Current Cirrhosis News and Events

Current Cirrhosis News and Events, Cirrhosis News Articles.
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Routine blood tests could be key to stopping the silent killer of liver disease
New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis. The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening using patient data they already hold. (2021-02-11)

Liver cancer 'signature' in gut holds clues to cancer risk
People with non-alcohol-related liver cancer have a unique gut microbiome profile which could help predict disease risk, a new UNSW Sydney study has found. (2021-02-03)

International research network identifies triggers for severe course of liver cirrhosis
Acute-on-chronic liver failure (ACLF) is a common cause of death in patients with cirrhosis. In ACLF the progressive loss of function of the scarred liver can no longer be compensated (acute decompensation). As a result, other organs such as the kidney or brain fail. The triggers for acute decompensation of liver cirrhosis and an ACLF are most frequently bacterial infections, liver inflammation caused by alcohol, or a combination of both factors. (2021-02-02)

CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
According to ARRS' American Journal of Roentgenology, Fibrosis-4 and multiple CT findings can identify patients with high-risk nonalcoholic fatty liver disease--advanced fibrosis or cirrhosis, that is--though the presence of nonalcoholic steatohepatitis remains elusive on CT. (2021-01-22)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

Beta-blockers display anti-inflammatory effects in advanced liver disease
Beta-blockers are used to prevent internal bleeding in patients with liver cirrhosis and portal hypertension. Researchers from MedUni Vienna have now shown that Beta-blockers also have beneficial effects on systemic inflammation and this translates into improved clinical outcomes. (2020-12-10)

Liver cirrhosis: Disease progression
Patients with liver cirrhosis display a wide range of clinical symptoms. A prospective study conducted by MedUni Vienna has now shown that blood levels of biomarkers for systemic inflammation increase over the various stages of the disease and can predict the development of complications, even in previously asymptomatic patients. (2020-11-30)

Liver scarring relatively common among middle-aged adults
A substantial minority of participants from the Framingham Heart Study, (nearly nine percent), had potentially clinically significant liver fibrosis (scarring). This the first study of this size and scale done in the United States. (2020-11-09)

Dietary supplement may help in the treatment of fatty liver
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats. Rats with fatty liver disease were fed with a dietary supplement that is known to increase the growth of good bacteria in the gut. Simultaneous with the increased abundance of the bacteria, the liver fat content decreased significantly. In addition, preliminary results from a human study seem promising. (2020-11-04)

Eating less suppresses liver cancer due to fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Fatty liver is often improved through eating less, getting more exercise, and reducing body weight. The research group posed the question, ''Can eating less also suppress liver cancer caused by fatty liver?'' (2020-10-29)

Even mild fatty liver disease is linked to increased mortality
Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the journal Gut. (2020-10-12)

Researchers discover gene that could decrease likelihood of developing alcoholic cirrhosis
Researchers at Indiana University School of Medicine are learning more about how a person's genes play a role in the possibility they'll suffer from alcoholic cirrhosis with the discovery of a gene that could make the disease less likely. (2020-09-11)

When liver cirrhosis is deadly
A study by an international team of researchers headed by Professor Jonel Trebicka from the Frankfurt University Hospital and funded by the foundation EF Clif, has discovered which patients are particularly at risk for acute-on-chronic liver failure. With their findings, the scientists have laid the foundation for the development of preventive therapy to prevent acute-on-chronic liver failure. (2020-08-27)

TGen review suggests postmenopausal women at risk for nonalcoholic fatty liver disease
NAFLD is the most common cause of liver damage, and can lead to liver cirrhosis and death. It affects nearly 1 in 4 people across the globe. It often is associated with obesity, abnormally high amounts of lipids in the blood, and type 2 diabetes. In the US, the number of NAFLD cases is expected to grow to more than 100 million within the next decade, annually costing an estimated at $292 billion. (2020-08-14)

