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Current Antibiotic News and Events, Antibiotic News Articles.
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Scientists turned toxic pesticide into treatment against antibiotic-resistant bacteria
Russian scientists from Kaliningrad and St. Petersburg have synthesized nitrogen-containing cyclic compounds that differ only in the relative position of side substituents. They are analogs of pesticides which are toxic and carcinogenic to humans, but the modifications allowed turning them into a powerful weapon against bacteria resistant to most antibiotics. (2020-12-29)

Wistar reports new class of antibiotics active against a wide range of bacteria
Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today in Nature. (2020-12-23)

Evolution of a killer: How African Salmonella made the leap from gut to bloodstream
University of Liverpool scientists have exploited the combined power of genomics and epidemiology to understand how a type of Salmonella bacteria evolved to kill hundreds of thousands of immunocompromised people in Africa. (2020-12-21)

How to stop infections caused by carbapenemase-producing bacteria
The authors aimed to evaluate in vivo the efficacy of imipenem plus meropenem in an experimental murine model of sepsis caused by clinical isolates of carbapenemase-producing A. baumannii. The results of this study show that the combination of imipenem plus meropenem could be effective in the treatment of infections caused by strains of carbapenemase-producing A. baumannii (OXA-23 and OXA-58). (2020-12-16)

New recipe for antibiotic could prevent deafness
Stanford Medicine scientists have discovered a simple method of reformulating gentamicin, a commonly used and highly effective antibiotic, that could prevent its toxic side effect of hearing loss. (2020-12-16)

Insecure livelihoods hindering efforts to combat anti-microbial resistance globally
Patients living in precarious circumstances are less likely to use antibiotics appropriately according to a new study from the University of Warwick, suggesting that efforts to improve conditions for those with little security in their livelihoods could have an unexpected benefit in helping to tackle antimicrobial resistance globally. (2020-12-09)

Quick and sensitive identification of multidrug-resistant germs
Researchers from the University of Basel have developed a sensitive testing system that allows the rapid and reliable detection of resistance in bacteria. The system is based on tiny, functionalized cantilevers that bend due to binding of sample material. In the analyses, the system was able to detect resistance in a sample quantity equivalent to 1-10 bacteria. (2020-12-07)

Medicine-carriers made from human cells can cure lung infections
Scientists used human white blood cell membranes to carry two drugs, an antibiotic and an anti-inflammatory, directly to infected lungs in mice. The nano-sized drug delivery method successfully treated both the bacterial growth and inflammation in the mice's lungs. The study shows a potential new strategy for treating infectious diseases, including COVID-19. (2020-12-03)

New lab-on-a-chip infection test could provide cheaper, faster portable diagnostics
A tiny new silicon-based lab-on-chip test could pave the way for cheap handheld infectious disease testing. (2020-12-02)

New device offers faster way to detect antibiotic-resistant bacteria
A new device for faster testing of antibiotic-resistant bacteria has been developed by researchers at Binghamton University, State University of New York. (2020-12-01)

'Anti-antibiotic' allows for use of antibiotics without driving resistance
An inexpensive, FDA-approved drug -- cholestyramine -- taken in conjunction with an antibiotic prevents the antibiotic from driving antimicrobial resistance, according to new research by scientists at Penn State and the University of Michigan. (2020-12-01)

Study finds false widow spiders bite can transmit harmful antibiotic-resistant bacteria
A team of zoologists and microbiologists from NUI Galway have published a new study showing that common house spiders carry bacteria susceptible to infect people, with the Noble False Widow spiders also carrying harmful strains resistant to common antibiotic treatments. (2020-12-01)

Gut microbes: a key to normal sleep
Researchers at the University of Tsukuba used a cocktail of antibiotics to deplete gut microbes in mice. They found that metabolites in the gut differed in these mice compared with controls. In particular, metabolic pathways involved in making important neurotransmitters like serotonin were affected. Additionally, these mice showed abnormal day-night distribution in sleep/wake patterns, particularly the amount of REM sleep, and frequent transitions between REM and non-REM sleep episodes. (2020-11-30)

Small molecules control bacterial resistance to antibiotics
Antibiotics have revolutionized medicine by providing effective treatments for infectious diseases such as cholera. But the pathogens that cause disease are increasingly developing resistance to the antibiotics that are most commonly used. Scientists at the Friedrich Schiller University Jena, Germany have discovered a molecule that influences the antibiotic-resistance of cholera bacteria. They have published their results in the scientific journal ''Nature Communications''. (2020-11-27)

