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Current Blood Cancer News and Events, Blood Cancer News Articles.
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Researchers discover mechanism to overcome drug-resistance in leukemia
In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published online today in the Proceedings of the National Academy of Sciences. (2021-02-01)

Mathematical method developed to predict cancer and drug-specific immunotherapy efficacy
Houston Methodist researchers have developed a mathematical model to predict how specific cancers will respond to immunotherapy treatments, thus enhancing chances for successful treatments from a wide variety of cancer-immunotherapy drug combinations. The results were recently published in Nature Biomedical Engineering in collaboration with researchers at MD Anderson Cancer Center. (2021-02-01)

Host immune classifier HIC assays may predict treatment response
Using a host immune classifier (HIC) test for patients with non-small cell lung cancer (NSCLC) may provide better predictors of treatment response and improve outcomes, according to research presented today at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer Singapore. (2021-01-30)

Blood discoveries advance efforts to grow organs, battle cancer
Researchers have developed a simple and efficient way to generate ''hemogenic endothelial cells,'' the first stop in the production line of blood cells. (2021-01-28)

NUS scientists discover a new pathway essential for blood formation
Scientists from the National University of Singapore have discovered how a protein called Tip60 plays a vital role in the renewal of blood cells in the body. Without it, the stem cells that make new blood suffer catastrophic damage. This discovery could lead to better treatments for life-threatening blood-related diseases like leukemia. (2021-01-28)

How blood stem cells maintain their lifelong potential for self-renewal
A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now discovered in mice that cells in the so-called ''stem cell niche'' are responsible for this, (2021-01-27)

A new study reveals an "Achilles heel" of cancer cells
? For the first time, a study shows how an abnormal number of chromosomes (aneuploidy) - a unique characteristic of cancer cells that researchers have known about for decades - can become a vulnerability of these cells. ? The study could lead, in the future, to the development of drugs that will use this trait to eliminate cancer. (2021-01-27)

New Tel Aviv University study reveals 'Achilles' heel' of cancer cells
A new study from Tel Aviv University (TAU) shows, for the first time, how an abnormal number of chromosomes (aneuploidy) -- a unique characteristic of cancer cells that researchers have known about for decades -- could become a weak point for these cells. The study could lead to the development of future drugs that will use this vulnerability to eliminate the cancer cells. (2021-01-27)

Cancer deaths attributable to cigarette smoking in 152 US metropolitan and micropolitan areas
A new study shows 4 in 10 cancer deaths are attributable to cigarette smoking in parts of the South region and Appalachia. (2021-01-26)

New study: Malaria tricks the brain's defence system
Malaria is one of the most common causes of death in children in Africa. When the parasite builds up in the blood vessels of the brain, it develops into one of the most dangerous forms of the disease, cerebral malaria. Though it wasn't certain if the parasite was able to penetrate the brain tissue, now researchers from the University of Copenhagen have found parasites can do that and have mapped the mechanism they utilise. (2021-01-26)

TGen-led study results suggest more accurate diagnostic for breast cancer
Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal Breast Cancer Research. (2021-01-26)

Two anti-viral enzymes transform pre-leukemia stem cells into leukemia
Viral infections and space travel similarly trigger inflammation and the enzymes APOBEC3C and ADAR1; UC San Diego researchers are developing ways to inhibit them as a means to potentially lower cancer risk for both astronauts and people on Earth. (2021-01-26)

Male breast cancer patients face high prevalence of heart disease risk factors
Male breast cancer patients were found to have a high prevalence of cardiovascular conditions, in a small study of this rare patient population presented at the American College of Cardiology's Advancing the Cardiovascular Care of the Oncology Patient Virtual course. (2021-01-25)

Cholesterol starvation kills lymphoma cells
Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer. (2021-01-25)

Novel target identified that could improve safety of therapy for pancreatic cancer
Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer. Using this protein as a target, the team successfully created a CAR T cell therapy - a type of immunotherapy - that killed pancreatic cancer cells in a pre-clinical model. (2021-01-22)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1266, Zhuzhi Wen, Jingying Hou, Zun Mai, Huifen Huang, Yangxin Chen, Dengfeng Geng and Jingfeng Wang from Sun Yat-sen University, Guangzhou, China and Guandong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China consider predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope. (2021-01-22)

Cancer can be precisely diagnosed using a urine test with artificial intelligence
The Korea Institute of Science and Technology(KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique for diagnosing prostate cancer from urine within only twenty minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor. (2021-01-21)

