Current Antibiotic Resistance News and Events | Page 2

Current Antibiotic Resistance News and Events, Antibiotic Resistance News Articles.
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In preclinical models, antiviral better inhibits COVID-19 than Remdesivir; further studies warranted
Working in preclinical models, researchers report that plitidepsin, a drug with limited clinical approval for the treatment of multiple myeloma, is more potent against SARS-CoV-2 than remdesivir, an antiviral that received FDA emergency use authorization for the treatment of COVID-19 in 2020. (2021-01-25)

Antibiotic resistance may spread even more easily than expected
Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers. (2021-01-21)

New study: nine out of ten US infants experience gut microbiome deficiency
A new peer-reviewed study reveals that the vast majority of US infants may be suffering from a substantial deficiency in an important bacterium key to breast milk utilization and immune system development, as well as protection against gut pathogens linked to common newborn conditions such as colic and diaper rash. The study is the largest to date to benchmark the widespread deficiency in gut bacteria among US infants, and the resulting diminished function of their gut microbiomes. (2021-01-21)

Hope for a vaccination against Staphylococcus areus infections?
Staphylococcus aureus (S. aureus) ranks among the globally most important causes of infections in humans and is considered a dreaded hospital pathogen. Active and passive immunisation against multi-resistant strains is seen as a potentially valuable alternative to antibiotic therapy. However, all vaccine candidates so far have been clinically unsuccessful. With an epitope-based immunisation, scientists at Cologne University Hospital and the German Center for Infection Research (DZIF) have now described a new vaccination strategy against S. aureus in the Nature Partner Journal NPJ VACCINES. (2021-01-20)

Message in a bottle: Info-rich bubbles respond to antibiotics
In a new study, Luis H. Cisneros and his colleagues describe the effects of antibiotics on membrane vesicles, demonstrating that such drugs actively modify the properties of vesicle transport. Under the influence of antibiotics, MVs were produced and released by bacteria in greater abundance and traveled faster and further from their origin. The work sheds new light on these important information-carrying entities, implicated in many cellular communication processes, including antibiotic resistance. (2021-01-20)

Inflamed environment is C. diff paradise
A new study shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive. (2021-01-19)

Research establishes antibiotic potential for cannabis molecule
The main nonpsychoactive component of cannabis has been shown to kill the bacteria responsible for gonorrhoea, meningitis and legionnaires disease, which could lead to the first new class of antibiotics for resistant bacteria in 60 years. (2021-01-19)

Unlocking 'the shape of water' in mechanisms of antibiotic resistance
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs. (2021-01-19)

Synthesis of potent antibiotic follows unusual chemical pathway
Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn State chemists, could allow researchers to adapt this and similar compounds for use in human medicine. (2021-01-18)

DNA test can quickly identify pneumonia in patients with severe COVID-19, aiding faster treatment
Researchers have developed a DNA test to quickly identify secondary infections in COVID-19 patients, who have double the risk of developing pneumonia while on ventilation than non-COVID-19 patients. (2021-01-15)

Researchers show Irish soil can offer more hope in fight against antibiotic resistance
Scientists who highlighted the bug-busting properties of bacteria in Northern Irish soil have made another exciting discovery in the quest to discover new antibiotics. (2021-01-14)

Evolution in a test tube: these bacteria survive on deadly copper surfaces
The descendants of regular wild-type bacteria can evolve to survive for a long time on metallic copper surfaces that would usually kill them within a few minutes. An international research team led by Martin Luther University Halle-Wittenberg (MLU) and the Bundeswehr Institute of Microbiology was able to produce these tiny survivalists in the lab and has been able to study them more closely. The team reports on its findings in Applied and Environmental Microbiology. (2021-01-13)

Monash University leads breakthrough against antibiotic-resistance
New research published today has discovered how to revert antibiotic-resistance in one of the most dangerous superbugs. (2021-01-12)

