Current Atherosclerosis News and Events

Current Atherosclerosis News and Events, Atherosclerosis News Articles.
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Radiomics shows cocaine fuels coronary artery disease risk
Radiomics--the extraction of very detailed quantitative features from medical images--provides a refined understanding of how cocaine use and other risk factors affect the course of coronary artery disease, according to a new study. Researchers said the study shows the power of radiomics to improve understanding of not just cardiovascular disease, but cancer and other conditions as well. (2021-02-16)

Spanish scientists uncover early links between cardiovascular risk and brain metabolism
Investigators at the CNIC have discovered a link between brain metabolism, cardiovascular risk, and atherosclerosis during middle age, years before symptoms appear (2021-02-15)

Mid-life cardiovascular disease prevention may protect against later dementia
Employing cardiovascular disease prevention strategies in mid-life may delay or stop the brain alterations that can lead to dementia later in life, according to a study in the Journal of the American College of Cardiology. (2021-02-15)

New synthetic peptides could attenuate atherosclerosis
Atherosclerosis, a lipid-triggered chronic inflammatory disease of our arteries, is the main cause of strokes and heart attacks. An international team of researchers led by the Technical University of Munich (TUM) and the LMU University Hospital has developed novel synthetic peptides that can help to prevent atherosclerosis in vitro, that is in the test tube, as well as in animal models. (2021-02-12)

Long-term stress linked to increased risk of heart attack
Can long-term stress lead to heart attacks? Most people would probably answer in the affirmative, but the scientific evidence of this is scarce. A new study by researchers from Linköping University in Sweden reveals that the levels of the stress hormone cortisol were increased in the months preceding a heart attack. The results, published in Scientific Reports, suggest that long-term stress is a risk factor for heart attacks. (2021-02-10)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease
Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. (2020-12-17)

Carrots are healthy, but active enzyme unlocks full benefits
Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin. (2020-12-11)

CNIC scientists identify a new diagnostic and therapeutic target for cardiovascular disease
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a mitochondrial protein as a potential marker for the diagnosis of cardiovascular disease (CVD) and as a possible target for future treatments. The study is published today in the journal Nature. (2020-12-02)

Pre-treating progenitor cells with protein-activator slows progression of atherosclerosis
A new treatment for atherosclerosis, commonly known as hardening of the arteries, may be on the horizon, according to a study released in STEM CELLS Translational Medicine (SCTM). (2020-11-24)

Link between periodontitis and cardiovascular disease in individuals with rheumatoid arthritis
Rates of both periodontal disease and cardiovascular disease are elevated in individuals with rheumatoid arthritis. New research published in Arthritis & Rheumatology suggests that immune responses to certain bacteria that cause periodontal disease may play a role in patients' higher cardiovascular disease risk. (2020-11-18)

New screening questionnaire can identify people at high risk of developing heart disease
A new study in a Swedish population of middle-aged adults found that four out of 10 people have atherosclerosis, a buildup of fatty deposits that reduce blood flow to the heart. Early detection of coronary artery disease is needed in order to provide preventive treatment and decrease the risk of heart attack. Researchers developed a personalized screening strategy to identify individuals with a higher probability of developing cardiovascular disease. (2020-11-13)

Down Syndrome-associated gene suppresses age-related corneal clouding
Down syndrome and hypercholesterolemia mouse models suggest that the DSCR-1 gene protects against abnormal cornea vascularization and associated blindness by suppressing oxidized LDL cholesterol production and downstream angiogenic signaling during chronic high cholesterol. While the neurological pathology of Down syndrome patients worsens with age, they are less susceptible to age-related vascular diseases. The responsible genes and mechanisms are not yet clear, but DSCR-1 is a strong candidate for a wide range of vascular diseases. (2020-11-05)

Researchers use gold nanorod scattering to identify immune system's 'killer and savior'
Researchers have utilized the scattering of gold nanorods to identify M1 and M2 macrophages. Further development of this technique will lead to a new point of care or a biopsy tool which can predict the stages of manifestation of diseases like cancer, atherosclerosis, and fibrosis just from the simple tissue fluids or blood samples. (2020-10-20)

How hormone therapy slows progression of atherosclerosis
As one of the most common treatments for effectively managing menopause symptoms, hormone therapy (HT) is also known to provide multiple health benefits, including slowing the progression of atherosclerosis. A study based on Early Versus Late Intervention Trial With Estradiol (ELITE) data evaluated the underlying mechanism of such benefit and will be presented during the 2020 Virtual Annual Meeting of The North American Menopause Society (NAMS), opening on September 28. (2020-09-28)

CNIC design an algorithm for personalized cardiovascular risk estimation in healthy people
A machine learning tool assesses a range of variables including age, blood pressure, diet, and blood and urine markers. (2020-09-28)

Uncovering the genetics behind heart attacks that surprise young, healthy women
New genetic research finds spontaneous coronary artery dissection, or SCAD, heart attacks may be more similar to different diseases than to other heart attacks. (2020-09-04)

Study leads to better understanding of blood pressure regulation, atherosclerosis
A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen contributes to blood pressure regulation and atherosclerosis. (2020-09-02)

How to treat the most common heart attacks
One in five patients die within a year after the most common type of heart attack. European Society of Cardiology (ESC) treatment guidelines for non-ST-segment elevation acute coronary syndrome are published online today in European Heart Journal, and on the ESC website. (2020-08-29)

Are all vegetarian diets healthy?
Vegetarian foods are not equally healthy, according to research presented today at ESC Congress 2020. (2020-08-27)

T cells can shift from helping to harming in atherosclerosis
At La Jolla Institute for Immunology (LJI) researchers are dedicated to finding a way to stop plaques from forming in the first place. In a new study, LJI scientists show that certain T lymphocytes, a type of white blood cell, that start out trying to fight the disease can end up increasing inflammation and making atherosclerosis cases even worse. (2020-07-24)

