Current Cloning News and Events

Current Cloning News and Events, Cloning News Articles.
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Direct cloning method CAPTUREs novel microbial natural products
Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at Illinois previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery. (2021-02-19)

Two new studies investigate the early, potent response of IgA antibodies against SARS-CoV-2
A new study of more than 150 COVID-19 patients shows that IgA antibodies dominate the early response to the SARS-CoV-2 virus, coming on more quickly and strongly than IgG and IgM antibodies. (2020-12-07)

Illuminating tiny proteins in living cells using single-residue labeling tags
SciLifeLab Fellow Simon Elsässer laboratory at Karolinska Institutet reports a method, which allows fluorescent tagging of proteins with the small perturbation -- a single amino acid -- added genetically on either end of a (micro)protein of interest. The method is termed Single-residue Terminal Labeling, STELLA. (2020-11-12)

Sea star's ability to clone itself may empower this mystery globetrotter
The identity of wild cloning sea star larvae has been a mystery since they were first documented in the Caribbean. The most commonly collected cloning species was thought to belong to the Oreasteridae, on the basis of similarity with sequences from Oreaster reticulatus and Oreaster clavatus. (2020-10-12)

Japanese sake: the new pick-me-up? Yeast strain makes fatigue-fighting ornithine
Researchers from the Nara Institute of Science and Technology and the Nara Prefecture Institute of Industrial Development have found that that a mutant strain of sake yeast produces high levels of the amino acid ornithine. Ornithine has been found to reduce fatigue and improve sleep quality, and the non-genetically modified mutant yeast strain discovered in this study could be easily applied to brewing sake, a traditional Japanese alcoholic beverage, as well as wine and beer. (2020-08-27)

Where did the Asian longhorned ticks in the US come from?
The invasive population of Asian longhorned ticks in the United States likely began with three or more self-cloning females from northeastern Asia, according to a Rutgers-led study. Asian longhorned ticks outside the U.S. can carry debilitating diseases. In the United States and elsewhere they can threaten livestock and pets. The new study, published in the journal Zoonoses and Public Health, sheds new light on the origin of these exotic ticks and how they are spreading across the United States. (2020-07-08)

Oncotarget: Tumor suppressor p53 regulates insulin receptor gene expression
Volume 11, Issue 25 of @Oncotarget reported that the present study was aimed at evaluating the hypothesis that p53 governs the expression and activation of the INSR gene in breast cancer cells. (2020-06-23)

June's SLAS Technology highlights papers authored by SLAS2019 Ignite award winner
The June issue of SLAS Technology features two related research papers authored by Georges Muller, Ph.D., (SEED Biosciences, Switzerland) the SLAS2019 Ignite Award winner and a top ten 2020 SLAS Innovation Award finalist. (2020-05-27)

COPD as a lung stem cell disease
Two internationally renowned stem cell researchers at the University of Houston have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. The team, who used single cell cloning of lung stem cells to make their discovery, is now targeting the cells for new therapeutics. (2020-04-15)

USDA-ARS scientists find new tool to combat major wheat disease
Agricultural Research Service (ARS) scientists and their colleagues have discovered a gene that can be used to develop varieties of wheat that will be more resistant to a disease that is a major threat both overseas and to the nation's $10 billion annual wheat crop. (2020-04-10)

Integral molecular announces preclinical P2X7 antibody assets for autoimmune disorders
Integral molecular announces preclinical P2X7 antibody assets for autoimmune disorders. (2020-01-09)

HKUST researchers unlock cancer-causing mechanism of E. coli toxin with synthetic biology approach
An inter-disciplinary team of researchers at the Hong Kong University of Science and Technology (HKUST) unraveled how a toxin released by Escherichia coli (E. coli) - a human gut bacteria, is connected to colorectal cancer, offering new insights to the health impact of this prevalent bacteria and facilitating future research on the prevention of this third most common cancer worldwide*. (2019-09-17)

Newly identified rice gene confers multiple-herbicide resistance
A rice gene that renders the crop resistant to several widely used beta-triketone herbicides has been identified, researchers report, revealing the genetic cause of herbicide susceptibility that has been identified in some important rice varieties. (2019-07-25)

The novel method Nested CRISPR enables efficient genome editing using long DNA fragments
The group of Dr. Cerón at IDIBELL used the model organism Caenorhabditis elegans to optimize the technique, leading to the development of the method called Nested CRISPR. This cloning-free method involves the insertion of long DNA fragments in two steps. (2019-02-07)