Gene-editing produces tenfold increase in superbug slaying antibiotics
Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics. (2021-01-12)

Beating the 'billion-dollar bug' is a shared burden
A new study linking land use patterns and pest outbreaks in Bt maize suggests that slowing the resurgence of western corn rootworm may require a larger-scale strategy than previously thought. (2021-01-12)

Core design strategy for fire-resistant batteries
The Korea Institute of Science and Technology(KIST) is proud to announce that the research team of Dr. Sang-baek Park at the Center for Energy Materials Research, in collaboration with the research team of Professor Hyun-jung Shin of Sungkyunkwan University, has developed a breakthrough material design strategy that can overcome the problem of high interfacial resistance between the solid electrolyte and the cathode, which is an obstacle to the commercialization of all-solid-state batteries. (2021-01-11)

Antibiotic resistance from random DNA sequences
An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely random DNA sequences. The results have been published in the journal PLOS Genetics. (2021-01-08)

Where antibiotic resistance comes from
By comparing thousands of bacterial genomes, scientists in Gothenburg, Sweden have traced back the evolutionary history of antibiotic resistance genes. In almost all cases where an origin could be determined, the gene started to spread from bacteria that, themselves, can cause disease. (2021-01-07)

Response to infection therapy better understood thanks to a new technique
A sequencing-based solution can be utilised to determine infection clearance and microbiota recovery. Next, the researchers will apply the technique to investigate the coronavirus disease. (2021-01-07)

Antibiotics not needed after most sinus surgeries: randomized controlled trial
Randomized controlled trial comparing antibiotics and placebo after routine endoscopic sinus surgery found no difference in outcomes including infection rates and symptoms. More gastrointestinal side effects were reported in patients taking antibiotics. (2021-01-06)

Not just a guys' club: Resistance training benefits older women just as much as older men
Sure, everything might come down to sex - but not when strength training is concerned. (2021-01-06)

New imaging method reveals if antibiotics reach bacteria hiding in tissues
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance. (2021-01-05)

Fluoride to the rescue?
Scientists have long been aware of the dangerous overuse of antibiotics and the increasing number of antibiotic-resistant microbes that have resulted. While over-prescription of antibiotics for medicinal use has unsettling implications for human health, so too does the increasing presence of antibiotics in the natural environment. The latter may stem from the improper disposal of medicines, but also from the biotechnology field, which has depended on antibiotics as a selection device in the lab. (2021-01-04)

New mutations in malaria parasite encourage resistance against key preventive drug
In the ongoing arms race between humans and the parasite that causes malaria, Taane Clark and colleagues at the London School of Hygiene and Tropical Medicine (LSHTM) report that new mutations that enhance resistance to a drug used to prevent malaria in pregnant women and children are already common in countries fighting the disease. The new results are published Dec. 31 in PLOS Genetics. (2020-12-31)

Scientists turned toxic pesticide into treatment against antibiotic-resistant bacteria
Russian scientists from Kaliningrad and St. Petersburg have synthesized nitrogen-containing cyclic compounds that differ only in the relative position of side substituents. They are analogs of pesticides which are toxic and carcinogenic to humans, but the modifications allowed turning them into a powerful weapon against bacteria resistant to most antibiotics. (2020-12-29)

The puzzle of nonhost resistance: why do pathogens harm some plants but not others?
There are many examples of plants that are susceptible to one pathogen but able to resist another closely related pathogen. By uncovering the mechanism behind resistance, we can obtain a deeper understanding of the plant immune system and can also uncover previously unknown aspects of immune signaling and regulation, which can help scientists improve resistance against a broader spectrum of pathogens. (2020-12-29)

Theory describes quantum phenomenon in nanomaterials
Theoretical physicists Yoshimichi Teratani and Akira Oguri of Osaka City University, and Rui Sakano of the University of Tokyo have developed mathematical formulas that describe a physical phenomenon happening within quantum dots and other nanosized materials. The formulas, published in the journal Physical Review Letters, could be applied to further theoretical research about the physics of quantum dots, ultra-cold atomic gasses, and quarks. (2020-12-23)

