Current Cocaine News and Events

Current Cocaine News and Events, Cocaine News Articles.
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Incentivizing vaccine adherence: could it be the key to achieving herd immunity?
To achieve success, experts estimate that at least 70 to 90 percent of the population must be inoculated with a COVID-19 vaccine to achieve herd immunity, but how can we ensure folks will voluntarily receive a vaccine? An examination of scientific evidence on incentivizing vaccine adherence found that modest financial incentives resulted in as much as a 7-fold increase in adherence compared to no incentives. (2021-01-20)

Novel anti-craving mechanism discovered to treat cocaine relapse
Cocaine continues to be one of the most commonly abused illicit drugs in the United States. Pre-clinical literature suggests that targeting glucagon-like peptide-1 receptors (GLP-1Rs) in the brain may represent a novel approach to treating cocaine use disorder. Specifically, GLP-1R agonists, which are FDA-approved for treating diabetes and obesity, have been shown to reduce voluntary drug taking and seeking in preclinical models of cocaine used disorder. (2020-12-07)

Circadian gene mutation increases self-administration of cocaine in mice
University of Pittsburgh researchers reveal a molecular basis for the deep and fundamental connection between the disruption in circadian rhythms and predisposition to substance abuse. (2020-12-02)

Study: Opioid overdose deaths involving other substances more common in youth
Results of a new study show that opioid overdose deaths involving more than one substance (polysubstances) are more common than opioid-only overdose deaths among youth. Led by researchers at Boston Medical Center's Grayken Center for Addiction, the data shows that cocaine and other stimulants like crystal methamphetamine are the substances most commonly involved in opioid overdose deaths in young people between the ages of 13 and 25. (2020-11-23)

Sleep-deprived mice find cocaine more rewarding
Sleep deprivation may pave the way to cocaine addiction. Too-little sleep can increase the rewarding properties of cocaine, according to new research in mice published in eNeuro. (2020-11-02)

Nucleus accumbens recruited by cocaine, sugar are different
In a study using genetically modified mice, a University of Wyoming faculty member found that the nucleus accumbens recruited by cocaine use are largely distinct from nucleus accumbens recruited by sucrose, or table sugar. Because they are separate, this poses the possibility that drug use can be addressed without affecting biologically adaptive seeking of reward. (2020-10-28)

Motivation to seek cocaine is driven by elegant cellular communication
In response to cocaine, the connections between neurons, or brain cells, strengthen due to signaling that starts outside those cells, report researchers at the Medical University of South Carolina and the National Institutes of Health in the Journal of Neuroscience. The strengthening of neuronal connections makes it more difficult to stop seeking drugs. These results provide potentially targetable molecules for treatment of addiction to prevent relapse. (2020-10-28)

Astrocytes build synapses after cocaine use in mice
Drugs of abuse, like cocaine, are so addictive due in part to their cellular interaction, creating strong cellular memories in the brain that promote compulsive behaviors. A new study shows that cocaine use in mice leads to the formation of synapses by an unexpected architect: a type of cell called astrocytes. (2020-10-15)

Cocaine addiction: Impact of genetic mutations elucidated
Cocaine addiction is a chronic disorder with a high rate of relapse for which no effective treatment is currently available. Scientists from the Institut Pasteur, the CNRS, Inserm and the Paris Public Hospital Network (AP-HP) recently demonstrated that two gene mutations involved in the conformation of nicotinic receptors in the brain appear to play a role in various aspects of cocaine addiction. (2020-09-25)

LBG individuals use stimulants at higher rates than heterosexuals
Lesbian, gay and bisexual (LGB) individuals report higher rates of medical, non-medical, and illegal stimulant use compared to heterosexuals, mirroring patterns seen in other substance use. The study by Columbia University Mailman School of Public Health researchers provides the most detailed picture to date on stimulant use by LGB subgroups and gender. Findings are published in the American Journal of Preventive Medicine. (2020-09-24)

College students with disabilities at greater risk for substance abuse
College students with physical and cognitive disabilities use illicit drugs more, and have a higher prevalence of drug use disorder, than their non-disabled peers, according to a Rutgers study. (2020-09-21)

Clubs closed? Study finds partygoers turn to virtual raves and happy hours during pandemic
People have traded in nightclubs and dance festivals for virtual raves and Zoom happy hours as a result of lockdowns during the COVID-19 pandemic--yet, many are using drugs in these socially distanced settings, according to a new study by researchers at NYU Grossman School of Medicine and the Center for Drug Use and HIV/HCV Research at NYU School of Global Public Health. (2020-08-26)

