Current Cholesterol News and Events

Current Cholesterol News and Events, Cholesterol News Articles.
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Cholesterol starvation kills lymphoma cells
Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer. (2021-01-25)

New perspectives challenge the idea that saturated fats cause heart disease
Why do saturated fats increase blood cholesterol, and why should this be dangerous? After all, saturated fats occur naturally in a wide variety of foods, including breast milk. (2021-01-22)

The important role of pharmacists for older adults' health
Pharmacists play an important role in managing medication-based therapies for older community-dwelling patients, according to a study published in the British Journal of Clinical Pharmacology. (2021-01-21)

Important cause of preeclampsia discovered
New findings show that cholesterol crystals in the uterine wall are the villain that researchers have been looking for. These crystals cause intensified inflammation in people who become ill. (2021-01-21)

Vegan diet significantly remodels metabolism in young children
University of Helsinki researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. The study found vegan children to have remarkably altered metabolism and lower vitamin A and D status compared to children with no special diet. (2021-01-21)

General health checkups may detect early signs of Parkinson's disease
A research team led by Nagoya University in Japan has found that blood pressure, the hematocrit, and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms. This finding may pave the way for early diagnosis and treatment of the disease. (2021-01-19)

Large transporter protein linked to schizophrenia
Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens. Now, Kazumitsu Ueda of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have provided evidence that mice with disrupted ABCA13 protein demonstrate a hallmark behaviour of schizophrenia. The team investigated ABCA13's functions and published their findings in the Journal of Biological Chemistry. (2020-12-29)

The ABCs of species evolution
Almost four decades of research have led scientists at Japan's Institute for Integrated Cell-Material Sciences (iCeMS) to propose that a family of transporter proteins has played an important role in species evolution. One protein in particular, called ABCA1, was likely crucial for vertebrate evolution by helping regulate when signals involved in cell proliferation, differentiation and migration enter a cell. This process was necessary for vertebrates to develop into more complex organisms with sophisticated body structures. (2020-12-23)

Protecting against atherosclerosis at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which CREB3L3 protects against atherosclerosis. By studying the absence or overexpression of the protein in mice prone to develop atherosclerosis, the researchers demonstrated that the absence of CREB3L3 exacerbates the formation of atherosclerosis, whereby the overexpression protects against atherosclerosis. At the molecular level, CREB3L3 exhibited its protective effects by inhibiting SREBP. This study could help develop a novel molecular target against atherosclerosis. (2020-12-20)

Fish oil supplements don't raise bad cholesterol
The Fatty Acid Research Institute (FARI) has published a new research paper in conjunction with The Cooper Institute on the omega-3s EPA and DHA in fish oil and low density lipoprotein cholesterol (LDL-C). (2020-12-17)

Mission to MAARS: Long non-coding RNA may play a key role in cardiovascular disease
Through utilization of genetically modified high-risk atherosclerotic mice, a research team from Brigham and Women's Hospital identified and characterized Macrophage-Associated Atherosclerosis lncRNA Sequence (MAARS), which is expressed specifically in macrophages in atherosclerotic plaques and contributes to the progression of the disease. (2020-12-17)

Carrots are healthy, but active enzyme unlocks full benefits
Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin. (2020-12-11)

How blood and wealth can predict future disability
Research shows that blood tests for biomarkers such as cholesterol and inflammation can predict disability in five years. Researchers studied blood biomarkers of 5,286 participants involved in the UK Household Longitudinal Study - and found that biological health can predict disability and healthcare demand in five years' time. They also found that people on higher-incomes were more likely to seek GP appointments and outpatient treatments for their medical problems. (2020-12-09)

Clinical trial results address concerns about pharmacogenetic testing
Researchers conducted a randomized controlled trial of pharmacogenetic testing related to cholesterol-lowering medications called statins.After one year, the cholesterol levels in the group who received their pharmacogenetic results were not higher than those in the group who did not receive their results, and they were not less likely to receive medical care meeting recommended guidelines. (2020-12-03)

