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Current Antibodies News and Events, Antibodies News Articles.
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Found: A potential new way to sway the immune system
A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis. (2016-08-01)

Scientists identify immunological profiles of people who make powerful HIV antibodies
People living with HIV who naturally produce broadly neutralizing antibodies (bNAbs) that may help suppress the virus have different immunological profiles than people who do not, NIAID-supported researchers report. While bNAbs cannot completely clear HIV infections in people who already acquired the virus, scientists believe a successful preventive HIV vaccine must induce bNAbs. Defining how to safely replicate these attributes in HIV-uninfected vaccine recipients may lead to better designed experimental vaccines to protect against HIV. (2016-07-29)

Tracking how HIV disrupts immune system informs vaccine development
One of the main mysteries confounding development of an HIV vaccine is why some people infected with the virus make the desired antibodies after several years, but a vaccine can't seem to induce the same response. (2016-07-29)

Zika infection is caused by one virus serotype, NIH study finds
Vaccination against a single strain of Zika virus should be sufficient to protect against genetically diverse strains of the virus, according to a study conducted by investigators from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health; Washington University in St. Louis; and Emory University in Atlanta. (2016-07-29)

Studies in mice provide insights into antibody-Zika virus interactions
In research that could inform prophylactic treatment approaches for pregnant women at risk of Zika virus infection, investigators conducted experiments in mice and identified six Zika virus antibodies, including four that neutralize African, Asian and American strains of the mosquito-borne virus. The NIAID-supported team also developed atomic-level X-ray crystal structure images showing four of the antibodies in complex with three distinct regions (epitopes) of a key Zika protein. (2016-07-27)

Mouse antibodies pinpoint Zika's weak spots
Antibodies that specifically protect against Zika infection have been identified in mice, report Washington University School of Medicine in St. Louis researchers on July 27 in Cell. This is the second publication in recent weeks (another paper showing human Zika antibodies appeared in Science on July 14) that explores the surfaces that the antibodies target on the virus. The information will help inform the development of vaccines, diagnostics, and antibody-based prophylactic and therapeutic agents. (2016-07-27)

Antibodies identified that thwart Zika virus infection
Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, a significant step toward developing a vaccine, better diagnostic tests and possibly new antibody-based therapies. (2016-07-27)

Imaging the brain at multiple size scales
MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to image molecules within cells or take a wider view of the long-range connections between neurons. The technique, magnified analysis of proteome, should help scientists chart the connectivity and functions of neurons in the human brain. (2016-07-26)

Statins improve birth outcomes for mothers with an autoimmune disorder
A new statin treatment shows promise for reducing premature births and increasing babies' chances of survival for mothers with an autoimmune disease. The small preliminary study of 21 women, published in the Journal of Clinical Investigation, found that all babies of mothers treated with statins survived compared with the standard treatment group; maternal health also improved after treatment with statins. (2016-07-25)

Vaccine strategy induces antibodies that can target multiple influenza viruses
Scientists have identified three types of vaccine-induced antibodies that can neutralize diverse strains of influenza virus that infect humans. The discovery will help guide development of a universal influenza vaccine, according to investigators at the National Institute of Allergy and Infectious Diseases (NIAID), and the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), and collaborators who conducted the research. (2016-07-22)

Penn study models how the immune system might evolve to conquer HIV
In a new paper in PLOS Genetics, University of Pennsylvania professor Joshua Plotkin, along with postdoctoral researcher Jakub Otwinowski and Princeton University research scholar Armita Nourmohammad, mathematically modeled the coevolutionary processes that describe how antibodies and viruses interact and adapt to one another over the course of a chronic infection, such as HIV/AIDS. (2016-07-21)

Comprehensive HIV vaccine project funded at $23 million by NIH
To support a coordinated, innovative approach to the development of an AIDS vaccine, Texas Biomedical Research Institute scientists, together with an international coalition of experts, have received a grant for $23 million from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. (2016-07-21)

Anti-tumor antibodies could counter atherosclerosis, Stanford study finds
Investigators at the Stanford University School of Medicine have learned the signal that tumor cells display on their surfaces to protect themselves from being devoured by the immune system also plays a role in enabling atherosclerosis, the process underlying heart attacks and strokes. (2016-07-20)