Experimental evolution reveals how bacteria gain drug resistance
A research team at RIKEN in Japan has succeeded in experimentally evolving the common bacteria under pressure from a large number of individual antibiotics, and identified the mechanisms and constraints underlying evolved drug resistance. Their findings help develop drug-treatment strategies that minimize the chance that bacteria will develop resistance. (2020-11-24)

Potential treatment against antibiotic-resistant bacteria causing gonorrhea and meningitis
A team from the Institut national de la recherche scientifique (INRS) has demonstrated the effectiveness of an inexpensive molecule to fight antibiotic-resistant strains of the bacteria responsible for gonorrhea and meningococcal meningitis. These two infections affect millions of people worldwide. The results of this research, led by Professor Frédéric Veyrier and Professor Annie Castonguay, have just been published online in the Antimicrobial Agents and Chemotherapy journal. (2020-11-24)

Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics. (2020-11-19)

Antibiotic resistance genes in three Puerto Rican watersheds after Hurricane Maria
In the aftermath of Hurricane Maria, a category 5 hurricane that made landfall in September 2017, flooding and power outages caused some wastewater treatment plants (WWTPs) to discharge raw sewage into waterways in Puerto Rico. Six months later, researchers monitored antibiotic resistance genes (ARGs) in three Puerto Rican watersheds, finding that the abundance and diversity of ARGs were highest downstream of WWTPs. They report their results in ACS' Environmental Science & Technology. (2020-11-18)

Antibiotic resistance surveillance tools in Puerto Rican watersheds after Hurricane Maria
Virginia Tech researchers and international collaborators have further developed an innovative antibiotic resistance surveillance approach by applying DNA sequencing techniques to detect the spread of disease in watersheds impacted by large-scale storms. (2020-11-18)

Compound for Alzheimer's combats bacterial resistance to last-resort antibiotics in mice
An experimental drug for neurodegenerative diseases can also reverse resistance to ''last-resort'' polymyxin antibiotics among bacteria that cause sepsis, a life-threatening complication from infections. (2020-11-18)

New research reveals Australia's multi-billion dollar superbug crisis
Analysis by national consortium, OUTBREAK, highlights how urinary tract infections (UTIs) are becoming more persistent and harder to treat, resulting in more people being admitted to hospital where they require longer stays and more costly medicines. (2020-11-17)

Environmental scientists' new ozonation method treats water from antibiotic residues
Clean drinking water is considered to be one of the earth's most precious and threatened resources. Recent studies show that increasing concentrations of pharmaceuticals can be found in surface waters, which can end up in drinking water. TalTech environmental scientists are looking for ways to treat drinking water from hazardous pharmaceutical residues. (2020-11-17)

Antibiotic exposure in children under age 2 associated with chronic conditions
Children under age 2 who take antibiotics are at greater risk for childhood-onset asthma, respiratory allergies, eczema, celiac disease, obesity and attention deficit hyperactivity disorder, according to a paper written jointly by Mayo Clinic and Rutgers researchers. While previous studies have looked at the association of antibiotics with single diseases, this is the first to look at the association across many diseases. (2020-11-16)

Rise in antibiotics prescribed to dental patients in England during COVID-19 lockdown
One of the unintended consequences of the COVID-19 lockdowns in England earlier this year has been a 25 per cent increase in the prescription of antibiotics by dentists, according to a new study published today in the British Dental Journal (BDJ). Prescription rates were the highest in London, with an increase of 60% for the same period and the lowest increases, less than 10%, were in the South-West of England. (2020-11-13)

Review of plants' role in antibacterial activity clears new paths for drug discovery
Chemical Reviews published the work by researchers at Emory University, which includes 459 plant natural products that met rigorous criteria for demonstrating antibacterial activity. The review is also deposited on the Shared Platform for Antibiotic Research and Knowledge (SPARK), sponsored by Pew Charitable Trusts. (2020-11-11)

Pediatric surgeon establishes first-ever guidelines for pediatric opioid prescribing
In addition to adults, opioid addiction and misuse affects the pediatric population. Pediatric surgeon forms group of health care providers and advocates to establish first ever pediatric opioid prescribing guidelines. (2020-11-11)

Researchers discover bacterial DNA's recipe for success
Biomedical engineers at Duke University have developed a way of modeling how potentially beneficial packages of DNA called plasmids circulate and accumulate through a complex environment that includes many bacterial species. The researchers hope that their new model will lay the groundwork for others to better model and predict how important traits such as antibiotic resistance in pathogens or metabolic abilities in bacteria bred to clean environmental pollution will spread and grow in a given environment. (2020-11-09)

