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Current Cleft Palate News and Events, Cleft Palate News Articles.
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Reconstructive technique provides option for difficult nasal plastic surgery
A surgical technique that requires the removal, restructure and re-implantation of the nasal septum (the partition of the nose between the nostrils) appears to be a useful option for repairing the hard-to-treat severely deviated septum, according to an article in the July/August issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals. (2005-07-18)

Revolutionary nanotechnology illuminates brain cells at work
Scientists at the Carnegie Institution's Department of Plant Biology and Stanford University are the first to accurately measure the levels of important chemicals in single brain cells in real time. They used a process known as fluorescence resonance energy transfer, or FRET, and introduced nanosensors into nerve cells to measure the release of the neurotransmitter glutamate -- the major brain chemical that increases nerve-cell activity in mammalian brains and contributes to diseases such as Alzheimer's and Parkinson's. (2005-05-30)

WHO centre calls for global action on cleft palate
A global research network is needed if scientists are ever going to understand and prevent cleft palate, say experts at the first World Health Organization Collaborating Centre set up to develop such a structure. (2005-05-11)

Tissue engineering experts discuss orthopaedics applications
A future in which laboratory-grown organs and stimulated growth of muscle, bones and nerves could play a major role in treating medical conditions was revealed at a recent Tissue Engineering Symposium at Wake Forest University Baptist Medical Center. (2005-04-11)

Fifteen-year hunt uncovers gene behind 'pseudothalidomide' syndrome
A team of scientists from Colombia, the United States and elsewhere has successfully completed a 15-year-plus search for the genetic problems behind the very rare Roberts syndrome, whose physical manifestations often include cleft lip and palate and shortened limbs that resemble those of babies whose mothers took thalidomide during pregnancy. (2005-04-11)

Disfigured patients may be forced to forego surgery
Increasing insurance company denials, restrictions on covered procedures and a new tactic of excluding specific procedures may be forcing some adults and children to live with painful medical conditions or disfigurement. This restrictive access to care contributed to a 10 percent decline in reconstructive plastic surgery procedures in 2004, according to the latest statistics by the American Society of Plastic Surgeons. (2005-03-16)

Determining the fate of cells in the human body
Anthony Firulli, Ph.D. of the Indiana University School of Medicine and colleagues studied how two proteins, Twist1 and Hand2, which are antagonists, couple to determine the number of digits on a hand, paw or wing, and whether these digits are webbed or not. In addition to limb abnormalities, these proteins are associated with cardiac and placental tissue defects. (2005-03-15)

Linking brain to mind in a common genetic disease
Certain genetic diseases affect children's educational abilities in a distinctive pattern: impairing their numerical abilities more than their verbal skills. New research sheds light on this split in abilities by investigating how differences in brain structures may influence how the mind works. Studying chromosome 22q11.2 deletion syndrome, a common chromosome disorder, researchers at The Children's Hospital of Philadelphia used high-tech imaging tools to identify abnormal brain tissue associated with problems in visual-spatial and numerical skills. (2005-03-03)

Recognizing new aneurysm syndrome can save lives
A research team led by Johns Hopkins doctors has defined the physical traits and genetic basis of a new aortic aneurysm syndrome that is extremely aggressive and can cause death in early childhood. Early diagnosis of the syndrome and rapid surgical repair of the swollen aorta can save lives, the researchers report in the Jan. 30 advance online section of Nature Genetics. (2005-01-30)

New method to fix cleft palate shows promise in Mayo Clinic lab study
Results from a Mayo Clinic laboratory study in animals suggest that using distraction osteogenesis, a procedure that uses the mechanical force of an appliance to lengthen soft tissue and bone, may be a feasible and effective method to repair cleft palate in the future. (2005-01-22)

Cleft palate research receives £200,000 award
Pioneering research that could lead to a breakthrough in understanding the causes of cleft palate in newborn babies has begun in Manchester. (2005-01-10)