Hepatitis B: Natural controllers shed light on immunity mechanisms
To improve our understanding of the antibody response conferring protection against HBV infection, scientists from the Institut Pasteur and Inserm, in collaboration with the Roche Innovation Center in Switzerland, produced and characterized human monoclonal antibodies specific to viral envelope antigens, referred as HBsAg, from blood memory B cells isolated from HBV vaccinees and natural controllers. (2020-08-13)

Aerobic exercise could have the final say on fatty livers
Trinity College Dublin study is the first to demonstrate significant improvements in biopsy-measured liver outcomes in a metabolic associated fat liver disease (MAFLD) cohort following an exercise-only intervention, without clinically significant weight loss. (2020-07-29)

Sobering reminder about liver disease
Alcohol's popularity and its central place in socialising in Australia obscures the dangers of excessive drinking and possible liver disease, Flinders University experts warn. As Dry July awareness month highlights the various health risks, the Head of Hepatology and Liver Transplantation at Flinders Medical Centre Associate Professor Alan Wigg says alcohol misuse remains a major health challenge in Australia as seen by high in rates of life-threatening liver disease. (2020-07-10)

Blood tests can predict the risk of liver cirrhosis
Repeated measurements of the biomarker FIB-4 in the blood every few years can predict the risk of developing severe liver disease, according to a new study from Karolinska Institutet in Sweden published in the Journal of Hepatology. The risk of liver cirrhosis increases if the levels of this biomarker rise between two testing occasions. (2020-07-02)

Giant leap in diagnosing liver disease
A collaborative team of Salk Institute and UC San Diego scientists have created a novel microbiome-based diagnostic tool that, with the accuracy of the best physicians, quickly and inexpensively identifies liver fibrosis and cirrhosis over 90 percent of the time in human patients. The non-invasive method relies on an algorithm to analyze patient stool samples--which contains traces of what lives in the gut--and could lead to improved patient care and treatment outcomes for liver disease. (2020-07-01)

Universal gut microbiome-derived signature predicts cirrhosis
UC San Diego School of Medicine researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis. (2020-06-30)

Strength training benefits patients with cirrhosis
Three hours of weekly strength training combined with protein supplements leads to both bigger and stronger muscles in patients with cirrhosis. This is shown by a new study from Aarhus University and Aarhus University Hospital. (2020-06-11)

Women are not more likely to die of cirrhosis than men, despite fewer liver transplants
Prior studies suggested women might have higher mortality of cirrhosis of the liver than men. Women are also less likely to receive liver transplantation. But the research was unclear. A comprehensive new Northwestern Medicine study shows women are not more likely to die of liver cirrhosis than men, demonstrating that this liver disease affects men and women similarly. (2020-06-04)

A single negative colonoscopy associated with long-lasting and significantly reduced cancer incidence
Having a single negative high-quality screening colonoscopy was associated with reduced colorectal cancer (CRC) incidence and mortality (by 84% and 90%, respectively) for up to 17.4 years. These findings suggest that the currently recommended 10-year screening interval could safely be extended. Findings from an observational study are published in Annals of Internal Medicine. (2020-05-25)

Mechanism underlying the development of diabetes and fatty liver illuminated
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease often associated with diabetes. However, it is unclear how NASH develops and there is currently no approved medication for the disease. A research group including Members of Kobe University's Graduate School of Medicine has clarified the mechanism behind NASH and diabetes. It is hoped that the pathway uncovered in this study will provide potential target for the development of new medications for these conditions. (2020-05-22)

Liver cancer: Awareness of hepatitis D must be raised
Scientists from the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) have studied the most serious consequence of chronic hepatitis: hepatocellular carcinoma. They demonstrated that people infected with Hepatitis D have up to three times the risk of developing that particularly aggressive and often fatal liver cancer compared to those infected only with Hepatitis B. These results, to be read in the Journal of Hepatology, plead for systematic screening of Hepatitis D in patients with Hepatitis B. (2020-05-18)

Fatty liver disease is underdiagnosed in the US
According to an analysis published in Alimentary Pharmacology & Therapeutics, nonalcoholic fatty liver disease (NAFLD) is grossly underdiagnosed in the United States. (2020-05-06)