Clothing, tattoos could be used to monitor patient health
A shirt that monitors your blood pressure or a pair of socks that can keep track of your cholesterol levels might be just a few years away from becoming reality. In Applied Physics Reviews, researchers examine the use of microfibers and nanofibers as wearable monitors that could keep track of a patient's vital signs. The microfiber- and nanofiber-based technology addresses growing concerns in the medical community about monitoring chronic illnesses as the population ages. (2020-12-01)

Children with familial hypercholesterolemia are diagnosed late and under-treated
Children born with a common genetic condition, familial hypercholesterolemia (FH), are at increased risk for atherosclerotic cardiovascular disease (ASCVD) early in life. Despite long-standing national guidelines, cholesterol screening -- for children at age 2 for those with a family history of heart disease and between the ages of nine to 11 for all children -- is not being implemented . (2020-11-18)

Remotely delivered program improves blood pressure, cholesterol control in 5,000 patients
A team from Brigham and Women's Hospital and Mass General Brigham Health System, led by Brigham cardiologist Benjamin Scirica, MD, MPH, developed a program that provides an end-to-end solution to improve blood pressure and cholesterol levels across a broad population of patients at high cardiovascular risk. (2020-11-17)

Algorithm-driven digital program helped lower patients' cholesterol, blood pressure
Researchers enrolled 5,000 patients across the Mass General Brigham health system in Boston, Massachusetts in a remote, cholesterol and blood pressure management program utilizing care navigators and pharmacists, supported by specialists and using specialist-designed algorithms to initiate and adjust medications. Participants who completed the cholesterol program achieved a 52 mg/dl (42%) reduction in LDL cholesterol levels. Participants who completed the blood pressure program saw an average systolic and diastolic blood pressure reduction compared to baseline of 14mmHg and 6mmHg, respectively. (2020-11-17)

Obese people found to be at increased risk of COVID-19
A new study led by researchers at Queen Mary University of London uses a novel approach to investigate the effects of cardiovascular risk factors on the risk of COVID-19 infection. (2020-11-16)

A novel monoclonal antibody therapy cuts LDL cholesterol by half in a high-risk patient population,
The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol--the so-called ''bad'' cholesterol--by 50 percent in patients with severe hypercholesterolemia whose condition is resistant to standard treatments, a phase 2 study from the Icahn School of Medicine of Mount Sinai and other global academic sites has found. (2020-11-15)

Side effects often attributed to statins were the same for those taking a placebo
Study participants who reported side effects from cholesterol-lowering medications known as statins also reported the same side effects when they unknowingly took placebo pills. These side effects are real, and it appears may be mostly due to the psychological rather than the pharmacological effects of statins since symptoms were consistent when taking the placebo. (2020-11-15)

New study confirms combo pill alone and with aspirin lowers heart disease risk
A ''polypill'' is a single pill that includes multiple medications to control more than one health risk factor (such as heart disease, high blood pressure, high cholesterol, Type 2 diabetes, kidney disease, stroke). In this large, international trial, the polypill included blood pressure and cholesterol lowering medications for people at risk for heart disease. Results from the randomized, placebo-controlled trial show that the combination of a polypill plus aspirin reduced cardiovascular disease by 31%, and the polypill without aspirin reduced CVD by 21%. (2020-11-13)

Most type 2 diabetes patients are at high risk of a fatal heart attack or stroke
'The most striking result of our study was that the vast majority of patients (93%) had a high or very high risk of fatal events within a decade. Half of patients in the very high-risk group had no history of heart disease, meaning they would not be receiving medications to prevent heart attacks and strokes,' said study author Dr. Manel Mata-Cases, a general practitioner for the Catalan Institute of Health in Sant Adrià de Besòs. (2020-11-13)

The Lancet: Older adults are at greater risk of cardiovascular events than younger people, and benefit at least as much from cholesterol-lowering medications, two studies suggest
Peer-reviewed / 1 Observational study + 1 Systematic review and meta-analysis / People (2020-11-10)

Down Syndrome-associated gene suppresses age-related corneal clouding
Down syndrome and hypercholesterolemia mouse models suggest that the DSCR-1 gene protects against abnormal cornea vascularization and associated blindness by suppressing oxidized LDL cholesterol production and downstream angiogenic signaling during chronic high cholesterol. While the neurological pathology of Down syndrome patients worsens with age, they are less susceptible to age-related vascular diseases. The responsible genes and mechanisms are not yet clear, but DSCR-1 is a strong candidate for a wide range of vascular diseases. (2020-11-05)

