Current Blood Transfusion News and Events

Current Blood Transfusion News and Events, Blood Transfusion News Articles.
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Swimming upstream on sound waves
ETH researchers are among the first scientists to have succeeded in propelling microvehicles against a fluid flow using ultrasound. In future, these tiny vehicles are set to be introduced into the human bloodstream, thereby revolutionising the field of medicine. (2021-02-19)

Zika vaccine candidate shows promise in phase I trial
The Zika virus candidate, Ad26.ZIKV.001, a replication-incompetent human adenovirus serotype 26 (ad26) vector showed promising safety and immunogenicity in a phase I clinical trial. Researchers say the vaccine warrants further development should the need reemerge. The findings are published in Annals of Internal Medicine. (2021-02-15)

Higher blood pressure at night than in daytime may increase Alzheimer's disease risk
Higher blood pressure at night than in daytime may be a risk factor for Alzheimer's disease in older men. This is suggested by a new study from researchers at Uppsala University, now published in the journal Hypertension. (2021-02-08)

Research finds COVID plasma donation is fuelled by kindness
Researchers have given new insights into why people would choose to donate Covid-19 plasma after recovering from the virus, which will be used to support the recruitment of convalescent plasma donors to help treat current Covid-19 patients and support ongoing trials. (2021-02-02)

Holonyak lab team creates fast, cheap, accessible COVID-19 antibody test
When COVID-19 began developing into a global crisis in early 2020, this research group was already working on an NIH-funded project to develop a ''flu chip'' that would rapidly determine the most likely cause of a fever by measuring several proteins within a droplet of blood. They decided to pivot their efforts to detect COVID-19 antibodies instead. (2021-02-01)

A potentially safer, more effective gene therapy vector for blood disorders
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a gene therapy vector for blood disorders like sickle cell disease and beta-thalassemia that is potentially safer and more effective than those currently used in gene therapy trials for those conditions. The vector, an engineered vehicle for delivering functional copies of the hemoglobin gene to correct a genetic abnormality, leads to the production of more hemoglobin with a lower dose, minimizing the risk of toxic side effects. (2021-01-29)

NUS scientists discover a new pathway essential for blood formation
Scientists from the National University of Singapore have discovered how a protein called Tip60 plays a vital role in the renewal of blood cells in the body. Without it, the stem cells that make new blood suffer catastrophic damage. This discovery could lead to better treatments for life-threatening blood-related diseases like leukemia. (2021-01-28)

New study: Malaria tricks the brain's defence system
Malaria is one of the most common causes of death in children in Africa. When the parasite builds up in the blood vessels of the brain, it develops into one of the most dangerous forms of the disease, cerebral malaria. Though it wasn't certain if the parasite was able to penetrate the brain tissue, now researchers from the University of Copenhagen have found parasites can do that and have mapped the mechanism they utilise. (2021-01-26)

Predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1266, Zhuzhi Wen, Jingying Hou, Zun Mai, Huifen Huang, Yangxin Chen, Dengfeng Geng and Jingfeng Wang from Sun Yat-sen University, Guangzhou, China and Guandong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China consider predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope. (2021-01-22)

COVID-19 infection in immunodeficient patient cured by infusing convalescent plasma
Under FDA emergency-use authorization, doctors successfully resolved COVID-19 in a seriously ill, immunodeficient woman using a very high-neutralizing antibody-titer convalescent plasma from a recovered COVID-19 patient. However, further study suggested that use of convalescent plasma may not be warranted in many cases, for two reasons: 1) titer levels are too low in many convalescent plasmas, and 2) there are high endogenous neutralizing antibody titers already present in COVID-19 patients prior to infusion. (2021-01-21)

Hydroxychloroquine blood levels predict clotting risk in patients with lupus
A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk. (2021-01-06)

Transfusions with higher red blood cell levels do not improve preterm baby outcomes
National Institutes of Health-funded randomized clinical trial is the largest study to-date to compare thresholds for blood transfusions in premature babies, offers guidance for health care providers. (2020-12-31)

Higher red cell transfusion threshold offers no advantage for treating preterm infants
Very low birthweight infants often need blood transfusions to survive. A National Institutes of Health-funded study suggests that providing a higher threshold of red cells within accepted limits offers no advantage in survival or reduction in neurological impairment over a lower threshold. (2020-12-30)

