Current Antibiotic Resistance News and Events | Page 25

Current Antibiotic Resistance News and Events, Antibiotic Resistance News Articles.
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Better assessing bacteria sensitivity to antibiotics could change how drugs are prescribed
We rely on antibiotics to treat bacterial infections, but the rise of antibiotic-resistant bacteria forces doctors and patients to contend with shifting treatment plans. Furthermore, current laboratory tests to determine what bacteria is causing a particular infection takes days to complete and can be too late for the patient. Mechanical engineers in Korea recently developed a microchip antibiotic testing platform that takes only six to seven hours to determine the appropriate medication. (2019-02-05)

Educational intervention cuts unnecessary antibiotic prescriptions in China
An educational intervention aimed at rural Chinese primary care doctors reduced antibiotic prescriptions for childhood upper respiratory tract infections (URTIs) by 36 percent, even a year after the intervention ended, according to a study published this week in PLOS Medicine by Xiaolin Wei from Dalla Lana School of Public Health of the University of Toronto in Canada, Qiang Sun from School of Health Care Management of the Shandong University in China, and colleagues. (2019-02-05)

Revealing the path of a metallodrug in a breast cancer cell
Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic molecule as an antitumor drug. Their research has given thorough insights into its mechanism in attacking cancer cells. This study is published in Angewandte Chemie. (2019-02-04)

Rapid gene cloning technique will transform crop disease protection
Researchers have pioneered a new method which allows them to rapidly recruit disease resistance genes from wild plants and transfer them into domestic crops. (2019-02-04)

Harvesting wild genes gives crops renewed resistance to disease
A global alliance of researchers has pioneered a new method to rapidly recruit disease-resistance genes from wild plants for transfer into domestic crops. The technique promises to revolutionize the development of disease-resistant varieties for the global food supply. (2019-02-04)

The web meets genomics: a DNA search engine for microbes
Microbes are the most common and diverse organisms on the planet. A new search engine, called BIGSI, allows scientists to search public microbial DNA data for specific genes and mutations. This could help researchers monitor the spread of antibiotic resistance genes, and understand how bacteria and viruses evolve and adapt. (2019-02-04)

Microbes hitched to insects provide a rich source of new antibiotics
In an exhaustive search of microbes from more than 1,400 insects collected from diverse environments across North and South America, a UW-Madison research team found that insect-borne microbes often outperformed soil bacteria in stopping some of the most common and dangerous antibiotic-resistant pathogens. (2019-02-01)

Insecticide resistance genes affect vector competence for West Nile virus
In a context of overuse of insecticides, which leads to the selection of resistant mosquitoes, it is already known that this resistance to insecticides affects interactions between mosquitoes and the pathogens they transmit. Researchers from the Institut Pasteur (Paris) and its partners prove that mechanisms of insecticide resistance, observed in Culex quinquefasciatus vector, impact the transmission of West Nile virus. (2019-01-31)

Study: Understanding white blood cells' defense mechanisms could lead to better treatments
A laboratory-created microscopic network of fibers helped researchers understand how white blood cells capture and even kill bacteria, offering insight into the effectiveness of antibiotics in the future. (2019-01-31)

Waterproof graphene electronic circuits
Water molecules distort the electrical resistance of graphene, but a team of European researchers has discovered that when this two-dimensional material is integrated with the metal of a circuit, contact resistance is not impaired by humidity. This finding will help to develop new sensors -- the interface between circuits and the real world -- with a significant cost reduction. (2019-01-30)

RCSI researchers develop new treatment for bone infection using copper-rich glass implant
A team of researchers led by RCSI (Royal College of Surgeons in Ireland), have developed a new treatment for the particularly difficult-to-treat bone infection, osteomyelitis. (2019-01-30)

Researchers develop new approach for vanquishing superbugs
A scientific team from Case Western Reserve University School of Medicine and Cleveland Clinic has developed a new way to identify second-line antibiotics that may be effective in killing germs already resistant to a first-line antibiotic -- potentially helping overcome antibiotic resistance. This new research provides an approach clinicians could consult when deciding which antibiotic treatment courses will be most effective for patients. (2019-01-30)

Train harder, for less time
New research, published in Experimental Physiology by researchers from the University of Glasgow, has highlighted several of the positive health effects of a short duration, high-intensity resistance exercise training program in overweight men. The findings of this study suggest that a six week program consisting of three 15-minute sessions per week dramatically improves insulin sensitivity, as well as muscle size and strength in this population. (2019-01-29)

