Current Ankylosing Spondylitis News and Events

Current Ankylosing Spondylitis News and Events, Ankylosing Spondylitis News Articles.
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AI accurately detects radiographic sacroiliitis in axial spondyloarthritis
New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that an artificial intelligence-based analysis model, called an artificial neural network, enables accurate detection of definite radiographic sacroiliitis in people with axial spondyloarthritis, an advance that could be useful for both diagnosis in the clinic and classification of patients for inclusion in clinical trials. (2020-11-06)

Minority patients with rheumatic diseases have worse COVID-19 outcomes
New research at ACR Convergence, the American College of Rheumatology's annual meeting, reveals that people of color with rheumatic disease have worse health outcomes from COVID-19 infection, are more likely to be hospitalized to treat their coronavirus infection, and are more likely to require invasive ventilator treatment. (2020-11-06)

Ankylosing spondylitis (AS): Becoming a mother despite having a rheumatic disease?
Women with ankylosing spondylitis (AS) can have children despite their rheumatic disease. But how do their children develop? A recent South Korean study has now come to the conclusion that the growth and development of infants and young children of mothers with AS are comparable to those of other mothers. Until now, several studies on the course of pregnancy in female AS patients had been conducted, but the development of their offspring had not been investigated. The study was presented at the EULAR 2020. (2020-08-04)

BIOCAD presents results of clinical trial proving efficacy of netakimab at EULAR 2020
BIOCAD presents results of clinical trial proving efficacy of netakimab in the treatment of psoriatic arthritis at the Annual European Congress of Rheumatology (EULAR 2020). Four abstracts present the results from an international randomized double-blind phase 3 clinical trial (PATERA) which demonstrate netakimab decreases disease activity and reduces skin manifestation of psoriatic arthritis through 24 weeks of therapy. (2020-06-04)

Babies exposed to TNFi or tofacitinib in utero experience very few serious infections
A new study found that very few serious infections were seen in children born to mothers with chronic inflammatory diseases who used non-TNFi biologics or tofacitinib during pregnancy compared to children not exposed to these drugs and children exposed to TNFi biologics in utero. These findings are being presented this week at the 2019 ACR/ARP Annual Meeting. (2019-11-09)

No link between cancer and tumor necrosis factor inhibitor (TNFi) use in psoriatic arthritis
The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) suggest that overall cancer risk is not linked to tumor necrosis factor inhibitor (TNFi) use in psoriatic arthritis. (2019-06-13)

Uncovering uncultivated microbes in the human gut
A human's health is shaped both by environmental factors and the body's interactions with the microbiome, particularly in the gut. Genome sequences are critical for characterizing individual microbes and understanding their functional roles. However, previous studies have estimated that only 50 percent of species in the gut microbiome have a sequenced genome, in part because many species have not yet been cultivated for study. (2019-03-14)

Immune therapy generates promising results in hard-to-treat ankylosing spondylitis
Results from a phase 3 clinical trial indicate that patients who have not benefited from standard therapy for ankylosing spondylitis (AS), a chronic inflammatory disease characterized by back pain and sacroiliac-joint damage, may have another treatment option in the biologic drug ixekizumab. (2018-10-20)

MSU scientists closer to solving arthritic condition in teens
A new Michigan State University study has found that a malfunctioning gene associated with a common arthritic disease that often starts in teenagers is now directly linked to the loss of vital immune cells that may prevent it. (2018-08-24)

IGC scientists discover a tap that controls the flow of pro-inflammatory molecules
One of the major therapeutic targets for inflammatory diseases is TNF. However, excess levels of TNF cause side effects and can lead to diseases. In a study published in eLIFE journal, a research team from Gulbenkian Institute of Science (IGC, Portugal) discovered a new protein, called iTAP, that controls the levels of TNF in circulation by regulating its release from immune cells. These findings open avenues for the design of improved therapeutics for inflammatory diseases. (2018-07-26)

Significant increase in self-harm attempts following ankylosing spondylitis diagnosis
The results of a population study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate a significantly increased rate of self-harm attempts in inflammatory arthritis (IA), particularly following a diagnosis of Ankylosing Spondylitis (AS). (2018-06-14)

Combining NSAIDs and TNFi may reduce radiographic progression in ankylosing spondylitis
The results of a cohort study presented at the Annual European Congress of Rheumatology (EULAR 2018) showed that, in patients with ankylosing spondylitis (AS) taking tumour necrosis factor (TNF) inhibitors, the addition of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with significantly less radiographic progression in a dose-related manner at four years. (2018-06-14)

A repurposed drug could open door to more stem cell transplants
Etanercept, a drug used to treat arthritis and psoriasis, boosted the survival of blood stem cells in a mouse model. The findings provide a strong basis for a clinical trial to see whether etanercept or a similar drug would improve outcomes for people receiving blood stem cell transplants. (2017-12-20)

