Current Cardiac Regenerative Therapies News and Events

Current Cardiac Regenerative Therapies News and Events, Cardiac Regenerative Therapies News Articles.
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Cre-controlled CRISPR: Conditional gene inactivation just got easier
The ability to turn a gene off only in a specific cell type is essential to modern life science. Thanks to the Cre-Controlled CRISPR it has just became simpler. The new method developed by researchers from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden with support from the DRESDEN-concept Genome Center (DCGC) offers a fast and easy approach for conditional gene inactivation. The findings were published in the journal ''Nature Communications.'' (2021-02-23)

Fat cells may influence how the body reacts to heart failure, study shows
University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells when in heart failure could help improve outcomes for patients. (2021-02-23)

'Walking' molecule superstructures could help create neurons for regenerative medicine
By discovering a new printable biomaterial that can mimic properties of brain tissue, Northwestern University researchers are now closer to developing a platform capable of conditions using regenerative medicine. (2021-02-22)

Periodontal disease increases risk of major cardiovascular events
People with periodontitis are at higher risk of experiencing major cardiovascular events, according to new research from Forsyth Institute and Harvard University scientists and colleagues. (2021-02-21)

South American lizard's blood pressure mechanism is more efficient at cool temperatures
The black and white tegu lizard, which depends on external environmental factors to regulate body temperature, can survive swings between 15 and 35 degrees Celsius in a single day while keeping blood pressure steady. (2021-02-18)

Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first
Scientists at the University of Cambridge have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. (2021-02-18)

Organoids grown from bile duct cells repair human livers; may aid liver transplant processes
Organoids grown from bile duct epithelial cells can be used to repair damaged bile ducts in transplanted human livers, researchers report. (2021-02-18)

Mount Sinai researchers identify mechanisms that are essential for proper skin development
Latest discovery could improve development of future stem cell therapies and cancer treatments. (2021-02-18)

Stents or bypass surgery more effective for stable patients with high-risk cardiac anatomy
A study by University of Alberta cardiologists at the Canadian VIGOUR Centre shows that a particular group of patients with stable ischemic heart disease have better outcomes with percutaneous coronary intervention (also called angioplasty with stent) or coronary artery bypass surgery and medication, versus conservative management with medication alone. (2021-02-18)

Phase I clinical trial shows promise of adipose-derived stem cells in treating lymphedema
Results of a phase I clinical trial released in STEM CELLS Translational Medicine shows there is a strong possibility that stem cells may alleviate lymphedema, a chronic debilitating condition affecting up to one in three women treated for breast cancer. (2021-02-17)

FSU College of Medicine researcher develops new possibilities to prevent sudden cardiac death
Stephen Chelko, an assistant professor of biomedical sciences at the Florida State University College of Medicine, has developed a better understanding of the pathological characteristics behind arrhythmogenic cardiomyopathy, as well as promising avenues for prevention. (2021-02-17)

Challenge to anorexia nervosa treatment guidelines
New analysis published in The Lancet Psychiatry has shown a lack of strong evidence to support current guidance on psychological therapies for treating anorexia nervosa over expert treatment as usual. The findings highlight a need for further research and support a call for individual trial data to be made available so the benefits of treatments in specific patient populations can be better understood. (2021-02-15)

Heartbeat secrets unlocked as cardiac rhythm gene role identified
Researchers have used the zebrafish (Danio rerio) to identify the role of a gene involved in cardiac rhythm, which could help explain the fundamentals of what it takes to make a human heartbeat. (2021-02-15)

TV and film 'thump' is not effective alternative to CPR, Warwick researchers demonstrate
A technique frequently portrayed in dramatic resuscitation scenes in television and film is among several alternative methods to CPR that have shown no benefit in saving lives in a review by University of Warwick researchers. (2021-02-15)

Study finds alligator hearts keep beating no matter what
A new study reported by Georgia Tech researchers finds that an alligator heart will not fibrillate when exposed to drastic temperature changes, unlike a rabbit (mammal) heart, which is critically vulnerable to heart trauma under those conditions. The research could help better understand how the heart works and what can cause a deadly arrhythmia - which fundamentally happens when the heart doesn't pump blood correctly any longer. (2021-02-15)

New discovery could pave the way for improved treatments for diabetes
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. (2021-02-12)

Novel protein could reverse severe muscle wasting in disease, aging and trauma
Muscle stem cells drive the tissue's growth and repair after such injuries. But growing these cells in the lab and using them to therapeutically replace damaged muscle has been frustratingly difficult. Australian researchers have discovered a factor that triggers these muscle stem cells to proliferate and heal. In a mouse model of severe muscle damage, injections of this naturally occurring protein led to the complete regeneration of muscle and the return of normal movement after severe muscle trauma. (2021-02-10)

New insights put a freeze on the mechanisms for safely cryopreserving biological materials
The ability to freeze cells and even whole organs without damaging them, known as cryoprotection, is of considerable interest to medical practitioners, and scientists have experimented with chemicals called polyampholytes as cryoprotectants. In an article recently published in Communications Materials, a team of Japanese scientists now describes the mechanisms by which polyampholytes act to enable cryoprotection. Their insights may aid efforts to develop improved chemical cryoprotection technologies. (2021-02-09)

A study presents an algorithm that automates electrocardiogram recordings
Artificial intelligence can help health personnel to diagnose heart diseases, as shown in a study published in Scientific Reports, by Guillermo Jiménez-Pérez and Oscar Camara, members of the PhySense group, and Alejandro Alcaine, a researcher at the University of San Jorge, Zaragoza. (2021-02-09)

