Current Cancer Cells News and Events

Current Cancer Cells News and Events, Cancer Cells News Articles.
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The unveiling of a novel mechanism of resistance to immunotherapy targeting HER2
VHIO investigators report how HER2 breast cancer cells adopt a strategy to resist clearance by redirected lymphocytes. Findings evidence that the disruption of interferon-gamma signaling confers resistance to these immunotherapies and promotes disease progression. Reported in Nature Communications, these results could help to potentiate future immune-based strategies and more precisely identify those patients who would be most likely to benefit from them. (2021-02-23)

Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Targeted delivery of highly toxic anti-cancer drug to brain tumors
University of Houston biomedical researcher Sheeren Majd is reporting the development and testing of a new nano-carrier as a potential treatment to deliver highly toxic medicine to glioblastomas, the most common and aggressive form of primary brain tumors. (2021-02-23)

Cancer cell vulnerability points to potential treatment path for aggressive disease
A new study in Nature Communications describes the discovery of a unique dependence of cancer cells on a particular protein, which could lead to desperately needed treatment for hard-to-treat cancers. (2021-02-22)

New insights on how inflammatory molecule contributes to skin and pancreatic cancers
An immune molecule called interleukin-33 can act within a cell's nucleus to stimulate abnormal growth and division, ultimately resulting in cancer. Targeting interleukin-33 in the nucleus may help prevent certain cancers. (2021-02-22)

Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Mechanisms underlying metabolic variations in hepatocellular carcinoma (HCC), a fast growing and invasive cancer, remain unclear. Now, researchers from Fudan University, China identified signatures of ''m6A,'' the most abundant ''post-transcriptional RNA modification,'' that segregate HCC into sub-types with distinct metabolic characteristics. They have also developed a novel m6A score that can quantify such modifications and aid risk assessment, prediction of prognosis, and response to treatment in patients with HCC. (2021-02-22)

Discovery of a mechanism by which epithelial tumours cause developmental delays
- Conducted on the fly Drosophila, the study shows that tumours caused by chromosomal instability delay entry into the adult phase. - The tumours produce the Upd3 protein (equivalent to human Interleukin-6) to block the production of developmental steroid hormones. - The work of IRB Barcelona's Growth Control and Development laboratory has been published in the journal Current Biology. (2021-02-22)

Improving immunotherapies for blood cancers: real-time exploration in the tumor
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called ''immunotherapies.'' But how do these antibodies function within the tumor? And how can we hope to improve their efficacy? Using innovative in vivo imaging approaches, scientists from the Institut Pasteur and Inserm visualized in real time how anti-CD20 antibodies, used to treat B-cell lymphoma, guide the immune system to attack tumor cells. (2021-02-21)

Good cop, bad cop
Serendipitous observation leads to novel insight into how cancer-immune crosstalk can either promote or suppress tumour growth. Ultimately, this study's results may help develop novel cancer therapies as well as an assay to select patients for immunotherapy treatment. (2021-02-19)

Turbocharging the killing power of immune cells against cancer
Creating ''super soldiers'' of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers. (2021-02-19)

Study reveals how a longevity gene protects brain stem cells from stress
A gene linked to unusually long lifespans in humans protects brain stem cells from the harmful effects of stress, according to a new study by Weill Cornell Medicine investigators. (2021-02-19)

Addressing the biological causes of racial disparities in prostate cancer
A new review published in Cancer Reports examines the biological differences in the development of prostate cancer across ethnicities. (2021-02-18)

Physical conditions linked to psychological distress in patients with cancer
Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. (2021-02-18)

Physics of tumours: Cancer cells become fluidised and squeeze through tissue
Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. The team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumour tissues and squeeze past neighbouring cells. They have now published their findings in 'Physical Review X'. (2021-02-18)

UCLA study finds combination therapy suppresses pancreatic tumor growth in mice
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). (2021-02-18)

