Current Cell Membrane News and Events

Current Cell Membrane News and Events, Cell Membrane News Articles.
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Attachable skin monitors that wick the sweat away?
A new preparation technique fabricates thin, silicone-based patches that rapidly wick water away from the skin. The technique could reduce the redness and itching caused by wearable biosensors that trap sweat beneath them. The technique was developed by bioengineer and professor Young-Ho Cho and his colleagues at KAIST and reported in the journal Scientific Reports last month. (2021-02-22)

Antibiotic tolerance study paves way for new treatments
The study in mice, 'A Multifaceted Cellular Damage Repair and Prevention Pathway Promotes High Level Tolerance to Beta-lactam Antibiotics,' published Feb. 3 in the journal EMBO Reports, reveals how tolerance occurs, thanks to a system that mitigates iron toxicity in bacteria that have been exposed to penicillin. (2021-02-22)

A new piece of the HIV infection puzzle explored
Researchers from the European Molecular Biology Laboratory and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics. (2021-02-18)

Selective concentration of cationic species
POSTECH Professor Geunbae Lim Develops a Multiscale-Porous Anion Exchange Membrane. (2021-02-18)

Researchers uncover new information on the effects of antidepressants
The findings of a new study challenge the prevailing thinking on the primary role of serotonin and other neurotransmitters in the effects of antidepressants. (2021-02-18)

Capturing the contours of live cells with novel nanoimaging technique using graphene
Researchers from DGIST have now found a way to keep living, wet cells viable in an ultra-high-vacuum environment, using graphene, allowing--like never before--accurate high-resolution visualization of the undistorted molecular structure and distribution of lipids in cell membranes. This could enhance our bioimaging abilities considerably, improving our understanding of mechanisms underlying complex diseases such as cancers and Alzheimer's. (2021-02-17)

A 'twisted elevator' could be key to understanding neurological diseases
For the first time, researchers have found one of the most important molecular machines in our cells uses a 'twisting elevator' mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another. (2021-02-17)

Fueling the future: Novel two-polymer membrane boosts hydrogen fuel cell performance
Fuel cells are an attractive sustainable energy source due to their eco-friendly by-product, water. However, existing fuel cells are either expensive or low performance. Now, scientists from Korea have designed a robust and highly conductive fuel cell ion-exchange membrane using two readily available polymer materials and a unique technique, opening doors to fuel cells that are both cheap and high performing, bringing us closer to realizing a hydrogen economy. (2021-02-17)

How the immune system paves the way for SARS-CoV-2
The immune system actually wants to fight SARS-CoV-2 with antiviral signaling molecules. But a research team from Charité and MDC has now shown how such a signaling molecule can promote the replication of the virus. The results have been published in the journal EMBO Molecular Medicine. (2021-02-16)

It takes two to tango: When cells interact
When normal, motile cells come into contact, they typically change direction to avoid collision. But cancer cells behave quite differently. A new statistical analysis sheds light on the basis for this difference. (2021-02-16)

Cells use concentration gradients as a compass
Biophysicists at Ludwig-Maximilians-Universitaet (LMU) in Munch have developed a new theory, which accounts for the observation that cells can perceive their own shapes, and use this information to direct the distribution of proteins inside the cell. (2021-02-16)

A boost for plant research
Optogenetics can be used to activate and study cells in a targeted manner using light. Scientists at the University of Würzburg have now succeeded in transferring this technique to plants. (2021-02-16)

Membrane building blocks play decisive role in controlling cell growth
Lipids are the building blocks of a cell's envelope - the cell membrane. In addition to their structural function, some lipids also play a regulatory role and decisively influence cell growth. This has been investigated in a new study by scientists at Martin Luther University Halle-Wittenberg (MLU). The impact of the lipids depends on how they are distributed over the plasma membrane. The study was published in 'The Plant Cell'. (2021-02-15)

