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Current Cancer Center News and Events, Cancer Center News Articles.
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In one cancer therapy, two halves are safer than a whole
Splitting one type of cancer drug in half and delivering the pieces separately to cancer cells could reduce life-threatening side effects and protect healthy, non-cancerous cells, a new study suggests. (2020-08-24)

Key molecule responsible for poor prognosis of breast cancer identified
Hokkaido University scientists have shown that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer. (2020-08-21)

Molecule secreted by cancer-associated fibroblasts promotes anticancer drug resistance
Joint research at Kumamoto University in Japan discovered a new mechanism for anticancer drug resistance in gastric cancer. Experiments clarified that the Annexin A6 molecule contained in extracellular vesicles (EVs) is secreted by cancer-associated fibroblasts (CAFs) and taken up by gastric cancer cells, resulting in resistance to anticancer drug treatment. New drug development that targets Annexin A6 and cancer-associated fibroblasts (CAFs) may be possible. (2020-08-21)

Intestinal bacteriophage alters effects of cancer therapies in mice
Enterococcus, a genus that includes common commensal bacteria found in the gut, harbors a bacteriophage that influences the effects of various cancer immunotherapies in ways that may be clinically relevant, researchers working in mice report. (2020-08-20)

Potency-enhancing drugs linked to decreased risks in men with colorectal cancer
A new study from Lund University and Region Skåne in Sweden indicates that potency-enhancing PDE5 inhibitor drugs have an anti-cancer potential with the ability to improve the prognosis in patients with colorectal cancer. PDE5 inhibitors include a few approved drugs in which sildenafil (Viagra) is the most well-known. The article is published in Nature Communications. (2020-08-17)

Regulation of cancer stemness by the best combination of nanotech and genetic engineering
Photo-active nanocomplexes are successfully developed. The nanocomplexes allow spatiotemporal controlling genetically-engineered cells that are overexpressing temperature-sensitive membrane proteins. The technology demonstrates effective cancer elimination and dramatic suppression of cancer stemness in cells and mice. (2020-08-17)

Smoking strongly linked to women's lower take up of cancer screening services
Smoking is strongly linked to lower use of cancer screening services by women, and more advanced disease once cancer is diagnosed, reveals research published in the online journal BMJ Open. (2020-08-13)

Increased breast cancer risk in obesity linked to fat cell chemicals
Obesity increases the release of tumour-promoting molecules from fat tissue and is associated with an increased risk of breast cancer, according to a study published in Endocrine-Related Cancer. The study found that fat tissue from people with obesity released increased amounts of extracellular vesicles (EV's) enriched in harmful and inflammatory molecules into the blood stream, which can alter breast cancer cells to become more aggressive and invasive. (2020-08-11)

HPV strains may impact cervical cancer prognosis
An analysis of cervical cancers in Ugandan women has uncovered significant genomic differences between tumours caused by different strains of human papillomavirus (HPV), signifying HPV type may impact cervical cancer characteristics and prognosis. (2020-08-10)

Study gauges specific site stomach cancer risks among ethnic groups
Non-white Americans, especially Asian Americans, are at disproportionately higher risk for gastric cancer compared to non-Hispanic white Americans. A new study breaks down this risk according to specific ethnicities and locations within the stomach. (2020-08-06)

New method to help spot gastric cancer cells
Researchers from the Shenyang Institute of Automation (SIA) of the Chinese Academy of Science (CAS) and City University of Hong Kong (CityU), in cooperation with doctors from the First Hospital of China Medical University, jointly proposed an optically induced electrokinetics (OEK) microfluidic method for label-free separation and characterization of gastric cancer cells. (2020-08-05)

HDAC6 can control tumor growth and halt metastasis in triple-negative breast cancer
Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the journal Cancer Research by investigators at the GW Cancer Center. (2020-08-05)

Study provides new insight on colorectal cancer growth
A new study by researchers at the University of Kentucky identifies a novel function of the enzyme spermine synthase to facilitate colorectal cancer growth. (2020-07-29)

A new way to target cancers using 'synthetic lethality'
Researchers at Ludwig Institute for Cancer Research and University of California San Diego School of Medicine report that inhibiting a key enzyme caused human cancer cells associated with two major types of breast and ovarian cancer to die and in mouse studies reduced tumor growth. (2020-07-27)

Higher end of normal blood platelet count could indicate cancer
Blood platelet counts at the higher end of normal suggest a high risk of cancer in men aged 60 or over, and should be investigated, according to new University of Exeter research. (2020-07-27)

Mix and match: New 3D cell culture model replicates fibrotic elements of pancreatic cancer
Pancreatic cancer is a deadly cancer characterized by prominent fibrosis, which plays a crucial role in disease progression and therapeutic resistance. Despite various efforts, experimental models to date have generally failed to fully recapitulate the extent of fibrosis in human tissue. Now, scientists at Okayama University, Japan, have reported a new method that uses a 3D cell culture technique to generate pancreatic cancer tissues in the laboratory with any given amount of fibrosis. (2020-07-22)

Immunotherapy safe for patients with COVID-19, cancer
Preliminary data from researchers at the University of Cincinnati Cancer Center show that immunotherapy doesn't necessarily worsen complications for patients with both COVID-19 and cancer. (2020-07-20)

Gum disease may raise risk of some cancers
People who have periodontal (gum) disease may have a higher risk of developing some forms of cancer, suggests a letter published in the journal Gut detailing a prospective study. (2020-07-20)

How breast cancer cells sneak past local immune defenses
Breast cancer cells grow locally, then metastasize throughout the body. They succeed in establishing tumors by sabotaging local immune cells embedded in tissues, thus evading detection and destruction by the body's roving immune defenses. (2020-07-15)