Handcuffing the culprit cancer: Immunotherapy for cold tumors with trispecific antibody
The recent discovery of ''bispecific antibodies'' has led to the development of effective immunotherapies against various cancers. Researchers have constructed a protein made up of anti-CD16, -IL-15, and -CD19 motifs, specifically designed to capture CD19-positive cancer cells and redirect them to natural killer (NK) cells. This protein also enhances the proliferation, homeostasis, activation, and survival of NK cells. This concoction has shown to induce killing of cancer cells in both cell cultures and in mouse models. (2021-02-18)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Scientists able to see how potential cancer treatment reacts in single cell
Using a 185 metre beamline at the Diamond synchrotron, researchers could see how Osmium, a rare precious metal that could be used for cancer treatments, reacts in a single human lung cancer cell. This is a major step forward in discovering new anti-cancer drugs for researchers at the University of Warwick. (2021-02-17)

Genotoxic E. coli 'caught in the act'
Max Planck researchers and their collaborators reveal transformation of colon organoids in vitro. (2021-02-17)

Proton therapy induces biologic response to attack treatment-resistant cancers
Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment. The technique is called LEAP, an acronym for 'biologically enhanced particle therapy.' The findings are published today in Cancer Research, the journal of the American Association for Cancer Research. (2021-02-17)

Researchers identify gene implicated in neuroblastoma, a childhood cancer
A new study by Mayo Clinic researchers has identified that a chromosome instability gene, USP24, is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for Cancer Research. (2021-02-17)

Cancer research: Targeted elimination of leukemic stem cells
Cancer research in Bern has discovered a further mechanism to combat leukemia: a research team at Inselspital, Bern University Hospital and the University of Bern has succeeded in identifying an important signaling pathway for regulating leukemic stem cells. With this discovery, the researchers are expanding the arsenal of potentially highly effective drugs against leukemia. (2021-02-16)

Researchers find a novel connection between cell metabolism and cell division
Many biological processes are subject to rhythmic changes. Well-known examples of this are the so-called circadian rhythm, an ''internal clock'' with a period of around 24 hours, or the shorter ultradian rhythm. Cell division is often linked to these rhythms. Biologists from Saarbrücken and Kaiserslautern have now found out that these rhythms and their coupling with cell division is closely related to hydrogen peroxide. The study was published in the renowned journal Nature Chemical Biology. (2021-02-16)

It takes two to tango: When cells interact
When normal, motile cells come into contact, they typically change direction to avoid collision. But cancer cells behave quite differently. A new statistical analysis sheds light on the basis for this difference. (2021-02-16)

Researchers take early step toward leukemia drug therapy
The team has discovered that for acute myeloid leukemia (AML) patients, there is a dopamine receptor pathway that becomes abnormally activated in the cancer stem cells. This inspired the clinical investigation of a dopamine receptor-inhibiting drug thioridazine as a new therapy for patients, and their focus on adult AML has revealed encouraging results. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

New immunotherapy target discovered for malignant brain tumors
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients. (2021-02-15)

Insight about tumor microenvironment could boost cancer immunotherapy
A paper published today in Nature shows how chemicals in the areas surrounding tumors - known as the tumor microenvironment - subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. (2021-02-15)

New discovery may enable accurate prediction of cancer spread before cancer develops
Researchers from Erler Group at the Biotech Research & Innovation Centre (BRIC) in Copenhagen have discovered that the rigidity of a thin membrane structure encompassing cells and lining all vessels regulates how easily cancer cells can breach tissues to spread through the body, and is thus a key determinant of cancer patient survival. The results are published in Nature Materials today. (2021-02-15)

Moffitt uses mathematical modeling to identify factors that determine adaptive therapy success
In a new article featured on this month's cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy. (2021-02-15)

Oncotarget: Cancer stem cells and macrophages against cancer
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

Melanoma patients respond to immunotherapy after changes to gut microbiome
Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit. (2021-02-14)

Researchers identify potential revolutionary new drug treatment for fatal childhood cancer
Research paper published reveals potential revolutionary drug combination that could become an effective treatment for DIPG. (2021-02-12)

Metabolic response behind reduced cancer cell growth
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease. (2021-02-12)

T cells depressed
In chronic infections, the immune system can become exhausted. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have looked into how this works. (2021-02-12)

Antitumoral effects of LXR activation
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs). (2021-02-12)

Going the distance--insights into how cancer cells spread
In a study published in Nature Communications, cancer researchers at Kanazawa University identify mechanisms by which malignant tumor cells extend their toxicity to distinct cell types and in turn help them spread. (2021-02-12)

Medication-based starvation of cancer cells
Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications. At the same time, they identified new innovative targeted cancer therapies. (2021-02-12)

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