Current Biomarkers News and Events

Current Biomarkers News and Events, Biomarkers News Articles.
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New therapeutic target for Huntington's treatment
Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations. The origin of this disease has been associated with the anomalous functioning of the mutated protein: mHTT, but recent data showed the involvement of other molecular mechanisms. (2021-02-23)

Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Immunosuppressive cell and cytokine response linked to bone nonunion
An abnormal suppression of the immune system linked to the onset of numerous diseases has been associated with poor functional regeneration of traumatic bone injuries. The discovery could guide a path for predicting which trauma patients may are less likely to respond to treatment. (2021-02-17)

Discovery of biomarker could help predict Alzheimer's years before symptoms emerge
A unique brain protein measured in the blood could be used to diagnose Alzheimer's disease decades before symptoms develop, according to new Edith Cowan University (ECU) research. (2021-02-17)

Researchers discover promising biomarkers to diagnose mild traumatic brain injury
Certain plasma microRNAs could serve as diagnostic biomarkers in mild traumatic brain injury, a new study from the University of Eastern Finland shows. The biomarkers were discovered in an animal model and they were successfully used also to diagnose mild traumatic brain injury in a subgroup of patients. (2021-02-15)

Detecting single molecules and diagnosing diseases with a smartphone
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers show that the light emitted by a single molecule can be detected with a low-cost optical setup. Their prototype could facilitate medical diagnostics. (2021-02-12)

TalTech scientists developed novel immune diagnostics of multiple sclerosis
Multiple sclerosis (MS) is the most common neurological disease in young adults, affecting more than 2 million individuals worldwide, with about 1500 cases in Estonia. About 20% of MS patients experience optic neuritis (ON) as the presenting symptom, but not all ON patients develop MS. (2021-02-11)

Biomarkers that could help determine who's at risk for severe COVID-19 symptoms
One of the many mysteries still surrounding COVID-19 is why some people experience only mild, flu-like symptoms, whereas others suffer life-threatening respiratory problems, vascular dysfunction and tissue damage. Now, researchers reporting in ACS' Analytical Chemistry have used a combination of metabolomics and machine learning to identify possible biomarkers that could both help diagnose COVID-19 and assess the risk of developing severe illness. (2021-02-10)

Using Artificial Intelligence to prevent harm caused by immunotherapy
Until recently, researchers and oncologists had placed these lung cancer patients into two broad categories: those who would benefit from immunotherapy, and those who likely would not. Now, researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy. (2021-02-04)

Role of cell cycle on analyzing telomerase activity with a fluorescence off-on system
Traditional detecting techniques for telomerase activity are mainly based on polymerase chain reaction (PCR)-based classic telomeric repeat amplification protocols (TRAPs) and quantitative reverse transcription PCR (RT-qPCR). However, those methods were mainly relied on the analysis of asynchronous cells with different phases of cell cycle, the heterogeneous behavior of cell cycle were overlooked, which might affect the accuracy of their detection results. (2021-02-04)

Study examines role of biomarkers to evaluate kidney injury in cancer patients
A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells. (2021-02-03)

An integrated approach for an effective prevention of Alzheimer´s disease
Recent studies demonstrate that styles of life involving interdependent actions of exercise, oriental practices such as QiGong, nutrition, mental and social activity and mindfulness are effective in preventing Alzheimer´s disease and other forms of dementia (2021-02-01)

New study points to better diagnostics for cancer
A new University of California, Irvine-led study finds a new method for identifying biomarkers may aid in early cancer diagnosis. The study focused on lung cancer, however the Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method has been tested on aging and Alzheimer's diseases as well and is expected to be effective for studying other diseases. (2021-01-27)

TGen-led study results suggest more accurate diagnostic for breast cancer
Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal Breast Cancer Research. (2021-01-26)

Continuous monitoring of proteins a game-changer for patients with deteriorating health
A world-first discovery by Australian researchers could become a game-changer for patients at risk of rapid health deterioration, such as heart complications, stroke, sepsis and cancer. Researchers developed an antibody as a biosensor, to continuously monitor rapid changes in the concentration of EGFR, a protein present on cancer cells and in body fluids. (2021-01-25)