Wistar reports new class of antibiotics active against a wide range of bacteria
Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature. (2020-12-23)

With COVID exacerbating superbug threat, researchers ID new weapon
Researchers have discovered a compound capable of pushing through barriers used by Gram-negative bacteria to resist antibiotics, damaging the bugs and preventing them from spreading. (2020-12-23)

Discovery of chemical clue may lead to solving cacao's black pod rot mystery
The finding of relatively high levels of the antimicrobial compound clovamide in the leaves of a disease-resistant strain of cacao has significant implications for breeding trees that can tolerate black pod rot, according to Penn State researchers who conducted a novel study. (2020-12-23)

Breaking bad: how shattered chromosomes make cancer cells drug-resistant
UC San Diego and Ludwig Cancer Research scientists describe how a phenomenon known as ''chromothripsis'' breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth. (2020-12-23)

Ludwig Cancer Research study reveals how ecDNA forms and drives cancer drug resistance
Researchers led by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the mystery of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to generate drug resistance in cancer. (2020-12-23)

Surveillance of antimicrobial resistance could be more challenging outside of the EU
In a new policy report from the Microbiology Society, experts from around the UK explain the desperate need for long-term and ambitious funding for surveillance and research into antimicrobial resistance (AMR). (2020-12-21)

Scientists develop an efficient way to produce low-cost heatsinks
NUST MISIS scientists found a way to reduce the cost of industrial and electronics heatsinks production up to 10 times. Consequently, the product itself would also cost less. The proposed methods presume the use of rubbers and silicon carbide as components, i.e. these components are mixed, pressed and sintered. The article on the research is published in Polymers. (2020-12-21)

Evolution of a killer: How African Salmonella made the leap from gut to bloodstream
University of Liverpool scientists have exploited the combined power of genomics and epidemiology to understand how a type of Salmonella bacteria evolved to kill hundreds of thousands of immunocompromised people in Africa. (2020-12-21)

Chemical composition of wild potato relative contributes to its resistance to pathogen
Potato (Solanum tuberosum) is the most consumed vegetable crop worldwide. However, despite its importance, potato production is severely affected by high susceptibility to a wide range of microbial pathogens, such as bacteria from the genus Pectobacterium, which cause various devastating diseases in potato and produce important economic losses. (2020-12-21)

Loss of anti-tumor protein may cause resistance to certain cancer therapies
The absence of a protein that works to prevent tumor formation may explain why some patients are resistant to a common cancer therapy, according to Penn State College of Medicine researchers. They said that testing cancers for the presence of this protein may help clinicians identify patients who may be resistant to or relapse when treated with the therapy. (2020-12-21)

How to stop infections caused by carbapenemase-producing bacteria
The authors aimed to evaluate in vivo the efficacy of imipenem plus meropenem in an experimental murine model of sepsis caused by clinical isolates of carbapenemase-producing A. baumannii. The results of this study show that the combination of imipenem plus meropenem could be effective in the treatment of infections caused by strains of carbapenemase-producing A. baumannii (OXA-23 and OXA-58). (2020-12-16)

An atlas of S. pneumoniae and host gene expression during colonization and disease
The bacteria Streptococcus pneumoniae colonizes the nasopharynx and can cause pneumonia. Then, it can spread to the bloodstream and cause organ damage. To understand how this pathogen adapts to different locations in the body, and also how the host responds to the microbe, researchers have measured bacterial and host gene expression at five different sites in a mouse model -- the nasopharynx, lungs, blood, heart and kidneys -- using three genetically different strains of S. pneumoniae. (2020-12-16)

New recipe for antibiotic could prevent deafness
Stanford Medicine scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. (2020-12-16)

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