Current Bone News and Events

Current Bone News and Events, Bone News Articles.
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Yale scientists repair injured spinal cord using patients' own stem cells
Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery. (2021-02-22)

Periodontal disease increases risk of major cardiovascular events
People with periodontitis are at higher risk of experiencing major cardiovascular events, according to new research from Forsyth Institute and Harvard University scientists and colleagues. (2021-02-21)

Certain factors are linked with an elevated risk of bone fractures
A new study published in the Journal of Bone and Mineral Research has identified various factors that may indicate whether a person faces a higher likelihood of experiencing a bone fracture over the next two decades. (2021-02-18)

Radioactive bone cement found to be safer in treating spinal tumors
A radioactive bone cement that's injected into bone to provide support and local irradiation is proving to be a safer alternative to conventional radiation therapy for bone tumors, according to a study led by University of California, Irvine researchers. (2021-02-16)

Avian insights into human ciliopathies
Ciliopathies are genetic disorders caused by defects in the structure and function of cilia, and present a wide range of clinical symptoms, leading to conditions such as micrognathia (an underdeveloped lower jaw that can impair feeding and breathing). Researchers have now discovered that ciliopathic micrognathia in an animal model results from abnormal skeletal differentiation and remodelling. (2021-02-15)

Enormous ancient fish discovered by accident
Fossilised remains of a fish that grew as big as a great white shark and the largest of its type ever found have been discovered by accident. (2021-02-15)

Unlocking the mystery behind skeletal aging
Researchers from the UCLA School of Dentistry have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings, published online in the journal Cell Stem Cell, could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population. (2021-02-15)

Sweet coating for sour bones
Scientists invent a bioactive coating to improve the function of titanium implants in osteoporotic bones. This coating, comprising a chemically-modified glycan, can sequentially turn on and off inflammation on titanium surface upon implantation. This modulation stimulates the body's immune system to promote bone healing in an effective and safe way, without addition of bone-forming genes or drugs, according to the data from a rat osteoporotic model. (2021-02-12)

Plant-based diet and bone health: adequate calcium and vitamin D intakes should be ensured
In a study conducted at the University of Helsinki, partial replacement of animal protein with plant protein in the diet altered bone metabolism and decreased calcium and vitamin D intakes. (2021-02-10)

Bone marrow 'map' opens path to organoid-like blood stem cell production
A study led by experts at Cincinnati Children's published Feb. 10, 2021, in Nature provides powerful new insights into how bone marrow tissue works. The study, (2021-02-10)

A 'skeletal age' calculator to predict bone fracture risk
Garvan researchers have developed a model to predict the biological age of bones that may improve the management of osteoporotic fractures. (2021-02-09)

Researchers use hot nano-chisel to create artificial bones in a Petri dish
In research in the journal Advanced Functional Materials, a team at the NYU Tandon School of Engineering and New York Stem Cell Foundation Research Institute (NYSF) detail a system allowing them to sculpt, in a biocompatible material, the exact structure of the bone tissue, with features smaller than the size of a single protein -- a billion times smaller than a meter. (2021-02-09)

Meet the Smurfs: A bone metabolism family
Researchers from Osaka University and Ehime University have found that protein Smurf2 can regulate a cellular pathway that affects bone metabolism. Smurf2 can mark certain messenger proteins--specifically those that are part of the bone morphogenetic protein signaling pathway--for destruction to prevent the signals from going out of control. The BMP-induced bone in mice without Smurf2 had higher mass and formation rates. These findings improve our understanding of various bone defects. (2021-02-08)

Study reveals how air pollution may increase the risk of cardiovascular disease
A new study has found a link between high levels of air pollution at an individual's home address and an elevated risk of developing cardiovascular disease. Air pollution exposure appears to heighten the production of inflammatory cells in the bone marrow, triggering inflammation of the arteries. (2021-02-04)