New data released on relationship between obesity and spondyloarthropathy outcomes
Obese patients with axial spondyloarthropathy have worse disease outcomes, including higher disease activity, worse physical function and lower quality of life, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego. (2017-11-04)

Medical consultation via mobile app lowers costs and delays for arthritis patients
Researchers in China have developed a new online consultation tool for rheumatic disease patients, which may strengthen the interaction between doctors and patients and lead to more efficient management of chronic illness, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego. (2017-11-04)

Subjective complaints may cause patients to stop treatment after switching to a biosimilar
A biosimilar is a biological medicine that shows no clinically meaningful differences with another already approved biological medicine (the 'reference medicine'). (2017-10-18)

Autoimmune diseases increase cardiovascular and mortality risk
Researchers from the Hospital del Mar Medical Research Institute (IMIM) and IDIAP Jordi Gol have just published an article showing that autoimmune diseases significantly increase cardiovascular risk as well as overall mortality. This is particularly pronounced in people suffering rheumatoid arthritis or systemic lupus erythematosus. In addition, it has been seen that inflammatory bowel diseases, such as Crohn's or ulcerative colitis, increase the risk of stroke and death through any cause. (2017-08-29)

New study shows for first time link between passive smoking in childhood and rheumatoid arthritis
The results of a study presented today at the Annual European Congress of Rheumatology 2017 press conference confirmed the link between active smoking and the risk of developing rheumatoid arthritis (RA). However, interestingly, it also suggested for the first time that in smokers, exposure to tobacco early in life through passive smoking in childhood significantly increased this risk. (2017-06-16)

New medication guidelines for rheumatic disease patients having joint replacement
In the first such collaboration of its kind, an expert panel of rheumatologists and orthopedic surgeons has developed guidelines for the perioperative management of anti-rheumatic medication in patients undergoing total hip or knee replacement. The guidelines aim to reduce the risk of infection after joint replacement. (2017-06-16)

Low-dose CT scanning improves assessment of ankylosing spondylitis patients
The results of a study presented today at the Annual European Congress of Rheumatology 2017 showed that low dose computed tomography is more sensitive than conventional radiographs (X-rays) in the monitoring of disease progression in patients with Ankylosing Spondylitis (AS). (2017-06-15)

Cutting-edge analysis reveals how different drugs interact with the same target
Osaka University-led researchers identified differences in how three drugs bind to tumor necrosis factor, a key mediator of inflammatory disease. The team used sedimentation velocity analytical ultracentrifugation to investigate drug-target binding in a physiological environment and at clinically-relevant concentrations. They revealed differences between the three drugs in the size and structure of the complexes formed, which may explain differences in the drugs' clinical efficacy. This technique could help optimize future drug design. (2017-05-14)

Genetic risk factors for autism, MS and other diseases differ between the sexes
A pair of studies by researchers at UC San Francisco suggest that genetic variants that have distinct effects on physical traits such as height, weight, body mass, and body shape in men versus women are also linked to men's and women's risk for a range of diseases -- including autism, multiple sclerosis, type 1 diabetes, and others. (2017-01-20)

Combination of NSAIDs and TNF-inhibitors shows benefit for ankylosing spondylitis
A combination of nonsteroidal anti-inflammatory drugs and TNF-inhibitors may help slow down spine damage in ankylosing spondylitis, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Washington. (2016-11-12)

Statins may lower mortality risk in ankylosing spondylitis and psoriatic arthritis patients
Patients with ankylosing spondylitis or psoriatic arthritis who take statins may have as much as a 33 percent lower mortality risk, according to new research findings presented this week at the American College of Rheumatology Annual Scientific Meeting in Washington. (2016-11-12)

Too many patients with inflammatory joint diseases undermanaged for cardiovascular risk
While patients with inflammatory rheumatic diseases such as rheumatoid arthritis or spondyloarthritis are at increased risk for cardiovascular disease, too few are prescribed preventive medications or meeting target goals to prevent heart-related events, according to new research findings presented this week at the 2016 ACR/ARHP Annual Meeting in Washington. (2016-11-12)

Women & long-term axial spondyloarthropathy patients at higher risk for manifestations
Gender and disease duration can help predict which axial spondyloarthritis patients will develop extra-articular manifestations such as uveitis, or inflammation of the eye, according to new research findings presented this week at the 2016 ACR/ARHP Annual Meeting in Washington. (2016-11-12)

Novartis drugs Cosentyx® and Gleevec® win Prestigious Prix Galien Awards for 2016 Best Biotechnology Product and 'Discovery of the Decade'
Novartis Drugs Cosentyx® and Gleevec® win prestigious Prix Galien Awards for 2016 Best Biotechnology Product and 'Discovery of the Decade.' (2016-10-28)

