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Current Cleft Palate News and Events, Cleft Palate News Articles.
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Salamanders chew with their palate
'According to the textbooks, amphibians swallow their prey whole, but we have been able to refute this,' says Dr. Egon Heiss of the University of Jena. Together with colleagues he has succeeded in proving that the crested newts do actually chew their prey, but in a way that is different from that of most other land-based vertebrates. (2019-03-22)

Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
Children who have behavior problems or are suspected to have ADHD might actually be suffering from a chronic lack of restorative sleep. Symptoms include snoring, restless sleep, excessive sleepiness, teeth grinding and jaw clenching, migraines, bedwetting, and irritability. Sleep apnea and related conditions can cause lasting damage to brain development during crucial years. As a result, children who go undiagnosed have been reported to use health care 226 percent more than the general population. (2019-02-12)

Interferon regulatory factor 6 mutations implicated in neural tube defects, including spina bifida
Mutations in a gene known as interferon regulatory factor 6 that cause cleft lip and palate also are implicated in neural tube defects such as spina bifida, suggests research by an international study team published online Jan. 25, 2019, in Human Molecular Genetics. (2019-01-25)

Bulldogs' screw tails linked to human genetic disease
With their small size, stubby faces and wide-set eyes, bulldogs, French bulldogs and Boston terriers are among the most popular of domestic dog breeds. Now researchers at the UC Davis School of Veterinary Medicine have found the genetic basis for these dogs' appearance, and linked it to a rare inherited syndrome in humans. (2019-01-03)

Chinese scientists unlock structural secrets of whale baleen
Chinese scientists working with other researchers have for the first time uncovered the underlying mechanisms of the hierarchical structure of baleen, with an eye toward developing advanced engineered materials. (2018-11-21)

Signal peptides' novel role in glutamate receptor trafficking and neural synaptic activity
Dr. SHENG Nengyin at the Kunming Institute of Zoology of the Chinese Academy of Sciences, in collaboration with Dr. SHI Yun's Lab at the Model Animal Research Center of Nanjing University, revealed a signal peptide function for glutamate receptor trafficking and uncovered a novel trafficking mechanism for glutamate receptors. (2018-11-19)

CRISPR gene editing will find applications in plastic and reconstructive surgery
The CRISPR genome editing technique promises to be a 'transformative leap' in genetic engineering and therapy, affecting almost every area of medicine. That includes plastic surgery, with potential advances ranging from prevention of craniofacial malformations, to therapeutic skin grafts, to new types of rejection-free transplants, according to a paper in the November issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). (2018-10-30)

New cell movement process key to understanding and repairing facial malformations
The embryonic stem cells that form facial features, called neural crest cells, use an unexpected mechanism of moving from the back of the head to the front to populate the face, finds a new UCL-led study. (2018-10-18)

New technique uses umbilical cord stem cells for early repair of cleft palate
A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer. (2018-10-02)

Scientists unlock secret of how the brain encodes speech
People like the late Stephen Hawking are unable to speak because their muscles are paralyzed. Scientists want to help these individuals communicate by developing a brain machine interface to decode the commands the brain is sending to the tongue, palate, lips and larynx. New research has moved science closer by unlocking new information about how the brain encodes speech. They discovered the brain controls speech in a similar way to how it controls arm movements. (2018-09-26)

Surprise finding uncovers balancing act between birth defects and cancer
Walter and Eliza Hall Institute researchers have made a surprise discovery about how subtle changes in the way cell survival is regulated during embryonic development can have drastic health implications. (2018-09-20)

Chitinase as 'burnt-bridge' Brownian monorail efficiently hydrolyzing recalcitrant biomass
Serratia marcescens Chitinase A (SmChiA) is a molecular motor efficiently hydrolyzing recalcitrant crystalline chitin by moving on the surface processively. By using gold-nanoparticle probe, researchers revealed 1-nm stepping motion of SmChiA rectified forward by fast catalysis. X-ray crystallography and molecular dynamics simulation also revealed that motion of SmChiA is driven by the Brownian motion. The results show SmChiA is 'burnt-bridge' Brownian ratchet monorail, and give an insight to design engineered and artificial molecular motors. (2018-09-19)

