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Current Antidepressants News and Events, Antidepressants News Articles.
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Worrying rise in use of antidepressants in children
The use of antidepressant drugs in children is increasing, although evidence for their effectiveness and safety in children and adolescents is scant and widely debated, particularly for selective serotonin reuptake inhibitors (SSRIs) argue researchers in a letter to this week's BMJ. (2004-03-18)

Poor prognosis for depression linked to an autoimmune thyroid condition?
Whether depression is linked to having an under-active thyroid gland has been debated for many years. Research published in BMC Psychiatry this week suggests that some patients with depression may be suffering from a subtle autoimmune thyroid condition, which could hinder their recovery. (2004-03-14)

Study shows women's medication use higher than expected
Women's use of all medications--including herbal supplements--is higher than anticipated, and they're unlikely to tell their health care providers about the medications they take, according to a University of Minnesota researcher. A study being published in the Feb. 24 issue of American Journal of Obstetrics and Gynecology determined that that health care providers need to spend more time asking about medication usage. (2004-02-24)

Undisclosed results of clinical trials
This issue of CMAJ includes a commentary decrying the suppression of data from clinical trials of selective serotonin reuptake inhibitors (SSRIs) in the treatment of adolescent depression. (2004-02-16)

Study examines inappropriate medication prescribing for elderly patients
Medications considered (2004-02-09)

Pain may interfere with depression improvement
Treatment for depression may be stymied in people with moderate to severe body pain, according to a new study. (2004-01-28)

Popular anti-epileptic drug also effective in controlling debilitating symptom of multiple sclerosis
A drug proven effective in controlling epileptic seizures also appears to treat one form of spasticity in multiple sclerosis patients, report researchers at UT Southwestern Medical Center at Dallas. Spasticity is a key factor in many MS patients' loss of the ability to walk. (2003-12-15)

Distress-prone people more likely to develop Alzheimer's disease
People who tend to experience psychological distress are more likely to develop Alzheimer's disease than people who are less prone to experience distress, according to a study published in the December 9 issue of Neurology, the scientific journal of the American Academy of Neurology. (2003-12-08)

Hot flash drug may hinder effectiveness of tamoxifen
An antidepressant used to ease a common side effect of the drug tamoxifen for breast cancer may conceivably reduce the effectiveness of tamoxifen by interfering with the breakdown of the drug into its active metabolites, according a new study in the December 3 issue of the Journal of the National Cancer Institute. (2003-12-02)

Tamoxifen's effectiveness may be compromised by hot flash drug
An Indiana University School of Medicine study suggests that tamoxifen's metabolism, and possibly its effectiveness, can be modified by the genetic makeup of the person taking the drug and by the use of another drug prescribed to reduce tamoxifen-related hot flashes according to IUSM pharmacogeneticist David Flockhart. (2003-12-02)

Treatment options expand for patients with neuropathic pain
Treatment options for people who suffer from severe pain caused by damage to nerves have expanded dramatically in just the past five years, say scientists and physicians who have published the first-ever guidelines for treating such pain. The guidelines for treating neuropathic pain, which occurs most often in patients who have shingles or diabetes, appear in the November issue of the Archives of Neurology. (2003-11-25)

Stanford research finds gene variations that alter antidepressant side effects
Researchers at Stanford University Medical Center have identified a genetic marker that can explain why some people experience side effects to common antidepressants while others do not. They also found that a key liver enzyme involved in breaking down these antidepressants surprisingly played no role in the development of side effects nor in how well the drugs worked. The findings may lead to fewer side effects for patients undergoing antidepressant drug therapy. (2003-09-30)

Post-stroke treatment with antidepressants appears to reduce death rate
Antidepressant treatment for people who have had stroke -- whether the patients are depressed or not -- appears to increase their chances of living longer. The antidepressants may reduce mortality by decreasing the number of cardiovascular events such as heart attack and recurrent stroke occurring during the follow-up period of both depressed and non-depressed patients who had a stroke. (2003-09-29)

