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Current Cancer Cells News and Events, Cancer Cells News Articles.
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New technology helps in hunt for new cancer drug combinations
A revolutionary new technology has been applied to reveal the inner workings of individual cancer cells - potentially identifying more effective treatment combinations for people with cancer. (2020-03-19)

New contrast agent for early diagnosis of brain metastases
A group of researchers led by Leif Schroeder from the Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated imaging than is possible with conventional methods of diagnosis. (2020-03-19)

Loss of protein disturbs intestinal homeostasis and can drive cancer
An international team of researchers from the University of Zurich, the University Hospital Zurich, Heidelberg and Glasgow has identified a novel function for the cell death regulating protein MCL1: It is essential in protecting the intestine against cancer development -- independent of bacterial-driven inflammation. These findings have implications for the use of MCL1 inhibitors, currently being tested for cancer treatment. (2020-03-18)

Therapeutic HPV vaccine may improve outcomes in advanced cervical cancer
Combining a therapeutic vaccine for human papilloma virus (HPV) with two standard chemotherapy drugs may extend survival in patients with advanced, recurrent cervical cancer, according to a phase 1/2 trial involving 77 patients. (2020-03-18)

Changes in cellular degradation hubs can lead to cancer
Cancer cells grow and divide in an uncontrolled manner. A new study from Uppsala University now shows how alterations in a cell's degradation hubs, called lysosomes, can cause abnormal cell growth. The results are published today in the scientific journal Nature Communications. (2020-03-17)

Finding the Achilles' heel of cancer cells
The key to effective cures for cancers is to find weak points of cancer cells that are not found in non-cancer cells. Researchers at the Tokyo Metropolitan Institute of Medical Science found that cancerous and non-cancerous cells depend on different factors for survival when their DNA replication is blocked. Drugs that inhibited the survival factor required by cancer cells would selectively make cancer cells more vulnerable to replication inhibition. (2020-03-17)

Silkworms provide new spin on sticky molecules
E-selectin is grown in silkworms for the first time, revealing new aspects of its binding dynamics. (2020-03-16)

Selective killing of cancer cells by cluttering their waste disposal system
Mixed-charge nanoparticles assemble into crystals and cause the death of thirteen types of cancer lines. (2020-03-16)

Cancer drug with better staying power, reduced toxicity promising in preclinical trial
A drug candidate has been found in preclinical trials to stop tumor growth entirely, deliver more cancer-busting power than many commonly used chemotherapy drugs and do so with fewer toxic side effects and more ability to overcome resistance. (2020-03-16)

Immunotherapy combo achieves reservoir shrinkage in HIV model
Stimulating immune cells with two cancer immunotherapies together can shrink the size of the viral 'reservoir' in SIV-infected non-human primates treated with antiviral drugs. The findings have important implications for the quest to cure HIV, because reservoir shrinkage has not been achieved consistently before. However, the combination treatment does not prevent or delay viral rebound once antiviral drugs are stopped -- illustrating how difficult achieving a cure will be. (2020-03-16)

One drug, three action modes
Clinicians combat the drug resistances of some cancer types by using a combination of different drugs. To make this approach more effective, chemists have designed a chemical conjugate that can simultaneously attack several cellular targets using different modes of action. Such a single-drug therapy would increase the chances of killing all cancer cells, the authors state in the journal Angewandte Chemie. (2020-03-13)

Learning how cancer cells coordinate and collaborate to multiply and metastasize
Researchers from Osaka University and the National Institute of Information and Communications Technology have cultured epithelial-like cancer cells on an artificial substrate and observed their collaborative self-organization into network structures that may function as nutritional conduits and provide vascular access. Understanding of the parameters that govern this coordinated behavior, including the various forces responsible, may explain tumor growth and metastasis, thus providing a basis for developing new anticancer drugs. (2020-03-12)

Statins starve cancer cells to death
More than 35 million Americans take statin drugs daily to lower their blood cholesterol levels. Now, in experiments with human cells in the laboratory, researchers at Johns Hopkins Medicine have added to growing evidence that the ubiquitous drug may kill cancer cells and have uncovered clues to how they do it. (2020-03-12)

