

Novel Therapeutic Approach To Treatment Of Arthritic Disease
Scientists at The Scripps Research Institute have studied an investigational anti-angiogenesis treatment -- previously employed against various forms of cancer -- to assess its impact on arthritic disease in an animal model. Their results, published in the January 1, 1999, issue of The Journal of Clinical Investigation, provides evidence for a central pathogenic contribution of angiogenic blood vessels to the maintenance and severity of arthritic disease. (1998-12-31)

Tumor Protein Structure Found At Cornell
For some years now, cancer researchers have known that cancerous tumors are fed nutrients and oxygen through blood vessels generated by endothelial cells. The hope is to develop drugs to prevent the cells from forming the blood vessels and thus starve the tumors. Cornell scientists describe a protein key to this process. (1998-11-12)

Wistar Scientists Find New Clue To Melanoma Development
Wistar scientist, Meenhard Herlyn, D.V.M., and his research team are studying the evolution of melanoma. His most recent studies focus on the (1998-11-02)

Discovery Of Possible New Weight Control Role For Leptin Announced By Yale University School Of Medicine Researchers
Researchers at Yale University School of Medicine and the Institutes for Pharmaceutical Discovery in Branford, Connecticut, have discovered a possible new mechanism for the body to control its fat stores by inducing the growth of new blood vessels, which suggests a new avenue for weight regulation. (1998-09-10)

Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer Center
Researchers at the UCSF Cancer Center are recruiting patients with advanced lung cancer for a clinical trial of a novel drug that they hope will inhibit the growth and spread of cancer. (1998-08-19)

Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer Center
Researchers at UCSF Cancer Center are recruiting patients with advanced lung cancer for a clinical trial of a novel drug they hope will inhibit the growth of blood vessels that nourish tumor cells. (1998-07-30)

Collaborative Research Provides New Information About Interleukin-12's Role In Angiogenesis
Interleukin-12 (IL-12), a cytokine discovered at The Wistar Institute in the mid-1980s, is known to engage in potent anti-tumor activities. Until recently, however, the biological events governing its behavior were little understood. New information shows that IL-12 provokes a series of events that ultimately interfere with tumor angiogenesis, or the formation of blood vessels that nourish and enlarge tumors. (1998-07-23)

Evidence From Old Tumors Foretells Which New Breast Cancer Patients Will RequireAdditional Treatment
In the largest study ever completed of node-negative breast cancer patients treated with surgery alone, researchers found that two biological markers -- nm23 and micro-vessel count -- could predict which breast cancers were likely to spread. Further analysis confirmed that these were (1998-07-01)

Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells
Aspirin's preventive effects on colon cancer may result from its influence on the development of blood vessels needed for tumor growth. (1998-05-29)

Angiogenesis Research May Lead To Treatments
Research on this process not only may lead to improved cancer treatments, but also may offer new approaches to treating a wide range of other medical problems, says Peter Polverini, U-M professor of dentistry and pathology who has been doing research on angiogenesis for 20 years. (1998-05-20)

Area of Research Outlined For Promising New Cancer Drugs
The effects of angiostatin and endostatin on mechanisms regulating angiogenesis in other processes besides tumor growth require additional study, says noted University of Notre Dame blood chemist Francis J. Castellino. Basic research conducted in Castellino's laboratory contributed to the identification of angiostatin, one of the promising new cancer drugs being heralded nationally this week. (1998-05-08)

Anti-Angiogenesis: A New Weapon In Cancer Therapy
As reported this week, Dr. Judah Folkman's work in cutting off a tumor's blood supply seems critical to the removal of tumors and the prevention of metastases. Related work is being done by Ribozyme Pharmaceuticals, using an anti-VEGF receptor ribozyme to inhibit angiogenesis and restrain tumor growwth. (1998-05-04)

Heart and Soul: The Blood Vessels And Brain Use Common Guide
A protein that helps wire the developing brain by preventing nerve cells from entering off-limits areas does double duty during the formation of blood vessels, ChildrenĀ¹s Hospital and Harvard Medical School researchers have found. Their findings, in the March 20 Cell, join two fast-paced fields of research: angiogenesis and axonal guidance. (1998-03-20)

Study Is First Ever To Document Protein Therapy Induces Creation Of New Blood Vessels To The Human Heart
-- For the first time, scientists have published research evidence that recombinant protein therapy can create new blood vessels to increase blood supply to the human heart. The report from German scientists appears in today's Circulation: Journal of the American Heart Association. (1998-02-24)

TSRI Scientists Discover Naturally-Occurring Mechanism Involved In Regulation Of Angiogenesis; New Anti-Cancer Therapeutic Agents Are Suggested
Scientists at The Scripps Research Institute have uncovered a naturally-occurring mechanism to help explain angiogenesis activity and developed a recombinant form of a protein fragment that blocks angiogenesis and tumor growth in an in vivo experimental model. This may provide a potentially novel therapeutic approach for diseases associated with neovascularization. (1998-02-06)

Plasminogen-related Growth Factors
Plasminogen-related growth factors presents a state-of-the- art account of a very active field of research. Suggests exciting new approaches to the treatment of cardiovascular disease and several forms of cancer. Examines in detail the role of individual domains for enzymatic proteins and plasminogen-related growth factors. (1998-01-22)

Ribozyme Pharmaceuticals Enters VEGF Receptor Ribozyme Into Product Development
This week at the AHA Conference, researchers reported on new advances in gene therapy using VEGF to treat artery blockage. Ribozyme Pharmaceuticals is working on the development of an anti-VEGF receptor ribozyme that has shown activity in animal models of angiogensis in both the eye and cancer. (1997-11-12)

Duke Researchers Show That Anti-Cancer Agents Protect Donor Livers Awaiting Transplantation
After noticing -- almost entirely by chance -- the striking cellular similarities between the damage that occurs to donor livers awaiting transplantation and the very early stages of tumor growth, Duke University Medical Center researchers believe they have found a novel way of extending the amount of time livers can remain safely. (1997-10-31)

Cancer Slowed When Blood Vessel Growth In Tumors Blocked
Researchers at Duke University Medical Center have been able to significantly slow the growth of tumors on rats by preventing the tumors from (1997-10-15)

Common High Blood Pressure Drug Is Also an Anti-cancer Agent
Captopril, a drug used by over 5 million people to treat high blood pressure and congestive heart failure, has been found effective in blocking the growth of tumors by depriving them of their essential blood supply, researchers at Northwestern Universityreport (1996-08-16)

NeXstar Creates Aptamer-Based Diagnostic Assay; Assay Aids Clinical Development Of VEGF Inhibitor
Scientists at NeXstar Pharmaceuticals have developed a new analytical method that uses aptamers to detect small amounts of clinically important substances. This technique, named the enzyme-linked oligonucleotide assay, or ELONA, not only has applicatiions in standardized-format clinical assays, but is also playing an important role in the Company's on-going development of its angiogenesis inhibitors as anti-cancer agents. (1996-08-06)

Jonsson Comprehensive Cancer Center At UCLA Is Using A New Experimental Therapy For Metastatic Breast Cancer
Angiogenisis therapy uses new drug on metastatic breast cancer for the first time in trial at UCLA (1996-07-08)

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