Peptide papers point to new ways of tackling bacteria
A team of researchers have solved a 20-year riddle of how a crucial step in the biosynthesis of 'last-resort' antibiotics occurs. The researchers have opened the way to potentially redesigning the antibiotics by altering the peptide assembly involved. This work is linked by a common enzymatic machinery that has great potential to produce highly complex bioactive molecules. (2019-01-28)

'Superbug gene' found in one of the most remote places on Earth
Antibiotic-resistant genes (ARGs) that were first detected in urban India have been found 8,000 miles away in one of the last 'pristine' places on earth, a new study has shown. (2019-01-27)

PopPUNK advances speed of bacterial pathogen surveillance
In a study published today in Genome Research, researchers developed PopPUNK (Population Partitioning Using Nucleotide K-mers), a computational tool for analyzing tens of thousands of bacterial genomes in a single run, up to 200-fold faster than previous methods. Researchers envision PopPUNK will expedite the identification of bacterial strains as the scale of bacterial genomes being sequenced increases and, importantly, allow public health agencies to quickly identify outbreak strains that pose a public health risk. (2019-01-24)

Greater access to information reduces unnecessary antibiotic prescriptions
A new study in the Journal of Antimicrobial Chemotherapy suggests that providing more information about how doctors prescribe drugs could reduce problems associated with overprescription. (2019-01-23)

Gene changes may predict breast cancer relapse, study suggests
Scientists at the University of Edinburgh have identified genetic changes that may predict the likelihood of breast cancer relapse in women taking a common type of hormone therapy. (2019-01-21)

New drug resistance process found in bacteria
Researchers at the UAB and the UMBC have described a new process capable of generating resistance to synthetic antibacterial drugs within bacterial populations long before their invention and without the existence of any similar substance in nature. The study has established that sulfonamide-resistant genes appeared million years ago thanks to a mutation in the drug's target gene. (2019-01-21)

Antibiotics still routinely prescribed in the ER for infants with viral lung infections
Despite recommendations first issued more than a decade ago, antibiotics are still routinely prescribed in US emergency rooms for infants with bronchiolitis, a common viral lung infection. Published in the Journal of the Pediatric Infectious Diseases Society, the findings highlight a concerning lag in translating evidence-based guidelines into clinical practice and underscore the need to continue educating health care providers and the public about appropriate antibiotic use. (2019-01-17)

Resist! TAK1 enables endothelial cells to avoid apoptosis
TNFα-induced cell death is tightly regulated and resisted in endothelial cells. Here, an Osaka University-led research team used a unique type of mouse, in which TAK1 could be deleted in specific tissues, to show that TAK1 is an essential component in ensuring survival of endothelial cells during inflammation and injury, and that TAK1 could be a novel target for anti-angiogenic therapy in cancer treatment. (2019-01-17)

Molecular machinery that makes potent antibiotic revealed after decades of research
Scientists at Rutgers and universities in Russia, Poland and England have solved a nearly 30-year mystery -- how the molecular machinery works in an enzyme that makes a potent antibiotic. The findings, which appear in the journal Molecular Cell, provide the tools to design new antibiotics, anticancer drugs and other therapeutics. (2019-01-17)

Whole genome sequencing method may speed personalized treatment of drug-resistant infections
Researchers at Johns Hopkins Medicine say they have added to evidence that rapid resistance gene sequencing technology can accurately speed the identification of specific antibiotic-resistant bacteria strains that sicken and kill some patients. A report on a proof of concept study, published in the January 2019 issue of Antimicrobial Agents and Chemotherapy, suggests the technology has the potential to hasten the 'personalized' choice of antibiotics critically ill patients need. (2019-01-17)

Potential biotech and health applications with new knowledge on bacteria and viruses
University of Otago research to better understand how bacteria and their viruses interact and evolve will enable future studies to exploit the use of bacteria and their viruses for potential biotechnology and health applications. (2019-01-17)

Fighting deadly drug resistant bacteria in intestines with new antibiotic
Clostridium difficile infection (CDI) is a potentially deadly infection in the large intestine most common in people who need to take antibiotics for a long period of time, particularly in Australia's ageing population. But when doses of a new antibiotic called Ramizol were given to hamsters infected with a lethal dose of the bacteria, a significant proportion of hamsters survived the infection. (2019-01-17)