Regularly attending religious services associated with lower risk of deaths of despair
People who attended religious services at least once a week were significantly less likely to die from 'deaths of despair,' including deaths related to suicide, drug overdose, and alcohol poisoning, according to new research led by Harvard T.H. Chan School of Public Health (2020-05-06)

TGF-β-driven reduction of CYGB is associated with oxidative DNA damage of HSCs in NASH
This study shows that the molecular regulatory mechanism of TGF-β-induced downregulation of CYGB expression in human HSCs, leading to the loss of cellular tolerance to exogenous oxidative stress and oxidative DNA damage in activated HSCs in human NASH with advanced fibrosis. Our findings provide new insights into the relationship between CYGB expression and the pathophysiology of NASH fibrosis in the human liver. (2020-04-21)

Not just for bones! X-rays can now tell us about soft tissues too
A new X-ray imaging technique could identify lesions and tumors before ultrasound or MRI can. (2020-03-31)

New hepatitis C cases down by almost 70% in HIV positive men in London and Brighton
New cases of hepatitis C amongst HIV positive men in London and Brighton have fallen by nearly 70% in recent years. (2020-03-25)

MAFLD: A new name and definition brings hope for patients with fatty liver disease
An international consensus panel led by researchers from The Westmead Institute for Medical Research (WIMR) has highlighted the need to redefine Non-Alcoholic Fatty Liver Disease (NAFLD), and to name it Metabolic Associated Fatty Liver Disease (MAFLD). Researchers highlighted that the new terminology will better reflect its causes, and improve public health initiatives. (2020-03-18)

Closing in on liver fibrosis: Detailing the fibrosis process at unprecedented resolution
Today, there is no effective way to treat liver fibrosis. In a new study, researchers from University of Southern Denmark present a new technology to investigate the cellular processes as they change during fibrosis development. Key findings are being validated in studies of human patients, paving the way for possible novel diagnostics and treatments. (2020-03-09)

Princeton researchers identify factors essential for chronic hepatitis B infection
A study published in the journal Nature Microbiology identified factors that the hepatitis B virus uses when establishing long-term infection in the liver. The findings could help lead to treatment strategies for chronic HBV infection, a condition that increases the risk of developing liver cancer and is responsible for almost 900,000 deaths worldwide each year. (2020-03-09)

Vitamin E effective, safe for fatty liver in HIV patients
A type of fatty liver disease that commonly affects patients with HIV can be safely treated with vitamin E, a McGill-led study has found. (2020-02-14)

Study: Two enzymes control liver damage in NASH
After identifying a molecular pathway that allows nonalcoholic steatohepatitis (NASH) to progress into liver cell death, University of California San Diego School of Medicine researchers were able to use these pathways to halt further liver damage. (2020-02-06)

Magnetic nanomaterials become an effective treatment against liver fibrosis
Fibrosis may affect different body organs. It develops as a reaction to long-time inflammation and is supposed to isolate the inflammation site from surrounding tissues. For example, chronic liver fibrosis may occur if the liver is constantly influenced by toxins, viruses, or metabolic disturbances. Liver damage is caused by the hepatocytes death, the main type of liver cells that secure the functioning of the organ. (2020-01-20)

Obesity crisis blamed for a rise in fatty liver disease amongst young adults
One in five young people have fatty liver disease (steatosis), with one in 40 having already developed liver scarring (fibrosis), research published today has found. The study, published in The Lancet Gastroenterology & Hepatology, is the first to attempt to determine the prevalence of fatty liver disease and fibrosis in young healthy adults in the UK. (2020-01-15)

Math equation predicts and detects liver cancer
University of California San Diego School of Medicine and Moores Cancer Center researchers developed a math equation to predict and detect liver cancer and identified when healthy cells become cancerous. (2019-12-16)

Diet, not exercise, may be key to addressing our biggest cause of liver disease
Edith Cowan University researchers have found that a chronic disease affecting up to 80 per cent of overweight people may be causing an iron deficiency that simply leaves them too tired to get off the couch. (2019-12-11)

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