Current Autoimmune News and Events

Current Autoimmune News and Events, Autoimmune News Articles.
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Mimicking a chronic immune response changes the brain
Abnormal production of Inflammatory cytokines by the immune system is responsible for a host of autoimmune disorders. One important cytokine is IL-17A, which is also involved in neurological diseases. Researchers at Tsukuba University in Japan made a mouse model of chronically high IL-17A and to study its effect on the brain. They show that it leads to reduced activity and density of microglia in the brain's hippocampus, but no obvious memory deficits. (2021-02-17)

Dennis tamed the protein from hell in seven years
A research group from Aarhus University has succeeded in understanding why a very extended structure is important for an essential protein from the human immune system. The new results offer new opportunities for adjusting the activity of the immune system both up and down. Stimulation is interesting in relation to cancer treatment, while inhibition of the immune system is used in treatment of autoimmune diseases. (2021-02-17)

Zika vaccine candidate shows promise in phase I trial
The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector showed promising safety and immunogenicity in a phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge. The findings are published in Annals of Internal Medicine. (2021-02-15)

New study identifies the main genetic causes of autoimmune Addison's disease
Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison's disease. (2021-02-12)

Gene variants increase risk of Addison's disease
Variants of nine genes increase the risk of developing Addison's disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison's disease. The findings help increase knowledge about what causes the disease. The study was conducted by researchers at Karolinska Institutet, Sweden, and Bergen University, Norway, and is published in the journal Nature Communications. (2021-02-11)

Substance in the blood of pregnant women fights pathological immune reaction
Scientists studied the effect of trophoblastic β1-glycoprotein in the blood of pregnant women on pro-inflammatory immune cells. Thanks to trophoblastic β1-glycoprotein, a woman's body does not adversely react to the fetus and supports its normal development until birth. It turned out that trophoblastic β1-glycoproteins also suppressed the development of pro-inflammatory lymphocytes and reduced their activity. (2021-02-10)

When hyperactive proteins trigger illnesses
Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities. (2021-02-02)

Childhood trauma could affect development, treatment of multiple sclerosis
Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood, a new study in mice found. Mice that had experienced stress when young were more likely to develop the autoimmune disorder and less likely to respond to a common treatment, researchers at the University of Illinois Urbana-Champaign found. However, treatment that activated an immune-cell receptor mitigated the effects of childhood stress in the mice. (2021-01-29)

Scientists find key function of molecule in cells crucial for regulating immunity
UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in autoimmune diseases. (2021-01-28)

Study finds especially high rates of lupus in certain racial/ethnic groups
The US prevalence of the autoimmune disease lupus is 72.8 cases per 100,000 individuals, according to an analysis of population-based registries. The analysis, which is published in Arthritis & Rheumatology, found that the rate is 9 times higher for females than males (128.7 vs. 14.6 per 100,000), and it's highest among American Indians/Alaska Natives and Black females. (2021-01-21)

Study reveals new insights into the link between sunlight exposure and kidney damage
A new collaborative study from researchers at the Geisel School of Medicine at Dartmouth and the University of Washington and published in the Proceedings of the National Academy of Sciences (PNAS), reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus. (2021-01-21)

Scientists discover key enzyme responsible for skin blistering in the elderly
The Granzyme B (GzmB) enzyme, which accumulates in certain tissues as we age, has been identified as a driver of itchy and sometimes life-threatening autoimmune conditions known as pemphigoid diseases (PDs), which cause blistering and skin erosion below the skin's surface. New research led by University of British Columbia (UBC) and Vancouver Coastal Health Research Institute (VCHRI) scientists has found that a gel containing a specific and potent inhibitor of GzmB activity, VTI-1002, resulted in significant improvements on skin affected by PDs. (2021-01-12)

A subtle change in the DNA may predispose to polyneuropathy after gut infection
Researchers from Tokyo Medical and Dental University (TMDU) identified a novel genetic variant associated with Guillain-Barré syndrome (GBS). By analyzing the DNA sequence of patients with the disease, the researchers identified two novel variants of the ganglioside-binding protein Siglec-10 accumulated in the patients. They found that one of these variants impairs the function of the protein, predisposing carriers to the development of GBS. This study improves our understanding of the pathophysiology of GBS. (2021-01-07)

Autoimmune diseases: similar molecular signatures in target tissues
A study conducted by Professor Decio L. Eizirik's group - ULB Center for Diabetes Research - and published in Sciences Advances shows that autoimmune diseases, including type 1 diabetes, must be studied in their entirety, taking into account not only the immune system but also the target tissues. Indeed, the key mechanisms induced by inflammation, potentially shared between type 1 diabetes, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis, could generate similar molecular signatures at the target tissue level. (2021-01-07)

Treating an autoimmune disease in mice with an mRNA vaccine
Christina Krienke and colleagues have designed an mRNA vaccine that delayed the onset of and reduced the severity of multiple sclerosis-like disease in mice. (2021-01-07)

Hydroxychloroquine blood levels predict clotting risk in patients with lupus
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk. (2021-01-06)

New research finds ginger counters certain autoimmune diseases in mice
The main bioactive compound of ginger root lowers autoantibody production and helps halt disease progression in mice with antiphospholipid syndrome and lupus. (2021-01-06)

A new approach to study autoimmune diseases
A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for autoimmune diseases requires studying together the immune system AND target tissues. This study, ''Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis and rheumatoid arthritis,'' is featured in the Jan. 6, 2021, edition of Science Advances. (2021-01-06)

Targeting T cell protein could prevent type 1 diabetes, study suggests
Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes. The study, which will be published December 9 in the Journal of Experimental Medicine (JEM), reveals that inhibiting a protein called OCA-B protects mice from type 1 diabetes by limiting the activity of immune cells that would otherwise destroy the pancreas' insulin-producing β cells. (2020-12-09)