Simple rules predict and explain biological mutualism
Scientists have long employed relatively simple guidelines to help explain the physical world, from Newton's second law of motion to the laws of thermodynamics. Biomedical engineers at Duke University have used dynamic modeling and machine learning to construct similarly simple rules for complex biology. They have devised a framework to accurately interpret and predict the behavior of mutually beneficial biological systems, such as human gut bacteria, plants and pollinators, or algae and corals. (2019-01-16)

Trends over time in antibiotic prescribing by dermatologists
This study looked at trends over time in oral antibiotic prescribing by dermatologists using commercial insurance claims data for almost 986,000 courses of oral antibiotics prescribed by nearly 12,000 dermatologists. (2019-01-16)

Unintended side effects: antibiotic disruption of the gut microbiome dysregulates skeletal health
Diet and exercise regulate the accrual of bone mass, but some evidence suggests the microbiome may also play a role. Researchers at the Medical University of South Carolina examined how the gut microbiome impacts skeletal health and what happens when the system is perturbed. They showed that antibiotic disruption of the gut microbiota induced a pro-inflammatory response that led to increased osteoclast activity and suppressed bone mass accrual in the post-pubertal developing skeleton. (2019-01-16)

Almost a quarter of antibiotic prescriptions in the US are inappropriate
Almost of quarter of antibiotic prescriptions claimed by privately insured outpatients in the US are inappropriate, reveals a study of over 19 million patients published in The BMJ today. (2019-01-16)

Nearly a quarter of antibiotic prescriptions for children and adults may be unnecessary
One in 10 children and about one in six adults with private insurance received antibiotics they didn't need at least once in 2016, a new Michigan Medicine study suggests. (2019-01-16)

Only 13 percent of outpatient antibiotic prescriptions considered appropriate
Only 13 percent of outpatient antibiotic prescriptions are considered appropriate and 36 percent considered potentially appropriate, according to a new study from Northwestern Medicine, the University of Michigan and Harvard University's Brigham and Women's Hospital. The study provides the most extensive assessment of outpatient antibiotic prescriptions to date and demonstrates the scale of inappropriate antibiotic prescribing in the US.  (2019-01-16)

JAMA report outlines recommendations for evaluation and management of penicillin allergy
A review article in the Jan. 15, 2019, issue of JAMA recommends best practices for evaluation of reported penicillin allergies and provides clinicians with guidance and tools to help determine appropriate procedures based on the severity of previously reported reactions. (2019-01-15)

Scientists identify gene contributing to prostate cancer drug resistance
Researchers have discovered how a gene involved in regulating hormone receptors may contribute to drug resistance in some prostate cancer patients. (2019-01-15)

UM professor co-authors report on the use of biotechnology in forests
University of Montana Professor Diana Six is one of 12 authors of a new report that addresses the potential for biotechnology to provide solutions for protecting forest trees from insect and pathogen outbreaks, which are increasing because of climate change and expanded global trade. (2019-01-15)

Blueprint for plant immune response found
Washington State University researchers have discovered the way plants respond to disease-causing organisms, and how they protect themselves, leading the way to potential breakthroughs in breeding resistance to diseases or pests. (2019-01-11)

Gene-editing tool CRISPR repurposed to develop better antibiotics
A University of Wisconsin-Madison researcher and his collaborators at the University of California, San Francisco have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ones. (2019-01-11)

New strategy may curtail spread of antibiotic resistance
In studying a bacterium that causes disease in hospitalized people, researchers at Washington University School of Medicine in St. Louis have figured out a key step in the transmission of antibiotic resistance from one bacterium to another. Their insight suggests a new strategy for stopping the spread of antibiotic resistance. (2019-01-09)

RCSI researchers develop new tuberculosis treatment
Led by researchers at RCSI (Royal College of Surgeons in Ireland), a team of researchers has developed a new treatment for tuberculosis (TB). This work could offer a practical treatment that has the potential to be scaled-up and mass-produced for clinical testing. (2019-01-08)

New anti-Wolbachia drug with potential to treat onchocerciasis and lymphatic filariasis
Researchers from LSTM and the University of Liverpool have successfully optimised a hit from a whole cell screening of a 10000-compound library to deliver the first novel fully synthetic and rationally designed anti-Wolbachia drug, AWZ1066S, which could potentially be used to treat onchocerciasis and lymphatic filariasis (LF). (2019-01-08)

Antibiotic resistance in the environment linked to fecal pollution
A study shows that 'crAssphage', a virus specific to bacteria in human feces, is highly correlated to the abundance of antibiotic resistance genes in environmental samples. (2019-01-08)

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