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Current Bleeding News and Events, Bleeding News Articles.
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Apixaban more effective than enoxaparin in preventing thromboembolism after knee surgery
This release contains information on this week's studies appearing in the Lancet. (2010-03-04)

Genetic cause discovered for rare bleeding disorder
A team led by McMaster University hematologist Dr. Catherine Hayward has discovered the genetic cause of Quebec platelet disorder. They have gone on to develop a genetic test for the condition -- a major advance in diagnosing this serious and unusual bleeding problem. (2010-03-04)

Platelet function tests may provide modest benefit in predicting cardiac outcomes
An analysis of six tests that are used to measure platelet function and help gauge the effectiveness of antiplatelet drugs for patients undergoing a cardiac procedure such as a coronary stent implantation found that only three of the tests were associated with a modest ability to predict outcomes such as heart attack or death, according to a study in the Feb. 24 issue of JAMA. (2010-02-23)

Bleeding risk associated with image-guided biopsies is low
Even among patients who have taken aspirin in proximity to an image-guided percutaneous biopsy, risk of major bleeding associated with the procedure is low, according to a study in the March issue of the American Journal of Roentgenology. Image-guided percutaneous biopsies are an important means of diagnosing disease in organs and other soft tissues. They involve the removal of cells or tissues for examination. (2010-02-19)

Neonatal and infant circumcision: Safe in the right hands
How safe is circumcision? A systematic review, published in the open-access journal BMC Urology has found that neonatal and infant circumcision by trained staff rarely results in problems. Risks can be higher among older boys, especially when undertaken by untrained providers with inappropriate equipment. (2010-02-16)

Herbal medicines can be lethal, pathologist warns
A University of Adelaide forensic pathologist has sounded a worldwide warning of the potential lethal dangers of herbal medicines if taken in large quantities, injected, or combined with prescription drugs. (2010-02-08)

Heart patients using herbal remedies may be at heightened risk of dangerous drug interactions
More and more Americans are turning to herbal remedies to help manage chronic conditions or promote general health and wellness. But many of today's popular herbal supplements, including St. John's wort, gingko biloba, garlic and even grapefruit juice can pose serious risks to people who are taking medications for heart disease, according to a review article published in the Feb. 9, 2010, issue of the Journal of the American College of Cardiology. (2010-02-01)

Groundbreaking research shows platelets can reproduce in circulation
University of Utah researchers led an international team of scientists that is the first to report on the previously undescribed ability of platelets to reproduce themselves in the circulation. Their revolutionary findings were published online ahead of print, Jan. 19, 2010, in the journal Blood. (2010-01-26)

CWRU research finds first oral bacteria linking a mother and her stillborn baby
Yiping Han, a researcher from department of periodontics at Case Western Reserve University School of Dental Medicine, reports the first documented link between a mother with pregnancy-associated gum disease to the death of her fetus. (2010-01-21)

Ticagrelor for heart attack patients -- a landmark event that should redefine patient care
New research shows that the stronger anti-clotting medication tricagrelor reduces death rates without increasing bleeding compared with the current standard treatment of clopidogrel for heart attack patients. This new analysis of the PLATO trial is reported in an article online first and in an upcoming edition of the Lancet. (2010-01-13)

Study shows pine bark naturally relieves symptoms of acute hemorrhoids
A study published in a recent issue of Phototherapy Research reveals Pycnogenol, an antioxidant plant extract from the bark of the French maritime pine tree, has important anti-inflammatory and anti-thrombotic properties that may be beneficial in patients with hemorrhoids, both for acute and chronic treatment, and in preventing new attacks. (2010-01-12)

Misoprostol tablets can be used in place of intravenous oxytocin to stop post-birth bleeding
Oxytocin is currently the gold-standard treatment for post-birth bleeding, but it needs refrigeration, intravenous infusion, and skilled health-care workers for optimum use. Two articles published online first look at the use of misoprostol in tablet form compared with oxytocin and help to define the potential roles of both drugs in treating excess bleeding after childbirth in different health care settings. (2010-01-06)

How to relieve the pain effectively after laparoscopic cholecystectomy?
Although the pain after laparoscopic cholecystectomy (LC) is markedly less than the pain after open cholecystectomy, pain is still the patient's first complaint after LC. A recent study found that implanting fibrin sealant with sustained-release ropivacaine in the gallbladder bed could relieve the pain after LC. (2009-12-21)