New discovery may enable accurate prediction of cancer spread before cancer develops
Researchers from Erler Group at the Biotech Research & Innovation Centre (BRIC) in Copenhagen have discovered that the rigidity of a thin membrane structure encompassing cells and lining all vessels regulates how easily cancer cells can breach tissues to spread through the body, and is thus a key determinant of cancer patient survival. The results are published in Nature Materials today. (2021-02-15)

Medication-based starvation of cancer cells
Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications. At the same time, they identified new innovative targeted cancer therapies. (2021-02-12)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Function identified of 'mystery protein' that kills brain cells of people with Parkinson's
Scientists have made a 'vital step' towards understanding the origins of Parkinson's Disease - the fastest growing neurological condition in the world. A study published in Nature Communications today (Wednesday 10 February) presents a compelling new evidence about what a key protein called alpha-synuclein actually does in neurons in the brain. (2021-02-10)

Anti-cancer drug's mode of operation deciphered
Freiburg researchers show how the membrane protein CD20 keeps the immune system's antibody-producing cells in check. (2021-02-10)

How cells recycle the machinery that drives their motility?
Research groups at University of Helsinki and Institut Jacques Monod, Paris, discovered a new molecular mechanism that promotes cell migration. The discovery sheds light on the mechanisms that drive uncontrolled movement of cancer cells, and also revises the 'text book view' of cell migration. (2021-02-09)

What rules govern the structure of membraneless organelles?
A study published on Feb. 8 in Nature Communications explores how membraneless organelles (MLOs) or biomolecular condensates, form and organize themselves. The research lays out physical rules controlling the arrangement of various types of synthetic MLOs created using just three kinds of building materials: RNA and two different proteins, a prion-like polypeptide (PLP) and an arginine-rich polypeptide (RRP). (2021-02-08)

Bernese researchers create sophisticated lung-on-chip
In collaboration with clinical partners from the Inselspital, researchers from the ARTORG Center for Biomedical Research of the University of Bern have developed a second-generation lung-on-chip model with life-size dimension alveoli in a stretchable membrane, made of purely biological material. The new model reproduces key aspects of the lung tissue architecture not found in previous lungs-on-chip. This opens up new possibilities for basic pneumological research, understanding lung pathologies, drug screening and precision medicine. (2021-02-08)

Today's stem cell special: Small intestine on a plate!
A team of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. The scientists used a procedure they previously developed on embryonic stem cells for this discovery. They claim that the grown cells can be used for laboratory studies focusing on human small intestinal drug transport and metabolism. (2021-02-05)

New microscopy concept enters into force
The first demonstration of an approach that inverts the standard paradigm of scanning probe microscopy raises the prospect of force sensing at the fundamental limit. (2021-02-05)

Fast-flying bats rely on late-night updrafts to reach great heights
Although scientists knew that some bats could reach heights of over 1,600 meters (or approximately one mile) above the ground during flight, they didn't understand how they managed to do it without the benefit of thermals that aren't typically available to them during their nighttime forays. Now, researchers reporting in the journal Current Biology on February 4th have uncovered the bats' secret to high-flying. (2021-02-04)

SARS-CoV-2 under the helium ion microscope for the first time
Scientists at Bielefeld University's Faculty of Physics have succeeded for the first time in imaging the SARS-CoV-2 coronavirus with a helium ion microscope. In contrast to the more conventional electron microscopy, the samples do not need a thin metal coating in helium ion microscopy. This allows interactions between the coronaviruses and their host cell to be observed particularly clearly. The findings have been published in the Beilstein Journal of Nanotechnology. (2021-02-04)

A revolutionary approach to increasing crop yield in rice
Overexpression of a plasma membrane proton pump gene in rice increases nutrient uptake and stomatal opening, promising solutions to food supply and environmental problems. (2021-02-03)

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT) has identified an inhibitor of the glutamate metabolic enzyme GLS1 so that its administration selectively eliminates senescent cells in vivo. They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and NASH. The results of this research were published in 'Science' on January 15, 2021. (2021-02-03)