New biomarker for dementia diagnosis
Medical researchers in the UK and Australia have identified a new marker which could support the search for novel preventative and therapeutic treatments for dementia. In an innovative new study, coordinated by Flinders University and University of Aberdeen, the researchers investigated the role of asymmetric dimethylarginine (ADMA), a blood marker associated with atherosclerosis and cardiovascular disease in epidemiological studies, on temporal changes in cognition in an established cohort of human ageing (the 1936 Aberdeen Birth Cohort). (2020-07-10)

LJI scientists investigate a powerful protein behind antibody development
Scientists at the La Jolla Institute for Immunology (LJI) have discovered a potential new way to better fight a range of infectious diseases, cancers and even autoimmune diseases. The new study, published recently in Nature Immunology, shows how a protein works as a ''master regulator'' in the immune system. (2020-06-22)

New nanoparticle drug combination for atherosclerosis
Physicochemical cargo-switching nanoparticles (CSNP) designed by KAIST can help significantly reduce cholesterol and macrophage foam cells in arteries, which are the two main triggers for atherosclerotic plaque and inflammation. (2020-06-17)

CAR T cells beyond cancer: Targeting senescence-related diseases
Scientists at Memorial Sloan Kettering have genetically engineered immune cells to find and kill cells that contribute to diseases caused by a tissue-damaging process called senescence. Studies in mice show that these engineered cells can kill their targets without causing undue toxicity. (2020-06-17)

Molecules that reduce 'bad' gut bacteria reverse narrowing of arteries in animal study
Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state. They also have shown--through experiments in mice--that this approach reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis. (2020-06-15)

Atherosclerosis screening plus physical activity assessment give doctors a more accurate picture of mortality risk
'On a scale of 1 - 10, how much do you exercise (0-none, 10-always).' Adding this simple question when assessing elderly patients undergoing coronary artery calcium (CAC) scans can help clinicians better understand and treat patients, report scientists in Mayo Clinic Proceedings: Innovations, Quality & Outcomes, published by Elsevier. (2020-06-05)

Exercise levels can help doctors predict risk of heart disease and death among elderly
Clinicians can use this information to improve care with early interventions. (2020-06-05)

Fitful nightly sleep linked to chronic inflammation, hardened arteries
Scientists begin to reveal what it is about fragmented nightly sleep that leads to the fatty arterial plaque buildup that can result in fatal heart disease. (2020-06-05)

Atherosclerosis -- How a microRNA protects vascular integrity
Ludwig-Maximilian-Universitaet (LMU) in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis. (2020-06-04)

Disrupted sleep increases the risk of cardiovascular disease by promoting inflammation
Sleep disruption has been shown to be associated with an increased risk of atherosclerosis, but the mechanism has been unclear. A new study in the open-access journal PLOS Biology by Raphael Vallat, Vyoma Shah, and Matthew Walker of the University of California at Berkeley and colleagues reveals that fragmented sleep exacerbates atherosclerosis and may raise the risk of stroke via an effect on inflammatory pathways. (2020-06-04)

Heart attack prevention lags for people with stroke, peripheral artery disease
Although all three conditions can lead to heart attack, people with stroke or peripheral artery disease were less likely to receive preventive treatments to prevent heart attack than people with coronary artery disease. Stroke survivors were more likely to report poor health care satisfaction and more emergency room visits. Patients with peripheral artery disease had the highest out-of-pocket health expenses of the three conditions. (2020-05-16)

Study finds association between atherosclerosis and changes in the structure, heart function
Even among individuals free of heart failure and myocardial infarction, there appears to be evidence of an association between calcium buildup in the coronary arteries (atherosclerosis) and changes in the structure and function of the heart. (2020-05-15)

Scientists invented an aging vaccine
A new way to prevent autoimmune diseases associated with aging like atherosclerosis, Alzheimer's disease, and Parkinson's disease was described in the article. (2020-05-03)

A new strategy to counter insulin damage in coronary artery disease
By studying blood vessel tissue from 674 patients, a research team has discovered how insulin contributes to the dysfunction of blood vessels in atherosclerosis, one of the most common chronic health conditions worldwide. (2020-04-29)

Spanish scientists identify a biomarker that detects atherosclerosis before the appearance of symptoms
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD) in Madrid have demonstrated that a proteins present in early atheroma plaques -- accumulations of cholesterol in the wall of arteries -- could be used as a biomarker to detect atherosclerosis in the subclinical phase, before the appearance of symptoms. (2020-04-21)

Atherosclerosis progresses rapidly in healthy people from the age of 40
A CNIC study published in JACC demonstrates that atheroma plaques extend rapidly in the arteries of asymptomatic individuals aged between 40 and 50 years participating in the PESA-CNIC-Santander study. (2020-04-06)

How trans fats assist cell death
Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. Their findings, published in the journal Science Reports, implicate their role in enhancing a mitochondrial signalling pathway that leads to programmed cell death. (2020-03-25)

How to slow down ageing?
Healthy ageing has become one of the priorities of research in Europe. Estonian researchers looked for differences in the immune systems of young and old people. They focused on monocytes and found that the monocytes of the elderly do not seem to produce as much energy, and there is an increase in inflammation markers compared to younger people. Looking into the future, this research gives food for thought as to how to slow down age-related changes. (2020-03-19)

Associations between vaspin levels and coronary artery disease
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0565, Lutfu Askin, Okan Tanriverdi, Hakan Tibilli and Serdar Turkmen from the Department of Cardiology, Adiyaman Education and Research Hospital, Adiyaman, Turkey consider associations between vaspin levels and coronary artery disease. (2020-03-19)

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