Current Clinical Trials News and Events

Current Clinical Trials News and Events, Clinical Trials News Articles.
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Hormone helps prevent muscle loss in mice on high fat diets, USC study finds
A new study suggests that a hormone known to prevent weight gain and normalize metabolism can also help maintain healthy muscles in mice. The findings present new possibilities for treating muscle-wasting conditions associated with age, obesity or cancer, according to scientists from the University of Southern California Leonard Davis School of Gerontology. (2021-02-22)

New study highlights lack of diversity and inclusion in vaccine clinical trials
A team of scientific experts from across the U.S. and Puerto Rico are advocating for increased diversity in vaccine trials after publishing a new report that highlights a decade's worth of disparities. (2021-02-19)

Including racial/ethnic minorities, females, older adults in vaccine trials
Using data from completed interventional vaccine trials from 2011 to 2020, researchers examined whether racial/ethnic minority groups, females and older adults were underrepresented in U.S.-based vaccine clinical trials. (2021-02-19)

New review compiles immunogenicity data on leading SARS-CoV-2 vaccine candidates
In a new Review, P.J. Klasse and colleagues present an extensive overview of the immunogenicity profiles of several leading SARS-CoV-2 vaccine candidates, including several developed under the auspices of (2021-02-19)

New recommendations aim to eliminate racial bias in myeloma trials
Recommendations designed to address the under-representation of African Americans in clinical trials for multiple myeloma (MM), a blood cancer that is twice as deadly in this demographic as in whites. (2021-02-18)

Protein linked to Alzheimer's, strokes cleared from brain blood vessels
Amyloid deposits in the brain increase the risk of dementia and strokes. Researchers at Washington University School of Medicine in St. Louis have identified an antibody that clears amyloid deposits from the brain without raising the risk of brain bleeds. (2021-02-17)

Challenge to anorexia nervosa treatment guidelines
New analysis published in The Lancet Psychiatry has shown a lack of strong evidence to support current guidance on psychological therapies for treating anorexia nervosa over expert treatment as usual. The findings highlight a need for further research and support a call for individual trial data to be made available so the benefits of treatments in specific patient populations can be better understood. (2021-02-15)

Cabozantinib most effective treatment for metastatic papillary kidney cancer
In a SWOG Cancer Research Network trial that put three targeted drugs to the test, the small molecule inhibitor cabozantinib was found most effective in treating patients with metastatic papillary kidney cancer - findings expected to change medical practice. (2021-02-13)

Stirring up conflicts in tumour cells
With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumour neuroblastoma can be disrupted at a key point causing tumour cell death. (2021-02-11)

Why Black men's prostate cancer may be more responsive to immunotherapy
Black men die more often of prostate cancer yet have greater survival benefits from immunotherapy treatment. A new study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. (2021-02-10)

A recipe for regenerating bioengineered hair
Scientists have recently developed ways to grow a variety of useful items in laboratories, from meat and diamonds to retinas and other organoids. At the RIKEN Center for Biosystems Dynamics Research in Japan, a team led by Takashi Tsuji has been working on ways to regenerate lost hair from stem cells. In an important step, a new study identifies a population of hair follicle stem cells in the skin and a recipe for normal cyclical regeneration in the lab. (2021-02-10)

Special Issue: Human genome at 20
In February 2001, the first drafts of the human genome were published. (2021-02-04)

Pharmacologist offers plan to solve disparities in designing medicine
In a new perspective piece published in the Feb. 5 issue of Science, Johns Hopkins pharmacologist Namandje Bumpus, Ph.D., outlines the molecular origins for differences in how well certain drugs work among distinct populations. She also lays out a four-part plan to improve the equity of drug development. (2021-02-04)

Most vulnerable often overlooked in clinical trials of new treatments for COVID-19
Not only are studies of COVID-19 treatments being conducted at locations that don't typically care for high proportions of Black and Hispanic patients, the studies frequently exclude individuals with high-risk chronic ailments or who are pregnant. (2021-02-03)

Bottoms are up at the HIV Research for Prevention Virtual Conference
Researchers seeking to develop on-demand and behaviorally congruent HIV prevention options for anal sex are reporting the results of three early phase clinical trials of rectal microbicides at the HIV Research for Prevention Virtual Conference. The Phase I studies, led by the National Institutes of Health-funded Microbicide Trials Network, found both of two gel-based products well-tolerated, with higher doses of the active drugs likely required to provide protection from HIV and other sexually transmitted infections. (2021-02-02)

Neuromuscular disease registry helps patients access research, clinical trials, new genetic tests, and therapies
Amsterdam, February 2, 2021 - The Canadian Neuromuscular Disease Registry (CNDR) was launched in 2010 to increase efficient patient access to cutting-edge research and clinical trials, to increase understanding of the natural history and epidemiology of neuromuscular disease across Canada, and to facilitate research collaboration. (2021-02-02)

Examining oncology clinical trials launched before, during COVID-19 pandemic
Researchers evaluated the association between the pandemic and clinical research and development by studying the initiation of oncology clinical trials over time. (2021-01-27)

Dietary adherence and the fight against obesity
While eating less and moving more are the basics of weight control and obesity treatment, finding ways to help people adhere to a weight-loss regimen is more complicated. Understanding what features make a diet easier or more challenging to follow can help optimize and tailor dietary approaches for obesity treatment. (2021-01-25)