New discovery sheds light on human history of symbols
A recent discovery by archeologists has uncovered evidence of what may be the earliest-known use of symbols. The symbols were found on a bone fragment in the Ramle region in central Israel and are believed to be approximately 120,000 years old. (2021-02-03)

Alternate type of surgery may prevent total knee replacement
An underused type of knee surgery in younger patients, called high tibial osteotomy, shows considerable success in reducing the need for total knee replacement, according to new research in CMAJ (Canadian Medical Association Journal) www.cmaj.ca/lookup/doi/10.1503/cmaj.200934. (2021-02-01)

Osteoporosis, controversial fractures and various bone markers
Aging and lifestyle-related metabolic imbalances cause the accumulation of advanced glycation end products (AGEs). A team of doctors from Shinshu University School of Medicine compared the impacts of AGEs on bone status and prevalent osteoporotic fractures in a cohort of postmenopausal women. They hope to provide an effective intervention for the AGEs accumulation in bone tissue leading to bone health retention in the elderly. (2021-01-28)

UMass Amherst researchers develop technique to replicate bone-remodeling processes
A multidisciplinary research team at the University of Massachusetts Amherst's Institute for Applied Life Sciences (IALS) have developed a technique to replicate bone tissue complexity and bone-remodeling processes. This breakthrough could help researchers further their study of bone biology and assist in improving development of drugs for osteoporosis. (2021-01-26)

A compound that slows bone loss, and a resource for developing treatments to slow aging
A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases. The study is currently online in the Journal of Bone and Mineral Research Plus. (2021-01-26)

Dinosaur embryo find helps crack baby tyrannosaur mystery
They are among the largest predators ever to walk the Earth, but experts have discovered that some baby tyrannosaurs were only the size of a Border Collie dog when they took their first steps. (2021-01-25)

Scientists use a novel ink to 3D print 'bone' with living cells
3D printers may one day become a permanent fixture of the operating theatre after UNSW scientists showed they could print bone-like structures containing living cells. (2021-01-25)

Whole body imaging detects myeloma in more patients, treatment initiated earlier
Researchers from King's College London have shown that whole body magnetic resonance imaging (WBMRI) not only detects more myeloma-defining disease than positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) but that it also allows critical treatment to be initiated earlier. (2021-01-21)

Early humans used chopping tools to break animal bones and consume the bone marrow
- Using advanced scientific methods, researchers from Tel Aviv University found that stone tools of the type known as 'chopping tools' were used to break open the bones of animals. - The researchers: ''The bones must be broken neatly in two, which requires great skill and precision''. - Tools of this type were used for over two million years. They were found in large quantities at prehistoric sites all over the Old World, but no one understood their exact function. (2021-01-20)

New method heals skeletal injuries with synthetic bone
Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone. The study, published in the research journal Science Advances, was conducted on rats, but the researchers think that the method in various combinations will soon be commonplace in clinical settings. (2021-01-19)

FGF23 hormone from red blood cell precursors promotes hematopoietic stem cell mobilization
A Kobe University research group have discovered that fibroblast growth factor-23 (FGF23) produced by erythroblasts (cells that are the precursors of red blood cells) promotes the movement of hematopoietic stem cells into the peripheral blood. It is hoped that this discovery will enable new strategies to be developed for harvesting hematopoietic stem cells from bone marrow transplant donors. (2021-01-18)

IOF and IFCC review calls for harmonization of assays for reference bone turnover markers
The newly published review 'Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood' describes the current status of assays for PINP and β-CTX in blood, as well as the plans for and ongoing progress towards the achievement of harmonization or standardization of commercial assays for these reference markers. (2021-01-15)

Discovery of 'adolescent' skeletal stem cells might someday help prevent osteoporosis
A new study reported in STEM CELLS reveals a unique population of skeletal stem cells (SSCs) that function during the transitional period between rapid bone growth and bone maintenance. (2021-01-13)