Intranasal flu vaccine produces long-lasting immune response in mice
Intranasal flu vaccines may be able to provide long-lasting protection against pandemic flu strains, according to a new study from immunologists at Columbia University Medical Center. (2016-07-18)

Cancer-fighting gene immunotherapy shows promise as treatment for HIV
A study from the UCLA AIDS Institute and Center for AIDS Research suggests that recently discovered potent antibodies can be used to generate a specific type of cell called chimeric antigen receptors, or CARs, that can be used to kill cells infected with HIV-1. (2016-07-15)

Checkpoint in B cell development discovered with possible implications on vaccine potency
University of Alabama at Birmingham researchers report a new quality-control checkpoint function in developing B cells, cells that produce antibodies to protect the body from pathogens. The checkpoint leads to more effective antibodies by favoring certain amino acids in the center of the heavy chain variable region, but it also restricts the repertoire of antibodies that B cells can produce. (2016-07-14)

Antibodies in patients with rare disorder may have role preventing type 1 diabetes
People with a rare autoimmune disorder produce autoimmune antibodies that appear to be linked to a reduced occurrence of type 1 diabetes, new research has found. The study, published in Cell, suggests these antibodies could limit immune-related diseases and may have therapeutic potential. (2016-07-14)

HIV vaccine research requires unprecedented path
Because the body does not readily make an adequate immune response to HIV infection, creating a preventive HIV vaccine remains a formidable challenge for researchers. To succeed in this endeavor, scientists have responded with complex, creative and elegant approaches unparalleled in other vaccine research pursuits, according to a new commentary from Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (2016-07-12)

Discovery of mechanisms triggering excess antibody production during chronic infection
Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this hypergammaglobulinemia? A team headed by INRS's Professor Simona St├Ąger has successfully identified the mechanisms triggering the phenomenon. For the first time ever, she has established a link between B-cell activation by a protein -- type 1 interferon -- and unusually high antibody levels. (2016-07-12)

Progress towards protection from highly lethal Ebola, Marburg viruses
Ebola and Marburg filovirus disease outbreaks have typically occurred as isolated events, confined to central Africa. However, the recent Ebola epidemic spread to several African countries, and caused 11,000 deaths. That epidemic underscored the need to develop vaccines and therapeutics that could be used to fight future disease outbreaks. Now new research suggests that antibodies to filoviruses from individuals who have survived these diseases may offer protection -- not only against the particular filovirus that infected an individual, but against other filoviruses, as well. (2016-07-12)

Discovery of a new defense system against microbial pathogens
For the first time in the world, a group of researchers discovered a human immune receptor, which detects the invasion of pathogenic microorganisms. They thereby succeeded in identifying a so far unknown host defense mechanism. These results will contribute to future developments in the treatment and prevention of infectious diseases. (2016-07-11)

Influenza-neutralizing antibodies generated in human subjects given experimental vaccine
In this issue of JCI Insight, James Crowe of Vanderbilt University and colleagues describe the isolation and characterization of monoclonal antibodies with influenza A virus H3N2v-neutralizing capacity from human subjects given an H3N2v candidate vaccine. (2016-07-07)

Penn engineers develop $2 portable Zika test
University of Pennsylvania engineers have developed a rapid, low-cost genetic test for the Zika virus. The $2 testing device, about the size of a soda can, does not require electricity or technical expertise to use. A patient would simply provide a saliva sample. Color-changing dye turns blue when the genetic assay detects the presence of the virus. (2016-07-05)

Maternal vaccination again influenza associated with protection for infants
How long does the protection from a mother's immunization against influenza during pregnancy last for infants after they are born? (2016-07-05)

Researchers develop effective strategy for disrupting bacterial biofilms
A discovery from the laboratories of Lauren Bakaletz, PhD, and Steven Goodman, PhD, in The Research Institute at Nationwide Children's Hospital, provides strong evidence that an innovative therapeutic approach may be effective in the resolution of bacterial biofilm diseases. (2016-06-30)

Vaccine against Zika virus tested successfully in mice
An experimental vaccine against Zika virus developed by Brazilian and US researchers has been tested successfully in trials with mice. The vaccine gave the mice 100% protection. The mice were vaccinated and then infected, and didn't present viremia, demonstrating that the vaccine induces antibody-mediated protection. (2016-06-29)

