Current Antidepressant News and Events

Current Antidepressant News and Events, Antidepressant News Articles.
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Do antidepressants help chronic back pain and osteoarthritis?
Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. (2021-01-20)

Scientists seek faster route to treat depression
The Brazilian research group used epigenetic modulators to try to 'erase' the damage done by stress to neuroplasticity. The study showed that acute intervention in epigenetic mechanisms produces antidepressant-like effects more rapidly than conventional drugs. (2021-01-04)

New use for an old drug: How does ketamine combat depression?
A group of proteins called 4E-BPs, involved in memory formation, is the key to unlocking the antidepressant effect of ketamine in the brain, according to researchers from three Canadian universities. The discovery could lead to better and safer treatments for certain patients suffering from major depression. (2020-12-16)

Gut microbiota plays a role in brain function and mood regulation
Depression is a mental disorder that affects more than 264 million people of all ages worldwide. Understanding its mechanisms is vital for the development of effective therapeutic strategies. Scientists from the Institut Pasteur, Inserm and the CNRS recently conducted a study showing that an imbalance in the gut bacterial community can cause a reduction in some metabolites, resulting in depressive-like behaviors. These findings, which show that a healthy gut microbiota contributes to normal brain function, were published in Nature Communications on December 11, 2020. (2020-12-11)

Existing antidepressant helps to inhibit growth of cancer cells in lab animals
New research has shown that the antidepressant sertraline helps to inhibit the growth of cancer cells. The substance acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals by researchers at KU Leuven. (2020-11-17)

Trace amine-associated receptor 5 (TAAR5) to rewire your brain naturally
Researchers have found a new role for recently discovered neurotransmitter system that uses the trace amine-associated receptor 5 (TAAR5) for neurotransmission. It has been observed that lack of TAAR5 in mice leads to a higher number of dopamine neurons and an increase in adult neurogenesis, i.e. the process by which new neurons are formed in the brain. (2020-11-10)

Single brain region links depression and anxiety, heart disease, and treatment sensitivity
Over-activity in a single brain region called the subgenual anterior cingulate cortex (sgACC) underlies several key symptoms of mood and anxiety disorders, but an antidepressant only successfully treats some of the symptoms. A new study, published today in the journal Nature Communications, suggests that sgACC is a crucial region in depression and anxiety, and targeted treatment based on a patient's symptoms could lead to better outcomes. (2020-10-26)

Higher suicide risk among older immigrants with untreated depression
The risk of suicide is clearly elevated in the category of older women with untreated depression who were born outside the Nordic region, compared with corresponding Swedish-born women. This is shown by a study from the University of Gothenburg, Sweden. (2020-10-08)

New study finds antidepressant drug effective in treating "lazy eye" in adults
In a new study, published in Current Biology, researchers from the University of California, Irvine School of Medicine reveal how subanesthetic ketamine, which is used for pain management and as an antidepressant in humans, is effective in treating adult amblyopia, a brain disorder commonly known as ''lazy eye.'' (2020-09-30)

Antipsychotics for treating adult depression linked with higher mortality
Rutgers researchers, together with colleagues at Columbia University, have reported an increased mortality risk in adults with depression who initiated augmentation with newer antipsychotic medications compared to a control group that initiated augmentation with a second antidepressant. (2020-09-30)

Measuring brainwaves while sleeping can tell if you should switch antidepressants
Scientists have discovered that measuring brainwaves produced during REM sleep can predict whether a patient will respond to treatment from depression. This enables patients to switch to a new treatment rather than continue the ineffective treatment (and the depression) for weeks without knowing the outcome. (2020-09-12)

Who Could Benefit From Exercise and Behavioral Treatment?
Aerobic exercise clearly benefits young adults with major depression, and a Rutgers-led study suggests it may be possible to predict those who would benefit from behavioral therapy with exercise. Unique to this precision medicine study, published in the journal Psychological Medicine, is an assessment of cognitive control and reward-related brain activity, two facets of brain function that are impaired in people with depression. (2020-08-24)

