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Current Cleft Palate News and Events, Cleft Palate News Articles.
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American Thoracic Society Journal News Tips for July (Second Issue)
Newsworthy research appearing in the second of two July issues of the ATS journal includes studies showing that snorers and persons with obstructive sleep apnea (OSA) demonstrated upper airway sensory impairment which could trigger airway obstruction; an expert view that the airway sensory dysfunction could be caused by motor neuron lesions in some snorers and in most with OSA; the use of low-tidal ventilation in the critically-ill works equally well across all clinical subgroups. (2001-08-02)

People with sleep apnea at higher risk of stroke
People with sleep-related breathing disorders, such as habitual snoring and sleep apnea, are at higher risk of suffering a stroke, according to a study by a Yale researcher published in the June issue of the journal Stroke. (2001-06-21)

Chicago surgeon and dentist team up to pioneer bone-lengthening treatment in severe craniofacial patients--Bold new treatment improves facial symmetry
Co-directors of the Rush Craniofacial Center Dr. John W. Polley, chairman of plastic and reconstructive surgery, and Dr. Alvaro A. Figueroa, a dentist with extensive training in craniofacial anomalies and orthodontics, have pioneered a bone-lengthening treatment, known as distraction osteogenesis, for patients with congenital facial disorders. (2001-05-06)

Offspring of men with birth defects twice as likely to have defects, too
Men born with a birth defect have a substantially increased risk of having a child with a birth defect, a large population study revealed today. Compared with other fathers, the risk was doubled. (2001-02-13)

Veterinary researchers seek secret to reversing birth defects
Virginia Tech researchers have observed that maternal immune stimulation causes altered expression of critical genes in the fetus and suggest that there is routine cross-talk between fetus and mother via chemical mediators. Optimal maternal immune health may be important for protection against agents or events that lead to many birth defects. (2001-01-24)

Snoring and sleep apnea treated with innovative somnoplasty technique at Yale
To treat snoring and obstructive sleep apnea, Yale physicians are using a radiofrequency technology called somnoplasty to shrink extra tissues in the nose and throat, and oral appliances to move the lower jaw forward during sleep. (2001-01-17)

Protein stimulates key link between nerve cells, suggesting possible target for mental retardation and nerve regeneration therapies
Researchers have exposed a single molecule that can stimulate the maturation of the synapses through which nerve cells communicate a key signal to one another, revealing a mechanism critical for supporting learning and memory and a possible target for treating mental retardation stroke and nerve damage following spinal cord injury. (2000-11-16)

Hereditary lymphedema genetic mutations found
University of Michigan scientists have identified genetic mutations that cause a serious medical condition called hereditary lymphedema-distichiasis or LD. Discovering the gene is the first step toward a future diagnostic test for LD and increased scientific understanding of the gene's impact on early development of the heart and lymphatic system. (2000-11-07)

Anti-acne drug that causes serious birth defects must be more strictly regulated, March of Dimes says
Warning that too many pregnant women are being exposed to Accutane (isotretinoin), which can cause severe birth defects, the March of Dimes today told the Food and Drug Administration at a public meeting that the drug must be regulated by the same rigorous system used for thalidomide. (2000-09-17)

UCSF researchers identify regulator of critical brain messenger, hinting at therapy
In the dynamic world of the central nervous system, the neurotransmitter glutamate is a key player, ceaselessly transmitting critical instructions between nerve cells. Now, UCSF researchers have identified the protein that transports the chemical signal to its launch site in nerve cells, offering a possible new target for therapies. (2000-08-10)

DNA details suggest how human chromosomes break, rearrange and cause a genetic disease
Chromosome 22, one of the smallest human chromosomes, is known to be a hot spot for disease. Genetics researchers at The Children's Hospital of Philadelphia are teasing out details of unusual, unstable DNA structures that make the chromosome particulaly vulnerable to defects and rearrangements that may result in diseases. (2000-06-25)

