Current Chemotherapy News and Events | Page 25

Current Chemotherapy News and Events, Chemotherapy News Articles.
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Ceritinib in advanced lung cancer: No hint of added benefit
The drug manufacturer's dossier contained no study data suitable for an assessment for any of the two research questions. (2015-10-06)

Targeted chemotherapy shows early signs of slowing tumor growth with less toxicity
Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself, mainly because of the toxic effects of chemotherapy. But a team of surgeons is in the nascent stages of developing a more targeted method of treating neuroblastoma patients with chemotherapy and lower toxicity. (2015-10-06)

Doctors often overtreat with radiation in late-stage lung cancer
Almost half of patients with advanced lung cancer receive more than the recommended number of radiation treatments to reduce their pain, according to a new study published in the Journal of the National Cancer Institute. (2015-09-30)

New portable device counts leukocytes through the skin
A novel way to count white blood cells without a blood test, simply by applying a small device on the fingertip, is being developed by a team of young bioengineers. The technology, that combines an optical sensor with algorithms, has already three prototypes on the go and is specially designed to be used on chemotherapy patients, who could know their immune system levels in real time. It could also serve to detect serious infections. (2015-09-30)

Intratumor morphological heterogeneity of cancer is not related to chromosome aberrations
Intratumor morphological heterogeneity (diversity) of breast cancer is not related to chromosome aberrations. This conclusion was made based on the study of one case with aggressive variant of breast cancer -- invasive micropapillary carcinoma by researchers from Tomsk State University, Tomsk Cancer Research Institute, and Institute of Medical Genetics. (2015-09-29)

Cancer diagnosis while pregnant should not lead to treatment delay or end of pregnancy
Women who are pregnant when diagnosed with cancer can start treatment for their disease immediately and do not need to terminate their pregnancy due to worries over the effects of therapy on the development of their child. (2015-09-28)

First 'targeted' treatment for small cell lung cancer shows promise
Today US researchers will present two novel findings with important implications for treatment of small cell lung cancer at the 2015 European Cancer Congress. (2015-09-28)

Multi-gene test enables some breast cancer patients to safely avoid chemotherapy
A major study published in the New England Journal of Medicine is providing the best evidence to date that a 21-gene test done on the tumor can identify breast cancer patients who can safely avoid chemotherapy. (2015-09-28)

New England Journal of Medicine publishes initial data from TAILORx breast cancer trial
Initial results announced today from the Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a prospectively conducted global trial in 10,000+ women with early stage breast cancer, found that 1,626 trial participants with low Oncotype DX® Recurrence Score® results (≤ 10) who got hormonal therapy alone without chemotherapy had <1 percent chance of distant recurrence at five years, providing evidence that women in the future may effectively forego chemotherapy if their Recurrence Score is ≤10. (2015-09-28)

Nivolumab improves the proportion of lung cancer patients alive after more than a year
Updated results from the CheckMate 057 phase III clinical trial show that nivolumab continues to show an overall survival benefit compared to docetaxel in patients with non-squamous non-small cell lung cancer. (2015-09-27)

Hormonal therapy may prevent ovarian failure and preserve fertility in breast cancer
Young women undergoing chemotherapy for breast cancer may be more likely to remain fertile if they also receive hormonal treatment. (2015-09-27)

Treatment of elderly breast cancer patients varies between different European countries
Largest international comparison of the treatment of elderly patients with breast cancer have shown there are substantial differences in the use of surgery, hormone therapy and chemotherapy between European countries. (2015-09-26)

Study: Brentuximab vedotin effective, safe in elderly Hodgkin lymphoma patients
A study published online in Blood, the Journal of the American Society of Hematology, reports that bretuximab vedotin is an effective and safe first course of treatment for older Hodgkin lymphoma patients unfit for chemotherapy. (2015-09-21)

Monitoring the microbiome in leukemia patients could reduce infections during chemotherapy
Researchers report that a patient's microbial diversity, even before they start cancer treatment, can be linked to risk of infection during induction chemotherapy. This research is presented at ASM's Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC/ICC). (2015-09-20)

Imaging method has potential to stratify head and neck cancer patients
Manchester researchers have identified a potential new way to predict which patients with head and neck cancer may benefit most from chemotherapy. (2015-09-18)

CTCA at Western launches immunotherapy clinical trial aimed at soft-tissue cancers
Cancer Treatment Centers of America® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Arizona, has begun Phase II of another arm of its multi-arm clinical trial that combines immunotherapy with chemotherapy. This arm was specifically designed to target soft-tissue cancers known as sarcomas. This multifaceted study evaluating novel combination therapies known as 'PembroPlus' is named for the immunotherapy compound pembrolizumab. (2015-09-17)

Antibacterial soap no more effective than plain soap at reducing bacterial contamination
Scientists in Korea have discovered that using antibacterial soap when hand-washing is no more effective than using plain soap, according to a paper published today in the Journal of Antimicrobial Chemotherapy. (2015-09-16)

UI Health validates cure for sickle cell in adults
Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings. The transplants were the first to be performed outside of the National Institutes of Health campus in Maryland, where the procedure was developed. (2015-09-16)

Drug resistance in cancer patients linked to oxygen-bearing molecules in body, study finds
Increased levels of certain chemically reactive, oxygen-containing molecules in the body can cause patients to become resistant to cancer drugs such as chemotherapy, according to researchers at Georgia State University. (2015-09-14)