These drugs carry risks and may not help, but many dementia patients get them anyway
Nearly three-quarters of older adults with dementia have filled prescriptions for medicines that act on their brain and nervous system, but aren't designed for dementia, a new study shows. That's despite the special risks that such drugs carry for older adults -- and the lack of evidence that they actually ease the dementia-related behavior problems that often prompt a doctor's prescription in patients with Alzheimer's disease and related disorders. (2020-08-18)

Trajectories of antidepressant medication use during pregnancy
In an analysis of women who started pregnancy when taking antidepressant medications, investigators identified three trajectories of antidepressant dispensing during pregnancy: more than half stopped their treatment, a quarter maintained their treatment throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period. (2020-08-05)

McLean hospital study examines the cost-effectiveness of esketamine
A paper authored by researchers from McLean Hospital has determined that esketamine, a nasal spray to treat severe depression, is currently too expensive for widespread use. (2020-07-13)

Adult stem cell study shows fish oil may help with depression
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response. (2020-06-11)

Researchers call for new approach to some mental disorders
Depression, anxiety and PTSD might not be disorders at all, according to a recent paper by Washington State University biological anthropologists. In the paper, the researchers propose a new approach to mental illness that would be informed by human evolution, noting that modern psychology, and in particular its use of drugs like antidepressants, has largely failed to reduce the prevalence of mental disorders. (2020-05-26)

New review of studies shows no link between prenatal antidepressant exposure and autism
A mother's use of antidepressants during pregnancy does not appear to increase her child's risk for autism, according to a new meta-analysis by Jeffrey Newport, M.D., published in the American Journal of Psychiatry. (2020-05-07)

Targeting depression: Researchers ID symptom-specific targets for treatment of depression
For the first time, physician-scientists at Beth Israel Deaconess Medical Center have identified two clusters of depressive symptoms that responded to two distinct neuroanatomical treatment targets in patients who underwent transcranial magnetic brain stimulation (TMS) for treatment of depression. The team's findings shed new light on the brain circuitry underlying specific symptoms of depression and may facilitate personalized TMS therapy for depression and other psychiatric or neurological disorders. (2020-05-04)

Structural protein may be new marker of depression
Scientists have zeroed in on a structural protein as a new target for the diagnosis and treatment of depression, according to research recently published in JNeurosci. (2020-04-13)

Depression in adults who are overweight or obese
In an analysis of primary care records of 519,513 UK adults who were overweight or obese between 2000-2016 and followed up until 2019, the incidence of new cases of depression was 92 per 10,000 people per year. The risk of depression also rose with higher weight, according to the Obesity analysis. (2020-04-08)

Promising advance in depression research
Despite their effectiveness, only 40% of patients respond to the first antidepressant they try. A recent paper in Nature Communication strongly suggests that a particular protein, GPR56, is involved in the biology of depression and the effect of antidepressants. The McGill led research team believe that this protein could offer a novel target for new antidepressant drugs. (2020-04-08)

Managing negative thoughts helps combat depression in Parkinson's patients
People with Parkinson's disease who engage in cognitive behavioral therapy -- a form of psychotherapy that increases awareness of negative thinking and teaches coping skills -- are more likely to overcome depression and anxiety, according to a Rutgers study. (2020-04-01)

Obesity alert for April 2020
All print, broadcast and online journalists who receive the Obesity embargo alert agree to abide by the embargo and may not publish, post, broadcast or distribute embargoed news releases or details of the embargoed studies before the embargo date and time. (2020-03-23)

New drug can ease the side effects of medication against severe depression
Today, severe depressions require a high dose of antidepressants. However, the high dose may also cause serious side effects. Now, researchers from the University of Copenhagen have found a substance that may ease the side effects while preserving the therapeutic effect. (2020-03-20)

Decades-old antidepressant may fend off prostate cancer's return
An antidepressant from the '50s, repurposed to fight prostate cancer, lowered PSA levels in men with recurrent disease, pilot study shows. (2020-03-04)