Burning mouth syndrome
Burning mouth syndrome (BMS), a painful disorder affecting mostly women, is a constant and aggravating source of discomfort for more than 1 million adults. New findings explain how anxiety and depression may be a precursor that triggers this difficult-to-diagnose syndrome, according to a new report that will be published in the September/October 2003 issue of General Dentistry, the Academy of General Dentistry's (AGD) clinical, peer-reviewed journal. (2003-09-03)

Study: Stereotypes prevail in media coverage of depression
The media's coverage of depression has changed dramatically in the age of Prozac, a new study finds. Articles are now far more likely to depict women's mental issues in relation to gender-stereotyped roles, such as marriage and motherhood, rather than in medical terms. But descriptions of depression in men have not shifted in the same way. (2003-08-25)

Creation of new neurons critical to antidepressant action in mice
Blocking the formation of neurons in the hippocampus blocks the behavioral effects of antidepressants in mice, say researchers. Their finding lends new credence to the proposed role of such neurogenesis in lifting mood. It also helps to explain why antidepressants typically take a few weeks to work If antidepressants work by stimulating the production of new neurons, there's a built-in delay. Stem cells must divide, differentiate, migrate and establish connections with post-synaptic targets. (2003-08-07)

Annals of Internal Medicine, tip sheet, August 5, 2003
Highlights from the August 5 edition of the Annals of Internal Medicine include (2003-08-04)

Antidepressant drugs may protect brain from damage due to depression
Studying women with histories of clinical depression, investigators at Washington University School of Medicine in St. Louis found that the use of antidepressant drugs appears to protect a key brain structure often damaged by depression. (2003-08-01)

UCLA-led study challenges bipolar depression treatment guidelines
A study led by a UCLA Neuropsychiatric Institute researcher challenges standard treatment guidelines for bipolar depression that recommend discontinuing antidepressants within the first six months after symptoms ease. The findings appear in the July 2003 edition of the American Journal of Psychiatry. (2003-07-01)

Following heart attacks, treatment helps depression but does not prevent future attacks, study finds
Following heart attacks, cognitive behavior therapy can help depressed patients and those lacking support from family and friends but will not cut their risk of having another attack or postpone death, a major multi-center study concludes. (2003-06-17)

No survival benefit for heart disease patients treated for depression and low social support
The first major study to evaluate the effects of treating depression and low social support in recent heart attack patients found no reduction in deaths or second heart attacks; however, study participants showed significant improvement in depression and social functioning. Results from the Enhancing Recovery in Coronary Heart Disease Patients Study (ENRICHD), which was supported by the National Heart, Lung, and Blood Institute (NHLBI), are published in the June 18 (2003-06-17)

Many pregnant women may have depression, but few getting treatment, study finds
One in five pregnant women may be experiencing symptoms of depression, but few are getting help for it, a new study finds. And those with a history of depression any time before their pregnancy - about one in four women -- are about twice as likely to show signs of depression while pregnant as those with no prior depression. (2003-05-20)

Bupropion triples quit rates among women and formerly depressed smokers, study shows
The use of the antidepressant, sustained release (SR) bupropion, triples quit rates among women and smokers with a history of depression as compared to placebo, according to a new study just published in Nicotine and Tobacco Research by researchers at the Center for Tobacco Research and Intervention, University of Wisconsin Medical School. (2003-03-18)

PET predicts response to Paxil in study
UCLA neuroscientists using PET have discovered distinct patterns of brain activity that predict the effectiveness of Paxil in treating obsessive compulsive disorder vs. major depression. (2003-03-10)

Cocaine use may alter brain cells, play role in depression
Chronic cocaine use may cause damage to brain cells that help produce feelings of pleasure, which may contribute, in part, to the high rates of depression reported among cocaine abusers. (2003-03-05)

Many depressed patients have low satisfaction with care
Antidepressant drugs are the most prevalent, and often the only, treatment offered to patients newly diagnosed with depression, even when mental health therapy is readily available, according to a new study. (2003-03-04)

