Current Colitis News and Events

Current Colitis News and Events, Colitis News Articles.
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First multi-whole-genome study of IBD in African Americans
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. (2021-02-19)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Surgery to heal inflamed gut may create new target for disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. (2021-02-02)

Scientists find key function of molecule in cells crucial for regulating immunity
UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in autoimmune diseases. (2021-01-28)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation
The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, a detailed understanding of the intestinal stem cell lineage and the signals regulating the recruitment of intestinal cell types is critical. (2021-01-11)

Researchers engineer novel disease model to identify potential targets for ulcerative colitis drugs
As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression. (2021-01-11)

Potential preventative treatment demonstrated for Crohn's disease
A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease. (2020-12-21)

UBCO researchers suggest stool transplants can battle serious infections
Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (2020-12-09)

Research reveals how a fungal infection activates inflammation
Scientists at St. Jude Children's Research Hospital have shed light on the mechanisms that underlie how Aspergillus fumigatus activates the inflammasome, with implications for therapeutic development. (2020-12-02)

Vitamin D regulates calcium in intestine differently than previously thought
A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (2020-12-01)

Genetic risk for fatal blood clots identified in IBD patients
In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases. (2020-11-11)

Therapeutic drug monitoring does not improve remission for patients starting infliximab
New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care. (2020-11-06)

COVID-19: Enzyme targeted by virus also influences gut inflammation
An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the possibility that anti-inflammatory drug therapies for IBD may aid recovery from coronavirus. (2020-11-05)

High-sugar diet can damage the gut, intensifying risk for colitis
DALLAS - Oct. 28, 2020 - Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut's protective mucus layer. (2020-10-28)

Severe form of Inflammatory Bowel Disease linked to a strain of mouth bacteria
Bacteria from the mouth could hold clues to understanding - and potentially treating - severe ulcerative colitis, a painful bowel disease. (2020-10-28)

Discoveries reshape understanding of gut microbiome
The findings redefine how the so-called gut microbiome operates and how our bodies coexist with some of the 100 trillion bacteria that make it up. The discoveries could lead to new therapies for inflammatory bowel disease and people who've had portions of their bowels removed due to conditions like colon cancer and ulcerative colitis. They also help explain why the use of antibiotics can create a multitude of problems in the digestive system. (2020-10-22)

Multi-mucus barrier segregates colon microbiota from host tissue
Whole-colon imaging in mice has revealed a continuous colonic mucus system, which forms a protective barrier between potentially harmful gut microbiota and host tissue by encapsulating fecal pellets as they form and as they are eliminated from the colon. (2020-10-22)

Treatment for inflammatory bowel disease doesn't always work; new study uncovers why
In preclinical study, researchers at Children's Hospital Los Angeles uncover role for TNF, the most common target in Inflammatory Bowel Disease. Results pave way for better understanding of how TNF functions in normal intestinal development and provide foundation for future new therapies. (2020-10-20)

Protein that keeps immune system from freaking out could form basis for new therapeutics
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction and supports a mechanism critical for survival in mouse models of sepsis and colitis, according to a UC San Diego study. (2020-10-14)

Drug found to correct gene defect that causes immune-driven gut leakiness
A team of researchers led by biomedical scientist Declan McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis and ulcerative colitis, can repair permeability defects in the intestine. ''Our work could help improve identification of patients who will be better responders to this drug,'' says McCole, a professor of biomedical sciences in the School of Medicine. (2020-09-29)

Cell therapy designed to treat inflammatory bowel disease
The UPV/EHU's NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. Biomaterials, a leading journal in the field of materials sciences and medicine, has just published the paper 'Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells'. (2020-09-28)

Team develops wearable sensor to help people with inflammatory bowel disease
University of Texas at Dallas researchers have designed a wearable device that monitors sweat for biomarkers that could signal flare-ups of inflammatory bowel disease (IBD). A team of bioengineers demonstrated the wristwatch-like device in a proof-of-concept study funded by the Crohn's & Colitis Foundation and published online July 28 and in the October print edition of the foundation's journal, Inflammatory Bowel Diseases. (2020-09-28)

University of South Carolina study reveals how cannabinoids may be useful to prevent colon cancer
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are caused by inflammation of the gastrointestinal tract. Patients with IBD are at a higher risk of developing colorectal cancer. A UofSC study shows that THC suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. (2020-09-15)

Researchers identify enzyme linked to colitis
An enzyme that usually stops bacterial growth in the large intestine stimulates inflammation in some people, resulting in ulcerative colitis - a chronic digestive disease. The gut enzyme lysozyme which normally functions to restrain bacterial growth, instead stimulates inflammation and results in the formation of ulcers and sores. (2020-08-18)

Antibiotics associated with increased risk of inflammatory bowel disease
Antibiotics use, particularly antibiotics with greater spectrum of microbial coverage, may be associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes ulcerative colitis and Crohn's disease. That is according to a study by researchers at Karolinska Institutet in Sweden and Harvard Medical School in the United States, published in The Lancet Gastroenterology & Hepatology. The association between antimicrobial treatment and IBD remained when patients were compared with their siblings. (2020-08-17)