Despite same treatment, obese women face more risks for postpartum hemorrhage complications
As part of an academic medical center initiative to improve maternal health, researchers at the University of South Florida Health (USF Health) and Tampa General Hospital (TGH) examined how obesity affected the management and outcomes of postpartum hemorrhage at a tertiary care center. The findings highlight that certain groups of high-risk obstetric patients, such as obese women, may need a different treatment protocol for postpartum hemorrhage, a potentially serious and largely preventable obstetric complication. (2020-12-21)

A full blood count of COVID-19 patients can predict disease severity
International research led by the Radboud university medical center shows that a full blood count of COVID-19 patients predicts fairly accurately whether the infection will have a complicated course or not. This makes it easier for healthcare providers to estimate the expected clinical picture. This study, conducted in eleven hospitals, has now been published in the scientific journal eLife. (2020-12-21)

New method to boost supply of life-saving stem cells
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have found a new method for growing a large quantity of life-saving blood stem cells. The scarcity of these cells is one of the greatest limitations for their use in a variety of medical procedures, from treatment of blood cancers to inherited blood disorders that require a bone marrow transplantation. (2020-12-08)

New study debunks blood type diet
A study published in the Journal of the Academy of Nutrition and Dietetics by researchers with the Physicians Committee for Responsible Medicine -- a nonprofit of 12,000 doctors -- debunks the 'blood type diet' by finding that blood type was not associated with the effects of a plant-based diet on body weight, body fat, plasma lipid concentrations, or glycemic control. (2020-12-04)

Octapharma presents research on congenital & acquired bleeding disorders at ASH Meeting
Octapharma USA will present multiple clinical research posters focused on the efficacy and safety of fibryga®, Fibrinogen (Human) Lyophilized Powder for Reconstitution, for Intravenous Use in the treatment of congenital and acquired bleeding disorders during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, a virtual medical congress to be held December 5 - 8, 2020. (2020-12-03)

Better diabetes treatment: New insulin molecule can self-regulate blood sugar
Researchers from the University of Copenhagen and biotech firm Gubra have developed a new insulin molecule that will make blood sugar regulation both easier and safer for those with type 1 diabetes. (2020-12-03)

Biofriendly protocells pump up blood vessels
In a new study published today in Nature Chemistry, Professor Stephen Mann and Dr Mei Li from Bristol's School of Chemistry, together with Associate Professor Jianbo Liu and colleagues at Hunan University and Central South University in China, prepared synthetic protocells coated in red blood cell fragments for use as nitric oxide generating bio-bots within blood vessels. (2020-11-20)

Analysis of seroprevalence in Kenya suggests virus exposure more extensive than reported
Researchers analyzing blood samples from blood donors across Kenya estimate that by June 2020, when many COVID-19 deaths were expected in the country but hadn't occurred at such scale, 4.3% of Kenyans had antibodies to the virus. (2020-11-11)

Critically ill infants given blood transfusions before surgery have poorer outcomes
Critically ill newborns who receive blood transfusions prior to surgery had about a 50% increased rate of complications or death than those who did not receive transfusions, according to a new study published today in Pediatrics by Nemours Children's Health System researchers. The findings demonstrate the potential danger that blood transfusions may have on the surgical outcomes of neonatal patients. (2020-10-21)

Ketamine, a painkiller used by the army, does not impair tolerance to blood loss
A low dose of ketamine, administered intravenously, does not alter a healthy human's tolerance to blood loss. In other words, if someone was given ketamine to kill pain associated with a battlefield injury, they would be able to tolerate blood loss just as well as someone who did not received this pain killer. (2020-10-21)

Patients who had more severe covid-19 may be the best donors for convalescent plasma therapy
Sex, age, and severity of disease may be useful in identifying COVID-19 survivors who are likely to have high levels of antibodies that can protect against the disease. (2020-10-19)

New evidence to guide the practice of blood transfusions in children with severe malari
Blood transfusions increase the survival of children admitted to the hospital with complications by severe malaria, and could be beneficial even at higher haemoglobin levels than those currently recommended. These are the main findings of a study led by ISGlobal, a centre supported by ''la Caixa'' Foundation, and published in The Lancet Haematology. (2020-10-19)