Researchers take the inside route to halt bleeding
Researchers led by Case Western Reserve University's Erin Lavik developed synthetic platelets from biodegradable polymers. In animal models, the synthetics attach to natural platelets and stem bleeding faster than current treatments. (2009-12-16)

Heart attack patients given more antithrombotic drugs have increased risk of hospital admission for bleeding
In heart attack patients, risk of hospital admission for bleeding increases with the number of antithrombotic drugs used. Patients with nonfatal bleeding are also much more likely to suffer repeat heart attack or die than those without this nonfatal bleeding. This analysis of more than 40,000 Danish patients is reported in an article in this week's edition of the Lancet. (2009-12-10)

Research opens door to new thrombosis treatments
The latest findings on how blood clots form could open the door to the development of new and better-targeted drugs for patients at risk of strokes or heart attacks. (2009-12-10)

Many dialysis patients undergoing PCI receive improper medication, with higher risk of bleeding
Approximately 20 percent of dialysis patients undergoing a percutaneous coronary intervention (PCI; procedure such as angioplasty) are given an antithrombotic medication they should not receive, which may increase their risk for in-hospital bleeding, according to a study in the Dec. 9 issue of JAMA. (2009-12-08)

ASGE issues guidelines on management of antithrombotic agents for endoscopic procedures
According to a new guideline from the American Society for Gastrointestinal Endoscopy regarding the management of antithrombotic agents for endoscopy, aspirin and/or NSAIDs may be continued for all elective endoscopic procedures. When high-risk procedures are planned, clinicians may elect to discontinue aspirin and/or NSAIDs for five to seven days before the procedure, depending on the underlying indication for antiplatelet therapy. The guideline appears in the December issue of GIE: Gastrointestinal Endoscopy. (2009-12-08)

3 anticoagulant studies may change current medical practice
Research presented today at the 51st Annual Meeting of the American Society of Hematology reveals that the practice of using the anticoagulants aspirin and heparin with the hope of preventing clots in placental blood vessels is ineffective for preventing unexplained, recurrent miscarriages. Two other studies look at treatments for venous thromboembolism, a common and sometimes deadly clotting disorder. (2009-12-06)

New drug shows promise for those with clotting disorders: McMaster researcher
Study shows that an oral drug called dabigatran etexilate, is as safe and effective as warfarin for combating VTE. (2009-12-06)

Embargoed news from Annals of Internal Medicine
Below is information about four articles being published in the Dec. 1 issue of Annals of Internal Medicine. The information is not intended to substitute for articles as sources of information. Annals of Internal Medicine attribution is required for all coverage. (2009-11-30)

Control of blood clotting by platelets described; provides medical promise
Cell fragments called platelets are essential to promote blood clotting. Virginia Tech faculty members and students have discovered novel molecular interactions at the surface of platelets that control blood clotting. (2009-11-23)

Can EP4 agonist alleviate gastric lesions?
A research team from the United States investigated the EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers. They found that EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and indomethacin-aggravated gastric ulcers, via promoting proliferation and survival of mucous epithelial cells. (2009-11-18)

Research highlights need to address hemophilia in developing world
When modern medicine finds a way to treat a medical condition, people often think that the problem is solved. But we also have to find ways to get that treatment into the hands of those who need it. For example, new research shows that much more needs to be done to help get existing treatment to hemophilia patients in the developing world, and that the current lack of treatment there is costing lives. (2009-11-16)

Popular anti-platelet therapy reduces risk of cardiovascular events in men and women
A new study, published in the Nov. 17, 2009, issue of the Journal of the American College of Cardiology, adds to a growing body of research seeking to evaluate and understand possible sex differences associated with anti-platelet therapies. (2009-11-09)

Mayo Clinic study shows people with heart devices can 'digest' advanced diagnostic technology safely
A new Mayo Clinic study suggests that video capsule endoscopy, a procedure that uses wireless technology in diagnosing intestinal disease, is safe for patients with heart devices. (2009-10-26)

Oklahoma scientists discover promising new path for treating traumas
A discovery by scientists at the Oklahoma Medical Research Foundation could help save lives threatened by traumatic injuries, severe infectious diseases and diabetes. In the journal Nature Medicine, researchers cast new light on how proteins called histones can enter the bloodstream and kill the lining of blood vessels, resulting in uncontrolled internal bleeding and edema. Building on this work, Esmon and a team of collaborators have discovered an antibody that could counter this deadly process. (2009-10-25)

