Current Chemotherapy News and Events | Page 2

Current Chemotherapy News and Events, Chemotherapy News Articles.
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The first mouse model of human pancreas cancer subtypes
Organoids power the first mouse model of two pancreas cancer subtypes, identifying genes influencing a lethal transformation of one subtype to the other. (2020-07-23)

New nano drug candidate kills aggressive breast cancer cells
Researchers at the University of Arkansas have developed a new drug candidate that kills triple negative breast cancer cells. The discovery will help clinicians target breast cancer cells directly, while avoiding the adverse, toxic side effects of chemotherapy. (2020-07-20)

How to repair your gut
In a world first, Monash University researchers have identified a key biomolecule that enhances the repair of your gut lining by prompting stem cells to regenerate damaged tissue. (2020-07-20)

MU advances chemotherapy-free treatment for cancer in animals and humans
Osteosarcoma, a common bone cancer in dogs, affects more than 10,000 dogs in the US each year. While chemotherapy is generally effective at killing some of the cancer cells, the numerous side effects can be painful and often a subset of cancer cells exist that are resistant to chemotherapy. (2020-07-17)

IU findings set new standard for blood-based biomarkers in prediction of cancer recurrence
Indiana University School of Medicine researchers Milan Radovich, PhD, and Bryan Schneider, MD, have discovered that the presence of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in the plasma of women's blood who have undergone chemotherapy prior to surgery for the treatment of stage 1, 2 or 3 triple negative breast cancer are critical indicators for the prediction of disease recurrence and disease-free survival. (2020-07-09)

Early clinical trial tests treatment strategy for pancreatic cancer
Pancreatic cancer carries a poor prognosis, and it often goes undetected until advanced stages. A new BJS (British Journal of Surgery) study indicates that a certain cocktail of chemotherapy drugs may be a safe and effective treatment option for patients with a metastatic form of the disease. (2020-07-08)

Enhancing chemotherapy by RNA interference - BIO Integration
Enhancing Chemotherapy by RNA Interference - BIO Integration https://doi.org/10.15212/bioi-2020-0003 Announcing a new article publication for BIO Integration journal. In this review article the authors Shuwen Cao, Chunhao Lin, Shunung Liang, Chee Hwee Tan, Xiaoding Xu and Phei Er Saw from Sun Yatsen University, Guangzhou, China and Guangzhou University of Chinese Medicine, Guangzhou, China consider enhancing chemotherapy by RNA interference. (2020-07-08)

Study: Surgical delay associated with increased risk in some gastrointestinal malignancies
Early in the COVID-19 pandemic, widespread cancellations of electively-scheduled or ''non-emergency'' operations were implemented to free up hospital beds and conserve protective equipment for health care workers. In a new study published in the Journal of Gastrointestinal Surgery, a team of investigators at Beth Israel Deaconess Medical Center examined the effects of delaying surgery for gastrointestinal cancers. (2020-07-07)

Popular chemotherapy drug may be less effective in overweight and obese women
Breast cancer patients who are overweight or obese might benefit less from treatment with docetaxel, a common chemotherapy drug, than lean patients, a new study finds. (2020-07-02)

Cancer cells make blood vessels drug resistant during chemotherapy
Scientists have identified how inflammatory changes in tumors caused by chemotherapy trigger blood vessel anomalies and thus drug-resistance. Through mice experiment, the team also found that the combined usage of an inhibitor and anticancer drug makes chemotherapy more effective. (2020-07-01)

New treatment strategy may benefit patients with brain cancer
A team led by investigators at Massachusetts General Hospital has uncovered a potentially promising strategy to treat gliomas with mutations in the IDH genes. (2020-06-30)

Breast cancer drug, olaparib, depletes store of immature eggs in mouse ovaries
Australian researchers have shown for the first time that a new drug used to treat breast cancer patients damages the store of immature eggs in the ovaries of mice. Authors of the study published in Human Reproduction journal say fertility counselling should be considered for young women who may be about to be treated with olaparib. (2020-06-30)