Biomarkers in mother's plasma predict a type of autism in offspring with 100% accuracy
UC Davis MIND Institute researchers used machine learning to crunch 10,000 autoantibody pattern combinations to identify maternal biomarkers associated with a sub-type of autism. The findings have implications for early diagnosis and intervention. (2021-01-25)

No more needles for diagnostic tests?
The lab of Srikanth Singamaneni at the McKelvey School of Engineering at Washington University in St. Louis developed a biosensing microneedle patch that can be applied to the skin, capture a biomarker of interest and, thanks to its unprecedented sensitivity, allow clinicians to detect its presence. (2021-01-22)

NAD+ can restore age-related muscle deterioration
Scientists at EPFL have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function. (2021-01-19)

MicroRNA may serve as therapeutic targets for traumatic brain injury
WRAIR scientists have shown that traumatic brain injury causes coordinated microRNA dysregulation followed by increased amounts of the beta-site amyloid cleaving enzyme, or BACE1, and loss of amyloid precursor protein. BACE-1 cleaves APP to generate amyloid beta peptides, a hallmark of neurodegenerative disease pathology and brain cells loss, which are the focus of several clinical trials for Alzheimer's disease. Future research will characterize the direct role of miRNAs and their relationship to BACE1 within TBI. (2021-01-14)

Study identifies immune response biomarkers, novel pathways in four marine mollusc species
A new study involving the University of Maine assessed immune responses in four economically important marine mollusc species -- the blue mussel, soft-shell clam, Eastern oyster, and Atlantic jackknife clam -- and identified new biomarkers relating to changes in protein function involved in novel regulatory mechanisms of important metabolic and immunological pathways. (2021-01-12)

Biomarkers in fathers' sperm linked to offspring autism
Epigenetic biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder. In the study, researchers identified a set of genomic features, called DNA methylation regions, in sperm samples from men who were known to have autistic children. Then in a set of blind tests, they were able to use the presence of these features to determine whether other men had fathered autistic children with 90% accuracy. (2021-01-11)

Study reveals strong links between gut microbes, diet and metabolic health
The largest and most detailed study of its kind has uncovered strong links between a person's diet, the microbes in their gut (microbiome) and their health. This interrelationship appears to associate with an individual's risk of some serious conditions, including diabetes and heart disease. The study shows that gut microbe composition is highly individualized, and these findings could be used to provide personal dietary advice for better health. (2021-01-11)

Landmark study reveals link between gut microbes, diet and illnesses
Diets rich in healthy and plant-based foods encourages the presence of gut microbes that are linked to a lower risk of common illnesses including heart disease, research has found. (2021-01-11)

Dual smoking and vaping doesn't cut cardiovascular risk: Boston University study
Cardiovascular disease is the leading cause of death associated with smoking cigarettes. But as use of e-cigarettes (''vaping'') becomes more popular, including as a way to cut back on cigarettes, little is known about its effect on cardiovascular health. Now, a new Boston University School of Public Health (BUSPH) study, published in the journal Circulation, finds that vaping may not cut risk of cardiovascular disease in the way that most adults use them--in combination with cigarettes. (2021-01-06)

ADDF presents vision of a consortium to accelerate research into speech and language biomarkers for Alzheimer's disease
In a commentary in Exploration in Medicine, Alzheimer's experts lay out a vision for a worldwide research consortium that can give clinicians -- and patients -- the answers to which speech and language changes may signal Alzheimer's in the form of digital biomarkers. (2021-01-05)

Vaping combined with smoking is likely as harmful as smoking cigarettes alone
People who smoked traditional cigarettes in addition to using e-cigarettes experienced health effects as harmful as those who smoked cigarettes exclusively; those effects are associated with a higher risk for cardiovascular disease and death. In a large data analysis of more than 7,100 U.S. adults, researchers examined the association of cigarette and e-cigarette use with inflammation and oxidative stress as biomarkers predicting cardiovascular disease. (2021-01-04)

Gene biomarkers indicate liver toxicity quickly and accurately
When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal studies. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a few days while maintaining a high level of accuracy. (2020-12-18)

Researchers discover brain pattern that could improve mental health disorder diagnosis
A pattern in how the brain breaks down tryptophan, a common amino acid consumed through food, was discovered by researchers at UTHealth. (2020-12-17)