CRISPR screen reveals new targets in more than half of all squamous cell carcinomas
Team of University of Colorado Cancer Center researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of cancer. (2018-09-18)

How skin begins: New research could improve skin grafts, and more
University of Colorado Boulder researchers have discovered a key mechanism by which skin begins to develop in embryos. (2018-09-13)

Samara Polytech geologists discovered the fullest skull of Wetlugasaurus
Traditionally, Petroleum Engineering Faculty staff and students of the Flagship University took part in the annual complex scientific expedition on monitoring the flora of Triassic and Jurassic deposits in the southeast of the Samara region. More than 50 specimens of the Triassic fauna containing amphibians and reptiles' bone fragments were collected. Unique geological material will replenish museum funds and will be used in interactive excursions and events. (2018-08-27)

3D-Printed implants shown to help grow 'real bone'
Chemically coated, ceramic implants successfully guided the regrowth of missing bone in lab animals while 'steadily dissolving,' researchers report. (2018-08-01)

Novel genome-wide association study risk loci for nonsyndromic orofacial clefts
At the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress, Azeez Butali, University of Iowa, Iowa City, USA, gave an oral presentation titled 'Novel Genome-wide Association Study Risk Loci for Nonsyndromic Orofacial Clefts.' (2018-07-27)

Surveys of patients about health care providers are likely of little use
For anyone who has ever taken a survey after a medical appointment and wondered whether the effort was worthwhile, the answer is probably 'No,' says a Baylor University psychologist and researcher. (2018-07-16)

A Fox code for the face
In the developing face, how do stem cells know whether to become cartilage, bones or teeth? To begin to answer this question, scientists from the USC Stem Cell laboratory of Gage Crump tested the role of a key family of genes, called 'Forkhead-domain transcription factors,' or Fox. Their findings appear in the journal Development. (2018-06-26)

About face: Special collection of papers celebrates research on how the human face forms
Our faces can reveal a lot about us, and now scientists are revealing a lot about faces. PLOS Genetics announces a special collection of papers to highlight recent advances in our understanding of how faces form, curated by Seth Weinberg of the University of Pittsburgh, and colleagues. The collection, entitled ''Craniofacial genetics: where have we been and where are we going,'' publishes June 22 and features research on the development of the face and skull, facial birth defects and normal facial variation. (2018-06-22)

In the gaping mouth of ancient crocodiles
A new study by a team of international experts, led by University of Witwatersrand PhD candidate Kathleen Dollman and Professor Jonah Choiniere published today in the American Museum Novitates, endeavoured to further explore the mouth of one of the earliest occurring and least understood groups of crocodilians, the shartegosuchids. (2018-06-18)

Fetal MRI can reliably spot holoprosencephaly as early as 18 gestational weeks
Fetal magnetic resonance imaging can reliably spot holoprosencephaly as early as 18 gestational weeks, providing an opportunity to counsel families earlier in their pregnancy, according to Children's-led research featured on the cover of the American Journal of Medical Genetics. (2018-05-21)

Surprise cell death discovery provides birth defect clues
Researchers have made a surprise discovery that could rewrite our understanding of the role programmed cell death plays in embryonic development and congenital birth defects. The team showed that, while programmed cell death -- or apoptosis -- is essential for healthy development overall, many organs and tissues do not require apoptosis to develop normally. The study also suggested that abnormalities in cell death processes are likely to contribute to some common birth defects in humans, such as spina bifida, heart vessel defects and cleft palate. (2018-05-17)

Blueprint for the skull
Once upon a time in Europe, pregnant women avoided rabbits to prevent their babies from being born with a 'harelip.' But, that isn't the only misconception about the condition now known as cleft lip. In the May 1 issue of Cell Reports, UConn Health researchers report the popular modern belief that the condition is caused by a gene is wrong. Their research could transform how we understand the formation of the face. (2018-05-01)

Remake, refill, reuse: Recycling at the synapse revealed
OIST Researchers have shown that the speed of neurotransmitter recycling at the synapse is determined by the refilling speed of vesicles. (2018-03-26)