Investigational combo therapy shows benefit for TP53 mutant MDS and AML patients
Moffitt Cancer Center is leading a national, multicenter clinical trial investigating a new therapy option for this group of patients. It builds upon the standard of care therapy, combining eprenetapopt (APR-246) with the chemotherapy azacitidine. Results of the phase 1b/2 trial to determine the safety, recommended dose and efficacy of the combination therapy were published in the Journal of Clinical Oncology. (2021-01-21)

Study updates breast cancer risk estimates for women with no family history
A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes. The findings of the CARRIERS Consortium study, published Jan. 20 in The New England Journal of Medicine, may allow health care providers to better assess the risk of breast cancer in women ? many of whom have no family history of breast cancer. (2021-01-21)

Researchers develop a new approach to detect pancreatic cancer
A protein found commonly in human blood might help with the detection of hard-to-diagnose pancreatic tumours. Researchers at Martin Luther University Halle-Wittenberg (MLU), the Alfried Krupp Hospital in Essen and the University of Witten/Herdecke have developed approach using the protein's structure and its function as a proxy for this. In a first study in ACS Pharmacology & Translational Science, the team shows how its method can also be used to differentiate between benign and malignant tumours. (2021-01-20)

Reviving exhausted immune cells to fight cancer
Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests. The findings, published online this week in the Journal for Immunotherapy of Cancer, could offer a new way to harness the body's immune system to attack cancers. (2021-01-20)

Target of new cancer treatment valid for breast as well as blood cancers: study
Newly published research shows that a new anti-cancer drug developed at the University of Alberta, set to begin human trials this year, may work against breast cancer as well as blood cancer. (2021-01-20)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

Single-cell test can reveal precisely how drugs kill cancer cells
Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt. (2021-01-19)

Report shows alcohol consumption linked to portion of cancer incidence and mortality
A new study finds that alcohol consumption accounts for a considerable portion of cancer incidence and mortality in all 50 states and the District of Columbia. (2021-01-19)

Simple, cheap test can help save lives from colorectal cancer
New research has demonstrated that a simple, cheap test can help identify who is at risk of developing colorectal cancer, aiding early diagnosis and potentially saving lives. (2021-01-18)

Esophageal cancer patients show abundance of oral pathogens
DNA from various oral bacterial pathogens has been found in tumors from esophageal cancer patients. Researchers led by Tokyo Medical and Dental University (TMDU) examined bacterial pathogens in plaque and saliva from esophageal cancer patients, determining that a prevalence of three species in particular, along with alcohol consumption, is associated with a high risk of esophageal cancer. Screening of oral pathogens could therefore be used for early disease detection. (2021-01-14)

Cancer research reveals how mutations in a specific gene cause different types of disease
Leading cancer expert solve long-standing question of how various types of mutations in just one gene cause different types of diseases (2021-01-14)

The cancer microbiome reveals which bacteria live in tumors
Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body. (2021-01-13)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

New insights into the control of inflammation
Wistar scientists discovered that EGR1inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions. (2021-01-13)

Study identifies exposure to common food-borne pathogen linked to rare brain cancer
A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. (2021-01-11)

Deep learning helps predicting occult peritoneal metastasis in stomach cancer
A new study led by the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences shows that deep learning can help predicting the occult peritoneal metastasis in stomach cancer. It provides a novel and noninvasive approach for stomach cancer patients and may inform individualized surgical management of stomach cancer. (2021-01-07)

IU research findings could reduce treatment-related complication for blood cancer patients
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia. (2021-01-07)

Hydroxychloroquine blood levels predict clotting risk in patients with lupus
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk. (2021-01-06)

In-utero exposures associated with increased risk of thyroid cancer
A recent study shows that thyroid cancer is related to in-utero exposures. (2021-01-05)

Anticoagulants reduce the number of brain metastases in mice
Brain metastases can only develop if cancer cells exit the capillaries and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as Heidelberg scientists have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the brain capillaries and then penetrate through the vessel wall. Drugs that inhibit thrombin were able to reduce the number of brain metastases. (2021-01-05)

Some English bulldogs thought to have cancer may have newly identified syndrome
Some English bulldogs diagnosed with a common cancer may instead have a newly described, non-cancerous syndrome called polyclonal B?cell lymphocytosis. The discovery was made by Morris Animal Foundation-funded researchers at Colorado State University during a study to better understand B-cell chronic lymphocytic leukemia (BCLL). The team published their findings in the Journal of Veterinary Internal Medicine. (2021-01-05)

Inflammation from ADT may cause fatigue in prostate cancer patients
Moffitt Cancer Center researchers are investigating whether inflammation in the body, a side effect of ADT, contributes to these symptoms in prostate cancer patients. In a new study published in the journal Cancer, they pinpoint a specific inflammation marker that is associated with increased fatigue in this group of patients. (2021-01-04)

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