Clinicians who prescribe unnecessary antibiotics fuel future antibiotic use
Receipt of antibiotics for acute respiratory infections makes it more likely that patients and their families will seek care and receive antibiotics for future respiratory viral infections. In the year after their visit, patients randomly assigned to clinicians who prescribed more antibiotics got 15 percent more antibiotics for viral respiratory infections compared with patients seen by clinicians who prescribed the fewest antibiotics. Antibiotics work against bacteria but not against viruses, and improper use can make bacteria resistant to these drugs. (2020-11-09)

Could SARS-CoV-2 evolve resistance to COVID-19 vaccines?
Similar to bacteria evolving resistance to antibiotics, viruses can evolve resistance to vaccines, and the evolution of SARS-CoV-2 could undermine the effectiveness of vaccines that are currently under development, according to a paper published November 9 in the open-access journal PLOS Biology by David Kennedy and Andrew Read from Pennsylvania State University, USA. The authors also offer recommendations to vaccine developers for minimizing the likelihood of this outcome. (2020-11-09)

Resensitizing 'last-resort' antibiotics for treatment of infections
A research team led by Professor Hongzhe SUN, Chair Professor from the Department of Chemistry, Faculty of Science, in collaboration with Dr Pak-Leung HO, Director of the HKU Carol Yu Centre for Infection from the Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKU) discovers that by repurposing an antirheumatic gold drug, auranofin (AUR), 'last-resort' antibiotics can be resensitized for treatment of infections caused by multidrug-resistant superbugs including bloodstream infections, pneumonia and wound infections. (2020-11-05)

New decision support tool can provide personalized antibiotic treatment recommendations
A new study led by researchers at the Harvard Pilgrim Health Care Institute developed an algorithm that could greatly reduce use of broad-spectrum antibiotics in outpatient settings, a step toward reducing antibiotic resistance. The findings will be published online November 4, 2020 in Science Translational Medicine. (2020-11-04)

Harnessing the 'wisdom of crowds' can help combat antibiotic over prescription
A new study has demonstrated that using the 'wisdom of crowds' (also known as collective intelligence) of three or more medical prescribers, can improve decisions about antibiotic prescribing and help combat rising levels of antibiotic resistance. (2020-11-03)

Decennial 2020 research sets the agenda for advancing safe healthcare
More than 700 studies, including 250 international abstracts, highlighting worldwide progress in preventing and controlling healthcare-associated infections and addressing antibiotic resistance were published today as part of the proceedings from the Sixth Decennial International Conference on Healthcare-Associated Infections. The Sixth Decennial, a conference co-hosted by the Centers for Disease Control and Prevention and SHEA, was cancelled in March due to the COVID-19 pandemic. All abstracts accepted for the meeting appear in a supplement for the journal Infection Control & Hospital Epidemiology. (2020-11-02)

A new lead for disarming antibiotic-resistant bacteria
A virus can stop bacteria from sharing genes for antibiotic resistance among themselves, Texas A&M AgriLife researchers have discovered. The results hint at new ways to treat infections and describe a new feature of a highly diverse, largely unexplored part of the biosphere. (2020-11-02)

Hospital floors are hotspot for bacteria, creating route of transfer to patients
The floors of hospital rooms are frequently contaminated with antibiotic-resistant bacteria within hours of patient admission, creating a route of transfer of potentially dangerous organisms to patients, according to a study published today as part of the proceedings from Decennial 2020: The Sixth International Conference on Healthcare-Associated Infections. Decennial 2020, an initiative of the CDC and SHEA, was cancelled in March due to the pandemic. (2020-10-30)

Microbial strains show individualized patterns of stability in the developing infant gut
Microbial strain stability studies of human infants and children, ages shortly after birth (about 6 months) to 6 years, show individualized patterns of microbial strain specificity as the infant gut microbiomes developed. (2020-10-28)

Drug resistance linked to antibiotic use and patient transfers in hospitals
Understanding the role of antibiotic use patterns and patient transfers in the emergence of drug-resistant microbes is essential to crafting effective prevention strategies, suggests a study published today in eLife. (2020-10-27)

New tricks for old antibiotics
The study published in the journal Immunity reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection. This finding opens new doors in the field of disease tolerance and positions this group of antibiotics as potential adjuvant treatment for sepsis, due to their effects that go beyond the control of bacterial burden. (2020-10-22)

Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces. (2020-10-20)

Scientists discover a new mechanism for cellular defense against viral and bacterial infections
Researchers of IDIBAPS, the University of Barcelona and CNIC have coordinated a study, published in Science, which describes a new mechanism of innate immunity by which cells fight viruses and bacteria. (2020-10-15)

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