Current Chronic Diseases News and Events

Current Chronic Diseases News and Events, Chronic Diseases News Articles.
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RUDN University and RLT scientists: Light, magnetic field, and ultrasound could help fight COVID-19
A team of researchers from RUDN University and RLT suggested restoring normal levels of lymphocytes in patients with COVID-19 and other viral diseases by subjecting them to the combined influence of light, magnetic field, and ultrasound. (2021-01-18)

Acute itching in eczema patients linked to environmental allergens
New research from Washington University School of Medicine in St. Louis indicates that allergens in the environment often are to blame for episodes of acute itch in eczema patients, and that the itching often doesn't respond to antihistamines because the itch signals are being carried to the brain along a previously unrecognized pathway that current drugs don't target. (2021-01-14)

Poor gut health connected to severe COVID-19, new review shows
In a review published this week in mBio, researchers examined emerging evidence suggesting that poor gut health adversely affects COVID-19 prognosis. (2021-01-12)

First-degree relative with kidney disease increases disease risk by three-fold
In a large population-based family study, family history of kidney disease was strongly associated with increased risk of chronic kidney disease. (2021-01-12)

Scientists discover key enzyme responsible for skin blistering in the elderly
The Granzyme B (GzmB) enzyme, which accumulates in certain tissues as we age, has been identified as a driver of itchy and sometimes life-threatening autoimmune conditions known as pemphigoid diseases (PDs), which cause blistering and skin erosion below the skin's surface. New research led by University of British Columbia (UBC) and Vancouver Coastal Health Research Institute (VCHRI) scientists has found that a gel containing a specific and potent inhibitor of GzmB activity, VTI-1002, resulted in significant improvements on skin affected by PDs. (2021-01-12)

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation
The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, a detailed understanding of the intestinal stem cell lineage and the signals regulating the recruitment of intestinal cell types is critical. (2021-01-11)

Autoimmune diseases: similar molecular signatures in target tissues
A study conducted by Professor Decio L. Eizirik's group - ULB Center for Diabetes Research - and published in Sciences Advances shows that autoimmune diseases, including type 1 diabetes, must be studied in their entirety, taking into account not only the immune system but also the target tissues. Indeed, the key mechanisms induced by inflammation, potentially shared between type 1 diabetes, systemic lupus erythematosus, multiple sclerosis and rheumatoid arthritis, could generate similar molecular signatures at the target tissue level. (2021-01-07)

COVID-19 outcomes for patients on immunosuppressive drugs on par with non- immunosuppressed patients
People taking immunosuppressive drugs to prevent organ transplant rejection or to treat inflammatory or autoimmune diseases do not fare worse than others on average when they are hospitalized with COVID-19. (2021-01-07)

Study: e-cigarettes trigger inflammation in the gut
Chemicals used for vaping break down zipper-like junctions between cells in the gut, leading to chronic inflammation and potential for other health concerns. (2021-01-07)

A new approach to study autoimmune diseases
A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, PhD, has found that identifying new treatments for autoimmune diseases requires studying together the immune system AND target tissues. This study, ''Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis and rheumatoid arthritis,'' is featured in the Jan. 6, 2021, edition of Science Advances. (2021-01-06)

Dental experts discover biological imbalance is the link between gum and kidney disease
An imbalance of the body's oxygen producing free radicals and its antioxidant cells could be the reason why gum disease and chronic kidney disease affect each other, a new study led by the University of Birmingham has found. (2021-01-05)

Traditional Ghanaian medicines show promise against tropical diseases
The discovery of new drugs is vital to achieving the eradication of neglected tropical diseases (NTDs) in Africa and around the world. Now, researchers reporting in PLOS Neglected Tropical Diseases have identified traditional Ghanaian medicines which work in the lab against schistosomiasis, onchocerciasis and lymphatic filariasis, three diseases endemic to Ghana. (2020-12-31)