Antidepressant harms baby neurons in lab-grown 'mini-brains'
Researchers at Johns Hopkins Bloomberg School of Public Health have demonstrated the use of stem-cell-derived 'mini-brains' to detect harmful side effects of a common drug on the developing brain. Mini-brains are miniature human brain models, developed with human cells and barely visible to the human eye, whose cellular mechanisms mimic those of the developing human brain. (2020-02-21)

Researchers say extended antidepressant use creates physical dependence
Researchers explain symptoms associated with Antidepressant Discontinuation Syndrome and provide a schedule for tapering various classes of antidepressants. Patients who stop medication without tapering often experience flulike symptoms, insomnia, nausea, imbalance, sensory disturbances often described as electric shocks or 'brain zaps', and hyperarousal. (2020-02-20)

Neural signature identifies people likely to respond to antidepressant medication
Researchers have discovered a neural signature that predicts whether individuals with depression are likely to benefit from sertraline, a commonly prescribed antidepressant medication. The findings, published in Nature Biotechnology, suggest that new machine learning techniques can identify complex patterns in a person's brain activity that correlate with meaningful clinical outcomes. The research was funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health. (2020-02-10)

AI, brain scans may alter how doctors treat depression
Artificial intelligence may soon play a critical role in choosing which depression therapy is best for patients. (2020-02-10)

Brain-wave pattern can identify people likely to respond to antidepressant, study finds
A new method of interpreting brain activity could be used in clinics to help determine the best treatment options for depression, according to a Stanford-led trial. (2020-02-10)

Antianxiety and antidepressant effects from a single dose of psychedelic drug persist years later in cancer patients
Following up on their landmark 2016 study, researchers at NYU Grossman School of Medicine found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients. (2020-01-28)

Doctors urged to recognize post-antidepressant sexual dysfunction
A psychiatrist specializing in sexual dysfunction caused by antidepressants is calling for greater recognition of the problems that can endure after treatment stops. Professor David Healy, writing in the Journal of the Royal Society of Medicine, said problems may begin after only a few doses and leave someone affected for life, or a relatively mild dysfunction can worsen dramatically when the person stops treatment. (2020-01-23)

Burnout linked with irregular heartbeat
Feeling excessively tired, devoid of energy, demoralized, and irritable? You may have burnout, a syndrome associated with a potentially deadly heart rhythm disturbance. That's the conclusion of a large study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). (2020-01-13)

Harnessing biology and technology to develop new depression treatments -- update from Harvard Review
New research into the biology of depression, along with new and evolving technologies, provides the basis for developing the next generation of treatments for major depressive disorder (MDD), according to the special January/February issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-01-09)

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro. (2019-12-16)

Academics call for targeted healthcare for pregnant women and new mums with depression
Pregnant women and new mothers who experience depression need improved healthcare say academics. (2019-11-20)

Depressed MS-patients suffer debilitating symptoms earlier
People with multiple sclerosis (MS) who also have depression are more likely to suffer debilitating symptoms early than people with MS who are not depressed, according to a study at Karolinska Institutet in Sweden that is published in the journal Neurology. The findings highlight the need for early recognition and treatment of depressive symptoms in patients with MS. (2019-11-08)

Significantly fewer pregnant women take antidepressants
A pregnancy is not always a happy event and as many as 10-15% of pregnant women in Denmark have depressive symptoms. A new study carried out by Aarhus University now shows a significant decrease in the use of antidepressants by pregnant women -- with consumption falling by more than 33% since 2011. (2019-10-29)

Study: In the long run, drugs and talk therapy hold same value for people with depression
Spending an hour in talk therapy with a trained counselor costs much more, and takes more time, than swallowing an inexpensive antidepressant pill. But for people with a new diagnosis of major depression, the costs and benefits of the two approaches end up being equal after five years, a new study shows. (2019-10-28)

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