Current Cell Growth News and Events

Current Cell Growth News and Events, Cell Growth News Articles.
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Cancer cell vulnerability points to potential treatment path for aggressive disease
A new study in Nature Communications describes the discovery of a unique dependence of cancer cells on a particular protein, which could lead to desperately needed treatment for hard-to-treat cancers. (2021-02-22)

The perfect recipe for efficient perovskite solar cells
A long-cherished dream of materials researchers is a solar cell that converts sunlight into electrical energy as efficiently as silicon, but that can be easily and inexpensively fabricated from abundant materials. Scientists at the Helmholtz-Zentrum Berlin have now come a step closer to achieving this. (2021-02-22)

Scientists model a peculiar type of breast cancer
Scientists led by EPFL have developed a breakthrough in vivo model for invasive lobular carcinoma, a serious yet understudied type of breast cancer. The work will open up previously inaccessible study of the tumor's biology and help discover new therapies. (2021-02-22)

Tweaking corn kernels with CRISPR
Corn has a highly complex genome, making it a challenge to apply genome-editing techniques to it. CSHL Professor David Jackson and postdoctoral fellow Lei Liu used CRISPR to tinker with the corn genome promoter regions and modify stem cell growth. They figured out which sections influence kernel yield, and they hope to make targeted genome-editing in corn more precise and efficient. (2021-02-22)

Antibiotic could be repurposed and added to tuberculosis treatment arsenal
Research has found fidaxomicin, an antibiotic usually used to treat bowel infections, prevents growth of resistant strains of Mycobacterium tuberculosis (MTb) in the lab. (2021-02-17)

Plant as superhero during nuclear power plant accidents
A collaborative study by a group of scientists from Iwate University, The University of Tokyo and Shimane University, Japan demonstrated for the first time that two ATP binding cassette proteins ABCG33 and ABCG37 function as potassium-independent cesium uptake carriers. (2021-02-16)

Researchers solve riddle of plant immune system
How do plants build resilience? An international research team led by the University of Göttingen studied the molecular mechanisms of the plant immune system. They were able to show a connection between a relatively unknown gene and resistance to pathogens. The results of the study were published in the journal The Plant Cell. (2021-02-16)

Membrane building blocks play decisive role in controlling cell growth
Lipids are the building blocks of a cell's envelope - the cell membrane. In addition to their structural function, some lipids also play a regulatory role and decisively influence cell growth. This has been investigated in a new study by scientists at Martin Luther University Halle-Wittenberg (MLU). The impact of the lipids depends on how they are distributed over the plasma membrane. The study was published in 'The Plant Cell'. (2021-02-15)

Integrating maths and plant science to explain how plant roots generate a hormone gradient
The research team that developed a biosensor that first recorded that a distinct gradient of the plant growth hormone gibberellin correlated with plant cell size has now revealed how this distribution pattern is created in roots. (2021-02-15)

Metabolic response behind reduced cancer cell growth
Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment by EZH2 inhibition. The study has been published in the journal Cell Death & Disease. (2021-02-12)

Medication-based starvation of cancer cells
Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications. At the same time, they identified new innovative targeted cancer therapies. (2021-02-12)

Bacterial degradation of the MYC oncogene -- a new cancer treatment strategy?
Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer. The study is now published in Nature Biotechnology. (2021-02-12)

Stirring up conflicts in tumour cells
With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumour neuroblastoma can be disrupted at a key point causing tumour cell death. (2021-02-11)

A recipe for regenerating bioengineered hair
Scientists have recently developed ways to grow a variety of useful items in laboratories, from meat and diamonds to retinas and other organoids. At the RIKEN Center for Biosystems Dynamics Research in Japan, a team led by Takashi Tsuji has been working on ways to regenerate lost hair from stem cells. In an important step, a new study identifies a population of hair follicle stem cells in the skin and a recipe for normal cyclical regeneration in the lab. (2021-02-10)

New factor in the carbon cycle of the Southern Ocean identified
The Southern Ocean is one of the key regions for understanding the climate system. The photosynthesis-performing plankton there contribute significantly to controlling the CO2 concentration in the atmosphere. But which factors favor or limit plankton growth? Researchers have now published a study showing for the first time that, in addition to the micronutrient iron, manganese can play an important role. Among other things, the results have implications for understanding ice ages in the past. (2021-02-09)

Known tumour suppressor gene found essential for development, regeneration&stress-response
- Experiments carried out in the Drosophila fly have led to the identification of the headcase (hdc) gene as pivotal for adult progenitor cells, allowing them to undergo metamorphosis and give rise to adult tissue structures. - The study by IRB Barcelona's Development and Morphogenesis in Drosophila lab has been published in PLOS Genetics. (2021-02-09)

Early study points to potential therapeutic avenue for a pair of rare pediatric diseases
Scientists have devised a new approach for detecting and potentially heading off the effects of two rare pediatric diseases before birth. The study, performed in mouse models of the diseases and published today in Cell Reports, represents an important step toward much-needed early interventions for Beckwith-Wiedemann syndrome and Silver-Russell syndrome. (2021-02-09)

Halt cell recycling to treat cancer
Targeting and changing autophagy, otherwise known as cell recycling, has been linked to helping control or diminish certain cancers. Now, University of Cincinnati researchers have shown that completely halting this process in a very aggressive form of breast cancer may improve outcomes for patients one day. (2021-02-08)

Technion researchers discover new pathway for attacking cancer cells
The folate cycle is a process essential to DNA and RNA production. As a result, it is highly important to both cancer cells and healthy cells. Because DNA production is a critical stage in cell division, and thus in tumor growth, the folate cycle is a common target for chemotherapy. However, for the very same reason, there are significant side effects to attacking it. (2021-02-05)

