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Current Breast Cancer News and Events, Breast Cancer News Articles.
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The true cost of chemotherapy
New research reveals the non-healthcare costs of chemotherapy for breast cancer patients. It includes the cost of lost productivity, work absence, and 'out-of-pocket' personal costs such as paying for transport and parking for treatment, the cost of wigs and new bras, and over the counter medications. The research team say that better targeting of treatment could help avoid placing unnecessary costs upon patients, their caregivers and wider society. (2021-01-04)

Combined approach could boost breast cancer immunotherapy, study suggests
Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of genetically engineered T cells to eradicate breast cancer in mice, according to a new study by researchers at the University of North Carolina. The study, to be published December 31 in the Journal of Experimental Medicine (JEM), suggests that CAR T cells, which are already used to treat certain blood cancers in humans, may also be successful against solid tumors if combined with other immunotherapeutic approaches. (2020-12-31)

Study points the way to boost immunotherapy against breast cancer, other solid tumors
UNC Lineberger Comprehensive Cancer Center researchers report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T cells to effectively attack solid tumors, such as breast cancers. The boost helps recruit more immune cells into battle at the tumor site, according to the study published in the Journal of Experimental Medicine. (2020-12-31)

COVID-19's impact on cancer prevention and control in Africa
When the COVID-19 pandemic reached Africa, the continent was already struggling to deal with another public health crisis - a growing cancer epidemic characterized by more than one million new cancer cases and nearly 700,000 deaths per year. (2020-12-31)

Discovery about how cancer cells evade immune defenses inspires new treatment approach
Researchers at Memorial Sloan Kettering have learned how chromosomal instability allows cancer cells to avoid immune defenses and metastasize (spread). The discovery opens up potential new avenues for treatment. (2020-12-28)

Molecular reporters expose the allies of the brain tumor
Until recently, it was unclear how and why cancer cells adapt to their environment. A team led by Gaetano Gargiulo at MDC has now developed a technology that can be used to observe the molecular processes in living cells. The researchers present their results in the journal Cancer Discovery. (2020-12-23)

Regulatory RNAs promote breast cancer metastasis
A gene-regulating snippet of RNA may contribute to the spread of many breast cancers. A molecule designed to destroy that RNA prevented metastases in animal models. The same strategy could be used to develop a new breast cancer drug. (2020-12-22)

Surgery may offer survival advantage in certain metastatic breast cancers
Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to Penn State College of Medicine and Penn State Cancer Institute researchers. They studied nearly 13,000 stage four breast cancer patients and found that those who had surgery in addition to their other treatments had a survival advantage over those who had other treatments alone. (2020-12-22)

Enzyme discovery can help rein in blood vessels that fuel cancer
Most living things need oxygen to grow and thrive. Even cancerous tumors. That's why tumors will readily sprout new blood vessels if their oxygen is starved, creating new lifelines for survival. A study published today from Scripps Research pinpoints the precise molecular machinery that makes this happen, providing scientific insights that can potentially be translated into medicines that help kill tumors and stop cancer from spreading in the body. (2020-12-22)

New mammogram measures of breast cancer risk could revolutionise screening
World-first techniques for predicting breast cancer risk from mammograms that were developed in Melbourne could revolutionise breast screening by allowing it to be tailored to women at minimal extra cost. (2020-12-22)

Researcher uses machine learning to demonstrate that DNA impacts cancer risk
University of Calgary researcher uses machine learning to demonstrate that DNA impacts cancer risk. Team identifies seven DNA fingerprints or patterns that define cancer risk. One of the seven germlines offers protection from developing cancer, and the other six germlines present a greater risk for cancer. It is the first time scientists have described these highly-specialized biological patterns applicable to cancer risk. Discovery refines the long-held views of why people get cancer. (2020-12-22)

The Achilles' heel of cancer stem cells
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. (2020-12-21)