Proenkephalin (penKid®) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients
The Acute Disease Quality Initiative (ADQI) recommends the use of novel biomarkers for AKI management, including functional biomarkers as penKid®. (2020-12-16)

Novel biomarkers predict the development of incident heart failure
Researchers at the University of Eastern Finland and Kuopio University Hospital have discovered several new biomarkers that are associated with incident heart failure. In a new study, several inflammatory biomarkers and cell energy metabolites were linked to an increased risk of incident heart failure. (2020-12-16)

Data-driven discovery of biomarkers pave way for improved diagnosis of contact allergy
With the help of algorithms, researchers at Karolinska Institutet in Sweden have identified markers that can differentiate between irritant eczema and contact allergy, two skin reactions that look similar but require different treatment. Their findings, which are published in the journal Proceedings of the National Academy of Sciences (PNAS), support the further development of an alternative to today's diagnostic patch tests. (2020-12-14)

Insufficient screening for heart damage after noncardiac surgery puts patients at risk
About five percent of patients experience heart muscle injury around the time of their surgery for a noncardiac condition, yet guideline recommendations to identify patients at risk using biomarkers are not being followed. A five-year study in Alberta, Canada appearing in the Canadian Journal of Cardiology, published by Elsevier, determined that the recommended biomarker screening is very much underutilized. (2020-12-10)

Genetic differences important in Alzheimer's diagnosis
The two used methods for detecting amyloid pathology in Alzheimer's disease do not give unambiguous results, with the risk of incorrect or delayed care interventions. Now, researchers at Karolinska Institutet in Sweden have found genetic explanations for the differences. The study is published in Molecular Psychiatry and may be important for more individual diagnostics and the development of future drugs. (2020-12-10)

How blood and wealth can predict future disability
Research shows that blood tests for biomarkers such as cholesterol and inflammation can predict disability in five years. Researchers studied blood biomarkers of 5,286 participants involved in the UK Household Longitudinal Study - and found that biological health can predict disability and healthcare demand in five years' time. They also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems. (2020-12-09)

Identifying markers of COVID-19 infection using blood tests
This study identifies the values for six biochemical biomarkers that indicate a patient may be infected with SARS-COV-2 (COVID-19). The key novelty of this study lies in the fact that it was carried out using a blood test and can provide a determination in about 60 minutes. (2020-12-04)

Predicting breast cancer recurrences
A new tool combining traditional pathology with machine learning could predict which breast cancer patients actually need surgery. The technology, reported in the November issue of American Journal of Physiology -- Cell Physiology (vol. 319: C910-C921; https://doi.org/10.1152/ajpcell.00280.2020), could spare women from unnecessary treatments, reduce medical expenses, and lead to a new generation of drugs to stop breast cancer recurrences. (2020-12-03)

Sensors for a 'smart' wound bandage may track healing, immune response: Study
Researchers from Skoltech and the University of Texas at Austin have presented a proof-of-concept for a wearable sensor that can track healing in sores, ulcers, and other kinds of chronic skin wounds, even without the need to remove the bandages. ''The next step is to utilize this sensor technology for in vivo studies and real-time monitoring of wound treatment effectiveness on human subjects in clinical settings,'' Skotech provost, Professor Keith Stevenson notes. (2020-12-02)

Deep learning predicts woman's risk for breast cancer
Researchers at Massachusetts General Hospital (MGH) have developed a deep learning model that identifies imaging biomarkers on screening mammograms to predict a patient's risk for developing breast cancer with greater accuracy than traditional risk assessment tools. Results of the study are being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-30)

Liver cirrhosis: Disease progression
Patients with liver cirrhosis display a wide range of clinical symptoms. A prospective study conducted by MedUni Vienna has now shown that blood levels of biomarkers for systemic inflammation increase over the various stages of the disease and can predict the development of complications, even in previously asymptomatic patients. (2020-11-30)

App predicts risk of developing Alzheimer's
A new study from Lund University in Sweden shows that validated biomarkers can reveal an individual's risk of developing Alzheimer's disease. Using a model that combines the levels of two specific proteins in the blood of those with mild memory impairment, the researchers are able to predict the risk of developing Alzheimer's. The researchers have also developed an app that doctors can use to give patients a risk assessment. (2020-11-30)

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