Current Cancer Drugs News and Events

Current Cancer Drugs News and Events, Cancer Drugs News Articles.
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Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Oncotarget: MEK is a promising target in the basal subtype of bladder cancer
''The @Oncotarget authors demonstrate that MEK inhibitors are a promising targeted therapy for the basal subtype of bladder cancer, and their data indicate that drug screening of 3D cultures provides an important resource for hypothesis generation'' (2021-02-22)

Sewage study shows which countries like to party hard
The Netherlands, United States, Australia and New Zealand are consuming the highest amounts of designer 'party' drugs, according to wastewater samples taken from eight countries over the New Year period. (2021-02-21)

Good cop, bad cop
Serendipitous observation leads to novel insight into how cancer-immune crosstalk can either promote or suppress tumour growth. Ultimately, this study's results may help develop novel cancer therapies as well as an assay to select patients for immunotherapy treatment. (2021-02-19)

Swimming upstream on sound waves
ETH researchers are among the first scientists to have succeeded in propelling microvehicles against a fluid flow using ultrasound. In future, these tiny vehicles are set to be introduced into the human bloodstream, thereby revolutionising the field of medicine. (2021-02-19)

Addressing the biological causes of racial disparities in prostate cancer
A new review published in Cancer Reports examines the biological differences in the development of prostate cancer across ethnicities. (2021-02-18)

Physical conditions linked to psychological distress in patients with cancer
Among patients with cancer, having additional physical comorbidities was linked with a higher risk of experiencing psychological distress. The finding comes from a Psycho-Oncology analysis of 2017 data from the National Health Survey of Spain. (2021-02-18)

UCLA study finds combination therapy suppresses pancreatic tumor growth in mice
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). (2021-02-18)

Targeting the SARS-CoV-2 main protease yields promise in transgenic mouse model
Inhibitors based on approved drugs and designed to disrupt the SARS-CoV-2 viral protein Mpro display strong antiviral activity both in vitro and in a transgenic mouse model, a new study reports. (2021-02-18)

How inflammatory signalling molecules contribute to carcinogenesis
A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signalling molecule and one of the main oncogenes. The study has been published in the leading journal 'Molecular Cancer'. (2021-02-17)

Scientists able to see how potential cancer treatment reacts in single cell
Using a 185 metre beamline at the Diamond synchrotron, researchers could see how Osmium, a rare precious metal that could be used for cancer treatments, reacts in a single human lung cancer cell. This is a major step forward in discovering new anti-cancer drugs for researchers at the University of Warwick. (2021-02-17)

Hide-and-seek can lead to higher drug prices
Pharmaceutical manufacturers and national authorities often negotiate secret rebates when determining drug prices. A UZH study shows that these rebate systems may hamper patient access to drugs. In the medium term, this practice can even lead to increasing drug prices. (2021-02-17)

New classification of leukemia subtypes reveals potential of existing drugs
Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) - called NPM1 - that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation. (2021-02-16)

Study demonstrates the reasons to screen children with cancer for inherited cancer genes
Experts at MSK Kids, the pediatric oncology program at MSK, have found that inherited cancer genes are more common than expected in children with cancer. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

A machine-learning approach to finding treatment options for Covid-19
MIT researchers have developed a machine-learning approach to identify drugs that could be repurposed to fight Covid-19. The advance could boost clinical trial efforts, and it could be adapted to a broader range of diseases. (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Exercise now proven to have mental health benefits for prostate cancer
New Edith Cowan University (ECU) research has found that exercise not only has physical benefits for men with prostate cancer, it also helps reduce symptoms of depression and anxiety. (2021-02-15)

Cabozantinib most effective treatment for metastatic papillary kidney cancer
In a SWOG Cancer Research Network trial that put three targeted drugs to the test, the small molecule inhibitor cabozantinib was found most effective in treating patients with metastatic papillary kidney cancer - findings expected to change medical practice. (2021-02-13)

Researchers identify potential revolutionary new drug treatment for fatal childhood cancer
Research paper published reveals potential revolutionary drug combination that could become an effective treatment for DIPG. (2021-02-12)

Promising new approach to stop growth of brain cancer cells
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. (2021-02-12)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

Study identifies never-before-seen dual function in enzyme critical for cancer growth
In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. New findings demonstrate a previously-unknown capability for polymerase theta (pol theta) - a key enzyme in this repair function - that shows promise as a new avenue for treatment development. (2021-02-11)

Ebola is a master of disguise
Ebola is so pernicious because it pulls a fast one on the body, disguising itself as a dying cell. A study published in the journal PLOS Pathogens, identifies a pathway that all filoviruses use to gain entry into our cells--and shows how they can be stopped in their tracks by at least one FDA-approved drug. (2021-02-11)

Why Black men's prostate cancer may be more responsive to immunotherapy
Black men die more often of prostate cancer yet have greater survival benefits from immunotherapy treatment. A new study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. (2021-02-10)

The therapeutic potential of peptides
There are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases. In Nature Reviews Drug Discovery, a team of Austrian and Australian scientists led by Markus Muttenthaler of the University of Vienna present an outlook on the latest trends in peptide drug discovery and development. (2021-02-10)

Oncotarget: Melatonin increases overall survival of prostate cancer patients
'The results of the use of melatonin drugs in palliative treatment of patients with end-stage prostate cancer are shown' (2021-02-10)

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. (2021-02-10)

New study discovers possible early detection method for elusive ovarian cancer
A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. (2021-02-09)

Combination therapy with radiation shows promise in treating glioblastoma
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma (2021-02-09)

Drug is promising against pancreatic and breast cancers
The drug is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Clinical trials are set to begin in 2021. (2021-02-09)

Six previously FDA-approved drugs appear promising against SARS-CoV-2 in laboratory testing
A team of investigators from the Republic of China has discovered that six drugs previously approved by the US Food and Drug Administration (FDA) for other indications could be repurposed to treat or prevent COVID-19. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. (2021-02-09)

STINGing tumors with nanoparticles
DALLAS - Feb. 8, 2021 - A new nanoparticle-based drug can boost the body's innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment. (2021-02-08)

New drug target for Ebola, Marburg viruses
Researchers have identified a previously unknown site on the filovirus glycoprotein to which small drug molecules can bind and prevent infection -- blocking both sites may be a more effective treatment while reducing the risk of side effects. (2021-02-08)

Researchers develop platform to identify cancer mutations that may be responsive to drug therapies
A Cleveland Clinic-led team of researchers has developed a personalized genomic medicine platform that will help advance accelerate genomic medicine research and genome-informed drug discovery, according to new study results published recently in Genome Biology. (2021-02-08)

Today's stem cell special: Small intestine on a plate!
A team of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. The scientists used a procedure they previously developed on embryonic stem cells for this discovery. They claim that the grown cells can be used for laboratory studies focusing on human small intestinal drug transport and metabolism. (2021-02-05)

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the NCI, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. (2021-02-04)

Using Artificial Intelligence to prevent harm caused by immunotherapy
Until recently, researchers and oncologists had placed these lung cancer patients into two broad categories: those who would benefit from immunotherapy, and those who likely would not. Now, researchers at Case Western Reserve University, using artificial intelligence (AI) to analyze simple tissue scans, say they have discovered biomarkers that could tell doctors which lung cancer patients might actually get worse from immunotherapy. (2021-02-04)

Researchers assess cognitive impairment in patients with breast cancer
A recent analysis of published studies in Psycho-Oncology estimates that one-quarter of adults with breast cancer have cognitive impairment before starting therapy. (2021-02-03)

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