Call for longer-term use of antidepressants
Authors of a UK study in this week's issue of The Lancet highlight how longer-term use of antidepressants--by a year or more in addition to standard 4-6 month treatment--could substantially reduce the risk of relapse for people with depressive disorders. (2003-02-20)

Both antidepressant therapy and counseling may help smokers achieve short-term abstinence
A study to determine whether counseling increases the efficacy of antidepressants in smoking cessation programs found that such combination therapy did not add benefit to antidepressant therapy. It also found that counseling increased short-term abstinence rates when it was added to medical management, but neither counseling nor antidepressant therapy produced long-term sustained abstinence. Counseling produced higher 7-day abstinence rates than medical management alone, but this improvement was not sustained over the course of the study. (2003-02-20)

Call for longer-term use of antidepressants
Authors of a UK study in this week's issue of the Lancet highlight how longer-term use of antidepressants-by a year or more in addition to standard 4-6 month treatment-could substantially reduce the risk of relapse for people with depressive disorders. (2003-02-20)

Brain images reveal effects of antidepressants
The experiences of millions of people have proved that antidepressants work, but only with the advent of sophisticated imaging technology have scientists begun to learn exactly how the medications affect brain structures and circuits to bring relief from depression. (2003-02-05)

Mail reminders help patients stick to antidepressant meds
Mailed reminders to physicians and their patients who take antidepressant drugs can help patients stick with their medication routine, according to a new study. The reminders significantly increased the number of patients who took their medications routinely, compared with patients who did not receive the reminders. (2003-01-22)

USF study: Nicotine antagonist relieves depression in children with Tourette's
A well-tolerated drug that blocks nicotine receptors in the brain appears to relieve depression and mood instability in children and adolescents with Tourette's syndrome, a preliminary study by University of South Florida College of Medicine researchers has found. The findings suggest that another way antidepressants may work is by inhibiting nicotine receptors. (2002-12-10)

Patients should be more involved in the clinical trial process
Patients should be treated as participants rather than subjects during clinical trials, suggest researchers in this week's BMJ. (2002-12-05)

Rutgers study shows learning ability under stress still strong in Prozac-treated females
The drug Prozac protects a female's learning abilities after a stressful or traumatic event, according to a new research study conducted at Rutgers. (2002-10-28)

Steep increase in antidepressant use, study shows
Canadians' use of antidepressants has soared by more than 300 per cent over the past two decades, says a study by researchers at the University of Toronto and The Hospital for Sick Children. (2002-10-16)

Opioid medications a good bet for shingles-related pain
Despite worries over side effects, morphine and other opiates appear to be effective in treating shingles-related nerve pain in older adults, a study at Johns Hopkins suggests. (2002-10-07)

Demystifying irritable bowel syndrome
A seminar in this week's issue of THE LANCET examines the history, epidemiology, and different treatment options for one of the most misunderstood medical complaints-irritable bowel syndrome (IBS). (2002-08-15)

An SSRI antidepressant is safe and effective for depressed, hospitalized heart patients
In the first study of an SSRI (selective serotonin reuptake inhibitor) antidepressant in 369 depressed patients recently hospitalized for heart attack, the drug sertraline (Zoloft) has been found to be safe and effective. (2002-08-13)

A drug's effectiveness for depression is linked to the body's unique response to treatment
The thousands of Americans who are clinically depressed seek therapeutic treatment. Their treatment consists of the most advanced prescription drugs - yet for a great number of these patients, treatment is ineffective leading to greater morbidity and mortality caused by this mental disorder. (2002-07-30)

How does serotonin effect depression
University Hospitals of Cleveland investigators, working to help predict who is vulnerable to major depression and also to help patients reduce their anti-depression dosages, have begun a clinical trial that looks at the effect of serotonin levels upon depression. The protocol calls for reducing serotonin levels in study subjects, including a control group with no depression, by a process called tryptophan depletion. (2002-06-10)

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