Mapping a genetic risk
Clinicians and health researchers often look at gene mutation to predict whether a fetus is at risk for a birth defect, or a person is at risk of developing a disease, but these predictions are not always accurate. University of Calgary researchers have discovered an important factor that changes our understanding of the relationship between gene mutations (genotype) and how they present in people (phenotype) that may, one day, help to improve this accuracy. (2018-03-07)

Cause of severe genetic disease identified
Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes. Their results were recently published in the scientific journal (2018-02-02)

Topiramate in early pregnancy increases risk of oral clefts
A new study by investigators from Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health suggest that using topiramate in early pregnancy, particularly at the high doses used for epilepsy, increases the risk of oral clefts. Their results are published in Neurology. (2017-12-28)

Does dosing of drug for mom make a difference for baby's risk of cleft lip, palate?
Taking a higher dose of topiramate during the first three months of pregnancy may increase a baby's risk of cleft lip or cleft palate more than when taking a lower dose, according to a study published in the Dec. 27, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2017-12-27)

Exposure to air pollution just before or after conception raises risk of birth defects
Women exposed to air pollution just prior to conception or during the first month of pregnancy face an increased risk of their children being born with birth defects, such as cleft lip or palate or abnormal hearts. (2017-12-11)

Take charge, wine lovers, and trust your palate
The traditional pairing of wine and food too often misses the mark - leaving people confused and intimated - and should be scrapped in favor of a more consumer-focused approach, a new study indicates. (2017-11-07)

Discovery lights path for alzheimer's research
A probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide -- the kind suspected of causing Alzheimer's disease -- has identified a specific binding site on the protein that could facilitate better drugs to treat the disease. (2017-10-25)

Discovery lights path for Alzheimer's research
A metallic probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide has identified a binding site that could facilitate better drugs to treat Alzheimer's disease. When the probe is illuminated, it catalyzes oxidation of the protein in a way that might keep it from aggregating in the brains of patients. (2017-10-19)

Augmented tongue ultrasound for speech therapy
Researchers have developed a system that can display the movements of our own tongues in real time. These movements are processed by a machine learning algorithm that controls an 'articulatory talking head.' This avatar shows the tongue, palate and teeth, which are usually hidden inside the vocal tract. This (2017-10-13)

Fever in early pregnancy linked to birth defects, animal study shows
UC Berkeley researchers have helped find evidence indicating that the fever itself, not its cause, is what interferes with the development of the heart and jaw during the first three to eight weeks of pregnancy. (2017-10-11)

How fever in early pregnancy causes heart, facial birth defects
Researchers have known for decades that fevers in the first trimester of pregnancy increase risk for some heart defects and facial deformities such as cleft lip or palate. Exactly how this happens is unclear. Scientists have debated whether a virus or other infection source causes the defects, or if fever alone is the underlying problem. (2017-10-10)

Warnings on Anesthesia before age 3 -- plastic surgeons get update on evidence
The evidence behind the US Food and Drug Administration (FDA) recent drug safety warning regarding prolonged anesthesia in infants and young children is discussed in the October issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). (2017-10-02)

Children with craniofacial defects face most difficult social pressures in grade school
Elementary school children with craniofacial anomalies show the highest levels of anxiety, depression and difficulties in peer interactions when compared to youths with craniofacial defects in middle and high schools. The findings suggest that keeping a close watch for these signs and educating the child's peers about their condition may be necessary for this age group. (2017-09-28)

JDR special issue on orofacial clefting and dental and craniofacial anomalies
The International and American Associations for Dental Research (IADR/AADR) have published a special issue in the Journal of Dental Research (JDR) on orofacial clefting and dental and craniofacial anomalies. Topics in this special issue range from tooth number and root formation, human and animal genetic studies on orofacial clefting, reviews that prioritize the variants most likely to cause disease, the pathways required for palatogenesis, experimental articles on the periderm and drug therapy articles that rescue cleft palate in mutant mice. (2017-09-20)

Ancient amphibian had mouthful of teeth ready to grab you: UTM research
The idea of being bitten by a nearly toothless modern frog or salamander sounds laughable, but their ancient ancestors had a full array of teeth, large fangs and thousands of tiny hook-like structures called denticles on the roofs of their mouths that would snare prey, according to new research by paleontologists at the University of Toronto Mississauga (UTM). (2017-09-15)

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