New taxonomy of non-skeletal rare disorders with impact on bone
A new paper published in Orphanet Journal of Rare Diseases by the International Osteoporosis Foundation (IOF) Skeletal Rare Diseases Working Group provides a first taxonomic classification of selected non-skeletal rare congenital disorders with an impact on bone physiology on the basis of phenotypes. The diseases have been described according to the systemic disease; genetic defect; pathophysiology of bone phenotype; and therapy, where available. (2021-01-12)

Scientists reveal how gut microbes can influence bone strength in mice
Gut microbes passed from female mice to their offspring, or shared between mice that live together, may influence the animals' bone mass, says a new study published today in eLife. (2021-01-12)

To understand periodontal disease, researchers examine the surprising behavior of T cells
In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone? In a paper published recently in Scientific Reports, researchers from the Forsyth Institute and the Universidad de Chile describe a mechanism that unlocks a piece of the puzzle. (2021-01-11)

Stem cells use a piston-like engine to 'drive' to their destinations
Researchers extracted stem cells from bone marrow and used hydrogels to mimic the tissues that compose their biological environments. They found that stem cells propel their nucleus into a needle-like protrusion that penetrates the physical barriers inside the body. The nucleus moves into the protrusion and, through a complex biochemical mechanism, inflates the protrusion like a balloon, creating an opening in the tissue wide enough for the entire stem cell to migrate through. (2021-01-08)

Study explains role of bone-conducted speech transmission in speech production and hearing
The perception of our own voice depends on sound transmission through air (air-conducted) as well as through the skull bone (bone-conducted or BC). The transmission properties of BC speech are, however, not well understood. Now, scientists from Japan Advanced Institute of Science and Technology report their latest findings on BC transmission under the influence of oral cavity sound pressure, which can boost BC-based technology and basic research on hearing loss and speech impairment. (2021-01-07)

Living alone may increase risk of dying after hip fracture
Individuals face a higher risk of dying following hip fractures. A new study published in the Journal of Bone and Mineral Research has found that living alone after experiencing a hip fracture may further elevate this risk. (2021-01-06)

Long-term study finds dozens of new genetic markers associated with lifetime bone growth
A multidisciplinary team of researchers has discovered several genetic markers associated with bone mineral accrual, which could ultimately help identify causes of eventual osteoporosis earlier in life through genetic testing. (2021-01-06)

Bone fracture risk may increase when critical enzymatic processes decline
A loss of enzymatic processes within the body can increase a person's risk of bone fracture. This new insight was recently published in eLife by an international team of scientists and engineers led by Deepak Vashishth, the director of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute. (2021-01-05)

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (2020-12-24)

Too much of a good thing - persistent IFNγ depletes progenitor blood cells via BST2
Long-term exposure to IFNγ stimulates the production of protein BST2 on blood stem cells, which resulted in their emergence from the quiescent state, persistent proliferation and finally exhaustion. (2020-12-22)

Researchers identify a rare genetic bone disorder through massive sequencing methods
Researchers of the Cell Biology and Physiology-LABRET group of the University of Malaga (UMA), together with the Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have described a new genetic skeletal disorder based on a precision medicine strategy. (2020-12-21)

Researchers determine how often cancer patients develop osteonecrosis of the jaw
A landmark study by researchers from the SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has found that 2.8 percent of patients on average develop osteonecrosis of the jaw, or ONJ, within three years of starting a common treatment for cancer that has spread to the bone. (2020-12-17)

Scientists: Xenon improves properties of maxillofacial and orthopedic implants
Scientists of Tomsk Polytechnic University (TPU) jointly with the colleagues from Siberian State Medical University (SSMU) and Immanuel Kant Baltic Federal University (IKBFU) studied the properties of calcium phosphate coatings deposited on titanium implants in various inert gases environment. The researchers managed to discover that the use of xenon positively affects the physicochemical, mechanical and biological properties of the coatings used in oral and maxillofacial surgery, orthopedics and traumatology. (2020-12-15)

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