Breast cancer study uncovers how macrophages may contribute to a therapeutic weak spot
Clinical trials have investigated pairing PARP inhibitor therapy with immunotherapy. Researchers are already looking ahead for ways to get even more benefit from PARP inhibitors plus checkpoint inhibitors in breast cancer patients. Investigators found macrophage-mediated immune suppression to be the weak spot of PARP inhibition treatment. Findings are published in Nature Cancer. (2020-12-18)

Oral contraceptive pills protect against ovarian and endometrial cancer
A comprehensive study from Uppsala University, involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use. The study is published in the journal Cancer Research. (2020-12-17)

Researchers determine how often cancer patients develop osteonecrosis of the jaw
A landmark study by researchers from the SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has found that 2.8 percent of patients on average develop osteonecrosis of the jaw, or ONJ, within three years of starting a common treatment for cancer that has spread to the bone. (2020-12-17)

'No such thing as a little bit of pain:' More cancer patients could benefit from rehabilitation
West Virginia University researchers identified the rehabilitation recommendations included in cancer-treatment guidelines from around the world. But the researchers discovered a disconnect between what the guidelines suggested and what many doctors do. (2020-12-17)

Blocking DNA repair enzyme could help treat certain cancers
Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease. (2020-12-16)

Oral hormone therapy shown to significantly alter metabolome of menopausal women
Groundbreaking research led by a team of scientists including a University of Massachusetts Amherst biostatistician shows that oral hormone therapy (HT) significantly alters the metabolome of postmenopausal women. This finding, which examined blood specimens from the landmark Women's Health Initiative (WHI) study, may help explain the disease risks and protective effects associated with different regimens of hormone therapy. (2020-12-16)

Can mammogram screening be more effective?
MIT economists have identified an important challenge in designing age-related guidelines for when to start breast cancer screenings: Women who start getting mammograms at age 40 may be healthier than the population of 40-year-old women as a whole, with a lower incidence of breast cancer at that age. (2020-12-16)

Drug for pulmonary hypertension may become an option against cancer
In experiments by Brazilian researchers with mice and tumor cell lines, the drug showed potential to combat metastasis. The scientists are planning to conduct clinical trials with patients who are on chemotherapy. (2020-12-15)

Undruggable diseases gain a new RNA drug-discovery tool
A new RNA-targeting tool enables scientists to tackle difficult molecular recognition problems to aid drug discovery for incurable diseases. (2020-12-15)

Immune cell that drives breast cancer could be effective target in novel immunotherapies
VCU Massey Cancer Center researcher Paula Bos, Ph.D., identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease. (2020-12-15)

Novel genomic tools increase the accuracy of breast cancer risk assessment
Findings from the FinnGen study encompassing 120,000 women indicate that inherited breast cancer risk should be assessed in an increasingly comprehensive manner. Currently, only individual gene mutations are taken into consideration in breast cancer therapy and prevention. The study demonstrates that more extensive genomic data can be used to identify women who are at high risk of breast cancer with considerably greater accuracy. Such knowledge can especially improve risk assessment among the close relatives of breast cancer patients. (2020-12-14)

Study finds paediatric cancer patients at no greater risk of severe COVID-19 infection
Children with cancer who test positive for COVID-19 do not appear to be at an increased risk of severe COVID-19 infection compared to healthy children, according a new UK study. (2020-12-14)

Financial distress negatively impacts well-being, satisfaction of breast cancer patients
Financial toxicity among breast cancer patients is independently associated with worse psychological well-being following a mastectomy or lumpectomy operation. However, even small improvements in financial pressure associated with treatment-related costs can lead to better mental well-being and higher patient satisfaction with breast reconstruction. (2020-12-11)

How AI could make therapeutic decision-making for breast cancer more accurate, affordable
Deep learning-enabled breast cancer technology could make breast cancer therapy decisions more accurate, affordable and accessible. For newly diagnosed breast cancer, estrogen receptor status (ERS) is a key molecular marker used for prognosis and treatment decisions. This is an expensive, time-consuming process. Here we show that machine learning can determine molecular marker status. Our approach could augment clinicians' capabilities in cancer prognosis and theragnosis by harnessing biological signals imperceptible to the human eye. (2020-12-11)

