Current Apoptosis News and Events

Current Apoptosis News and Events, Apoptosis News Articles.
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Cell biology - Overseers of cell death
A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed. (2021-02-10)

Oncotarget: The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer
The objective of this Oncotarget study was to elucidate the molecular mechanism of actions of 2MeOE2, a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors (2021-02-01)

Toho university scientists find new mechanism to keep cell death pathway suppressed
A research group led by Prof. Hiroyasu Nakano at the Department of Biochemistry, Toho University Faculty of Medicine, identified Mind bomb-2 (MIB2) as an enzyme that ubiquitinates and modifies the protein cFLIP, which plays a central role in suppressing cell death. This finding indicates that ubiquitination of cFLIP by MIB2 plays an essential role in suppressing caspase 8-mediated cell death, suggesting that ubiquitination of cFLIP may be a promising target for development of therapies to control cell death. (2021-01-27)

Participation in competitive sport in adolescence brings midlife health benefits to women
Females who participate in competitive sport during adolescence have better fitness at midlife than do females with no competitive sport background in adolescence, reveals a study conducted at the University of Jyväskylä. (2020-12-07)

Gasdermin offers insight into coral necrotic death
A research team led by Professor SUN Li from the Institute of Oceanology of the Chinese Academy of Sciences (IOCAS), in collaboration with Professor ZHOU Zhi from Hainan University, has identified gasdermin E (GSDME) from the reef-building coral Orbicella faveolata and demonstrated that coral GSDME triggers pyroptosis and is involved in pathogen-induced coral death. (2020-12-04)

Why long-suffering hosts grow a thick skin
Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ. (2020-12-01)

Mild electrical stimulation with heat shock ameliorates kidney disease
The combination of mild electrical stimulation and heat shock at 42 °C (MES+HS) exerts anti-inflammatory and anti-fibrotic effects in a mouse model of nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells. Clinical data have shown that the medical device used for this therapeutic approach is safe in humans. Researchers believe that it can be applied clinically to control the pathologies of NS. (2020-11-30)

Cellular survivors
When it comes to complex life -- that of the multicellular variety -- cell death can be just as important as survival. It allows organisms to clean house and prevent the proliferation of damaged cells that could compromise tissue function. (2020-11-12)

Photopharmacology - A light-trigger for the proteasome
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have designed a light-sensitive inhibitor that can control cell division and cell death - and provides a promising approach for studies of essential cellular processes and the development of novel tumor therapies. (2020-10-30)

Oncotarget: Evaluation of cellular alteration & inflammatory profile of cells
Oncotarget recently published ''Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis'' (2020-10-24)

Thymoquinone induces apoptosis & DNA damage in 5-Fluorouracil-resistant colorectal cancer
Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion. (2020-10-22)

Technology shines the light on ovarian cancer treatments
A Purdue University scientist and entrepreneur is working to use simple LED light to help determine if certain chemotherapy options will work for specific patients. (2020-10-22)

Senescent cells may be good when it comes to a bad injury
It's called senescence, when stressed cells can no longer divide to make new cells, and it's considered a factor in aging and in some diseases. Now scientists have some of the first evidence that at a younger age at least, senescent cells show up quickly after a major injury and are protective. (2020-09-29)

Identified the cellular process by which Cisplatin chemotherapy causes neuronal damage
Cisplatin induces senescence of peripheral neurons through overexpression of the p21 protein, which would explain the neuropathy. (2020-09-29)

Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells -- which were all derived from human induced pluripotent stem cells -- yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells. (2020-09-29)

Stop Livin to make lymphoma cells stop living
Researchers at the University of Tsukuba have shown that the protein Livin, an inhibitor of apoptosis or programmed cell death, mediates resistance to immunotherapy in some lymphoma variants. Therapeutically targeting Livin with IAP inhibitors or BET inhibitors may provide a practical strategy for patients with Livin-positive and other refractory B-cell lymphomas. (2020-09-16)

Protein causes mutations that lead to breast cancer cell aggression
In her previous research, University of Alberta biochemist Ing Swie Goping identified that the protein, BCL-2 interacting killer (BIK), was associated with relapses in breast cancer patients. In a new study published in the journal Cell Death and Disease, she found that the problem lies with the cellular 'self-destruct' process of apoptosis. (2020-09-08)

Shigella prevents infected cells from sacrificing themselves for the greater good
Researchers from Tokyo Medical and Dental University (TMDU) investigated how Shigella survive and multiply to cause severe inflammatory colitis. By screening several effector proteins that Shigella inject into colon cells, the researchers identified the effector proteins OspC1 and OspD3 as molecular measures through which Shigella inhibit both apoptosis and necroptosis. These findings help understand the molecular mechanisms of bacterial infections of the intestinal system. (2020-08-18)

Bacteria's secret weapon revealed
Monash Biomedicine Discovery Institute (BDI) scientists have discovered a previously unknown method used by bacteria to evade immune responses. (2020-08-17)

Genetic cause of congenital malformation discovered
Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia. This is shown in an international study led by the University of Bonn and published in the journal ''Frontiers in Cell and Developmental Biology''. The researchers also owe their findings to an unusual model organism: the zebrafish. (2020-08-07)

Neurons are genetically programmed to have long lives
Most neurons are created during embryonic development and have no ''backup'' after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with nerve cells. A research team led by Sika Zheng, a biomedical scientist at the University of California, Riverside, has challenged this notion and reports the continuous survival of neurons is also intrinsically programmed during development. (2020-07-24)

Oncotarget: RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation
The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al. (2020-06-23)

