Current Bone News and Events

Current Bone News and Events, Bone News Articles.
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UMass Amherst researchers develop technique to replicate bone-remodeling processes
A multidisciplinary research team at the University of Massachusetts Amherst's Institute for Applied Life Sciences (IALS) have developed a technique to replicate bone tissue complexity and bone-remodeling processes. This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis. (2021-01-26)

A compound that slows bone loss, and a resource for developing treatments to slow aging
A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases. The study is currently online in the Journal of Bone and Mineral Research Plus. (2021-01-26)

Dinosaur embryo find helps crack baby tyrannosaur mystery
They are among the largest predators ever to walk the Earth, but experts have discovered that some baby tyrannosaurs were only the size of a Border Collie dog when they took their first steps. (2021-01-25)

Scientists use a novel ink to 3D print 'bone' with living cells
3D printers may one day become a permanent fixture of the operating theatre after UNSW scientists showed they could print bone-like structures containing living cells. (2021-01-25)

Whole body imaging detects myeloma in more patients, treatment initiated earlier
Researchers from King's College London have shown that whole body magnetic resonance imaging (WBMRI) not only detects more myeloma-defining disease than positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) but that it also allows critical treatment to be initiated earlier. (2021-01-21)

Early humans used chopping tools to break animal bones and consume the bone marrow
- Using advanced scientific methods, researchers from Tel Aviv University found that stone tools of the type known as 'chopping tools' were used to break open the bones of animals. - The researchers: ''The bones must be broken neatly in two, which requires great skill and precision''. - Tools of this type were used for over two million years. They were found in large quantities at prehistoric sites all over the Old World, but no one understood their exact function. (2021-01-20)

New method heals skeletal injuries with synthetic bone
Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone. The study, published in the research journal Science Advances, was conducted on rats, but the researchers think that the method in various combinations will soon be commonplace in clinical settings. (2021-01-19)

FGF23 hormone from red blood cell precursors promotes hematopoietic stem cell mobilization
A Kobe University research group have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement of hematopoietic stem cells into the peripheral blood. It is hoped that this discovery will enable new strategies to be developed for harvesting hematopoietic stem cells from bone marrow transplant donors. (2021-01-18)

IOF and IFCC review calls for harmonization of assays for reference bone turnover markers
The newly published review 'Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood' describes the current status of assays for PINP and β-CTX in blood, as well as the plans for and ongoing progress towards the achievement of harmonization or standardization of commercial assays for these reference markers. (2021-01-15)

Discovery of 'adolescent' skeletal stem cells might someday help prevent osteoporosis
A new study reported in STEM CELLS reveals a unique population of skeletal stem cells (SSCs) that function during the transitional period between rapid bone growth and bone maintenance. (2021-01-13)

New taxonomy of non-skeletal rare disorders with impact on bone
A new paper published in Orphanet Journal of Rare Diseases by the International Osteoporosis Foundation (IOF) Skeletal Rare Diseases Working Group provides a first taxonomic classification of selected non-skeletal rare congenital disorders with an impact on bone physiology on the basis of phenotypes. The diseases have been described according to the systemic disease; genetic defect; pathophysiology of bone phenotype; and therapy, where available. (2021-01-12)

Scientists reveal how gut microbes can influence bone strength in mice
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife. (2021-01-12)

To understand periodontal disease, researchers examine the surprising behavior of T cells
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone? In a paper published recently in Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. (2021-01-11)

Stem cells use a piston-like engine to 'drive' to their destinations
Researchers extracted stem cells from bone marrow and used hydrogels to mimic the tissues that compose their biological environments. They found that stem cells propel their nucleus into a needle-like protrusion that penetrates the physical barriers inside the body. The nucleus moves into the protrusion and, through a complex biochemical mechanism, inflates the protrusion like a balloon, creating an opening in the tissue wide enough for the entire stem cell to migrate through. (2021-01-08)

Study explains role of bone-conducted speech transmission in speech production and hearing
The perception of our own voice depends on sound transmission through air (air-conducted) as well as through the skull bone (bone-conducted or BC). The transmission properties of BC speech are, however, not well understood. Now, scientists from Japan Advanced Institute of Science and Technology report their latest findings on BC transmission under the influence of oral cavity sound pressure, which can boost BC-based technology and basic research on hearing loss and speech impairment. (2021-01-07)

Living alone may increase risk of dying after hip fracture
Individuals face a higher risk of dying following hip fractures. A new study published in the Journal of Bone and Mineral Research has found that living alone after experiencing a hip fracture may further elevate this risk. (2021-01-06)

Long-term study finds dozens of new genetic markers associated with lifetime bone growth
A multidisciplinary team of researchers has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing. (2021-01-06)

Bone fracture risk may increase when critical enzymatic processes decline
A loss of enzymatic processes within the body can increase a person's risk of bone fracture. This new insight was recently published in eLife by an international team of scientists and engineers led by Deepak Vashishth, the director of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute. (2021-01-05)

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (2020-12-24)

Too much of a good thing - persistent IFNγ depletes progenitor blood cells via BST2
Long-term exposure to IFNγ stimulates the production of protein BST2 on blood stem cells, which resulted in their emergence from the quiescent state, persistent proliferation and finally exhaustion. (2020-12-22)

Researchers identify a rare genetic bone disorder through massive sequencing methods
Researchers of the Cell Biology and Physiology-LABRET group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy. (2020-12-21)