Enzyme discovered in the gut could lead to new disease biomarker
Enzymes used by bacteria to break down mucus in the gut could provide a useful biomarker for intestinal diseases, according to new research published in Nature Communications. (2020-08-11)

Antibiotics use early in life increases risk of inflammatory bowel disease later in life
Even short, single antibiotic courses given to young animals can predispose them to inflammatory bowel disease (IBD) when they are older, according to Rutgers researchers. The study, published in Genome Medicine, provides further evidence supporting the idea that the use of antibiotics in children under 1 year old disrupts the intestinal microbiota - the trillions of beneficial microorganisms that live in and on our bodies - that play a crucial role in the healthy maturation of the immune system and the prevention of diseases. (2020-07-28)

ASCRS issues updated guidelines on surgery for Crohn's disease
Although rates of surgery for Crohn's disease have decreased over the years, many patients still require surgical treatment - due to inadequate responses to medical therapy, severe attacks of acute colitis, and many other situations. Reflecting the latest research evidence and clinical practice, an updated set of recommendations for surgery in patients with Crohn's disease have been published in Diseases of the Colon & Rectum (DC&R), the official journal of the American Society of Colon and Rectal Surgeons (ASCRS). (2020-07-23)

How to repair your gut
In a world first, Monash University researchers have identified a key biomolecule that enhances the repair of your gut lining by prompting stem cells to regenerate damaged tissue. (2020-07-20)

Gut Piezo1 regulates gut and bone homeostasis via RNA sensing.
Gut enterochromaffin cells regulate gut and bone homeostasis via serotonin production. A recent report suggested that gut microbes regulate serotonin levels, but the underlying molecular mechanisms are unexplored. Here, Piezo1 is reported to be crucial for serotonin production from gut. Researchers discovered that bacterial derived RNA could activate Piezo1, leading to the production of serotonin from enterochromaffin cells, and that the RNA-Piezo1 axis could be an important target for treatment of bone and gut disorders. (2020-07-07)

Location, location, location -- Even gut immune response is site-specific
Researchers at W├╝rzburg University are using mini-organs to model the digestive tract in the laboratory. These so-called organoids provide insights into the inflammatory processes that play a role in diseases such Crohn's and ulcerative colitis. (2020-07-03)

Vitamin D may help prevent a common side effect of anti-cancer immunotherapy
New research published in CANCER indicates that taking vitamin D supplements may help prevent a potentially serious side effect of a revolutionary form of anti-cancer therapy. (2020-06-22)

Could the cure for IBD be inside your mouth?
A new collaborative study from the U-M Medical and Dental Schools reveals that inflammatory bowel disease (IBD) may be the latest condition made worse by poor oral health via a clash between the mouth and gut microbiomes. (2020-06-16)

AGA does not recommend the use of probiotics for most digestive conditions
After a detailed review of available literature, the American Gastroenterological Association (AGA) has released new clinical guidelines finding that for most digestive conditions there is not enough evidence to support the use of probiotics. This is the first clinical guideline to focus on probiotics across multiple GI diseases while also considering the effect of each single-strain or multi-strain formulation of probiotics independently instead of grouping them all under the single umbrella of 'probiotics.' These guidelines are published in Gastroenterology, AGA's official journal. (2020-06-09)

Yes, inflammatory bowel disease and celiac disease are linked
A systematic review and meta-analysis that has determined there is a nine-fold increased risk of having IBD for patients with a previous diagnosis of celiac disease. Similarly, the risk for celiac disease is increased in IBD patients, though to a smaller extent. (2020-05-13)

Uncovering how 'dark matter' regions of the genome affect inflammatory diseases
A study led by researchers at the Babraham Institute in collaboration with the Wellcome Sanger Institute has uncovered how variations in a non-protein coding 'dark matter' region of the genome could make patients susceptible to complex autoimmune and allergic diseases such as inflammatory bowel disease. Published in the leading scientific journal Nature, the research identifies a new potential therapeutic target for the treatment of inflammatory diseases. (2020-05-13)

Management of inflammatory bowel diseases: Clinical perspectives
In a new special issue of Clinical Gastroenterology and Hepatology, the clinical practice journal of the American Gastroenterological Association (AGA), leading international experts provide a comprehensive update on the treatment of inflammatory bowel diseases (IBD) for the practicing clinician (2020-05-06)

Researchers find certain foods common in diets of US adults with inflammatory bowel disease
Foods, such as French fries, cheese, cookies, soda, and sports and energy drinks, are commonly found in the diets of United States adults with inflammatory bowel disease, according to a new study by researchers in the Institute for Biomedical Sciences at Georgia State University. (2020-05-06)

Researchers reveal important genetic mechanism behind inflammatory bowel disease
Researchers at Children's Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target. (2020-04-09)

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