Tak Mak lab discovers how the immune system 'thinks'
New research from the laboratory of cancer scientist Dr. Tak Mak, renowned for cloning the human T-cell receptor, has demonstrated that immune cells make brain chemicals to fight off infections. (2019-02-07)

Rapid gene cloning technique will transform crop disease protection
Researchers have pioneered a new method which allows them to rapidly recruit disease resistance genes from wild plants and transfer them into domestic crops. (2019-02-04)

Harvesting wild genes gives crops renewed resistance to disease
A global alliance of researchers has pioneered a new method to rapidly recruit disease-resistance genes from wild plants for transfer into domestic crops. The technique promises to revolutionize the development of disease-resistant varieties for the global food supply. (2019-02-04)

Gene-edited disease monkeys cloned in China
National Science Review, a leading journal from China that reports on significant advances in natural sciences, publishes on-line two research articles in tandem on the generation of macaque monkeys with phenotypes of circadian disorders by gene-editing of monkey embryos, and the generation a group of cloned monkeys using somatic cells from one of the gene-edited monkeys, showing that macaque monkey disease models with uniform genetic background could now be produced for biomedical research. (2019-01-23)

OHSU discovers molecular channel that regulates blood pressure
New research for the first time reveals the three-dimensional structure of a membrane channel that's critical in controlling blood pressure. The findings, published today in the open-access journal eLife, represent the first time the human epithelial sodium channel has been shown so precisely since it was first isolated and described through expression cloning more than two decades ago. (2018-09-25)

Australian, UK scientists solve 30-year wheat rust genetics puzzle
Researchers have isolated the first major resistance genes against the stripe rust disease that is devastating wheat crops worldwide. The breakthrough by the scientists, who have cloned three related rust resistance genes -- called Yr7, Yr5, and YrSP -- will enable these important genes to be accurately monitored and integrated into breeding programs in the fight against ever-changing pathogens that can kill about 70 percent or more of whole wheat crops at a time. (2018-08-27)

Scientists surmount epigenetic barriers to cloning with two-pronged approach
An international group of researchers have raised the viability of mice that were cloned using a method called somatic cell nuclear transfer, by stimulating two epigenetic factors, and by doing this have shown that creating cloned animals more efficiently will require further work in the area of epigenetics. They have also uncovered a key epigenetic mechanism that appears to be a major impediment to the development of the fetus after implantation. (2018-07-19)

Polyps will let unrelated 'others' fuse to them and share tissue, scientists discover
University of Kansas scientists discovered that polyps have no qualms about treating a nonrelated individual like part of the family. This goes way beyond sharing meals or even a roof. Polyps of the marine hydrozoan Ectopleura larynx allow nonrelated individuals to fuse their bodies to the familial colony and share what is essentially skin and a stomach. The findings appeared yesterday in the journal Evolution Letters.  (2018-07-12)

Analysis of the 9p21.3 sequence associated with coronary artery disease
Before a conclusive link between the SDs and the cardiovascular diseases can be made, further analysis is required on the CAD interval in more patients with coronary artery disease and in the human population, using the TAR cloning technique in combination with qPCR or Droplet digital PCR developed in this work. (2018-03-26)

Diet or Regular? Decoding behavioral variation in ant clones
Clonal ants appear to be diverse in responding to sweetened water, suggesting epigenetic regulation in behavioral variation and colony survival. (2018-02-20)

Approximate quantum cloning: The new way of eavesdropping in quantum cryptography
Cloning of quantum states is used for eavesdropping in the context of quantum cryptography or for quantum computation. Uncertainty at the quantum scale makes exact cloning of quantum states impossible. Yet, they may be copied in an approximate way using a method called probabilistic quantum cloning, or PQC. In a new study published in EPJ D, Pinshu Rui from Anhui Xinhua and Anhui Universities, Hefei, China, and colleagues demonstrate that partial PQC is possible. (2018-02-20)

Diet or regular? Decoding behavioral variation in ant clones
Clonal ants appear to be diverse in responding to sweetened water, suggesting epigenetic regulation in behavioral variation and colony survival. (2018-02-13)

Active genetics technology opens new horizons
Employing CRISPR/Cas9 advancements, UC San Diego researchers are using new active genetics technology to reveal new fundamental mechanisms that control gene activity. The authors also provide experimental validation for using active genetics as an efficient means for targeted gene insertion, or 'transgenesis,' and single-step replacement of genetic control elements. (2018-02-06)