Muscle-building therapy may reduce overly nasal speech, says study
For people with hypernasal speech, many of them with repaired cleft palates, there have been few remedies other than surgery, and the surgery comes with risks. Some of these people, however, may find help in a kind of weight-lifting for the soft palate, says a professor of speech and hearing science at the University of Illinois. (2000-03-30)

Making bottled green tea taste fresh-brewed
Cornell food scientists find the chemicals to make bottled or canned green tea that tastes like fresh brewed. (2000-03-28)

Smoking during pregnancy found to increase risk of cleft lip and palate
Women who smoke while pregnant are 50 to 70 percent more likely than nonsmokers to give birth to a baby with a cleft lip or palate, according to a new study at the University of Michigan. The risk of the disfiguring facial defect rises with the number of cigarettes smoked each day. (2000-03-27)

Details of chromosome 22 structure offer clues to how genes are lost in a genetic disease
Chromosome 22, a hot spot for human disease, yielded a few more secrets to genetics researchers at The Children's Hospital of Philadelphia who analyzed details of the chromosome's structure. The researchers found evidence that sites with repetitive DNA sequences are unstable areas, prone to rearrangements that cause a loss of important genes. (2000-02-29)

UCSF researcher reports on protein therapy to reverse facial birth defects
New research from UCSF shows that a brief deprivation of vitamin A in the heads of developing chickens can generate severe craniofacial deformities, and that dosing the chicken embryo with a regulatory protein can restore a near normal face. (2000-02-14)

3-D Ultrasound's "true-to-life" images aid in prenatal diagnosis at Cedars-Sinai Medical Center
With the advent of three-dimensional ultrasound, clinicians are gaining unparalleled insight into the human body - viewing internal structures and functions with amazing clarity. At Cedars-Sinai Medical Center, this new technology is enabling physicians to observe fetal development and diagnose abnormalities with advanced accuracy. (2000-01-02)

Researchers at Children's Hospital of Philadelphia play major role in genetic milestone - first full sequencing of a human chromosome
Researchers at The Children's Hospital of Philadelphia played a major role in today's landmark announcement of the first sequencing of a complete human chromosome--chromosome 22. Building on their previous work in producing a general map of that chromosome, the Hospital's researchers processed large numbers of DNA segments for use in the sequencing. (1999-12-01)

New nasal obstruction procedure offers cheaper, pain-free alternative to surgery
An ear, nose and throat doctor at the University of North Carolina-Chapel Hill is using a new technology that has already proven successful in treating snoring to provide a less expensive, relatively pain-free alternative to traditional nasal obstruction surgery. (1999-10-01)

New mouse model could be key to understanding role of folic acid in preventing birth defects
Researchers have created the world's first genetically- engineered mouse model to explain how folic acid protects against human birth defects. The development of this tool will enable researchers to understand how folic acid protects against birth defects such as neural tube defects and cleft lip and palate. (1999-09-30)

NIH taps Hopkins craniofacial program as 'center of discovery', awards $7.5million grant
What is the likelihood that a baby will be born with a cleft palate? How will smoking or a glass of wine consumed during pregnancy affect a fetus's skull development? Johns Hopkins researchers will use a $7.5 million research grant from the National Institute of Dental and Craniofacial Research (a division of the National Institutes of Health) to answer these questions and others. (1999-08-27)

Chemists and chef report on new food production technologies
Food experts will report on chemistry's role in improving today's food and how these changes are impacting the quality of life and lowering the risk of chronic disease during a special Presidential Symposium at the 218th national meeting in New Orleans of the American Chemical Society, the world's largest scientific society. (1999-08-22)

SIDS prevention tactic leads to epidemic of 'misshapen head' in infants
While the potentially life-saving benefits of the (1999-07-08)

Researchers Discover Mechanism Of Cleft Palate Development
Researchers led by a team of UC San Francisco scientists have identified the mechanism by which cleft palate develops. The most common craniofacial birth defect in humans occurs when the palate does not properly fuse during fetal development, leaving an opening or cleft in the roof of the mouth. (1999-05-01)