Researchers identify "rescue" mechanism that helps cells survive malfunctioning split
Cells replicate their genetic material and divide into two identical clones to perpetuate life. Some cells pause in the process with a single, undivided nucleus. When the cell resumes division after such a pause, the nucleus can become caught in the fissure, splitting violently, and killing both cells. But that is not always the case. Researchers from Hiroshima University in Japan are starting to understand how active nuclear displacement rescues cell death. (2021-02-03)

Biosensors require robust antifouling protection
Some promising biosensors and medical devices work well within pristine laboratory environments but may stop working once exposed to real-world conditions. A thick layer of foulants will quickly cover biosensors, and there is no good way to revive them once they quit working. Essentially, a biosensor is only as good as its antifouling properties. In APL Materials, researchers review a variety of approaches developed to combat fouling. (2021-02-02)

Neurons: 'String of lights' indicates excitation propagation
A type of novel molecular voltage sensor makes it possible to watch nerve cells at work. The principle of the method has been known for some time. However, researchers at the University of Bonn and the University of California in Los Angeles have now succeeded in significantly improving it. It allows the propagation of electrical signals in living nerve cells to be observed with high temporal and spatial resolution. (2021-02-02)

Origami with DNA
To study the behaviour of T-cells, an unusual method was used at TU Wien: DNA molecules were folded in an ingenious way, similar to the paper folding art origami. In this way, not just a double helix is created, but a rectangular ''molecular raft'' that floats across a cell membrane and serves as a tool for novel measurements. (2021-02-01)

Double delight: New synthetic transmembrane ion channel can be activated in two ways
Scientists at Tokyo Institute of Technology (Tokyo Tech) and University of Tokyo, Japan, have, for the first time, synthesized a novel artificial transmembrane ion channel--modelled on a naturally found transmembrane channel involved in neuron signaling--that responds to both chemical and electrical stimuli. Given its overall properties, this artificial channel opens doors to novel fundamental research into cellular transport and signaling, new possibilities in drug development, and the potential for new types of biosensors. (2021-02-01)

New protein neutralizes COVID in tiny human kidney
Northwestern Medicine scientists have developed a new protein that acts as a trickster to neutralize the COVID-19 infection in a human kidney organoid, a miniature organ made from stem cells in the lab. (2021-02-01)

New discovery for how the brain 'tangles' in Alzheimer's Disease
University of Queensland researchers have discovered a new 'seeding' process in brain cells that could be a cause of dementia and Alzheimer's disease. (2021-02-01)

How lipids distribute proteins within cells
Researchers have observed how lipids distribute proteins within cells, a discovery that could open the door to understanding the causes of protein transport related diseases, such as cancer or neurodegenerative diseases (2021-01-29)

Novel therapy-resistance mechanism promoting the growth of breast cancer brain metastasis
SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing SORLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. (2021-01-29)

Singles or pairs in cancer cells
An important receptor on the surface of cancer and immune cells prefers to remain noncommittal; sometimes it is present as a single, sometimes as a pair. This was first shown by an MDC team in the journal PNAS, and will decisively advance the development of new medications. (2021-01-29)

Deeper insight into how tick spit suppresses cattle immunity
A tick saliva study reveals immune responses that could lead to better protection for cattle. (2021-01-28)

How a cancer drug carrier's structure can help selectively target cancer cells
Porphyrins are interesting drug delivery vehicles that can specifically accumulate in cancer cells. However, how the structure of the drug-conjugated porphyrin affects its ability to penetrate and accumulate within cancer cells is not well understood. Researchers from Tokyo University of Science now investigate the correlation between the structure and tumor accumulation of porphyrin derivatives. Their findings can help to optimize drug delivery, possibly advancing cancer treatment. (2021-01-28)

Parkinson's disease risk and severity is tied to a channel in cells' 'recycling centers
Genetic variations associated with both increases and reductions in risk of the neurodegenerative disease alter the action of ion channels within cellular organelles called lysosomes, a new Penn study finds. (2021-01-27)

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