Current Annual Trottier Symposium News and Events

Current Annual Trottier Symposium News and Events, Annual Trottier Symposium News Articles.
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The Protein Society announces 2022 appointment of Protein Science Editor-in-chief
The Protein Society is thrilled to announce the appointment of John Kuriyan, Ph.D., University of California, Berkeley as Editor-in-Chief of Protein Science, effective January 1, 2022. He will succeed outgoing editor Dr. Brian Matthews, who has served in this role since 2005 and provided continuous outstanding service to our society and the broader community. (2020-12-11)

Physicians don't always recognize patients' radiation therapy side effects
Physicians did not recognize side effects from radiation therapy in more than half of breast cancer patients who reported a significant symptom, a new study finds. (2020-12-09)

High-risk, HR+, HER2-, early-stage BC patients continue to benefit from abemaciclib
Extended follow-up data from the phase III monarchE trial showed that adding the cyclin-dependent kinase (CDK) inhibitor abemaciclib (Verzenio) to standard adjuvant endocrine therapy continued to improve invasive disease-free survival (IDFS) among patients with high-risk, node-positive, early-stage, HR-positive, HER2-negative breast cancer, according to data presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Under-recognition of symptoms may be common in breast cancer patients receiving radiation
Among patients with breast cancer treated with radiotherapy, under-recognition of symptoms was common in reports of pain, pruritus, edema, and fatigue, with younger patients and Black patients having significantly increased odds of symptom under-recognition. (2020-12-09)

CTC dynamics may predict treatment response/prognosis in metastatic breast cancer patients
Early circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer, according to a meta-analysis presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Mastectomy and reconstructive surgery may lead to patients becoming persistent drug users
Women who receive mastectomy and reconstructive surgery as part of breast cancer treatment may face the risk of developing persistent use of opioids and sedative-hypnotic drugs, according to data presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Postmenopausal women with early-stage BC/low recurrence score could skip adjuvant chemo
After a median follow-up of 5.1 years, among women with lymph node-positive early-stage breast cancer and a recurrence score of 25 or lower who received adjuvant endocrine therapy with or without chemotherapy, postmenopausal patients had no added benefit from chemotherapy, while premenopausal patients who received chemotherapy had improved invasive disease-free survival (IDFS) and an early indication of improved overall survival (OS), according to data from the SWOG S1007 RxPONDER clinical trial. (2020-12-09)

Omitting radiation therapy after breast-conserving surgery may not impact 10-year survival rates for older patients with HR-positive breast cancer
Older patients with hormone receptor-positive breast cancer who did not receive radiation therapy after breast-conserving surgery had higher rates of local recurrence but similar 10-year survival rates when compared to patients who received postoperative radiation therapy, according to updated 10-year data from the PRIME II study, presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Breast cancer survivors are less likely to get pregnant, but often have healthy babies and good long-term health
A large meta-analysis of breast cancer survivors of childbearing age indicated that they are less likely than the general public to get pregnant, and they face higher risk of certain complications such as preterm labor. However, most survivors who do get pregnant deliver healthy babies and have no adverse effects on their long-term survival, according to data presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Lab closed? Head to the kitchen
Studies explore fluids in pancakes, beer, and the kitchen sink. (2020-11-23)

Supersized wind turbines generate clean energy--and surprising physics
As wind energy scales up, researchers study the fluid dynamics challenges. (2020-11-23)

COVID leads to measurable life expectancy drop in Spain, study finds
Spain's annual life expectancy at birth dropped by 0.9 years between 2019 and the annual period up until July 2020 due to the COVID-19 pandemic, according to a new study published this week in the open-access journal PLOS ONE by Sergi Trias-Llimos of the Center for Demographic Studies, Spain, and colleagues. (2020-11-11)

Machine learning helps predict survival rates of out-of-hospital cardiac arrest
Machine learning predictions about the survival rate of an out-of-hospital cardiac arrest were more accurate when neighborhood-level factors were added to the data analysis. Future research can use this newly developed model to identify neighborhood-level intervention methods to decrease death rates from an out-of-hospital cardiac arrest. (2020-11-09)

Detection of a short, intense radio burst in Milky Way
New data from a Canadian-led team of astronomers, including researchers from the McGill Space Institute and McGill University Department of Physics, strongly suggest that magnetars -- a type of neutron star believed to have an extremely powerful magnetic field -- could be the source of some fast radio bursts (FRBs). (2020-11-04)