Raised mortality from cardiac arrest in people with COVID-19
Sudden cardiac arrest is more often fatal in people with COVID-19, a new study shows. Those responsible for the research see the results as a wake-up call for the public and care providers alike. (2021-02-05)

New guidance on how cardiac patients with diabetes can exercise more safely
Cardiac patients who also have diabetes will be able to do their rehabilitation exercises more safely, thanks to the world's first guidance on the subject, which has been published by international experts including a Swansea University academic. The guidance will be a crucial resource for healthcare professionals, so they can help the growing number of cardiac rehabilitation patients who also have diabetes. (2021-02-04)

Uncovering a link between inflammation and heart disease
Patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. A new study published in Circulation reveals a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. (2021-02-04)

New stem cell therapy in dogs -- a breakthrough in veterinary medicine
A team of scientists in Japan has developed a novel method to induce stem cell generation from the blood samples of dogs. Through this technique, the scientists hope to advance regenerative therapies in veterinary medicine. This would mean that, in the near future, veterinarians might be able to reverse conditions in dogs that were previously thought incurable. (2021-02-03)

Women at higher-risk of fatal, nightime cardiac arrest
A new Cedars-Sinai study shows that during nighttime hours, women are more likely than men to suffer sudden death due to cardiac arrest. The findings were published in the journal Heart Rhythm. (2021-02-03)

Test for early detection of heart problems reduces risk of heart damage from chemotherapy
Results of a multi-centre, international, clinical trial co-led by Peter Munk Cardiac Centre (PMCC) cardiologist Dr. Dinesh Thavendiranathan point to the benefit of using a more sensitive test to detect heart function issues early, so cancer patients don't have to fight heart failure too. (2021-02-02)

Women undergo less aggressive open heart surgery, experience worse outcomes than men
Women are significantly less likely than men to undergo coronary artery bypass grafting (CABG) using guideline-recommended approaches, which may result in worse outcomes after surgery. (2021-01-30)

'COVID effect' leads to fewer heart surgeries, more patient deaths
The most deadly global health crisis in a century has resulted in a substantial decline in overall heart surgery volume and an unexplained increase in deaths after coronary artery bypass grafting. (2021-01-30)

First hybrid gene therapy shows early promise in treating long QT syndrome
In a new study published in Circulation, Mayo Clinic researchers provide the first preclinical, proof-of-concept study for hybrid gene therapy in long QT syndrome, a potentially lethal heart rhythm condition. (2021-01-28)

Blood discoveries advance efforts to grow organs, battle cancer
Researchers have developed a simple and efficient way to generate ''hemogenic endothelial cells,'' the first stop in the production line of blood cells. (2021-01-28)

Exercise-based cardiac rehab added to stroke recovery improved strength, cardiac endurance
In a small study, stroke survivors who completed a three-month cardiac rehabilitation program focused on aerobic exercise significantly improved their physical endurance and strength. Six months after the program more, 83.3% of participants reported that they continued exercising at least once a week. (2021-01-27)

Study introduces mRNA-LNP as a safe therapeutic intervention for liver regeneration
When severely or chronically injured, the liver loses its ability to regenerate. A new study led by researchers at the Center for Regenerative Medicine at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) now describes a safe new potential therapeutic tool for the recovery of liver function in chronic and acute liver diseases. (2021-01-27)

Scientists discover a new promising target for diabetes treatment
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission. (2021-01-27)

Life-threatening complications during pregnancy: greater long-term risk of death
A research team from the CHUM Research Centre (CRCHUM) has shown that women who have had serious complications during pregnancy are twice as likely to die up to three decades later. (2021-01-26)

Automated imaging reveals where TAU protein originates in the brain in Alzheimer's disease
Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals. (2021-01-20)

Cartilage matrix as natural biomaterial for cartilage regeneration
A working group at MedUni Vienna develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration. (2021-01-20)

Rush researchers demonstrate success with new therapy for COVID-19
A new therapy developed by researchers at Rush University Medical Center is showing success as a way to prevent COVID-19 symptoms in mice. (2021-01-19)

Where COVID-19 hit hardest, sudden deaths outside the hospital increased
A new study comparing the incidence of sudden deaths occurring outside the hospital across New York City's highly diverse neighborhoods with the percentage of positive SARS-CoV-19 tests found that increased sudden deaths during the pandemic correlate to the extent of virus infection in a neighborhood. The analysis appears in Heart Rhythm, the official journal of the Heart Rhythm Society, the Cardiac Electrophysiology Society, and the Pediatric & Congenital Electrophysiology Society, published by Elsevier. (2021-01-18)

Flip the script: cardiac rehabilitation is underused, but a simple change could fix that
Making doctors opt out from prescribing cardiac rehabilitation instead of opting in increased referrals by roughly 70 percent (2021-01-14)

High levels of clinician burnout identified at leading cardiac centre
More than half the clinicians surveyed at the Peter Munk Cardiac Centre reported burnout and high levels of distress according to a series of studies published in the Canadian Medical Association Journal Open (CMAJ-OPEN). In the studies carried out before the COVID-19 pandemic, 78% of nurses, 73% of allied health staff and 65% of physicians described experiencing burnout. (2021-01-12)

Hope for children with rare heart condition: novel stem cell therapy to save the day
In a new study, scientists at Okayama University isolated cardiac stem cells and assessed their potential use as regenerative therapy in young patients with cardiac defects. They confirmed the safety and effectiveness of their proposed treatment in early-phase trials and even identified the mechanism through which the stem cells improved cardiac function. Based on these preliminary findings, they hope to proceed to larger clinical trials and move towards pharmaceutical approval in the future. (2021-01-12)

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