Current Chagas Disease News and Events

Current Chagas Disease News and Events, Chagas Disease News Articles.
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Enhanced scorpion venom molecules can be used to treat Chagas disease
Brazilian researchers tested the antichagasic properties of VmCT1, obtained from the venom of Vaejovis mexicanus, a scorpion harmless to humans, and synthesized novel analogs to redesign the native molecule (2020-12-21)

Study suggests metabolism influences parasite's resistance to drugs
New insight on how a parasite can resist current therapies has been published today in the open-access eLife journal. (2020-12-01)

Parasitology - Bringing the locals onboard
A new study examines local perceptions of Chagas disease in a region where the infectious agent is endemic. The results underline the need to take social and cultural factors into account in campaigns designed to curb infectious diseases. (2020-10-30)

Stronger treatments could cure Chagas disease
Researchers in the University of Georgia's Center for Tropical and Emerging Global Diseases have found that a more intensive, less frequent drug regimen with currently available therapeutics could cure the infection that causes Chagas disease (2020-10-29)

Study finds asymptomatic Chagas patients are at a high risk for cardiac disease
People living with Chagas disease without symptoms or signs of cardiac injury are at high risk of developing cardiomyopathy, a progressive heart disease, and the risk more than doubled among patients with acute infections, according to a new study from the University of Colorado School of Medicine at the Anschutz Medical Campus. (2020-08-31)

Chemical offers new hope of finding treatments for neglected tropical diseases
Scientists say they are a step closer to developing a drug to kill the trypanosome parasite that causes human African trypanosomiasis, otherwise known as sleeping sickness, paving the way for a potential cure. (2020-07-13)

Kissing bugs also find suitable climatic conditions in Europe
An infection with Chagas disease is only possible in Latin America since the insect species that spread the disease only occur there. Scientists at Goethe University and the Senckenberg Society for Natural Research have now used ecological niche models to calculate the extent to which habitats outside of the Americas may also be suitable for the bugs. (2020-06-10)

Lipophilic guanylhydrazone analogues as promising trypanocidal agents: An extended SAR study
In this report, a team of researchers lead by Dr. Grigoris Zoidis at the National and Kapodistrian University of Athens (Athens, Greece), in collaboration with researchers at the Ruder Boskovic Institute (Zagreb (Croatia), and the London School of Hygiene and Tropical Medicine (London, United Kingdom) have attempted to extend the structure-activity relationship (SAR) analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of T. brucei and T. cruzi. (2020-04-30)

Open access hardware & 3D printing can help tackle demand for health supplies
Free open source hardware and 3D printing could help to alleviate the burden of Covid-19 on global health systems, according to scientists at the University of Sussex. (2020-04-27)

Autoimmunity-associated heart dilation tied to heart-failure risk in type 1 diabetes
In people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies against heart muscle proteins was associated with cardiac magnetic resonance (CMR) imaging evidence of increased volume of the left ventricle (the heart's main pumping chamber), increased muscle mass, and reduced pumping function (ejection fraction), features that are associated with higher risk of failure in the general population (2020-04-06)

Clemson researchers ID protein function in parasites that cause sometimes fatal diseases
In the quest to develop more effective treatments for parasitic diseases, scientists look for weaknesses in the organisms' molecular machinery. A team of College of Science researchers at Clemson recently contributed to that understanding by discovering the function of a specific protein in the three related parasites that cause African sleeping sickness, Chagas disease and Leishmaniasis -- diseases that are sometimes fatal and afflict millions worldwide. (2020-02-24)

Tulane math professor leads effort to map spread of coronavirus
Hyman says mathematical modeling can help public health officials prepare the medical care and allocate resources needed to confront the epidemic. (2020-02-18)

Brazilian scientists unveil chemotherapy resistance mechanism related to p53 mutation
Brazilian study uncovered an anticancer chemotherapy resistance mechanism related to amyloid aggregation of mutant p53. The research was conducted in cells derived from glioblastoma, a super aggressive brain tumor, and in living cells. The results open up new opportunities for the development of more effective therapies against cancer. (2020-01-08)

New clues about the origins of familial forms of Amyotrophic lateral sclerosis
A Brazilian study made important progress in understanding the accumulation of one of the proteins involved in amyotrophic lateral sclerosis (ALS). Scientists were able to gain insight into the interaction between normal and mutant forms of a protein known as superoxide dismutase 1 (Sod1). The process alters protein accumulation in the cell, but also impairs the function of Sod1 protein, thus contributing to the development of the disease. (2019-12-02)

How does the prion protein clump? DNA-modulated liquid droplets may explain
Researchers at the Federal University of Rio de Janeiro (UFRJ), in Brazil, have found that the prion protein (PrP) suffers liquid-liquid phase separation, and that this mechanism is finely controlled by some DNA sequences. This could explain the formation of irreversible clumping of PrP, structure responsible for neurodegenerative disorders, such as Creutzfeldt-Jakob disease. (2019-11-22)