First analysis of chicken genome offers many new insights
The first detailed analysis of the chicken genome has identified a chicken counterpart to an important human immune system protein, revised scientists' assessment of the chicken's sense of smell, and suggested that the chicken, long used to study gene activity in the earliest stages of life, may provide a good model for studying changes in DNA linked to aging and death. (2004-12-08)

UCSD researchers derive lessons about human evolution from chicken genome
UC San Diego experts in bioinformatics have co-authored with other scientists the first large-scale comparison of mammal and bird genomes, published in the December 9 edition of Nature. The journal's cover story includes a draft sequence of the chicken genome assembled and analyzed by members of the International Chicken Genome Sequencing Consortium. (2004-12-08)

Imaging technology solves 400-year-old mystery
Using multi-detector computed tomography (MDCT), scientists have confirmed that scurvy killed nearly half of America's first colonists on Saint Croix Island 400 years ago, according to research presented today at the annual meeting of the Radiological Society of North America (RSNA). (2004-11-29)

Researchers report new gene test for isolated cleft lip and palate
Researchers have developed a new genetic test that can help predict whether parents who have one child with the (2004-09-10)

Bacteria use 'molecular lasso' to cop copper
The bacteria that destroy about one-third of the potent greenhouse gas methan use a small organic compound as a (2004-09-09)

Gene linked to cleft lip and palate identified
A gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families has been identified by an international team of scientists supported in part by the March of Dimes. (2004-08-18)

Researchers report new gene test for isolated cleft lip and palate
Researchers report they now can predict whether some parents are more likely than others to have a second child with the (2004-08-18)

Stanford researcher's findings may shed light on common, deadly birth defect
Now for the first time, researchers at the Stanford University School of Medicine and the University of California-San Francisco have provided a powerful example of how one genetic pathway can wend its way through an emerging (2004-08-16)

Sex pheromone blocked in bug
Science can put a dent in the sex life of a scarab beetle by blocking its ability to pick up female scent. The research could eventually lead to methods to control insect pests without affecting harmless or beneficial insects. (2004-08-09)

Visiting dental researcher at Case invents new technology
Young Jin Jeon, a visiting assistant professor at the Case Western Reserve University School of Dental Medicine and an orthodontist from Pusan National University in Korea, developed a new grid device during his yearlong residency at Case that will help orthodontists accurately place and guide the newly approved mini-orthoscrews without damaging the teeth. (2004-07-20)

MRI more accurate for prenatal cleft lip and palate than sonography
Fetal MRI allows more detailed and conclusive prenatal evaluation of the upper lip than sonography alone, allowing for better diagnosis of cleft lip and palate in fetuses, according to researchers from Harvard Medical School and Beth Israel Deaconess Medical Center and Children's Hospital in Boston, MA. (2004-07-01)

An eye on the tongue
A system developed by neuropsychologist Maurice Ptito at the Université de Montréal, together with colleagues from Denmark and USA, can activate brain areas that are normally reserved for visual information to allow blind people to (2004-06-02)

Solving the mystery of the dancer mice, and cleft lip too
By watching mice (2004-04-30)

Emory researcher examines effects of antiepileptic drugs on pregnant women and their offspring
Preliminary data show that babies of epileptic mothers who take antiepileptic drugs (AEDs) during pregnancy absorb the medication to substantial degrees in utero, and some of these babies may develop birth defects, other disabilities or even die. Although the majority of children born to mothers with epilepsy are normal, researchers believe some of these babies are at an increased risk for birth defects or developmental delays. (2004-04-28)

USC human speech study
USC researchers - in linguistics and engineering - have developed a new tool which captures orchestration of normal speech. The researchers believe their new technique may help people learn a foreign language, teach machines to speak more naturally and possibly suggest therapy for those with speech problems due to stroke. (2004-04-20)

Seeking a mechanical solution to nation's number-one children's illness
As bacteria become resistant to the antibiotics prescribed for ear infections, the researchers use finite element analysis and mathematical modeling to study the eustachian tube. Keeping the tube open, they say, prevents bacteria from building up and inflammation from occurring in the middle ear. Another question the researchers hope to answer: Why does the tube open readily in some people but not in others? (2004-02-25)

