Current Colon Cancer News and Events

Current Colon Cancer News and Events, Colon Cancer News Articles.
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Cancer deaths attributable to cigarette smoking in 152 US metropolitan and micropolitan areas
A new study shows 4 in 10 cancer deaths are attributable to cigarette smoking in parts of the South region and Appalachia. (2021-01-26)

TGen-led study results suggest more accurate diagnostic for breast cancer
Patrick Pirrotte, Ph.D., an Assistant Professor and Director of TGen's Collaborative Center for Translational Mass Spectrometry, and an international team of researchers developed a test that can detect infinitesimally small breast cancer biomarkers that are shed into the bloodstream from cells surrounding cancer known as extracellular matrix (ECM), according to the findings of their study recently published in the scientific journal Breast Cancer Research. (2021-01-26)

University of Cincinnati research unveils possible new combo therapy for head and neck cancer
Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they're using a Food and Drug Administration-approved drug to do it, this could help people sooner than later. (2021-01-22)

Strange colon discovery explains racial disparities in colorectal cancer
The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer - the cancer that killed beloved 'Black Panther' star Chadwick Boseman at only 43. (2021-01-21)

New, simplified genetic test effectively screens for hereditary cancers
Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers. This alternative to complex, multi-step testing workflows can also determine causes of MMR deficiency often missed by current clinical tests. Their results are presented in The Journal of Molecular Diagnostics, published by Elsevier. (2021-01-21)

Study updates breast cancer risk estimates for women with no family history
A new multi-institution study led by Fergus Couch, Ph.D., a Mayo Clinic pathologist, provides more accurate estimates of breast cancer risk for U.S. women who harbor inherited mutations in breast cancer predisposition genes. The findings of the CARRIERS Consortium study, published Jan. 20 in The New England Journal of Medicine, may allow health care providers to better assess the risk of breast cancer in women ? many of whom have no family history of breast cancer. (2021-01-21)

Reviving exhausted immune cells to fight cancer
Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study led by UT Southwestern researchers suggests. The findings, published online this week in the Journal for Immunotherapy of Cancer, could offer a new way to harness the body's immune system to attack cancers. (2021-01-20)

Target of new cancer treatment valid for breast as well as blood cancers: study
Newly published research shows that a new anti-cancer drug developed at the University of Alberta, set to begin human trials this year, may work against breast cancer as well as blood cancer. (2021-01-20)

Cancer-related suicide declined in the US during the past two decades
Despite increases in overall suicide rates in the United States during the past two decades, cancer-related suicides declined by 2.8% per year, according to a new study by the American Cancer Society. (2021-01-19)

Single-cell test can reveal precisely how drugs kill cancer cells
Researchers from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have developed a method named D2O-probed CANcer Susceptibility Test Ramanometry (D2O-CANST-R) to see, at single-cell/organelle level, how pharmaceuticals induce cancer cell death and how cancer cells adapt. (2021-01-19)

Report shows alcohol consumption linked to portion of cancer incidence and mortality
A new study finds that alcohol consumption accounts for a considerable portion of cancer incidence and mortality in all 50 states and the District of Columbia. (2021-01-19)

Esophageal cancer patients show abundance of oral pathogens
DNA from various oral bacterial pathogens has been found in tumors from esophageal cancer patients. Researchers led by Tokyo Medical and Dental University (TMDU) examined bacterial pathogens in plaque and saliva from esophageal cancer patients, determining that a prevalence of three species in particular, along with alcohol consumption, is associated with a high risk of esophageal cancer. Screening of oral pathogens could therefore be used for early disease detection. (2021-01-14)

Cancer models created by mechanical engineers offer new insight into tumor growth
In research published today in Integrative Biology, a team of engineers from Rensselaer developed an in vitro -- in the lab -- lymphatic vessel model to study the growth of tumor emboli, collections of tumor cells within vessels that are often associated with increased metastasis and tumor recurrence. (2021-01-14)

Deep learning helps predicting occult peritoneal metastasis in stomach cancer
A new study led by the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences shows that deep learning can help predicting the occult peritoneal metastasis in stomach cancer. It provides a novel and noninvasive approach for stomach cancer patients and may inform individualized surgical management of stomach cancer. (2021-01-07)

Gut microbe may promote breast cancers
A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. (2021-01-06)

In-utero exposures associated with increased risk of thyroid cancer
A recent study shows that thyroid cancer is related to in-utero exposures. (2021-01-05)

COVID-19's impact on cancer prevention and control in Africa
When the COVID-19 pandemic reached Africa, the continent was already struggling to deal with another public health crisis - a growing cancer epidemic characterized by more than one million new cancer cases and nearly 700,000 deaths per year. (2020-12-31)

Triple chemotherapy combination improves metastatic colorectal cancer outcomes
Researchers from SWOG Cancer Research Network, a cancer clinical trials group funded by the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that a triple drug combination -- of irinotecan, cetuximab, and vemurafenib -- is a more powerful tumor fighter and keeps people with metastatic colon cancer disease free for a significantly longer period of time compared with patients treated with irinotecan and cetuximab. (2020-12-23)

The Achilles' heel of cancer stem cells
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. (2020-12-21)

Loss of anti-tumor protein may cause resistance to certain cancer therapies
The absence of a protein that works to prevent tumor formation may explain why some patients are resistant to a common cancer therapy, according to Penn State College of Medicine researchers. They said that testing cancers for the presence of this protein may help clinicians identify patients who may be resistant to or relapse when treated with the therapy. (2020-12-21)