Study identifies links between atopic dermatitis and autoimmune diseases
In a recent study published in the British Journal of Dermatology, individuals with atopic dermatitis, or eczema, were more likely to also have various autoimmune diseases, especially those involving the skin, the gastrointestinal tract, or the connective tissue. (2020-12-07)

The impact of Neandertal DNA on human health
A researcher at the University of Tartu described new associations between Neandertal DNA and autoimmune diseases, prostate cancer and type 2 diabetes. (2020-12-03)

Vaccination against tuberculosis can reduce the spread of COVID-19 and ease its course
St Petersburg University scientists have analysed about 100 academic papers and statistics on the incidence of COVID-19 in different countries of the world. Analysis of these data showed that the spread of the new coronavirus infection occurs more slowly where there is a large percentage of people vaccinated against tuberculosis with the BCG vaccine. Moreover, this vaccination itself, given in early childhood, changes the immune system in such a way that the new coronavirus disease course tends to be less severe. (2020-12-03)

Genetically engineered T cells could lead to therapies for autoimmune diseases
University of Arizona Health Sciences immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes. (2020-12-03)

People with rare autoimmune diseases at increased risk of dying during COVID-19 pandemic
A new study, led by experts from the University of Nottingham, has shown that people with rare autoimmune rheumatic diseases are at a greater risk of dying at a younger age during the COVID-19 pandemic. (2020-12-03)

Study explores sleep apnea, autoimmune disease link
New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies. (2020-11-17)

Cleveland Clinic researchers identify melatonin as possible COVID-19 treatment
CLEVELAND - Results from a new Cleveland Clinic-led study suggest that melatonin, a hormone that regulates the sleep-wake cycle and is commonly used as an over-the-counter sleep aid, may be a viable treatment option for COVID-19. (2020-11-09)

Safe pregnancy is possible for women with interstitial lung disease
A new study shows that women with interstitial lung disease (ILD) related to autoimmune disease may not need to terminate their pregnancies--despite the increased risk of adverse outcomes--provided they have close monitoring from their team of multidisciplinary physicians before, during and after pregnancy. Results of the research was presented at ACR Convergence, the American College of Rheumatology's annual meeting. (2020-11-06)

A novel immunotherapy proves effective in animal models of multiple sclerosis
Jefferson researchers develop an approach to specifically impede the autoimmune response that drives the disease, while leaving the rest of the immune system fully functioning. (2020-11-04)

Unraveling the genetic determinants of small vessel vasculitis
Researchers from the University of Tsukuba have shown that the single-nucleotide variants of TERT and DSP, which promote risk for idiopathic pulmonary fibrosis (IPF), are significantly associated with susceptibility to microscopic polyangiitis and myeloperoxidase-ANCA associated vasculitis. Interestingly, there was no clear link to the severe complication interstitial lung disease (ILD). These findings suggest a shared genetic susceptibility between IPF and ANCA-associated vasculitides that may be independent of ILD risk. (2020-11-03)

Immunotherapy side effect could be a positive sign for kidney cancer patients
An autoimmune side effect of immune checkpoint inhibitor (ICI) drugs could signal improved control of kidney cancer, according to a new study by researchers in UT Southwestern's Kidney Cancer Program (KCP). (2020-11-02)

New cause of COVID-19 blood clots identified
A new study reveals that COVID-19 triggers production of antibodies circulating through the blood, causing clots in people hospitalized with the disease. (2020-11-02)

Unravelling the origins of autoimmune psychosis
Anti-NMDAR encephalitis is an autoimmune brain illness that is often mistaken by a psychiatric disorder since it causes psychoses and other behaviour alterations. Despite having these similarities, the illness does not respond to common antipsychotic treatments. (2020-10-29)

UMass Amherst research compares sensitivity of all genes to chemical exposure
A University of Massachusetts Amherst environmental health scientist has used an unprecedented objective approach to identify which molecular mechanisms in mammals are the most sensitive to chemical exposures. (2020-10-29)

New insights into a potential target for autoimmune disease
With insights into a molecular pathway that regulates the activity of Tregs, a type of T cell involved in immunosuppression, research by the University of Pennsylvania's George Hajishengallis and colleagues opens up possibly new avenues for treating inflammatory and autoimmune diseases. (2020-10-26)

New population of immune cells could play a role in multiple sclerosis
Researchers uncover defining features of a subset of T-cells that may drive autoimmunity in MS, and could prove to be a new target for therapy. (2020-10-23)

Multiple sclerosis as the flip side of immune fitness
About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study led by the University of Zurich has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells which - although they are effective in fighting off pathogens such as Epstein-Barr virus - also attack brain tissue. (2020-10-22)

Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D. (2020-10-22)

Gut bacteria in multiple sclerosis: Probiotic or commensal, good or bad?
Though evidence suggests that the gut microbiome modulates risk of multiple sclerosis, new findings from the University of Vermont highlight complex interactions between host genetics and environmental factors impact susceptibility to multiple sclerosis. Strategies to prevent or treat multiple sclerosis should take into account host genetics, the pre-existing gut microbiome, and the timing or mode of the intervention. (2020-10-19)

Study identifies key enzyme for development of autoimmune diseases
An enzyme associated with energy production in cells also participates in the differentiation of immune cells involved in exacerbated inflammation. The discovery could lead to more effective treatment. (2020-10-19)

New therapy improves treatment for multiple sclerosis
A new therapy that binds a cytokine to a blood protein shows potential in treating multiple sclerosis, and may even prevent it. (2020-10-12)

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