Study: Birth Defects Decrease Survival, Childbirth, Boost Risk Of Similar Defects
A new study of nearly a half million girls and women shows that those born with birth defects are less likely to survive, especially during the first years of life, than others born without them. Survival is lowest for such catastrophic conditions as anencephaly, hydrocephalus, other syndromes and central nervous system irregularities and highest for cleft palate and lip, clubfoot and malformations of skin, hair, nails and genitals. (1999-04-08)

Researchers Isolate Gene For Heart And Facial Defects
Researchers at UT Southwestern Medical Center at Dallas have isolated the gene they believe is responsible for the most common genetic cause of heart and facial birth defects. (1999-02-19)

Serotonin May Be Better Target For Attention Deficit Hyperactivity Disorder Treatment
Ritalin has long been used to treat attention deficit hyperactivity disorder (ADHD). Researchers thought it worked by altering dopamine levels in the brain. Now HHMI researchers show that serotonin may be a better target than dopamine for ADHD treatment. (1999-01-14)

Structure Of Enzyme Involved In Gentamicin Resistance Revealed For First Time
A team of scientists, led by researchers from the Howard Hughes Medical Institute (HHMI) at The Rockefeller University, has determined the three-dimensional structure of an enzyme responsible for resistance of certain bacteria to the antibiotic gentamicin. The structure, reported in the August 21 Cell, is the first for this family of antibiotics and presents a possible target for designing drugs to thwart resistance. (1998-08-21)

Biochemists Gain Crystal-Clear Insight into 'Ancient' Enzyme
Biochemists from the University of Pennsylvania and Duke University Medical Center have reported analytical studies revealing unexpected new insights into how two very different molecules - a protein and an RNA - work together to form an enzyme that performs one of the fundamental tasks of constructing the protein-making machinery of the cell. (1998-05-14)

Researchers Shed Light On Snoring, Stroke Risk
Sleep disorders associated with heavy snoring pose the greater stroke risk, researchers reported today in Stroke: Journal of the American Heart Association. The study by U.S. and German researchers is the first to indicate a possible mechanism for stroke risk that could explain why some sleep disorders are more dangerous than others. (1998-01-09)

Treatment Of Young With Sleep Apnea Needs To Be More Aggressive
Researchers have found that the most severe cases of sleep apnea occur in young people under age 45 and should be treated more aggressively once it is diagnosed so that problems like hypertension and other cardiovascular problems can be reduced. (1998-01-05)

Genetic "Short Circuit" Leads To Cleft Palate
Scientists have identified not just a single gene but a genetic circuit, that when broken, causes cleft palate in newborn mice. The findings may help define the genetic components of cleft palate in humans, and explain the link between clefting and risk factors that raise the level of steroids in the body. (1997-12-22)

Miraculous High-Tech Glasses Could Help Millions See Better
Her new glasses are no miracle, but donĂ¢t try telling that to Jenna Meck, a visually impaired 21-year-old junior at Meredith College in Raleigh. She says the battery-powered, self-focusing, computer-controlled telescopic glasses are the next best thing. (1997-02-06)

USDA Develops Tasty No-Cal, High Fiber Fat Substitute
U.S. Department of Agriculture food researchers have developed a fiber-rich, no-calorie substitute fat, Z-Trim, made from natural byproducts like oat hulls and corn bran. Z-Trim, a powder, is mixed with water for use in foods ranging from cheese to hamburger to brownies. (1996-08-26)

Chemotherapy Improves Treatment Of Nasopharyngeal Carcinoma
Combining two widely known anti-cancer drugs with radiation therapy dramatically improves the survival of patients with nasopharyngeal carcinoma. In most cases, physicians now recommend only radiation therapy for such patients. The new combination treatment resulted in a three-year survival rate of 76 percent, compared to 45 percent for radiation alone (1996-07-11)

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