Blocking cholesterol storage could stop growth of pancreatic tumors
Scientists at Cold Spring Harbor Laboratory found they can stop the growth of pancreatic cancer cells by interfering with the way the cells store cholesterol. Their findings in mice and lab-grown pancreas models point toward a new strategy for treating deadly pancreatic cancer. (2020-07-07)

Discovery of key protein behind cancer relapse and progression can lead to new therapies
Reports show that cancer is the second-highest leading cause of death globally. A recent study by scientists from Duke-NUS Medical School provides new evidence supporting the presence of a key mechanism behind progression and relapse in cancer. The study, published in Proceedings of the National Academy of Sciences (PNAS), discusses the role of MBNL1 protein as a biomarker for cancer prognosis, which can lead to the development of new treatment strategies for cancer. (2020-06-30)

University of Cincinnati research uncovers clues in use of immunotherapy for breast cancer
UC researchers have found a potential new combination therapy for breast cancer that would integrate use of the body's immune system with targeted treatment for a particular protein that advances cancer. (2020-06-24)

Study shows better option for treatment of inoperable anal cancer
People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered. (2020-06-24)

Study examines how the COVID-19 pandemic impacts quality of life in patients with cancer
Quality of life of cancer patients during coronavirus disease (COVID-19) pandemic. (2020-06-18)

Susceptibility to carcinogens varies due to genetics
A new study led by Michele Carbone of the University of Hawai'i Cancer Center looks into how and why certain individuals develop cancer and others do not. (2020-06-15)

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill. (2020-06-10)

Association between outdoor light at night & breast cancer risk among postmenopausal women
Outdoor light at night was linked to a higher risk of breast cancer in a study published in the International Journal of Cancer. (2020-06-03)

Study puts price tag on lost earnings from racial disparities in cancer mortality
A new American Cancer Society study puts a price tag on racial disparities in cancer mortality, finding that $3.2 billion in lost earnings would have been avoided in 2015 if non-Hispanic (NH) blacks had equal years of life lost from cancer deaths and earning rates as NH whites. (2020-06-03)

Cancer cells cause inflammation to protect themselves from viruses
Researchers at the Francis Crick Institute have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease. (2020-06-01)

Cancer researchers gain valuable insights through a comprehensive review of Clioquinol
Researchers at Karmanos Cancer Institute of Wayne State University compiled the latest cancer research on clioquinol (CQ), an anti-fungal/anti-protozoal hydroxyquinoline family drug. The authors reported that although CQ isn't suitable for cancer therapy currently, using CQ derivatives or analogues such as nitroxoline as well as combining CQ with other drugs, including docahexaenooic acid or disulfiram, are potential cancer treatments, as supported by strong positive preclinical results. (2020-05-21)

Treatment guidance for lung cancer patients during the COVID-19 pandemic
To help oncologists address the many challenges COVID-19-positive lung cancer patients present, a team of global lung cancer specialists this week published a review of lung cancer treatments for patients with COVID-19 in the current issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC). (2020-05-15)

Cancer cells deactivate their 'Velcro' to go on the attack
To form metastases, cancer cells must be able to migrate. But cancer cells are connected to each other by 'Velcro'. University of Louvain (UCLouvain) researchers have discovered that certain cancer cells manage to suppress this 'Velcro' effect so that they can migrate more easily. It's a mechanism called endocytosis. The next step? Understanding the role of this mechanism (endocytosis) in the formation of metastases, which could ultimately help fight them! (2020-05-13)

EULAR 2020
Breast cancer patients don`t have an increased risk of developing rheumatoid arthritis. (2020-05-13)

Prevalence of benign gynecologic lesions higher than previously reported
Over the last decade researchers have become concerned about a possible link between a benign gynecologic lesion called endosalpingiosis (ES) and ovarian cancer. However, using a diagnostic method typically reserved for specimens suspicious for cancer, a team of researchers led by a Baylor College of Medicine physician found the prevalence of ES and other gynecological lesions was substantially higher than previously reported, even among women without cancer. (2020-05-13)

After cancer: The role of primary care in cancer survivorship care
Primary care physicians are treating an increasing number of cancer survivors, yet they have no clear guidance on how best to care for such patients. This study considers how primary care physicians perceive their role in delivering care to cancer survivors. (2020-05-12)

Cancer survivors' experiences with financial toxicity
A recent Psycho-Oncology analysis of published studies found that few cancer survivors received financial information support from healthcare facilities during their initial treatment, even though cancer-related financial toxicity has multiple impacts on survivors' health and quality of life. (2020-05-06)

Clinically-applicable math model predicts patient outcomes to cancer immunotherapy
A group of our cancer and mathematics researchers at Houston Methodist have developed a clinically-applicable mathematical model to predict patient outcomes to cancer immunotherapy. (2020-04-30)

Improving immunotherapy for cancer
One of the reasons why cancer develops is because regulatory cells inhibit the body's immune defense. Researchers under the helm of the Technical University of Munich (TUM) have discovered a mechanism for identifying regulatory cells in tumor tissue that suppress an immune response. Their findings may contribute to improving diagnosis and immunotherapy of cancer. (2020-04-29)

Disruptions in health insurance coverage are common and affect cancer care and survival
A new study finds disruptions in health insurance coverage are common in the United States and are associated with poorer cancer care and survival. (2020-04-27)

Early GP referrals are leading to cancer patients surviving longer
Early GP referrals are likely to lead to cancer patients surviving longer, a study by King's College London has found. (2020-04-20)

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