Being in treatment with statins reduces COVID-19 mortality by 22% to 25%
A research by the Universitat Rovira i Virgili (URV) and Pere Virgili Institut (IISPV) led by Lluís Masana has found that people who are being treated with statins have a 22% to 25% lower risk of dying from COVID-19. (2020-11-04)

Muscle pain and energy-rich blood: Cholesterol medicine affects the organs differently
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly used in the treatment of elevated cholesterol, but the new results may help design drugs for a number of conditions. (2020-10-29)

Adults with endocrine disorders have an increased risk of heart disease
All adults with endocrine disorders should be tested for high cholesterol and triglycerides to evaluate their risk of heart attack or stroke, according to a Clinical Practice Guideline issued today by the Endocrine Society. (2020-10-28)

Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. (2020-10-21)

Statins may reduce cancer risk through mechanisms separate to cholesterol
Cholesterol-lowering drugs called statins may reduce cancer risk in humans through a pathway unrelated to cholesterol, says a study published today in eLife. (2020-10-13)

Study highlights shortcomings in telemedicine despite large increases in remote consults during COVID-19 pandemic
Despite increased use of telemedicine during the COVID-19 pandemic, Americans have had significantly fewer consultations with primary care doctors and markedly fewer assessments of common cardiac risk factors. (2020-10-02)

Statins reduce COVID-19 severity, likely by removing cholesterol that virus uses to infect
Analyzing anonymized patient medical records, UC San Diego researchers discovered that cholesterol-lowering statins reduced risk of severe COVID-19 infection, while lab experiments uncovered a cellular mechanism that helps explain why. (2020-09-23)

Having high cholesterol levels early in life leads to heart problems by middle age
Having elevated cholesterol during the teens or early twenties increases a person's risk of having a heart attack, stroke or other cardiovascular event during middle age. That is the finding a new landmark study led by researchers at the University of Maryland School of Medicine (UMSOM). (2020-09-22)

Generic cholesterol drugs save medicare billions of dollars, study finds
The switch from brand name to generic cholesterol medications that occurred between 2014 and 2018 has saved Medicare billions of dollars, even as the number of people on cholesterol-lowering drugs has increased, UT Southwestern scientists have calculated. Their data, published in the journal JAMA Cardiology, suggest that policymakers and clinicians could help cut Medicare costs even further by switching more patients to generic drugs. (2020-09-09)

Cholesterol's effects on cellular membranes
The findings have far-reaching implications in the general understanding of disease, the design of drug delivery methods, and many other biological applications that require specific assumptions about the role of cholesterol in cell membranes.    (2020-09-08)

Insomnia identified as a new risk factor for type 2 diabetes in new study which also confirms many other risk and protective factors
A new 'global atlas' study published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) is the first to identify insomnia as a risk factor associated with increased risk of developing type 2 diabetes (T2D). The study identifies 34 risk factors that are thought to increase (19) or decrease risk (15), as well as a further 21 'suggestive' risk factors where evidence was not quite as strong. (2020-09-08)

Cholesterol drug combinations could cut health risk for European patients
More patients could benefit from combinations of cholesterol-lowering drugs to reduce their risk of stroke and heart attacks. (2020-08-28)

Metabolic syndrome linked to worse outcomes for COVID-19 patients
Patients hospitalized with COVID-19 who had a combination of high blood pressure, obesity and diabetes were over three times more likely to die from the disease, according to a new Tulane University study published in Diabetes Care. (2020-08-25)

Study focuses on low-carb, high-fat diet effect on older populations
Amy Goss, Ph.D., RDN, says egg consumption can be incorporated into the diet in a healthful way without adversely impacting blood cholesterol in older adults. (2020-08-20)

Scan for arterial plaque is better at predicting heart attack than stroke
The amount of calcified plaque in the heart's arteries is a better predictor of future heart attacks than of strokes, with similar findings across sex and racial groups, according to new research from UT Southwestern. (2020-08-18)

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