Deciphering the early stages of Parkinson's disease is a matter of time
Researchers at the Federal University of Rio de Janeiro, Brazil, and the University of Virginia School of Medicine, USA, identified for the first time the initial steps of alpha-synuclein protein aggregates related to early onsets of hereditary Parkinson cases. The results may help the understanding of the early stages of the disease and how it develops over time. (2019-10-11)

Alzheimer's drug also treats parasitic Chagas disease
The drugs currently used to treat Chagas disease, a neglected tropical disease, have serious side effects and limited use in those with chronic disease. Now, researchers have reported in PLOS Neglected Tropical Diseases that memantine, a drug currently used to treat Alzheimer's disease, can diminish the number of parasites in mice with Chagas disease, and increase the survival rate of the animals. (2019-09-19)

'Asexual' Chagas parasite found to sexually reproduce
The parasite that causes Chagas disease, which had largely been thought to be asexual, has been shown to reproduce sexually after scientists uncovered clues hidden in its genomic code. (2019-09-10)

Zika virus infects the adult human brain and causes memory deficits in animal models
A new study conducted by Brazilian researchers found that Zika virus infects and replicates in adult human brain tissue. Scientists also found that infection causes long-lasting learning and memory deficits in adult mice. The results demonstrate that the adult brain (and not only the developing brain, as previously thought) is attacked and damaged by ZIKV, and indicate the need to investigate memory and cognitive deficits as potentially serious comorbidities in ZIKV-infected adults. (2019-09-05)

Alberta researchers find elusive key to stopping neglected tropical diseases
Researchers at the University of Alberta have found an important protein in the cells of a deadly infectious parasite, opening the door to less harmful treatment for millions of people suffering from diseases like sleeping sickness in Africa and Chagas disease in South America. (2019-08-26)

Keeping parasites from sticking to mosquito guts could block disease transmission
Infections such as Chagas disease, African sleeping sickness, and leishmaniasis are caused by a group of microorganisms called kinetoplastids. In a new study, a research team from Penn and Penn State Brandywine used a non-disease-causing kinetoplastid to investigate how these parasites adhere to their insect hosts' insides. Their findings could help in the development of targeted therapies that prevent insects from transmitting these diseases to humans. (2019-07-30)

Biocompound from Atlantic Rainforest combats leishmaniasis and Chagas disease
Researchers find that substances synthesized from plant species endemic to the biodiversity hotspot can kill the parasites that cause these neglected diseases. (2019-07-15)

Artificial intelligence identifies 'kissing bugs' that spread Chagas disease
A University of Kansas researcher publishes proof-of-concept research showing artificial intelligence can recognize 12 Mexican and 39 Brazilian species of kissing bugs with high accuracy by analyzing ordinary photos -- an advantage for officials looking to cut the spread of Chagas disease. (2019-06-20)

NMR structure of a key anticoagulant protein may help prevent thrombosis
A group of researchers from Brazil and the United States describes for the first time the structure of Ixolaris, an important anticoagulant protein found in tick saliva, and its interaction with Factor Xa, a key enzyme in the process of blood clotting. The results may benefit cancer patients, of whom approximately 20% will develop thrombosis during the disease progression. (2019-05-27)

DNDi and Atomwise collaborate to advance drug development using AI for neglected diseases
Atomwise Inc., a biotech company using artificial intelligence (AI) for drug discovery, and the Drugs for Neglected Diseases initiative (DNDi), a not-for-profit research and development organization working to deliver new treatments for neglected diseases, today announced that promising drug-like compounds have been discovered in a program to develop first-in-class treatments for Chagas disease. The research collaboration is part of Atomwise's Artificial Intelligence Molecular Screen (AIMS) Awards program. (2019-04-16)

Scientists identify a key gene in the transmission of deadly African sleeping sickness
An international team of life scientists has identified a key gene in the transmission of African sleeping sickness -- a severe disease transmitted by the bite of an infected, blood-sucking tsetse fly, which is common in Sub-Saharan Africa. The disease is fatal if untreated. Tens of millions of people in 36 countries are at risk. There is no vaccine, and conventional drug treatments are not very effective and have severe side effects. (2019-04-10)

Parasitology: Exotic signaling mechanism in pathogens
The unicellular parasite that causes sleeping sickness differs from other eukaryotes in the mode of regulation of an essential cellular signaling pathway. This provides a promising point of attack for drug development. (2019-04-02)

Neglected diseases continue to require attention despite progress
Few novel drugs have been developed to treat neglected diseases in recent decades, Brazilian researchers warn. (2019-03-21)