GI side effects of chemotherapy reduced in mice by targeting gut microbes
The blame for some of chemotherapy's awful side effects may lie with our gut microbes, early evidence suggests. As chemotherapy drugs are eliminated from the body, bacteria in the gastrointestinal tract can latch onto them and transform them into toxic species that cause severe diarrhea. In Chemistry & Biology researchers present ways to shut down the ability of GI microbes to convert chemotherapy drugs in mice as a first step to helping cancer patients. (2015-09-10)

Discovery offers hope for treating leukemia relapse post-transplant
Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia relapse after a stem cell transplant, according to Penn State College of Medicine researchers. (2015-09-10)

Rare plant reveals its recipe for potent chemotherapeutic agent
Inconveniently, the only current method to synthesize the chemotherapy agent etoposide is by using extracts from a plant, but researchers have successfully manipulated Nicotiana benthamiana (tobacco) to create a more immediate and potent precursor. (2015-09-10)

New drug-like compounds may improve odds of men battling prostate cancer, researchers find
Researchers at Southern Methodist University, Dallas, have discovered new drug-like compounds that could ultimately be developed into medicines that offer better odds of survival to prostate cancer patients. The new compounds target the human protein P-gp, which causes resistance against a majority of the drugs currently available for treating cancer and HIV/AIDS. The new compounds, discovered via computer-generated models, are good candidates for development into drugs since the compounds have low toxicity to noncancerous cells. (2015-09-08)

Many childhood brain tumor survivors experience seizures
New research reveals that seizures are frequent in childhood brain tumor survivors. (2015-09-08)

21-gene recurrence score and receipt of chemotherapy in patients with breast cancer
Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test among a large group of Medicare beneficiaries, according to an article published online by JAMA Oncology. (2015-08-27)

Genetic mutations may help predict risk of relapse, survival for leukemia patients
In preliminary research, the detection of persistent leukemia-associated genetic mutations in at least 5 percent of bone marrow cells in day 30 remission samples among adult patients with acute myeloid leukemia was associated with an increased risk of relapse and reduced overall survival, according to a study in the Aug. 25 issue of JAMA. (2015-08-25)

Relapse, poor survival in leukemia linked to genetic mutations that persist in remission
New research suggests that genome sequencing while a cancer patient is in remission can help physicians assess response to treatment and determine whether aggressive, follow-up treatment is necessary. The study, published Aug. 25 in JAMA, involved patients with acute myeloid leukemia. (2015-08-25)

Reducing resistance to chemotherapy in colorectal cancer by inhibition of PHD1
Scientists at VIB and KU Leuven have shown that blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy. Chemotherapy resistance remains a major clinical issue in the treatment of CRC. These findings indicate that PHD1 inhibition may have valuable therapeutic potential. The study was published in the leading medical journal EMBO Molecular Medicine, which features molecular biology-driven research. (2015-08-19)

Study reveals effects of chemoradiation in brains of glioblastoma patients
A study from Massachusetts General Hospital Cancer Center researchers -- the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients -- reveals not only specific structural changes within patients' brains but also that the effect of cancer therapy on the normal brain appears to be progressive and continues even after radiation therapy has ceased. (2015-08-17)

UTHealth research: Older breast cancer patients less likely to benefit from chemo
Chemotherapy prolongs life for older adults with most types of cancer, but for women over the age of 80 with breast cancer, the chances of survival due to chemotherapy are significantly lower, according to a study led by researchers from The University of Texas Health Science Center at Houston (UTHealth). (2015-08-12)

Combining chemotherapy with an immune-blocking drug could stop cancer growing back
Giving patients a drug that blocks part of the immune system from going into overdrive might help prevent cancer coming back in some people, according to research published in Cancer Research. (2015-08-12)

Anti-aging researchers develop new algorithm that provides precision medicine for cancer patients
A targeted drug therapy avoids many of the negative side effects of traditional chemotherapy because it more specifically targets tumor cells. However, it has been limited in its effectiveness because it needs to be tailored to each individual patient. InSilico Medicine, Inc. has developed an algorithm to more effectively gauge what targeted drugs work on which patient. This algorithm will be presented at Basel Life Science Week 2015. (2015-08-07)

To beat cancer at its own game
The National Institutes of Health has awarded $747,000 to Worcester Polytechnic Institute professor Amity Manning for a three-year research project to explore the molecular mechanisms associated with the genetic mutations and chromosome instability observed in all cancer cells. The goal is to turn the genetic tables against cancer by learning more about the molecular basis of cancer cells' uncontrolled growth, knowledge that may bolster the effectiveness of cancer treatments and improve patient outcomes. (2015-08-06)

Two-drug combination boosts survival in metastatic prostate cancer
Men with metastatic, hormone-sensitive prostate cancer gained more than a year of survival when they received both hormone-blocking medications and chemotherapy right after diagnosis, rather than delaying the chemo until the cancer worsened, according to a study led by Dana-Farber's Christopher Sweeney published in the New England Journal of Medicine. (2015-08-05)

Combination therapy may be more effective against the most common ovarian cancer
High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery. (2015-08-03)

Stress responder is a first responder in helping repair DNA damage and avoiding cancer
DNA damage increases the risk of cancer, and researchers have found that a protein, known to rally when cells get stressed, plays a critical, early step in its repair. (2015-08-03)

Scientists identify gene vital for rebuilding intestine after cancer treatment
Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9. (2015-07-29)

In lab tests, new therapy slows spread of deadly brain tumor cells
The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty. (2015-07-27)

Chemotherapy and quality of life at the end of life
Chemotherapy for patients with end-stage cancer was associated with worse quality of life near death for patients with a good ability to still perform many life functions, according to an article published online by JAMA Oncology. (2015-07-23)

Stem cell transplantation for children with rare form of leukemia improves outcomes
Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children's Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia. (2015-07-23)

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