Antibodies to dengue may alter course of Zika virus infection
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, find cross-reactivity that may influence plans for Zika and dengue vaccine studies. (2016-06-27)

NIH scientists decode how anthrax toxin proteins might help treat cancerous tumors
Scientists from the National Institute of Allergy and Infectious Diseases, the National Institute of Dental and Craniofacial Research, and the National Heart, Lung and Blood Institute, all parts of NIH, describe how combining engineered anthrax toxin proteins and existing chemotherapy drugs could potentially yield a therapy to reduce or eliminate cancerous tumors. The findings, based on testing in mice, will appear in the Early Edition of the Proceedings of the National Academy of Sciences. (2016-06-27)

Antibodies that are effective against both dengue and Zika viruses
Scientists from the Institut Pasteur and the CNRS, in collaboration with Imperial College London and the University of Vienna, Austria, have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. The description of the binding site for these antibodies on the viral envelope, identical for both viruses, could lead to the development of a universal vaccine that offers simultaneous protection against dengue and Zika virus disease. (2016-06-23)

Dengue virus exposure may amplify Zika infection
Previous exposure to the dengue virus may increase the potency of Zika infection, according to research from Imperial College London. The early-stage laboratory findings, published in the journal Nature Immunology, suggests the recent explosive outbreak of Zika may have been driven in part by previous exposure to the dengue virus. (2016-06-23)

Novel study in Nairobi infants may accelerate path to HIV vaccine
The first and only study to look at isolate HIV-neutralizing antibodies from infants has found that novel antibodies that could protect against many variants of HIV can be produced relatively quickly after infection compared to adults. This suggests that various aspects of HIV-vaccine development, from design to administration, could be improved by mimicking infection and immune response in infants. (2016-06-23)

People allergic to insect venom need precision medical diagnosis and treatment
Three to 5 percent of the European population is allergic to insect venom, and many of them are at risk of anaphylaxis if they are stung. Some patients do not respond properly to immunotherapy and in some cases the treatment has reduced or no effect at all -- which can be fatal. Researchers at Aarhus University are now developing artificial allergens and human antibodies in order to enable individualized immunotherapeutic treatment. (2016-06-20)

Mosquito saliva increases disease severity following dengue virus infection
Insects transmit diseases when, probing for blood vessels, they inject saliva together with viral, bacterial, or parasitic pathogens into the skin of mammalian hosts. A study in mice published on June 16, 2016 in PLOS Pathogens suggests a critical role of mosquito saliva in the outcome of dengue virus infection. (2016-06-16)

The use of Camelid antibodies for structural biology
The use of Camelid antibodies has important implications for future development of reagents for diagnosis and therapeutics in diseases involving a group of enzymes called serine proteases. (2016-06-15)

Study suggests another look at common treatments for hemophilia
A study published in the New England Journal of Medicine on May 26 showed that participants who received a recombinant therapy-- the present standard in the United States -- developed antibodies or 'inhibitors' to the treatments at almost twice the rate as those whose treatments were made from human plasma. (2016-06-13)

Biosimilar switching not suitable for all patients
Patients with antibodies to biological infliximab are less likely to benefit from infliximab biosimilar (CT-P13) (2016-06-09)

Enzyme keeps antibodies from targeting DNA and driving inflammation in lupus
Failure of an enzyme to break down DNA spilling into the bloodstream as cells die may be a major driver of inflammation in lupus. (2016-06-09)

Blood test can help predict RA treatment response
Blood test can help predict RA treatment response (2016-06-09)

Preliminary data for pre-kidney transplant being presented June 13
Early findings by researchers at the University of Cincinnati College of Medicine suggest that the use of a second generation cancer drug, carfilzomib, may provide an improved approach for the reduction of antibodies in potential kidney transplant candidates. (2016-06-09)

Test holds potential to diagnose myriad conditions with drop of blood
Researchers at the University of Pittsburgh have developed a unique method for detecting antibodies in the blood of patients in a proof-of-principle study that opens the door to development of simple diagnostic tests for diseases for which no microbial cause is known, including auto-immune diseases, cancers and other conditions. (2016-06-09)

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