Shorter treatment for Chagas disease could be just as effective, and significantly safer
A two-week treatment course for adult patients with chronic Chagas disease showed, when compared to placebo, similar efficacy and significantly fewer side effects than the standard treatment duration of eight weeks, according to the results of a clinical trial in Bolivia led by the Drugs for Neglected Diseases initiative (DNDi). (2019-03-14)

The Lancet Infectious Diseases: Experts warn of a surge in vector-borne diseases as humanitarian crisis in Venezuela worsens
The ongoing humanitarian crisis in Venezuela is accelerating the re-emergence of vector-borne diseases such as malaria, Chagas disease, dengue, and Zika virus, and threatens to jeopardize public health gains in the country over the past two decades, warn leading public health experts. The conclusion comes from a Review paper that provides the most comprehensive assessment of the impact of the crisis in Venezuela, published in The Lancet Infectious Diseases journal. (2019-02-21)

Combination therapy more effective in treating patients with leishmaniasis and HIV
The results of clinical trials conducted in Ethiopia by the Drugs for Neglected Diseases initiative (DNDi), in partnership with Médecins Sans Frontières (MSF), the University of Gondar, and Addis Ababa University, open the way for more effective and safer treatments for people with both HIV and visceral leishmaniasis (VL), a group of patients who have historically suffered from poor treatment options. The results were published today in PLOS Neglected Tropical Diseases. (2019-01-17)

Mobile device by UCLA makes the detection of parasitic infections faster and more sensitive
Researchers at the UCLA Henry Samueli School of Engineering have developed an inexpensive and portable platform that can rapidly detect motile parasites in bodily fluids automatically. Using their platform, more than 3 mL of a bodily fluid sample can be imaged and analyzed within 20 min, providing a throughput that is orders of magnitude better than traditional optical microscopy-based examination. (2018-12-13)

UK scientists opening up access to science through DIY equipment
Scientists at the University of Sussex have developed a piece of hardware to demonstrate how our brains function, as part of a growing range of equipment which uses DIY and 3D printable models to open up access to science education. (2018-11-08)

Biomarkers may predict Zika-related birth defects
The highest risk of birth defects is from Zika virus infection during the first and second trimester. A prenatal test has the potential to relieve the concerns of many expectant mothers (2018-11-02)

Long-term prognosis of Chagas patients improved with anti-parasite drug
Researchers have found that the anti-parasite drug benznidazole may improve the long-term prognoses of patients with chronic Chagas disease, according to a study published in PLOS Neglected Tropical Diseases, by Clareci Silva Cardoso at the Federal University of São João del-Rei, Divinópolis, Brazil, and colleagues from the SaMi-Trop study, a project funded by NIAID/NIH. (2018-11-01)

New report finds tropical disease causing heart problems in dogs assisting with homeland security duties
More than 100 working dogs employed by the federal government across the United States have been infected with the parasite Trypanosoma cruzi, the cause of Chagas disease, which may lead to heart problems, according to a new study presented today at the American Society for Tropical Medicine and Hygiene (ASTMH) Annual Meeting. Chagas disease is a tropical infection spread by a blood-sucking triatomine or 'kissing bug' that may pose a growing threat in the United States. (2018-10-31)

Chagas disease, caused by a parasite, has spread outside of...
Chagas disease is caused by a parasite, transmitted by a blood-sucking insect -- Trypanosoma cruzi -- and less frequently, from mother to fetus or by contaminated food or drink. About one third of infected individuals develop chronic heart disease. Though mostly found in Central and South America, Chagas disease has become more common worldwide, including an estimated 300,000 infected persons in the United States. (2018-08-20)

Discovery of a new potential treatment for visceral leishmaniasis
A new preclinical candidate drug with the potential to treat visceral leishmaniasis, one of the world's major neglected diseases, has been discovered through a close collaboration between the University of Dundee, GSK and Wellcome. Visceral leishmaniasis is a disease which kills tens of thousands of people every year, mainly among the poorest in the world. (2018-07-25)

Study describes enzyme's key role in immune response to Chagas disease parasite
A study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia. Heart tissue analyses involving human patients who developed cardiopathy in the disease's chronic stage also provided results. The next challenge is to devise treatment for Chagas using molecules capable of modulating the cellular signaling pathway mediated by PI3Kγ. (2018-07-13)

Kissing bugs kiss their hiding spots goodbye, thanks to tiny radio transmitters
In a new pilot study, researchers in Texas successfully attached miniature radio transmitters to kissing bugs and tracked their movements. Also known as triatomine bugs, kissing bugs transmit the pathogen that causes Chagas disease in humans and animals. They typically move at night and hide during day, and uncovering their secretive movements could play a key role in reducing their impact as a disease vector. (2018-07-09)

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