Yale Cancer Center study validates combination therapy for aggressive endometrial cancer
Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer. These results may help to change the standard of care worldwide for the disease. The findings are published today in the journal Clinical Cancer Research. (2020-06-29)

Side effects of testicular cancer predicted by machine learning
In collaboration with Rigshospitalet, researchers from DTU Health Technology have developed a machine learning model that can predict chemotherapy-associated nephrotoxicity, a particularly significant side effect in patients treated with cisplatin. (2020-06-26)

MSK researchers find that common cancer treatments don't worsen coronavirus infection
A team of researchers at Memorial Sloan Kettering Cancer Center (MSK) reported on the epidemiology of COVID-19 illness experienced at an NCI-designated cancer center during the height of pandemic in New York City. (2020-06-24)

Study shows better option for treatment of inoperable anal cancer
People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered. (2020-06-24)

Starved cancer cells became more sensitive to chemotherapy
By preventing sugar uptake, researchers succeeded in increasing the cancer cells' sensitivity to chemotherapeutic treatment. The studies, led by researchers at Lund University in Sweden, were carried out on cancer cells in a lab environment. The results were recently published in the research journal Haematologica. (2020-06-23)

New class of precision medicine strips cancer of its DNA defenses
A new precision medicine targeting cancer's ability to repair its DNA has shown promising results in the first clinical trial of the drug class. The new study, designed to test the drug's safety, found that half of patients given the new drug either alone or with platinum chemotherapy saw their cancer stop growing, and two patients saw their tumours shrink or disappear completely. (2020-06-22)

A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. They showed that within a 5-year period, this therapy could provide a favorable prognosis without severe non-hematological side effects. These findings could provide new insights into a novel treatment option for patients with high-risk neuroblastoma. (2020-06-19)

Nanoparticle for overcoming leukemia treatment resistance
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. A research team found that repurposing a commonly used chemotherapy drug using a nanoparticle developed at UConn was more effective than both a solution of the pure drug and other available treatments. (2020-06-18)

Study examines how the COVID-19 pandemic impacts quality of life in patients with cancer
Quality of life of cancer patients during coronavirus disease (COVID-19) pandemic. (2020-06-18)

Call for caution for using a CAR-T immunotherapy against acute myeloid leukemia
Researchers from the Josep Carreras Leukaemia Research Institute prove that the preclinical implementation of Acute Myeloid Leukaemia immunotherapy, based on CD123-redirected CAR T-cells, affects hematopoiesis, blood cells production, and reconstitution. (2020-06-17)

Vitamin D could help mitigate chemotherapy side effects
New findings by University of South Australia researchers reveal that Vitamin D could potentially mitigate chemotherapy-induced gastrointestinal mucositis and provide relief to cancer patients. (2020-06-17)

Novel treatment for mesothelioma shows promise for patients
novel treatment for advanced mesothelioma is safe and effective and may improve the quality of life for patients who have few treatment options, according to a research abstract presented during a virtual session of the Society of Interventional Radiology's 2020 Annual Scientific Meeting on June 14. (2020-06-15)

Drug with new approach on impeding DNA repair shows promise in first clinical trial
Berzosertib, an ATR-targeting drug, improves progression-free survival in combination with chemotherapy in patients with high-grade serous ovarian cancer. (2020-06-15)

Royal Marsden trial leads to practice changing milestone for advanced anal cancer
Results from the first ever randomised clinical trial in advanced anal cancer patients, led and supported by The Royal Marsden NHS Foundation Trust and Cancer Research UK, in collaboration with colleagues in the US, Norway and Australia, has led to a practice changing milestone with a new approach to treatment which is safer and more effective than previously recommended treatments for this group of patients. Published in the Journal of Clinical Oncology today, (Friday 12th June 2020). (2020-06-12)