Cancer: The immune system attacks tumors remotely
How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely. (2020-03-12)

Careless cancer cells may be susceptible to future drugs
Could the ability of cancer cells to quickly alter their genome be used as a weapon against malignant tumors? Researchers at Uppsala University have succeeded in developing a substance that has demonstrated promising results in experiments on both animal models and human cancer cells. The study is published in the journal Nature Communications. (2020-03-11)

Researchers promote cancer cell growth in the near infrared region by using silica coated gold nano
In a report published in NANO, a group of researchers from the Republic of Korea have discovered a method to promote cancer cell growth using silica-coated gold nanorods. The cell growth by near infrared (NIR) exposure of Si-AuNRs nano heat islands revealed a higher growth rate of 36.13% than the normal incubator condition. (2020-03-11)

Gasdermin E: A new approach to cancer immunotherapy that could have broad reach
Tumors have various ways of dodging attacks by the immune system. Medicine has fought back with cancer immunotherapies, primarily checkpoint inhibitors and CAR T-cell therapy. Now, research from Boston Children's Hospital adds another strategy to the arsenal, one that could potentially work in more types of cancer. It reactivates a gene called gasdermin E, harnessing an immune response we already have but that is suppressed in many types of cancer. (2020-03-11)

Researchers identify marker that may predict whether lung cancer likely to spread
Researchers at Tulane University have identified a protein on tumor-derived extracellular vesicles that indicates if a NSCLC tumor is likely to metastasize, according to a new study in Science Advances. (2020-03-11)

Two-pronged attack on DNA repair could kill drug-resistant cancers
Launching a two-pronged attack on cancer's ability to safeguard its DNA could offer an effective new way of treating the disease, a new study reports. (2020-03-11)

Cancer cells spread using a copper-binding protein
Researchers at Chalmers University of Technology, Sweden, have shown that the Atox1 protein, found in breast cancer cells, participates in the process by which cancer cells metastasise. The protein could therefore be a potential biomarker for assessing the aggressiveness of the disease, as well as a possible target for new drugs. The research was recently published in the journal PNAS. (2020-03-10)

Chip for liquid biopsy will help to detect prostate cancer
Researchers of Sechenov University together with their colleagues from Australia used the microfluidics technology to develop a device able to isolate cancer cells from urine of patients with prostate cancer. The study showed high sensitivity and specificity of the new method in diagnosing prostate cancer. The results obtained were published in Cancers. (2020-03-10)

Tracking down false parkers in cancer cells
In squamous cell carcinoma, a protein ensures that unneeded proteins are no longer disposed of. A research team at the University of Würzburg has switched off this protein for the first time. (2020-03-10)

Arming the body's immune cells
Researchers at UC have discovered a previously unknown mechanism that could explain the reason behind decreased immune function in cancer patients and could be a new therapeutic target for immunotherapy for those with head and neck cancers. (2020-03-10)

Intralipid improves efficacy of chemotherapy treatment
Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University and Taiwan's National Health Research Institutes. In addition, pretreatment with the supplement promotes the production of tumor-killing macrophages, making it a promising complement and supplement to existing chemotherapies. (2020-03-10)

Older women with breast cancer may benefit from genetic testing, study suggests
About 1 in 40 postmenopausal women diagnosed with breast cancer before age 65 have cancer-associated mutations in their BRCA1 or BRCA2 genes, according to a Stanford-led study of more than 4,500 participants in the long-running Women's Health Initiative. (2020-03-10)

Possible treatment for breast cancer patients could roll out to clinical trial immediately
A worldwide collaborative study involving scientists at the University of Sussex has proposed a new treatment strategy for patients with a rare but aggressive subtype of cancer known as triple negative breast cancer. (2020-03-10)

Cancerous tumors, surrounding cells illuminated by new imaging agent
Scientists at Washington University School of Medicine in St. Louis have developed a new imaging agent that could let doctors identify not only multiple types of tumors but the surrounding normal cells that the cancer takes over and uses as a shield to protect itself from attempts to destroy it. (2020-03-10)