3-day course of antibiotics may be sufficient following tonsillectomy
Children who receive a three-day course of antibiotics following tonsillectomy rather than a seven-day course appear to have no differences in pain or how quickly they return to a normal diet and activity level, according to a report in the October issue of Archives of Otolaryngology -- Head & Neck Surgery, one of the JAMA/Archives journals. (2009-10-19)

Designing drugs and their antidotes together improves patient care
Imagine a surgical patient on a blood-thinning drug who starts bleeding more than expected, and an antidote that works immediately -- because the blood thinner and antidote were designed to work together. Researchers at Duke University Medical Center have engineered a way to do this for an entire, versatile class of drugs called aptamers and published their findings in Nature Medicine. (2009-10-04)

Complications are not best predictor of hospital mortality
The assumption is high mortality hospitals have high complication rates. But in this week's New England Journal of Medicine a University of Michigan report shows complications are common after major surgery -- about one in six patients. What distinguishes good and bad hospitals is how proficient they are at rescuing patients from those complications. Patients at high mortality hospitals are twice as likely to die from a post-surgical complication. (2009-09-30)

New blood-thinning drug safer than rat poison
A new drug has been declared to be safer but as effective as the standard anti-coagulant drug warfarin for treating patients with abnormal heart rhythms. (2009-09-29)

Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine
Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors, did not lead to adverse events, as some prior studies had suggested. The results were presented at the 21st annual Transcatheter Cardiovascular Therapeutics scientific symposium, sponsored by the Cardiovascular Research Foundation. (2009-09-24)

1-year results from Horizons-AMI trial reported at TCT 2009
Two subset analyses from the landmark HORIZONS-AMI trial show that the anticoagulant bivalirudin lowers major bleeding and cardiac death versus the combination of heparin and a GP IIb/IIIa inhibitor in patients with ST-segment myocardial infarction who have disease of the left anterior descending artery, while in STEMI patients at highest risk for death, bivalirudin also confers the greatest mortality benefit. (2009-09-21)

What are the risk factors for rebleeding after negative angiography?
A research team form South Korea investigated possible predictive factors for re-bleeding after angiographically negative findings in patients with acute nonvariceal gastrointestinal bleeding. They found that clinical factors including underlying malignancy, liver cirrhosis and hematemesis are important predictors for rebleeding after angiographically negative findings in patients with acute nonvariceal gastrointestinal bleeding. (2009-09-16)

Popular stomach acid reducer triples risk of developing pneumonia
A popular stomach-acid reducer used to prevent stress ulcers in critically ill patients needing breathing machine support increases the risk of those patients contracting pneumonia threefold, according to researchers at Wake Forest University School of Medicine. (2009-09-14)

MSU researchers use newborn blood data to study cerebral palsy
A statewide team of researchers led by a Michigan State University epidemiologist are hoping Michigan's archive of newborn blood spots will help them uncover the causes of cerebral palsy, the most common disabling motor disorder in children with annual health costs of $12 billion. (2009-09-01)

Results from the PRAGUE-7 study
The outcome of patients with acute myocardial infarction (AMI) complicated by cardiogenic shock is generally very poor. Although early mechanical revascularization by primary PCI has been shown as superior to medical treatment, the mortality range remains high (at about 45-60 percent). (2009-08-31)

Nadroparin almost halves the risk of developing blood clots in ambulatory cancer patients receiving chemotherapy
Nadroparin, a blood-thinning drug, halves the risk of developing blood clots in ambulatory cancer patients receiving chemotherapy, and as such could become an important preventive treatment in these patients, according to an article published online first and in the October edition of the Lancet Oncology. (2009-08-31)

New assessment quantifies risks and benefits of warfarin treatment for atrial fibrillation
Warfarin therapy for patients with atrial fibrillation -- the most common type of significant heart rhythm disorder -- appears to be most beneficial for the oldest patients, those who have had a prior stroke and for patients with multiple risk factors for stroke. (2009-08-31)

Results from the TRIANA trial
Primary angioplasty is superior to thrombolysis in the treatment of very old patients with acute myocardial infarction, according to results from the TRIANA study, a randomized trial sponsored by the Spanish Society of Cardiology. (2009-08-31)

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