Immunotherapy improves responses w/o reducing quality of life in early breast cancer
Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows. (2020-12-10)

The immunomodulatory activity of a drug would improve the efficacy of immunotherapy in breast cancer
* The team of Eva González-Suarez, from the CNIO and IDIBELL, and the team of Christos Sotiriou, from the Jules Bordet Institute, demonstrate that a drug already used to treat osteoporosis promotes the infiltration of immune cells in breast tumours * These findings propose a new target to increase the antitumor immune response and make breast cancer more sensitive to immunotherapy (2020-12-10)

New treatment could spare early-stage rectal cancer patients life-altering side effects
A new and less invasive treatment developed by Cancer Research UK researchers is safer than standard major surgery for early-stage rectal cancer, giving patients a better quality of life with fewer life-altering side effects, results from a pilot study show. (2020-12-10)

Nearly 72% of Black patients with gynecologic cancer and COVID-19 were hospitalized for the virus compared with 46 percent of non-Blacks
COVID-19 deaths among Black patients with gynecologic cancer disproportionately higher compared to non-Black patients. (2020-12-09)

Uniquely human gene may drive numerous cancers
A new study published in FASEB BioAdvances reveals a human-specific connection between advanced carcinomas and a gene called SIGLEC12. (2020-12-09)

Evolution may be to blame for high risk of advanced cancers in humans
UC San Diego researchers discovered that most people no longer produce the Siglec-12 protein, but some of those who do are at twice the risk for advanced cancer. (2020-12-09)

Some postmenopausal women with common breast cancer may forgo chemotherapy
Postmenopausal women with a common form of breast cancer may safely skip chemotherapy, according to study results from SWOG Cancer Research Network, funded by the National Cancer Institute, to be released at the San Antonio Breast Cancer Symposium. (2020-12-09)

Physicians don't always recognize patients' radiation therapy side effects
Physicians did not recognize side effects from radiation therapy in more than half of breast cancer patients who reported a significant symptom, a new study finds. (2020-12-09)

High-risk, HR+, HER2-, early-stage BC patients continue to benefit from abemaciclib
Extended follow-up data from the phase III monarchE trial showed that adding the cyclin-dependent kinase (CDK) inhibitor abemaciclib (Verzenio) to standard adjuvant endocrine therapy continued to improve invasive disease-free survival (IDFS) among patients with high-risk, node-positive, early-stage, HR-positive, HER2-negative breast cancer, according to data presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Under-recognition of symptoms may be common in breast cancer patients receiving radiation
Among patients with breast cancer treated with radiotherapy, under-recognition of symptoms was common in reports of pain, pruritus, edema, and fatigue, with younger patients and Black patients having significantly increased odds of symptom under-recognition. (2020-12-09)

CTC dynamics may predict treatment response/prognosis in metastatic breast cancer patients
Early circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer, according to a meta-analysis presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Mastectomy and reconstructive surgery may lead to patients becoming persistent drug users
Women who receive mastectomy and reconstructive surgery as part of breast cancer treatment may face the risk of developing persistent use of opioids and sedative-hypnotic drugs, according to data presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

Postmenopausal women with early-stage BC/low recurrence score could skip adjuvant chemo
After a median follow-up of 5.1 years, among women with lymph node-positive early-stage breast cancer and a recurrence score of 25 or lower who received adjuvant endocrine therapy with or without chemotherapy, postmenopausal patients had no added benefit from chemotherapy, while premenopausal patients who received chemotherapy had improved invasive disease-free survival (IDFS) and an early indication of improved overall survival (OS), according to data from the SWOG S1007 RxPONDER clinical trial. (2020-12-09)

Omitting radiation therapy after breast-conserving surgery may not impact 10-year survival rates for older patients with HR-positive breast cancer
Older patients with hormone receptor-positive breast cancer who did not receive radiation therapy after breast-conserving surgery had higher rates of local recurrence but similar 10-year survival rates when compared to patients who received postoperative radiation therapy, according to updated 10-year data from the PRIME II study, presented at the 2020 San Antonio Breast Cancer Symposium. (2020-12-09)

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