Chemotherapy/immunotherapy combo shows promise for first-line treatment of mesothelioma
Inoperable malignant pleural mesothelioma, is a rare and aggressive cancer of the protective lining of the lungs, or pleura, often caused by exposure to asbestos. (2020-06-11)

University of Cincinnati research points to potential new treatment for pancreatic cancer
As the next step in finding a potential targeted treatment for pancreatic cancer, researchers at the University of Cincinnati are publishing a new study revealing how a combination therapy may improve outcomes for patients with this disease. (2020-06-08)

New algorithm helps select patients for urgent surgery or chemotherapy during pandemic
A new approach to better select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic has been developed by researchers at The Royal Marsden and the Breast Cancer Now Research Centre at The Institute of Cancer Research, London, in collaboration with colleagues in the UK, Germany and US. (2020-06-08)

Better detection of a type of ovarian cancer could lead to better treatments
Scientists have found that a specific type of ovarian cancer could possibly benefit from existing platinum-based chemotherapy and new DNA repairing treatments, following better testing. (2020-06-08)

Diet, gut microbes affect cancer treatment outcomes, research suggests
What we eat can affect the outcome of chemotherapy - and likely many other medical treatments - because of ripple effects that begin in our gut, new research suggests. (2020-06-05)

For acute myeloid leukemia, genetic testing is often worth the wait
New tailored therapies offer exciting prospects for treating acute myeloid leukemia (AML), but taking advantage of them may require waiting a week or more for genetic testing before starting treatment, posing a dilemma for doctors and patients facing this deadly and often fast-moving disease. A new study bolsters the evidence that this approach is safe for most patients under careful clinical oversight. (2020-06-04)

Leukemia immune profiles predict drug resistance and benefits of immunotherapy
By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), researchers have identified new immune classes of the disease that predict the likelihood of drug resistance and positive responses to immunotherapy. (2020-06-04)

Phase III results show rituximab excels against pediatric Burkitt lymphoma
Results of the phase III Inter-B-NHL-ritux 2010 clinical trial reported today in the New England Journal of Medicine show 95 percent three-year survival for pediatric patients with advanced B-cell non-Hodgkin lymphoma treated with the addition of anti-cancer immunotherapy rituximab to standard chemotherapy. (2020-06-03)

New CRISPR advance may solve key quandary
A mutation unique to certain cancer tumors is a potential homing beacon for safely deploying CRISPR gene editing enzymes to disarm DNA that makes cancer cells resistant to treatment, while ignoring the gene in normal cells where it's critical to healthy function, according to to a new study from ChristianaCare's Gene Editing Institute in the journal Molecular Cancer Research. (2020-06-02)

The fight goes on: Clinical trial shows promising new treatment for rare blood cancer
Although lymphoma is one of the most common types of blood cancer, it has a rare subtype for which no effective treatment regimens are known. For the first time, Nagoya University researchers and colleagues in Japan have conducted clinical trials for a new treatment protocol and report it to be quite promising. (2020-05-30)

Immunotherapy for bowel cancer could change clinical practice
A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy. (2020-05-29)

Combined cediranib and olaparib presents similar activity to standard of care treatment
Results of the NRG Oncology phase III clinical trial NRG-GY004 indicated that the addition of the investigational agent cediranib to olaparib and standard platinum-based chemotherapy did not improve progression-free survival (PFS) outcomes for women with platinum-sensitive ovarian cancer;, however, activity between the treatments were similar in patients. (2020-05-29)

Immunotherapy improves survival in patients with advanced bladder cancer
An immunotherapy drug called 'avelumab' has been shown to significantly improve survival in patients with the most common type of bladder cancer, according to results from a phase III clinical trial led by Queen Mary University of London and Barts Cancer Centre, UK. (2020-05-28)

An exploratory study of metformin and rapamycin as maintenance therapy
Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival. (2020-05-27)

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