Cannabis use blunts stress reactivity in female rats
Female rats that inhaled vaporized cannabis daily for a month developed a blunted physiological response to stress, according to a new study by Washington State University researchers. In contrast, male rats that were provided access to the same potency of cannabis over the same 30-day window did not experience any physiological changes in how they responded to a stressful situation. (2020-12-22)

Perspective: Why opioids cannot fix chronic pain
New epidemiological and neuroscientific evidence suggests that the relationship between chronic pain and emotional distress is bidirectional. Pain experts at University of Washington School of Medicine explain the relation in Annals of Family Medicine. (2020-12-22)

Finding a personalized approach to treating chronic rejection after lung transplantation
By studying the roles of an inflammatory protein and antibodies in chronic rejection after lung transplantation, researchers discover possibilities for new treatments. (2020-12-17)

New guideline supports behavioral, psychological treatments for insomnia
The American Academy of Sleep Medicine has published a new clinical practice guideline establishing recommendations for the use of behavioral and psychological treatments for chronic insomnia disorder in adults. (2020-12-16)

Clowns may help children cope with the pain and anxiety of hospital treatment
Hospital clowns might help improve physical symptoms and psychological wellbeing in children and adolescents having treatment for acute or chronic conditions, finds a study in the Christmas issue of The BMJ. (2020-12-16)

Chronic stress? Zebrafish to the rescue
A team of researchers led by MIPT's Allan Kalueff has studied chronic stress in zebrafish and determined that the animal can serve as a valuable model species for research into the associated brain diseases, complementing research currently done on rodents. The paper was published in Scientific Reports. (2020-12-14)

RUDN immunologists developed method for assessing inflammation in respiratory tract diseases
A team of immunologists from RUDN University suggested a new tool to control inflammation levels in asthma patients with accompanying diseases. To obtain information about disease flow and risks of complications, they used different types of cytokines found in the patients' nasal swabs. (2020-12-05)

First in nation treatment for chronic subdural hematoma at Los Robles Health System
Los Robles Health System is leading the way in neurovascular clinical trials. Interventional neurologist, Dr. Asif Taqi, is the principal investigator of the STEM Study, a landmark trial that can change the management of chronic subdural hematomas completely. Los Robles enrolled and treated the first patient in the nation into this trial. (2020-12-04)

Patients with kidney disease may delay AVF creation
Many patients start hemodialysis with temporary vascular access despite regular kidney care and pre-dialysis education. Delay is often related to patient choice but research on patients' perspectives is limited. In this study, researchers surveyed pre-dialysis patients and their family members about their perceptions of chronic kidney disease (CKD) and their intentions to undergo access creation. They also report on a new survey instrument to measure attitudes towards hemodialysis preparation. (2020-12-03)

Kidney disease leading risk factor for COVID-related hospitalization
An analysis of Geisinger's electronic health records has revealed chronic kidney disease to be the leading risk factor for hospitalization from COVID-19. (2020-12-02)

Animal-free method predicts nanoparticle toxicity for safer industrial materials
Researchers at Helmholtz Zentrum München together with scientists across Europe developed a novel animal-free method to predict the toxic effect of nanoparticles to the human lung. The method aims to enable the safety-by-design development of safer industrial materials. (2020-11-24)

Dormant threat: Abnormal proteins unleash latent toxicity in neurodegenerative diseases
Though neurodegenerative diseases are becoming more common in today's aging societies, the exact way in which accumulated abnormal proteins become toxic to neurons is unknown. In a recent study conducted at Daegu Gyeongbuk Institute of Science and Technology, Korea, scientists have discovered a new mechanism of action by which these abnormal proteins actually unlock the normally latent toxicity of native proteins. Their results represent a completely new avenue toward the development of effective therapies. (2020-11-20)

Potential new target to combat inflammatory diseases
An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases - including COVID-19. WEHI's Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was recently published in EBioMedicine. (2020-11-19)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