Next generation BRAF inhibitor cancer drug shows promise in early patient trial
A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial presented at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-25)

Vaccine to treat and prevent lung, bowel and pancreatic cancer shows promise in the lab
An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (2020-10-22)

Simple software creates complex wooden joints
Wood is considered an attractive construction material for both aesthetic and environmental purposes. Construction of useful wood objects requires complicated structures and ways to connect components together. Researchers created a novel 3D design application to hugely simplify the design process and also provide milling machine instructions to efficiently produce the designed components. The designs do not require nails or glue, meaning items made with this system can be easily assembled, disassembled, reused, repaired or recycled. (2020-10-21)

Existing heart drugs may help cancer patients respond better to PD(L)1 immunotherapy
Researchers have found that a class of commonly-used heart drugs may also improve patients' responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-21)

Results from the VOYAGER PAD Trial reported at TCT Connect
A large subgroup analysis of a randomized clinical trial showed neither a mortality risk nor benefit associated with the use of paclitaxel drug-coated devices (DCD) in the treatment of peripheral artery disease (PAD). The study also found that the benefit of rivaroxaban use on reducing ischemic limb and cardiovascular outcomes was consistent regardless of whether a DCD was used. (2020-10-19)

Results from host-reduce-polytech-ACS trial reported at TCT Connect
A randomized clinical trial found that drug-eluting stents (DES) with durable polymers are non-inferior to DES with biodegradable polymers in patients with acute coronary syndrome (ACS). Findings were reported today at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. (2020-10-17)

Results from the cobra-reduce trial reported at TCT Connect
For patients undergoing percutaneous coronary intervention (PCI) that also require oral anticoagulation, treatment with a nanotechnology polymer-coated stent plus 14-day dual anti-platelet therapy (DAPT) did not reduce bleeding or establish non-inferior outcomes for thrombotic events compared with a drug-eluting stent (DES) and standard three or six-month DAPT therapy. (2020-10-17)

Results from the optimize trial reported at TCT Connect
The OPTIMIZE randomized trial comparing a novel, low-profile drug-eluting stent (DES) facilitating transradial access (TR) and direct stenting (DS) to existing DES did not establish non-inferiority of the new stent based on the prespecified study statistical analysis plan, likely due to the definition of periprocedural target vessel myocardial infarction (TVMI) coupled with a large proportion of high-sensitive cardiac troponin assays used in the trial. (2020-10-17)

Results from the FORECAST Trial reported at TCT Connect
In the FORECAST randomized clinical trial, the use of fractional flow reserve management derived from computed tomography (FFRCT) did not significantly reduce costs but did reduce the use of invasive coronary angiography (ICA). (2020-10-16)

Results from the TARGET FFR study reported at TCT Connect
Results from the randomized controlled TARGET FFR trial show that while a physiology-guided percutaneous coronary intervention (PCI) optimization strategy did not achieve a significant increase in the proportion of patients with final FFR ?0.90, it reduced the proportion of patients with a residual FFR ?0.80 following PCI. (2020-10-16)

Results from the DEFINE-FLOW study reported at TCT Connect
A new observational study of deferred lesions following combined fractional flow reserve (FFR) and coronary flow reserve (CFR) assessments found that untreated vessels with abnormal FFR but intact CFR do not have non-inferior outcomes compared to those with an FFR greater than 0.8 and a CFR greater than or equal to two when treated medically. (2020-10-16)

Strategic interventions in dairy production in developing countries can help meet growing global demand for milk
Feed the Future Innovation Lab for Livestock Systems hosted the ''MILK Symposium: Improving Milk Production, Quality, and Safety in Developing Countries'' at the 2019 American Dairy Science Association® Annual Meeting to address factors that cause low dairy consumption in low- and middle-income countries and discuss strategies to address them. The Journal of Dairy Science invited speakers to submit articles on topics from the symposium to reach a wider audience. (2020-10-15)

New bioprosthetic valve for TAVR fails to demonstrate non-inferiority
In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve. (2020-10-15)

Results from the REFLECT II Trial reported at TCT Connect
The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of the device for the primary hierarchical efficacy endpoint. (2020-10-15)

Results from the MITHRAS trial reported at TCT Connect and published in Circulation
The MITHRAS randomized clinical trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair (TMVR) was not superior to conservative medical treatment with regard to the primary endpoint of change in six-minute walking distance. (2020-10-15)