In preclinical models, antiviral better inhibits COVID-19 than Remdesivir; further studies warranted
Working in preclinical models, researchers report that plitidepsin, a drug with limited clinical approval for the treatment of multiple myeloma, is more potent against SARS-CoV-2 than remdesivir, an antiviral that received FDA emergency use authorization for the treatment of COVID-19 in 2020. (2021-01-25)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Pre-surgery chemotherapy is possible for early stage pancreatic cancer patients
A first-of-its-kind randomized clinical trial found that patients with pancreatic cancer didn't live any longer than expected after receiving pre-operative chemotherapy from either of the two standard regimens, according to trial results published in JAMA Oncology. (2021-01-21)

Randomized trials could help to return children safely to schools - study
Schools are closing again in response to surging levels of COVID-19 infection, but staging randomized trials when students eventually return could help to clarify uncertainties around when we should send children back to the classroom, according to a new study. (2021-01-21)

Do antidepressants help chronic back pain and osteoarthritis?
Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm. (2021-01-20)

Antidepressants largely ineffective for back pain and osteoarthritis
Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today. (2021-01-20)

Target of new cancer treatment valid for breast as well as blood cancers: study
Newly published research shows that a new anti-cancer drug developed at the University of Alberta, set to begin human trials this year, may work against breast cancer as well as blood cancer. (2021-01-20)

Study demonstrates efficacy of new treatment for neurofibromatosis type 1-related tumors
Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1). The results of the Phase 2 clinical trial, co-chaired by Michael J. Fisher, MD at CHOP, were published recently in Nature Medicine. (2021-01-14)

New PTSD biotypes enables improved tests, sheds light on divergent treatments efficacy
Researchers from the PTSD Systems Biology Consortium identified distinct biotypes for post-traumatic stress disorder, the first of their kind for any psychological disorder. These biotypes can refine the development of screening tools and may explain the varying efficacy of PTSD treatments. PTSD diagnosis is complicated by over-reliance on self-reporting of patient symptoms, particularly underreporting signs of distress due to perceived stigma. Researchers identified two PTSD biotypes with differing genetic markers and underlying mechanisms of disease. (2021-01-14)

Scientists are a step closer to developing 'smart' stem cells - made from human fat
These new, adaptive stem cells can lie dormant until needed, a new animal study using human cells shows. (2021-01-13)

Is the COVID-19 vaccine safe for nursing mothers?
The Academy of Breastfeeding Medicine (ABM) does not recommend cessation of breastfeeding for individuals who are vaccinated against COVID-19. (2021-01-12)

Scientists reach new milestone in vaccine development for leishmaniasis
Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines. (2021-01-11)

Physician-pharmacist collaboration may increase adherence to opioid addiction treatment
A collaborative approach to treating opioid use disorder that relies heavily on community pharmacists is feasible and may increase adherence and participant satisfaction, according to a pilot study published today in Addiction. The study was supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, through the NIDA Center for the Clinical Trials Network. (2021-01-11)

Study explains why patients with cancer spread to the liver have worse outcomes
A new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver in mice restored the immune cell function and led to better outcomes. (2021-01-04)

Combined approach could boost breast cancer immunotherapy, study suggests
Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of genetically engineered T cells to eradicate breast cancer in mice, according to a new study by researchers at the University of North Carolina. The study, to be published December 31 in the Journal of Experimental Medicine (JEM), suggests that CAR T cells, which are already used to treat certain blood cancers in humans, may also be successful against solid tumors if combined with other immunotherapeutic approaches. (2020-12-31)

E-cigarettes, as consumer products, do not help people quit smoking, study finds
E-cigarette use has risen steeply and mostly without regulation over the past decade. The devices have diversified into a dizzying array of vape pens, tank systems, ''mods,'' and more, mass-marketed and sold to the public. The U.S. Food and Drug Administration (FDA) is in the midst of considering whether to approve thousands of pre-market applications for the sale of e-cigarettes as consumer products. (2020-12-22)

Sex-specific Alzheimer's treatment could benefit males over females
A University of Ottawa study found a specific Alzheimer's treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments. (2020-12-21)

New toolkit aims to improve quality of thrombosis data in COVID-19 trials
The ASH Research Collaborative (ASH RC) and the International Society of Haemostasis and Thrombosis (ISTH), two organizations with multidisciplinary expertise in blood clotting and bleeding disorders, have developed a toolkit to help clinical researchers from across medical disciplines design clinical trials that further the understanding of blood clotting events associated with COVID-19. (2020-12-17)

Two-year study details dynamics of Huntington's disease markers in patients
A new two-year longitudinal study reveals how two proteins linked to Huntington's disease - an incurable neurodegenerative disorder - change over time in patients and in as-yet asymptomatic people who carry a mutation that causes the condition. (2020-12-16)

The Lancet Global Health: Pregnant women excluded from three-quarters of COVID-19 treatment trials
Pregnant women are among those most in need of safe and effective therapies against COVID-19, but they are routinely excluded from the majority of clinical treatment trials, according to authors of an opinion piece based on a review of international trial registry data, published in The Lancet Global Health journal. (2020-12-16)

Clowns may help children cope with the pain and anxiety of hospital treatment
Hospital clowns might help improve physical symptoms and psychological wellbeing in children and adolescents having treatment for acute or chronic conditions, finds a study in the Christmas issue of The BMJ. (2020-12-16)

Study finds paediatric cancer patients at no greater risk of severe COVID-19 infection
Children with cancer who test positive for COVID-19 do not appear to be at an increased risk of severe COVID-19 infection compared to healthy children, according a new UK study. (2020-12-14)

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