Study shows swimming is an effective part of the treatment for fibromyalgia
A study performed by researchers at the Federal University of São Paulo shows swimming is as effective as walking to relieve pain and improve quality of life for patients with fibromyalgia, that experience chronic diffuse non-inflammatory pain in the musculoskeletal system deriving from malfunctioning of the system that transmits and modulates the transmission of nervous stimuli between the periphery of the body and the brain. The study involved 75 sedentary women who had fibromyalgia. (2016-08-18)

Facebook key to identifying thousands with inflammatory back pain
Facebook key to identifying thousands with inflammatory back pain. (2016-06-10)

Biosimilar switching not suitable for all patients
Patients with antibodies to biological infliximab are less likely to benefit from infliximab biosimilar (CT-P13) (2016-06-09)

High-throughput, sensitive approach helps reveal what's 'real' in genome-wide association data
Tackling one of the key challenges facing current human genetics, two multi-institutional research teams have demonstrated a tool that should help untangle which genetic variants actually create risk for heart disease, diabetes and a host of other diseases. The research employs an experimental technique called the 'massively parallel reporter assay' that lets researchers probe thousands of DNA variations to identify ones that affect gene regulation -- how genes are turned on and turned off. (2016-06-02)

Secukinumab in ankylosing spondylitis or psoriatic arthritis: Added benefit not proven
Drug manufacturer presented no relevant data and claimed no added benefit. Notable was the non-publication of literature searches and analyses. (2016-03-18)

Global study reveals genes as major cause of inflammatory diseases
A world-first study led by Australia's Queensland University of Technology and Germany's Christian-Albrechts-University is likely to result in new treatments for five common and painful inflammatory diseases that affect millions of people around the world. The research found genes are the major cause of them rather than environment. (2016-03-14)

Vilcek Foundation honors prominent immunologist and young researchers of promise
The Vilcek Foundation announces the winners of the 2016 Vilcek Prizes in Biomedical Science: Dan R. Littman, Professor of Molecular Immunology, NYU School of Medicine; Fernando Camargo, Associate Professor of Stem Cell & Regenerative Biology, Boston Children's Hospital and Harvard Stem Cell Institute; Roberta Capp, Assistant Professor of Emergency Medicine, University of Colorado School of Medicine; and Houra Merrikh, Assistant Professor of Microbiology, University of Washington School of Medicine. (2016-02-02)

Genetic study of patients with inflammatory bowel disease could lead to better treatments
Genetic variation in patients with inflammatory bowel disease appears to play a major role in determining how sick they will become and could provide a road map for more effective treatments. (2015-11-30)

New XELJANZ® (tofacitinib citrate) data to be presented at ACR/ARHP 2015
Pfizer Inc. announced today that 26 new scientific abstracts, including 20 presentations for XELJANZ® (tofacitinib citrate) in rheumatoid arthritis will be presented on behalf of Pfizer at the American College of Rheumatology/Association of Rheumatology Health Professionals 2015 Annual Meeting. (2015-11-02)

Researchers gauge heritability of childhood-onset autoimmune diseases
Scientists have calculated more precise measurements of heritability -- the influence of underlying genes -- in nine autoimmune diseases that begin in childhood. The research may strengthen researchers' abilities to better predict a child's risk for associated autoimmune diseases. Autoimmune diseases, such as type 1 diabetes, Crohn's disease and juvenile idiopathic arthritis, collectively affect one in 12 persons in the Western hemisphere. (2015-10-09)

Genetic overlapping in multiple autoimmune diseases may suggest common therapies
Scientists who analyzed the genes involved in 10 autoimmune diseases that begin in childhood have discovered 22 genome-wide signals shared by two or more diseases. These shared gene sites may reveal potential new targets for treating many of these diseases, in some cases with existing drugs already available for non-autoimmune disorders. (2015-08-24)

More precise colon cancer screening?
A clinical scoring system for colon cancer risk could help physicians identify which average-risk patients could potentially skip a colonoscopy and instead be screened with a less-invasive method. The researchers suggest that this approach could increase the uptake and efficiency of colorectal cancer screening. The cross-sectional study is published in Annals of Internal Medicine. (2015-08-10)

Biologics improve productivity and reduce missed workdays in rheumatic disease
The results of a systematic review of published studies presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) press conference showed that biologics improve both absenteeism (not showing up for work) and presenteeism (being at work but not functioning fully) in patients with chronic inflammatory arthritides. Rheumatic conditions are the most frequently cited reason for absence from work, and these findings suggest that biologics could significantly reduce the economic burden of these diseases. (2015-06-12)

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