Results from PROSPECT ABSORB reported at TCT Connect and published simultaneously in JACC
New data from PROSPECT ABSORB, a pilot randomized trial of percutaneous coronary intervention (PCI) of non-flow-limiting vulnerable plaques in native coronary arteries, found that PCI was safe, substantially enlarged follow-up lumen areas, and was associated with favorable long-term clinical outcomes. (2020-10-14)

Results from COMBINE (OCT-FFR) reported at TCT Connect
Data from COMBINE (OCT-FFR) found that the use of FFR combined with OCT imaging can help improve the accuracy of high-risk lesion identification in patients with diabetes. Findings were reported today at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world's premier educational meeting specializing in interventional cardiovascular medicine. (2020-10-14)

Results of an individual patient data pooled analysis reported at RCT Connect
An individual patient data pooled analysis comparing the use of bivalirudin versus heparin in heart attack patients undergoing percutaneous coronary intervention (PCI) found that bivalirudin use was associated with similar overall rates of 30-day mortality across all heart attack patients, but lower rates of serious bleeding events. Moreover, mortality was reduced in patients with ST-segment elevation myocardial infarction (STEMI) who were treated with a post-PCI bivalirudin infusion. (2020-10-14)

NIRS-IVUSimaging can help identify high-risk plaques that can lead to adverse outcomes
New data from the PROSPECT II study shows that NIRS-IVUS intracoronary imaging can help identify angiographically non-obstructive lesions with high-risk characteristics for future adverse cardiac outcomes. (2020-10-14)

Advances in nonhormone therapies provide women with more options for managing hot flashes
Although many women manage menopause symptoms with hormone therapy, increasing numbers of women are considering nonhormone options. Dr. Susan Reed from the University of Washington School of Medicine is a featured speaker during the 2020 Pre-Meeting Symposium of The North American Menopause Society (NAMS) and will discuss the latest advances in nonhormone hot flash management. One of the more promising drug developments targets the KNDy neuron complex. (2020-09-28)

New hormone therapies for hot flashes offer enhanced benefits and minimized risk
Hormone therapy remains the best proven method for managing menopause symptoms such as hot flashes. Research continues, however, in the area to identify novel approaches to estrogen therapy that minimize any associated risks. Dr. Hugh Taylor from Yale School of Medicine will discuss some of the latest developments, including fetal estrogens, during the 2020 Pre-Meeting Symposium of The North American Menopause Society (NAMS). (2020-09-28)

Study reveals design flaws of chatbot-based symptom-checker apps
Millions of people turn to their mobile devices when seeking medical advice. They're able to share their symptoms and receive potential diagnoses through chatbot-based symptom-checker (CSC) apps. But how do these apps compare to a trip to the doctor's office? Not well, according to a new study. Researchers from Penn State's College of Information Sciences and Technology have found that existing CSC apps lack the functions to support the full diagnostic process of a traditional visit to a medical facility. (2020-09-25)

Popular messenger services are extremely insecure
Researchers from the Technical University of Darmstadt and the University of W├╝rzburg show that popular mobile messengers expose personal data via discovery services that allow users to find contacts based on phone numbers from their address book. (2020-09-15)

Spotlight on artificial intelligence: ONR to highlight AI research at DoD Symposium
Leaders from the Office of Naval Research will discuss how the Department of the Navy can best harness the power and potential of artificial intelligence (AI) during two panel sessions at the Department of Defense (DoD) Artificial Intelligence Symposium and Exposition, held Sept. 9-10, 2020. The two-day virtual event is sponsored by the DoD's Joint Artificial Intelligence Center. (2020-09-09)

New research on Post-fracture Care Coordination Programs highlighted at WCO-IOF-ESCEO
After the first fragility fracture, there is a high risk of subsequent fractures, with the risk highest in the following two years. This is why secondary fracture prevention, and specifically topics related to Post-fracture Care Coordination Program (such as Fracture Liaison Service - FLS) development, are a focus of several live and pre-recorded presentations at the virtual World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2020 from August 20-22, 2020. Several of these important sessions and related abstracts are highlighted. (2020-08-21)

PARP inhibitor becomes new treatment option for some men with advanced prostate cancer
Results from an international clinical trial found that men with advanced prostate cancer who have mutated BRCA1/BRCA2 genes can be treated successfully with a targeted therapy known as rucaparib. (2020-08-14)

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