Today's stem cell special: Small intestine on a plate!
A team of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. The scientists used a procedure they previously developed on embryonic stem cells for this discovery. They claim that the grown cells can be used for laboratory studies focusing on human small intestinal drug transport and metabolism. (2021-02-05)

'Stealthy' stem cells better for treating tendon injuries in horses
Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid ''tripping'' the immune response in recipients, according to new research. (2021-02-04)

Garlic and selenium increase stress resistance in carps, says a RUDN University biologist
A biologist from RUDN University confirmed that selenium nanoparticles and garlic extract can effectively reduce the negative impact of stress on the health of grass carp in the breeding industry. (2021-02-04)

Zinc may help with fertility during COVID-19 pandemic, researchers report
Wayne State University School of Medicine researchers have reported that zinc supplements for men and women attempting to conceive either naturally or through assisted reproduction during the COVID-19 pandemic may prevent mitochondrial damage in young egg and sperm cells. (2021-02-04)

How plants stabilize their water pipes
New techniques allow live-observation of forming cell walls in the vascular tissue (2021-02-02)

Potential drug target found for treating rare genetic disorder in children
Scientists have identified a potential new treatment approach for Hutchinson-Gilford progeria syndrome (HGPS), a progressive genetic disorder that causes rapid and premature aging in children. (2021-02-02)

BU researchers identify promising therapeutic agent against melanoma
There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease. A new study from Boston University School of Medicine (BUSM) has discovered that a drug (YK-4-279) that was previously created to target one specific type of protein has much broader use against a family of proteins that act to promote melanoma. (2021-02-01)

Human activity caused the long-term growth of greenhouse gas methane
Decadal growth rate of methane in the atmosphere varied dramatically over the past 30 yeas with three distinct periods of slowed (1988-1998), quasi-stationary (1999-2006) and renewed (2007-2016) phases. An inverse analysis with atmospheric chemistry transport modeling explained these variations consistently. While emissions from oil and gas exploitation and natural climate events caused the slowed growth and the temporary pause, those from coal mining in China and livestock farming in the tropics drove the renewed growth. (2021-01-29)

Local emissions amplify regional haze and particle growth
A Finnish-Chinese research team performed simultaneous measurements of aerosol composition and particle number size distributions at ground level and at 260 m in central Beijing, China, during a total of 4 months in 2015-2017. The team found concentration of both primary and secondary particles in the accumulation mode would decrease drastically, and the haze formation would be reduced if the emission cuts are higher than 30%. (2021-01-29)

Novel therapy-resistance mechanism promoting the growth of breast cancer brain metastasis
SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. (2021-01-29)

By changing their shape, some bacteria can grow more resilient to antibiotics
New research led by Carnegie Mellon University Assistant Professor of Physics Shiladitya Banerjee demonstrates how certain types of bacteria can adapt to long-term exposure to antibiotics by changing their shape. (2021-01-29)

Oncotarget: Drug-resistant cells grow exponentially in metastatic prostate cancer
The Oncotarget authors show that the drug-resistant, metastasis-causing cells are capable of producing drug-resistant, exponentially growing tumors, responsible for tumor growth as a patient receives different treatments (2021-01-25)

Fighting cancer from a chair
Cisplatin has been used to treat cancer since the 1970s. Since then, many other platinum-containing cytostatic drugs have been developed, such as triplatinNC, a highly charged complex that contains three ligand-bridged platinum atoms. Unlike cisplatin, this drug also directly inhibits metastasis. The reason for this seems to be modulation of the geometry of a sugar component of heparan sulfate, an important component of the extracellular matrix, reports a research team in the journal Angewandte Chemie. (2021-01-25)

A new mechanism protects against cancer cell migration and neuron hyperexcitability
G3BP proteins inhibit the metabolic driver MTOR - a signaling protein that plays a central role in tumor diseases and developmental disorders of the brain. This is reported in this week´s issue of the renowned journal Cell. The study was led by scientists from the University of Innsbruck and the German Cancer Research Center (DKFZ) in collaboration with the Medical University of Innsbruck and a Europe-wide research network. (2021-01-25)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Sloan Kettering Institute scientists solve a 100-year-old mystery about cancer
A long-standing mystery is why fast-growing cells, like cancer cells and immune cells, rely on a seemingly inefficient form of metabolizing glucose to power their activities. In a new study, scientists at the Sloan Kettering Institute offer a compelling solution. (2021-01-21)

The physics behind tumor growth
Researchers at Duke University have developed a predictive theory for tumor growth that approaches the subject from a new point of view. Rather than focusing on the biological mechanisms of cellular growth, the researchers instead use thermodynamics and the physical space the tumor is expanding into to predict its evolution from a single cell to a complex cancerous mass. (2021-01-20)

Parkinson's: Initial steps to show nerves their growth direction magnetically
One reason why nerve damage in the brain cannot regenerate easily is that the neurites do not know in which direction they should grow. A team of researchers from Ruhr-Universität Bochum (RUB), Sorbonne University Paris, and the Technische Universität Braunschweig is now working on showing them the direction using magnetic nanoparticles. (2021-01-18)

Researchers link cellular transport pathway to aggressive brain cancer
Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins. The study, which will be published January 14 in the Journal of Cell Biology (JCB), suggests that the pathway, which involves a protein called Rab35, is defective in many patients with glioblastoma and that restoring Rab35's activity could be a new therapeutic strategy for this deadly form of brain cancer. (2021-01-14)

Triggering tumor antiviral immune response in triple negative breast cancer
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response. (2021-01-14)

Moffitt researchers discover biochemical pathway that protects cells from ferroptosis
In an article published in Cell Metabolism, Moffitt Cancer Center researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis. (2021-01-14)

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