Oral contraceptive pills protect against ovarian and endometrial cancer
A comprehensive study from Uppsala University, involving more than 250,000 women, shows that oral contraceptive use protects against ovarian and endometrial cancer. The protective effect remains for several decades after discontinuing the use. The study is published in the journal Cancer Research. (2020-12-17)

Incidence of esophageal adenocarcinoma is increasing in younger adults
Esophageal adenocarcinoma is occurring more frequently in adults under age 50, and these younger adults are more likely to be diagnosed at advanced stages. (2020-12-16)

The bull's eye: New modified stem cells can deliver drugs specifically to tumor cells
Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability. Now, researchers from Tokyo University of Science have successfully modified MSCs to deliver large quantities of anti-cancer drugs in a targeted manner to developing cancer cells. (2020-12-16)

SU2C research leads to FDA approval of new first-line treatment for colorectal cancer
The FDA recently approved the immunotherapy drug pembrolizumab as a first-line treatment for patients with certain types of advanced colorectal cancer. This is the 9th FDA approval supported by Stand Up To CancerĀ® (SU2C) research. Patients newly diagnosed with advanced or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer previously would have been prescribed pembrolizumab only after exhausting standard chemotherapy treatments. (2020-12-16)

Study finds paediatric cancer patients at no greater risk of severe COVID-19 infection
Children with cancer who test positive for COVID-19 do not appear to be at an increased risk of severe COVID-19 infection compared to healthy children, according a new UK study. (2020-12-14)

New combination therapy could help fight difficult-to-treat cancers with common mutations
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1. (2020-12-14)

Nearly 72% of Black patients with gynecologic cancer and COVID-19 were hospitalized for the virus compared with 46 percent of non-Blacks
COVID-19 deaths among Black patients with gynecologic cancer disproportionately higher compared to non-Black patients. (2020-12-09)

Study reveals distinct genomic landscape for young adults with appendiceal cancer
The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease. (2020-12-09)

Hydrogen peroxide keeps gut bacteria away from the colon lining
An enzyme in the colon lining releases hydrogen peroxide - a known disinfecting compound- to protect the body from gut microbial communities. Findings from the UC Davis Health study points to the importance of considering a different approach to treating gut inflammation and bacterial imbalance in the colon. (2020-12-09)

New treatment in development for irritable bowel syndrome with constipation
Researchers devised a plan to treat IBS with constipation by delivering chenodeoxycholic acid in a bilayered capsule, finding that this mode of delivery could decrease colon cramping and thus produce a better patient experience. (2020-12-08)

Researchers create framework to help determine timing of cancer mutations
UCLA researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes. (2020-12-07)

Huntsman Cancer Institute researchers identify promising drug combination for melanoma
Researchers at Huntsman Cancer Institute at the University of Utah have identified a potential drug combination to treat uveal melanoma, a type of eye cancer. Lead author Amanda Truong, trainee in the McMahon Lab at HCI and student at the U of U, explains uveal melanoma patients frequently have changes in genes called GNAQ and GNA11, which are key targets for these drugs. This study was published in the journal Clinical Cancer Research. (2020-12-03)

AI predicts which drug combinations kill cancer cells
A machine learning model developed in Finland can help us treat cancer more effectively. (2020-12-01)

Genomic analysis of mako shark reveals genes relating to tumor suppression in humans
Genetic mapping of the shark's liver and eye tissue showed overexpression of nine genes known for action in tumor suppression, wound healing, and probable monochrome vision. The species is considered globally endangered and caught on a large scale by industrial fishing vessels. (2020-12-01)

City of Hope developed cancer-killing virus: activates immune system against colon cancer
A cancer-killing virus that City of Hope scientists developed could one day improve the immune system's ability to eradicate tumors in colon cancer patients, reports a new study in Molecular Cancer Therapeutics. The preclinical research is a first step to showing that City of Hope's oncolytic virus CF33 can target hard-to-treat tumors that 'handcuff' the immune system and keep T cells from activating the immune system to kill cancer cells. (2020-12-01)

AI-based 'OxyGAN' is a robust, effective method to measure tissue oxygen levels
In a new study published in the Journal of Biomedical Optics, researchers from Johns Hopkins University, Mason T. Chen and Nicholas J. Durr, have proposed an end-to-end technique for accurate calculation of tissue oxygenation from single snapshots, called OxyGAN. (2020-12-01)

Oncotarget launches special collection on breast cancer
Breast Cancer Collection published in honor of breast cancer awareness. (2020-12-01)

Black bear gut biome surprisingly simple, scientists say
In recent decades, researchers have found that most mammals' guts are surprisingly complex environments - home to a variety of microbial ecosystems that can profoundly affect an animal's well-being. Scientists have now learned that the bear appears to be an exception, with its gut playing host to a microbial population that varies little across the intestinal tract. (2020-11-30)

Medicaid expansion may result in earlier diagnosis of colon cancer
The Affordable Care Act's Medicaid expansion for low-income people appears to lead to earlier diagnosis of colon cancer, enhanced access to care, and improved surgical care for patients with this common cancer. (2020-11-23)

Therapeutic PD-1 cancer vaccine shown to be safe and effective in animal study
A study led by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor. (2020-11-23)

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