Smartphone use offers tool to treat MS, other diseases
Monitoring how patients with multiple sclerosis or other degenerative diseases use their smartphones could provide valuable information to help get them better treatment. In the journal Chaos, researchers used an app to record the keystroke dynamics of a control group and those of subjects in various stages of MS treatment. In doing so, they observed changes in the way people with MS typed that were not seen in subjects who did not have the disease. (2020-11-17)

Home oxygen therapy for adults with COPD and ILD: New ATS clinical practice guideline
The latest clinical practice guideline on home oxygen therapy addresses long-term and ambulatory oxygen therapy for adults with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) and includes the most comprehensive review of the evidence of any oxygen guideline to date. (2020-11-17)

How to ensure patients manage their chronic kidney disease
A Singapore study finds patients with chronic kidney disease need tailored nutrition guidance, as well as better communication with doctors and family support, to empower them to manage their condition. (2020-11-13)

Early-life events linked to lung health in young adulthood
Early-life events, such as the exposure to air pollutants, increases the risk of chronic lung disease in young adulthood, according to new results by researchers at Karolinska Institutet, Sweden, published in the European Respiratory Journal and Thorax. The studies add to the growing evidence that chronic lung disease in adulthood can be traced back to childhood. (2020-11-12)

Vaping may increase respiratory disease risk by more than 40%: BU study
A growing body of evidence points to the health risks of using e-cigarettes (or ''vaping''). But because e-cigarettes are marketed as a less harmful alternative to traditional cigarettes, it has been difficult to tell whether the association between vaping and disease is just a matter of smokers switching to vaping when they start experiencing health issues. (2020-11-12)

New European consensus on management of osteoporosis in advanced chronic kidney disease
This Consensus is authored by the European Renal Osteodystrophy Working Group, with expertise from the European Renal Association-European Dialysis and Transplant Association and the International Osteoporosis Foundation. It provides a succinct review of current clinical practice, and outlines practical recommendations for diagnosis, assessment of fracture risk, intervention thresholds, non-pharmacological and pharmacological intervention strategies, monitoring, and secondary fracture prevention. (2020-11-11)

Researchers examine if online physician reviews indicate clinical outcomes
Dr. Atanu Lahiri and Dr. Zhiqiang Zheng studied the relationship between online reviews of physicians and their patients' actual clinical outcomes. They wanted to know how much consumers can rely on the reviews, specifically in regard to chronic-disease care. (2020-11-09)

Key features of chronic nonbacterial osteomyelitis identified in groundbreaking study
New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, identified key clinical features of chronic nonbacterial osteomyelitis (CNO), which leads to an important step toward the development of much-needed classification criteria for a disease that affects children and young adults worldwide. (2020-11-06)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

Mathematical modeling of processes in neurons to assist the treatment of epilepsy and depression
Researchers study the effect of neural stimulation by ultrasonic waves and analyzing the influence of ultrasonic wave parameters on the excitation of electrical signals in the nerves. The obtained results have a great practical value for further studies related to the issues of human brain modeling. (2020-11-02)

New cause of inflammation in people with HIV identified
A new study led by researchers at Boston Medical Center examined what factors could be contributing to this inflammation, and they identified the inability to control HIV RNA production from existing HIV DNA as a potential key driver of inflammation. (2020-10-30)

Intensive urate lowering reduces urine albumin excretion
Phase 2 trial of verinurad with febuxostat vs. placebo shows 49% reduction in albuminuria (2020-10-29)

New model predicts which patients with kidney disease may develop heartbeat irregularities
* A new model that incorporates a type of artificial intelligence can accurately predict which individuals with chronic kidney disease face a high risk of developing atrial fibrillation. * Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-24)

New therapeutic approach against leukemia
Using an RNA molecule complex, researchers can prevent retention of cancer stem cell in their tumor supporting niche (2020-10-23)

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