Heavy class A drug use linked to heightened risk of sight loss in US military
Heavy use of class A drugs, such as heroin, methamphetamine, or cocaine is linked to a heightened risk of partial or total blindness among US military personnel, finds research published online in the journal BMJ Military Health. (2020-08-13)

Remember the first time you...? Mysterious brain structure sheds light on addiction
Do you remember where you were when you first heard that two planes had crashed into New York's Twin Towers? Or where you had your first kiss? Our brains are wired to retain information that relates to the context in which highly significant events occurred. This mechanism also underlies drug addiction and is the reason why hanging out in an environment or with people associated with memories of drug use often leads to relapse. (2020-07-23)

A complex gene program initiates brain changes in response to cocaine
Researchers used single-nucleus RNA sequencing to compare transcriptional responses to acute cocaine in 16 unique cell populations from the brain nucleus accumbens. The atlas is part of a major study that used multiple cutting-edge technologies to describe a dopamine-induced gene expression signature that regulates the brain's response to cocaine. The study shows neurobiological processes that control drug-related adaptations and reveals new information about how transcriptional mechanisms regulate activity-dependent processes within the central nervous system. (2020-07-09)

Motherhood overrides the brain's decision-making
Motherhood takes over the brain's decision-making regions to prioritize caring for offspring, according to new research in rats published in eNeuro. (2020-07-06)

Some people are easily addicted to drugs, but others do not
Research team led by Prof. Joung-Hun Kim and Dr. Joo Han Lee of POSTECH and Dr. Ja Wook Koo of KBRI publishes new findings in Biological Psychiatry (2020-06-02)

New molecule stops drug cravings in mice, with fewer side effects
Duke University researchers have developed a synthetic molecule that selectively controls the physiological rewards of cocaine in mice. It also may represent a new class of small-molecule drugs that are more specific and have fewer side effects. The molecule selectively activates beta-arrestin without activating the G protein, making its signal to the cell much more specific. (2020-05-28)

Nordic countries struggle with a severe drug overdose problem
Despite the fact that the Nordic countries are often seen as ideal in practically every global ranking of quality of life and social equality, the number of drug-related deaths in these countries are among the highest in Europe. (2020-05-27)

Job skills training leads to long-term reduction in drug abuse
Job skills training for low-income youth does more than just help them get better jobs - it makes them significantly less likely than others to use some illicit drugs, even 16 years later. (2020-05-13)

Less addictive form of buprenorphine may help curb cocaine relapse
New research performed in mice suggests that chemical modifications to buprenorphine can improve its effectiveness to treat cocaine addiction while minimizing abuse potential. (2020-04-27)

New study could lead to therapeutic interventions to treat cocaine addiction
A new study explains how cocaine modifies functions in the brain revealing a potential target for therapies aimed at treating cocaine addiction. The study was published this week in Cell Reports. (2020-04-22)

Extra payments motivate sobriety and employment among people recovering from addiction
After a yearlong study of people with opioid dependence, Johns Hopkins Medicine researchers report evidence that adding $8 an hour to their paychecks may help those in recovery stay drug free longer, as well as encourage them to get and hold regular jobs. (2020-04-20)

Early exposure to cannabis boosts young brains' sensitivity to cocaine, rodent study finds
Cannabis use makes young brains more sensitive to the first exposure to cocaine, according to a new study on rodents led by scientists at Columbia University and the University of Cagliari in Italy. By monitoring the brains of both adolescent and adult rats after giving them synthetic psychoactive cannabinoids followed by cocaine, the research team identified key molecular and epigenetic changes that occurred in the brains of adolescents -- but not adults. (2020-04-20)

New York nightlife venues recruited in effort to prevent overdoses due to fentanyl
Bars and nightclubs are a promising site for efforts to increase awareness of the risk of opioid overdose due to fentanyl-laced cocaine, suggests a study in the Journal of Public Health Management and Practice (JPHMP). The journal is published in the Lippincott portfolio by Wolters Kluwer. (2020-04-16)

Mount Sinai researchers discover a novel role for dopamine that impacts gene expression related to cocaine abuse
Scientists at the Icahn School of Medicine at Mount Sinai have discovered a new role for the brain chemical dopamine that is independent of classic neurotransmission. The new role appears to be critical to changes in gene expression related to chronic exposure to, or abuse of, cocaine, according to a study published Friday, April 10, 2020 in the journal Science. (2020-04-09)

Study shows rising age of first drug use in teens, young adults
The average age at which teens and young adults start using drugs has been rising, according to a study published in JAMA Pediatrics. The study examined changes in the average age of first drug use for 18 different drugs--including alcohol and tobacco products--between 2004 and 2017 and found that average ages had increased for the majority of those drugs. (2020-03-02)