Researchers determine how often cancer patients develop osteonecrosis of the jaw
A landmark study by researchers from the SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has found that 2.8 percent of patients on average develop osteonecrosis of the jaw, or ONJ, within three years of starting a common treatment for cancer that has spread to the bone. (2020-12-17)

Scientists: Xenon improves properties of maxillofacial and orthopedic implants
Scientists of Tomsk Polytechnic University (TPU) jointly with the colleagues from Siberian State Medical University (SSMU) and Immanuel Kant Baltic Federal University (IKBFU) studied the properties of calcium phosphate coatings deposited on titanium implants in various inert gases environment. The researchers managed to discover that the use of xenon positively affects the physicochemical, mechanical and biological properties of the coatings used in oral and maxillofacial surgery, orthopedics and traumatology. (2020-12-15)

HSS bone study sheds light on complications after spinal surgery
The microscopic structure of bone appears to predict which patients will experience poor outcomes after spinal fusion, according to a new study by researchers at Hospital for Special Surgery (HSS) in New York City. (2020-12-15)

Exercise may protect bone health after weight loss surgery
Although weight loss surgery is a highly effective treatment for obesity, it can be detrimental to bone health. A new study published in the Journal of Bone and Mineral Research suggests that exercise may help address this shortcoming. (2020-12-09)

Batteries mimic mammal bones for stability
Sodium-ion batteries offer several advantages over lithium-ion batteries; however, it is difficult to develop sodium cathodes, materials through which electrons can enter a battery. Many candidate materials are unstable or cannot withstand high voltages. To find a solution, researchers turned to nature. They created a porous system of NVP structures, surrounded by a dense shell of reduced graphene oxide. They describe the mammal bone-inspired sodium cathode in the journal Applied Physics Reviews. (2020-12-08)

New method to boost supply of life-saving stem cells
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have found a new method for growing a large quantity of life-saving blood stem cells. The scarcity of these cells is one of the greatest limitations for their use in a variety of medical procedures, from treatment of blood cancers to inherited blood disorders that require a bone marrow transplantation. (2020-12-08)

Children's Hospital Colorado study published in Science Immunology
Children's Hospital Colorado (Children's Colorado) Center for Cancer and Blood Disorders (CCBD) announced today that a study about the manipulation of bone marrow stem cells into innate lymphoid and natural killer cells will be published in Science Immunology, a well-respected, high-impact medical journal. (2020-12-07)

Participation in competitive sport in adolescence brings midlife health benefits to women
Females who participate in competitive sport during adolescence have better fitness at midlife than do females with no competitive sport background in adolescence, reveals a study conducted at the University of Jyväskylä. (2020-12-07)

Can we make bones heal faster?
A new paper in Science Advances describes for the first time how minerals come together at the molecular level to form bones and other hard tissues, like teeth and enamel. (2020-12-03)

Research identifies nanoscale effect of water and mineral content on bone
Researchers conducted the first study of the effect of water and mineral content on collagen fibrils, the essence of bone material, which will aid the development of synthetic materials to mimic bone. (2020-12-03)

Retinal transplant boost opens door to treat eyesight loss
Researchers have identified two cell signals - Ccr5 and Cxcr6 - that are sent out by dying retinal cells to recruit stem cells and repair eye damage. When genetically engineered stem cells with an overabundance of Ccr5 and Cxcr6 cell receptors were transplanted into human and mouse models, they displayed a significantly higher rate of migration to degenerating retinal tissue, rescuing them from death and preserving their function. (2020-12-01)

Obesity increases the risk of early hip fracture in postmenopausal women
Obese women have an increased risk of hip fracture earlier than others, already well before the age of 70, a new study from the University of Eastern Finland shows. The study followed 12,715 women for a period of 25 years. (2020-12-01)

Vitamin D regulates calcium in intestine differently than previously thought
A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (2020-12-01)

Researchers develop new biomaterial that helps bones heal faster
Scientists have developed a new biomaterial that helps bones heal faster by enhancing adults' stem cell regenerative ability. (2020-11-27)

From fins to limbs and water to land
The study shows how and when the first groups of land explorers became better walkers than swimmers. The analysis spans the fin-to-limb transition and reconstructs the evolution of terrestrial movement in early tetrapods. (2020-11-25)

Popular weight-loss surgery in teenagers weakens bones
A common weight loss surgery for adolescents with obesity called sleeve gastrectomy has harmful effects on bones, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-24)

Scoring system improves screening for "dual" heart disease
Aortic stenosis is one of the most common heart valve defects. As well as conventional valve replacement involving open-heart surgery, a less invasive procedure has now been available for some time in the form of transcatheter aortic valve replacement (TAVR). (2020-11-24)

Ireland's only dinosaurs discovered in antrim
The only dinosaur bones ever found on the island of Ireland have been formally confirmed for the first time by a team of experts from the University of Portsmouth and Queen's University Belfast, led by Dr Mike Simms, a curator and palaeontologist at National Museums NI. (2020-11-24)

From the woodworking shop to the operating room: New technique uses mortise and tenon joints to repair unstable shoulders
Orthopaedic surgery techniques for treatment of recurrent shoulder instability are effective, but prone to problems with nonunion of bone grafts held in place by screws alone. A new technique - borrowing a design used for centuries in Chinese architecture and woodworking - provides an effective approach to shoulder stabilization, suggests a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer. (2020-11-24)

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