Slow release of two chemicals protects the heart after experimental heart attacks
A novel treatment reduces heart damage after serious heart attacks in two animal models. Injections of two chemicals in a slow-release form significantly reduced the size of the dead heart tissue, known as the infarct, and improved the function of the left ventricle, as compared to untreated subjects. (2020-06-22)

New technique may quickly and accurately predict effective therapies in solid tumors
A new method of screening thousands of drugs in freshly collected human tumor cells can help identify which of the drugs are most likely to be effective against those cancers. (2020-06-16)

Silicones may lead to cell death
Silicone molecules from breast implants can initiate processes in human cells that lead to cell death. Researchers from Radboud University have demonstrated this in a new study that will be published on 12 June in Scientific Reports. ''However, there are still many questions about what this could mean for the health effects of silicone breast implants. More research is therefore urgently needed,'' says Ger Pruijn, professor of Biomolecular Chemistry at Radboud University. (2020-06-12)

Newly synthesized fungal compound can switch on a self-destruct button for cancer
Cancers cells use a special technique to propagate; they delete their 'programmed death' gene through mutation, 'forget' to die when their lifetime is over, and continue to grow instead. A research team from Tokyo University of Science has developed a method through which a fungal compound capable of rearming the self-destruct gene in certain cancer cells can be artificially produced in marketable quantities, providing a potential cancer therapeutic strategy. (2020-06-10)

Physical activity in all of its forms may help maintain muscle mass in midlife
Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. Physical activity in all of its forms may help maintain muscle mass in midlife. (2020-06-08)

Atherosclerosis -- How a microRNA protects vascular integrity
Ludwig-Maximilian-Universitaet (LMU) in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis. (2020-06-04)

Near-atomic 'blueprint' reveals inner workings of drug target for cancer, other diseases
Van Andel Institute scientists have for the first time described the near-atomic level structure of a molecular pathway that plays critical roles in human development, blood pressure regulation, inflammation and cell death. The findings were published today in the journal Nature. (2020-06-03)

Study resolves controversy surrounding tumor suppressor gene's role in pluripotent ESCs
A new study released in STEM CELLS sorts through the maze of contradictions to finally determine that the multiple roles of p53 in cell cycle regulation and apoptosis are acquired during pluripotent stem cell differentiation. (2020-06-01)

New LAT1 inhibitor can boost cancer treatment
Researchers at the University of Eastern Finland have developed a new and promising drug compound for the treatment of cancer that inhibits natural amino acids from entering cancer cells. Since amino acids are essential for the growth and division of cancer cells, the new LAT1 inhibitor makes it possible to inhibit their growth. (2020-05-18)

New players in the programmed cell death mechanism
Skoltech researchers have identified a set of proteins that are important in the process of apoptosis, or programmed cell death. These newly identified proteins can become targets in the development of drugs against cancer or other diseases. (2020-04-30)

A cellular mechanism protecting against cancer
Susanne Hellmuth and Olaf Stemmann from the University of Bayreuth have discovered a natural protective mechanism that leads to the programmed death of potentially diseased cells. It protects from cancer that can develop as a result of irregular distribution of genetic information to daughter cells. The enzyme separase plays a central role in these processes. The findings published in ''Nature'' offer promising approaches for cancer therapy. (2020-04-23)

Discovering the secrets of the enigmatic caspase-6
Researchers identified the mechanisms underlying the innate immune function of the enzyme caspase-6, offering ways to combat viral infection, inflammatory diseases and cancer. (2020-04-15)

Keratin scaffolds could advance regenerative medicine and tissue engineering for humans
Researchers at Mossakowski Medical Research Center of the Polish Academy of Science have developed a simple method for preparing 3D keratin scaffold models which can be used to study the regeneration of tissue. (2020-04-14)

A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 -- a member of the BCL2 protein family known as the gatekeepers of apoptosis -- and the cell-cycle checkpoint protein P18. Through this link, MCL1, which functions in the decision between either cell survival or programmed death, can also directly initiate cell proliferation. (2020-04-03)

Physical activity contributes to positive mental well-being in menopausal women
Late menopausal status is associated with an elevated level of depressive symptoms that indicate the negative dimension of mental well-being. However, menopause was not linked to positive dimensions of mental well-being in women aged 47 to 55. The results also suggest that a high level of physical activity was linked to fewer depressive symptoms, higher satisfaction with life and higher positive affectivity in menopausal women. (2020-04-01)

Destroying DNA to save the genome -- study offers new insights into sepsis and its treatment
Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment. Now, researchers from Tata Memorial Centre, India, led by Prof. Dr Indraneel Mittra, have uncovered an important molecular mechanism underlying different aspects of sepsis--chromatin released by dying host cells after infection or injury. The scientists also put forth a novel treatment strategy for sepsis, which targets cell-free chromatin. (2020-03-26)

How trans fats assist cell death
Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. Their findings, published in the journal Science Reports, implicate their role in enhancing a mitochondrial signalling pathway that leads to programmed cell death. (2020-03-25)

Antioxidant treatment in acute ischemic stroke may delay the onset of Alzheimer's dementia
There is a considerable overlap between vascular risk factors and risk factors of Alzheimer's disease (AD). In addition, incident stroke approximately doubles the risk of developing AD. Oxidative stress is significantly involved in the pathogenesis of AD and suffers a dramatic increase in the setting of acute ischemic stroke, especially in cardioembolic stroke, followed by lacunar stroke. Dampening this oxidative burst could delay the onset of subsequent dementia in stroke survivors. (2020-03-17)

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