Childhood sleep-disordered breathing severity related to tonsil size, oropharyngeal volume
A study is the first of its kind to examine sleep-disordered breathing, pharyngeal size and soft tissue anatomy during childhood development. (2003-12-03)

Brain activity abnormal in children with delayed speech
Children with unusually delayed speech tend to listen with the right side of the brain rather than the left side of the brain. In addition, speech-delayed children may be increasingly less receptive to language as they age. (2003-11-25)

Genetics mutations resulting in delayed puberty are focus of MCG study
Identifying genetic mutations that delay puberty in a small number of children may also lead to better infertility treatment and birth control, says a Medical College of Georgia physician-scientist. (2003-11-12)

Burning mouth syndrome
Burning mouth syndrome (BMS), a painful disorder affecting mostly women, is a constant and aggravating source of discomfort for more than 1 million adults. New findings explain how anxiety and depression may be a precursor that triggers this difficult-to-diagnose syndrome, according to a new report that will be published in the September/October 2003 issue of General Dentistry, the Academy of General Dentistry's (AGD) clinical, peer-reviewed journal. (2003-09-03)

Wake Forest researcher identifies syndrome as leading cause of death in premature infants
A Wake Forest School of Medicine researcher has identified brain malformations that appear to be part of a syndrome that could potentially be a leading cause of death in premature infants. (2003-05-03)

Embryonic facial development subject to insult or repair longer than expected
The sculpting of the face during embryonic development - the physical molding that determines what we will look like - may remain open to change much longer than had been thought, according to research by UCSF scientists. (2003-03-24)

Identification of the first gene in posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) is a common chronic anxiety disorder that follows exposure to traumatic events. A large twin study of Vietnam veterans had demonstrated a significant genetic contribution to chronic PTSD. The underlying genes, however, have not been described. Researchers at the Hadassah Hebrew University Medical Center in Jerusalem now report that a dopamine transporter (DAT) gene may increase risk for PTSD. If replicated, findings suggest that genetically-determined changes in brain dopamine reactivity may contribute to the occurrence of PTSD among trauma survivors. (2002-09-23)

Yale researchers find potential target for treatment and prevention of osteoporosis
By identifying a genetic mutation that causes extremely high bone density in people, Yale researchers have found a potential target for the prevention or treatment of osteoporosis, it was reported Thursday in the New England Journal of Medicine. (2002-05-15)

Proximity to landfill sites linked to increased risk of congenital chromosomal abnormalities
New data from a 1998 study to assess the potential risks of chromosomal abnormalities of residents living near landfill sites is detailed in a research letter in this week's issue of THE LANCET. The findings suggest that the increased risk of chromosomal abnormalities is of a similar magnitude to the increased risk of non-chromosomal abnormalities previously reported. (2002-01-24)

Thyroid disease raises risk for birth defects
Women with thyroid disease are more likely to give birth to babies with heart, brain and kidney defects even if the thyroid function tests are normal during the pregnancy, according to new research from Johns Hopkins. (2002-01-17)

Researchers identify gene causing rare form of cleft palate
The identification of a gene that causes a rare form of the congenital defect, cleft palate, may offer an important insight into human development and the mechanisms involved in the condition. Researchers led by Dr Philip Stanier from Imperial College have found that the sex-linked form of cleft palate (CPX) and an associated form of the disorder known as tongue-tie are caused by mutations in a gene called T-box 22. The study is published online today in the journal Nature Genetics. (2001-09-16)

Improved snoring treatment: less pain, more gain
A new study at the University of North Carolina at Chapel Hill School of Medicine offers new hope for habitual snorers and those who must endure their nighttime cacophonies. (2001-09-14)

Mayo Clinic study finds complications in postoperative patients with sleep apnea
Patients with obstructive sleep apnea syndrome experienced a greater number of serious medical complications following elective knee or hip replacement surgery than patients without the syndrome, Mayo Clinic researchers report. (2001-09-11)

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