Research could change how blood pressure is managed in spinal cord injury patients
New research from the International Collaboration on Repair Discoveries (ICORD) challenges the current standard for managing blood pressure in people with spinal cord injury (SCI). (2020-10-15)

Studies offer new evidence for possible link between blood type & COVID-19 susceptibility
Two studies published today in Blood Advances suggest people with blood type O may have a lower risk of COVID-19 infection and reduced likelihood of severe outcomes, including organ complications, if they do get sick. (2020-10-14)

First reported UK case of sudden permanent hearing loss linked to COVID-19
Although uncommon, sudden permanent hearing loss seems to be linked to COVID-19 infection in some people, warn doctors, reporting the first UK case in the journal BMJ Case Reports. (2020-10-13)

Scientists discover mosquitoes' unique blood-taste detectors
Scientists aren't sure how mosquitoes sense taste of blood, or how they know that this, of all things, is something to gorge on. Nothing else, not even sweet nectar, makes them pump as ferociously as when they're draining our veins. New research identifies a unique group of neurons that don't care about simple tastes like sweet or salty. Rather, they activate only when sugar, salt, and other components of blood are all present at once. (2020-10-12)

High blood pressure linked to baroreflex in rats
Researchers describe a newly observed phenomenon in the way blood pressure is maintained in certain rats. (2020-10-03)

Unconventional T cell subset enriched in airways of some patients with severe COVID-19
Unconventional T cells called mucosa-associated invariant T (MAIT) cells are recruited to the airways and strongly activated in some patients with severe COVID-19, a new study has found, suggesting the cells' possible involvement in the development of disease. (2020-09-28)

Children who take steroids at increased risk for diabetes, high blood pressure, blood clots
Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers. The Rutgers study is the first to quantify these complications of oral steroids in a nationwide population of children. (2020-09-17)

Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)

Scientists develop low-cost chip to detect presence and quantity of COVID-19 antibodies
Robust and widespread antibody testing has emerged as a key strategy in the fight against SARS-CoV-2, the virus responsible for the COVID-19 pandemic. However current testing methods are too inaccurate or too expensive to be feasible on a global scale. But now, scientists at the Okinawa Institute of Science and Technology Graduate University (OIST) have developed a rapid, reliable and low-cost antibody test. (2020-09-08)

Small study shows convalescent plasma is safe to use in pediatric patients with COVID-19
Early findings from researchers at Children's Hospital of Philadelphia (CHOP) show that convalescent plasma appears to be a safe and possibly effective treatment for children with life-threatening cases of COVID-19. The results were published online Friday by the journal Pediatric Blood and Cancer. (2020-09-08)

Blood breakdown product commandeers important enzyme
The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, 'heme' is produced, which in turn can influence the protein cocktail in the blood. Researchers at the University of Bonn have now discovered in complex detective work that the 'activated protein C' (APC) can be commandeered by heme. At the same time, APC can also reduce the toxic effect of heme. (2020-09-04)

Genetic information can predict predisposition to rare and common blood diseases
Two large-scale genetic studies have identified the bulk of genetic variation that influences medically-important characteristics of our blood cells. Researchers from the Wellcome Sanger Institute, the Broad Institute of MIT and Harvard, and colleagues from 101 research institutions world-wide, have studied hundreds of thousands of participants and identified over 7,000 regions of the human genome that control blood cell characteristics, such as the numbers of red and white cells. (2020-09-03)

Virus in the blood can predict severe COVID-19
A blood test on hospital admission showing the presence or absence of SARS-CoV-2 can identify patients at a high risk of severe COVID-19. Admitted patients without virus in their blood have a good chance of rapid recovery. This according to researchers at Karolinska Institutet and Danderyd Hospital in a new study published in the scientific journal Clinical Infectious Diseases. (2020-09-02)

Trial clarifies use of blood transfusion in anaemic heart attack patients
Restricting blood transfusion in anaemic heart attack patients to those with very low haemoglobin levels saves blood with no negative impact on clinical outcomes. That's the finding of the REALITY trial presented in a Hot Line session today at ESC Congress 2020. Anaemia affects approximately 5-10% of patients with myocardial infarction and is an independent predictor of cardiac events and increased mortality. (2020-09-02)

Study leads to better understanding of blood pressure regulation, atherosclerosis
A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen contributes to blood pressure regulation and atherosclerosis. (2020-09-02)

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