Experimental fingerprint test can distinguish between those who have taken or handled cocaine
An experimental fingerprint detection approach can identify traces of cocaine on human skin, even after someone has washed their hands -- and the test is also smart enough to tell whether an individual has actually consumed the class A drug, or simply handled it. (2020-02-06)

Chemicals between us: Surprising effects of oxytocin on cocaine addiction
Medical University of South Carolina researchers have discovered gender-based differences in response to therapeutic oxytocin treatment in cocaine-addicted individuals with a history of childhood trauma. Oxytocin has been shown previously to function as a potential therapeutic in cases of addiction by reducing cravings. This study found that only men with past trauma had a reduction in cravings after oxytocin. Surprisingly, women with past trauma had a greater response to visual drug cues following oxytocin. (2020-01-15)

Study contests use of smoked cannabis in treatment of cocaine addiction
Researchers in Brazil evaluated cocaine and crack addicts undergoing rehabilitation for six months and observed a higher relapse rate and worse cognitive impairment among patients who smoked cannabis to try to mitigate their craving for cocaine. (2020-01-15)

Study examines opioid involvement in US drug overdoses
A recent analysis published in Addiction reveals how fatal overdoses involving stimulants (cocaine and other psychostimulants, primarily methamphetamine) have been increasing over the past few years. (2020-01-08)

Mayo Clinic researchers pursue single-dose gene therapy to treat cocaine addiction
In a radical new approach to treat cocaine addition, researchers at the Mayo Clinic are seeking approval for first-in-human studies of a single-dose gene therapy. (2020-01-07)

Regional trends in overdose deaths reveal multiple opioid epidemics, according to new study
A recently published study shows the United States in the grip of several simultaneously occurring opioid epidemics, rather than just a single crisis. The epidemics came to light after the researchers analyzed county-level data on drug overdose deaths. The study highlights the importance of different policy responses to the epidemics rather than a single set of policies. (2019-12-09)

New protein function could be key to treatment of drug addiction and behavioral disorders
The reward pathway of the brain causes feelings of happiness but is also involved in behavioral disorders like schizophrenia and addiction. A breakthrough study by scientists in Japan has now identified the role of a protein called Npas4 in the reward pathway, mediated by the well-known proteins MAPK and CBP, opening doors to potential therapies for associated disorders. Cocaine-treated mice with inactivated Npas4 exhibited considerable reduction in cocaine-seeking behavior, emphasizing the relevance of the protein. (2019-12-05)

Relevant social stimuli may reduce interest in drugs
Researchers of the Faculty of Psychology of the University of Malaga (UMA), specialized in addictive disorders, have demonstrated in an animal model that the presence of a relevant social stimulus reduces interest in cocaine. (2019-11-15)

Injection drug use: a new study shows a mixed Canadian portrait
In Canada, 171,900 people injected drugs in 2016, up from 130,000 in 2011. In a study published in the American Journal of Public Health, researchers at the University of Montreal Hospital Research Centre (CRCHUM) estimated, using multiplier methods, the number of people who injected drugs in 11 of the 13 Canadian provinces (Nunavut and Northwest Territories not included) and reported a 30-per-cent increase in the period studied. (2019-11-14)

Seeing past the stigma
Plants of the genus Erythroxylum are mainly known due to their use either in Coca Cola or as the drug cocaine. The controversial cultivation of the plants is an important income source for many farming communities in South American countries. A new interdisciplinary review now highlights the domestication history of the genus and examines numerous possible positive use cases of Erythroxylum, e.g. as medicines. (2019-11-14)

Drug dust
Researchers at Harvard University and the Drug Enforcement Administration have designed a promising new tool that can identify smaller concentrations of drug powders than any other device. Portable, simple to use, and cost effective, the technology could provide law enforcement officers and forensic chemists a quick and accurate way to identify unknown, potentially dangerous, substances. (2019-11-12)

Fingerprint test can distinguish between those who have taken or handled heroin
A state-of-the-art fingerprint detection technology can identify traces of heroin on human skin, even after someone has washed their hands -- and it is also smart enough to tell whether an individual has used the drug or shaken hands with someone who has handled it. (2019-11-11)

Study: A mother's warmth, sensitivity can mitigate obesity risk factors in infants
An ongoing longitudinal University at Buffalo study being presented Nov. 5, 2019 in Las Vegas at ObesityWeek is among the first to explore how mother-infant behaviors during feeding and active play (non-feeding situations) affect infants and children in families with low socioeconomic status. (2019-11-05)

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