'Primitive' stem cells shown to regenerate blood vessels in the eye
Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases. (2020-03-09)

Princeton researchers identify factors essential for chronic hepatitis B infection
A study published in the journal Nature Microbiology identified factors that the hepatitis B virus uses when establishing long-term infection in the liver. The findings could help lead to treatment strategies for chronic HBV infection, a condition that increases the risk of developing liver cancer and is responsible for almost 900,000 deaths worldwide each year. (2020-03-09)

Smart scaffolding to monitor tumor growth in real time and controlled environments
Building three-dimensional scaffolding to guide the growth of tumors in controlled environments, to monitor the evolution of each of their cells in real time and to record the release of tumor metabolites and other indicators of cell activity under different conditions. That is the ultimate aim of the 4DbioSERS project on which the research group led by Luis Liz-Marzán, Ikerbasque professor and CIC biomaGUNE's scientific director, is working. (2020-03-09)

Scientists propose nanoparticles that can treat cancer with magnetic fluid hyperthermia
A group of Russian scientists have synthesized manganese-zinc ferrite nanoparticles that can potentially be used in cancer treatment. Due to their unique magnetic properties, the particles can serve as deactivators of affected cells while having almost no negative impact on healthy tissues. The results have been published in the Journal of Sol-Gel Science and Technology. (2020-03-06)

Study reveals breast cancer cells shift their metabolic strategy to metastasize
New discovery in breast cancer could lead to better strategies for preventing the spread of cancer cells to other organs in the body, effectively reducing mortality in breast cancer patients. According to a study, published today in Nature Cell Biology, breast cancer cells shift their metabolic strategy in order to metastasize. Instead of cycling sugar (glucose) for energy, they preferentially use mitochondrial metabolism. (2020-03-06)

Engineered bone marrow cells slow growth of prostate and pancreatic cancer cells
In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response. (2020-03-05)

New drug combination could support better cancer treatments
Researchers have identified a promising new drug combination that could significantly help the immune system target cancer cells and kill them. (2020-03-05)

Intestinal microbes reprogram genetic activity of gut mucosa
Scientists from the German Cancer Research Center and the Hebrew University in Jerusalem demonstrated in mice that intestinal bacteria reprogram DNA activity in cells of the gut mucosa and thus have a considerable impact on the development of the healthy gut. Acute intestinal inflammation induced under experimental conditions led to a huge increase in the activity of inflammation-related and cancer-promoting genes in the mucous membrane cells of microbe-colonized animals. (2020-03-05)

UConn researchers discover new stem cells that can generate new bone
A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the UConn School of Dental Medicine. (2020-03-05)

New platform for cancer diagnostics and drug testing
Parts of tumor tissue, which is normally discarded in cancer surgery, bear information about the disease. So far, as studies at the University of Gothenburg show, this has been unexploited. This research forms the basis for a new experimental platform for cancer diagnostics, prognoses and testing cancer drugs. (2020-03-04)

Being overweight may raise your risk for advanced prostate cancer
A new study links being overweight in middle age and later adulthood to a greater risk of advanced prostate cancer. Jeanine Genkinger, PhD, an epidemiologist at Columbia University Mailman School of Public Health, and colleagues published the study in Annals of Oncology, the journal of the European Society for Medical Oncology and Japanese Society of Medical Oncology. (2020-03-04)

NYU Abu Dhabi researchers design new technology for targeted cancer drug delivery
A team of researchers at NYU Abu Dhabi has developed a biocompatible, biodegradable, and economical nanocarrier for safer and more effective delivery of anticancer drugs. Researchers demonstrate that the novel pH-responsive hybrid (i.e. multi-component) nanoparticles can be loaded with a wide range of chemotherapeutics to effectively and specifically target cancer cells. (2020-03-03)

It's what's inside that matters: Locking up proteins enables cancer metastasis
Researchers from Tokyo Medical and Dental University (TMDU) found that internalizing claudin-1 enables cancer cells to increase cell motility and to metastasize to lymph nodes. These findings could be exploited to develop novel therapies for cancer metastasis. (2020-03-03)

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