Meet Zhong Zhong and Hua Hua, the first monkey clones produced by method that made Dolly
The first primate clones made by somatic cell nuclear transfer are two genetically identical long-tailed macaques born recently at the Chinese Academy of Sciences Institute of Neuroscience in Shanghai. Researchers named the newborns Zhong Zhong and Hua Hua after the Chinese adjective 'Zhonghua,' which means Chinese nation or people. The technical milestone, presented in the journal Cell, makes it a realistic possibility for labs to conduct research with customizable populations of genetically uniform monkeys. (2018-01-24)

Breakthrough enables screening millions of human antibodies for new drug discovery
A new paper in Nature Biotechnology outlines a pioneering method of screening a person's diverse set of antibodies for rapid therapeutic discovery. Antibody proteins are an important part of the human immune system that specifically target foreign viruses and bacteria, and they have been the fastest-growing class of approved drugs in the past several decades. (2018-01-17)

Radiographs of Dolly's skeleton show no signs of abnormal osteoarthritis
Original concerns that cloning caused early-onset osteoarthritis in Dolly the sheep are unfounded, say experts at the University of Nottingham and the University of Glasgow. The team, who published last year's Nottingham Dollies research which showed that the 8 year-old Nottingham 'Dollies' had aged normally, have now published a radiographic assessment of the skeletons of Dolly herself, Bonnie (her naturally conceived daughter) and Megan and Morag (the first two animals to be cloned from differentiated cells). (2017-11-23)

AI uses less than two minutes of videogame footage to recreate game engine
Game studios and enthusiasts may soon have a new tool at their disposal to speed up game development and experiment with different styles of play. Georgia Institute of Technology researchers have developed a new approach using an artificial intelligence to learn a complete game engine, the basic software of a game that governs everything from character movement to rendering graphics. (2017-09-11)

Scientists discover powerful potential pain reliever
Chemists have discovered a powerful pain reliever that acts on a previously unknown pain pathway. The compound is as effective at relieving neuropathic pain in injured mice as a drug widely used for pain relief called gabapentin. If they can demonstrate that it is safe, effective and nonaddictive in humans -- a process that typically takes years -- the discovery could address one of today's biggest public health challenges: the opioid abuse epidemic. (2017-08-16)

Powerful new technique can clone thousands of genes at once
Scientists at Johns Hopkins, Rutgers, the University of Trento in Italy, and Harvard Medical School report they have developed a new molecular technique called LASSO cloning, which can be used to isolate thousands of long DNA sequences at the same time, more than ever before possible. (2017-07-05)

Cloning thousands of genes for massive protein libraries
Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists at Rutgers University-New Brunswick in collaboration with Johns Hopkins University and Harvard Medical School have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics. (2017-06-26)

Why does so much of nature rely on sex for reproduction?
Why is sex so popular among plants and animals, and why isn't asexual reproduction, or cloning, a more common reproductive strategy? (2017-05-04)

New hope in the fight against superbugs
In a new paper published in the journal Structure, researchers from McGill University present in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class of antibiotics and an alternative medication for patients with penicillin allergies. The study shows for the first time how these kinases recognize and chemically destroy macrolide antibiotics. (2017-05-03)

How can a legally binding agreement on human cloning be established?
Since Dolly the Sheep was cloned, the question of whether human reproductive cloning should be banned or pursued has been the subject of international debate. Adèle Langlois, of the University of Lincoln, UK, argues that a robust global governance framework on human cloning should draw on recent successes in climate change and business ethics for inspiration. The report is published in Springer Nature's open access journal Palgrave Communications. (2017-03-21)

FASEB Science Research Conference: Glucose Transport: Gateway for Metabolic Systems Biology
This SRC will provide a lively mix of glucose transporter biology, metabolic regulation, and systems biology methods with multiple lectures that feature disease translational themes. (2017-02-28)

How do we regulate advanced technologies along social or ethical lines?
Society faces several new and powerful technologies that could alter the human trajectory into the future and, the public wants clear guidelines as to how these technologies like gene editing are managed to ensure they are used safely. But the public's wariness with these new technologies is largely based on ethical, religious and social concerns, rather than concerns about safety or efficacy, which is what regulatory agencies are limited to consider. (2017-02-17)

Protecting quantum computing networks against hacking threats
As we saw during the 2016 US election, protecting traditional computer systems, which use zeros and ones, from hackers is not a perfect science. Now consider the complex world of quantum computing, where bits of information can simultaneously hold multiple states beyond zero and one, and the potential threats become even trickier to tackle. Researchers at the University of Ottawa have uncovered clues that could help administrators protect quantum computing networks from external attacks. (2017-02-03)

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