Current Combination News and Events

Current Combination News and Events, Combination News Articles.
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UCLA study finds combination therapy suppresses pancreatic tumor growth in mice
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). (2021-02-18)

Vets' depression, social support & psychological resilience play role in later well being
Veterans who experienced the combination of low depression, high social support and high psychological resilience as they left military service were most likely to report high well-being a year later. (2021-02-17)

Combination therapy with radiation shows promise in treating glioblastoma
In a study of mice, researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new approach that combines an anti-psychotic drug, a statin used to lower high cholesterol levels, and radiation to improve the overall survival in mice with glioblastoma (2021-02-09)

New combination therapy offers chance of healing hepatitis B
Around 260 million people, more than three percent of the global population, are chronically infected with the hepatitis B virus (HBV); in the long term, this often leads to complications such as liver cirrhosis and liver cancer. A cure is not yet possible with the available medication. Scientists at the German Center for Infection Research (DZIF) and the University Hospital Eppendorf (UKE) have now investigated a new combination therapy that has proven highly effective in their infection model. (2021-02-04)

Safe gun storage counseling and lock distribution could lower military suicide rate
Military members who receive gun locks and lethal means counseling, which focuses on ways to limit a person's access to specific methods for suicide, are more likely to use a gun safe and unload firearms before they are stored, according to the Gun Violence Research Center, based at Rutgers (2020-12-22)

New combination therapy could help fight difficult-to-treat cancers with common mutations
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1. (2020-12-14)

Immunotherapy improves responses w/o reducing quality of life in early breast cancer
Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows. (2020-12-10)

Researchers discover treatment that suppresses liver cancer
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. (2020-12-08)

Drug for rare disorder shows promise for treating herpes viruses
New research shows that the antiviral activity of the drug -- called phenylbutyrate, or PBA -- was even better when used along with acyclovir, a common HSV-1 treatment. When used in combination, less acyclovir is needed to effectively suppress the virus compared to acyclovir alone -- this is important because acyclovir is also known to have toxic side effects in the kidneys. (2020-12-07)

Combined exercise, mindfulness training may help reduce fatigue in cancer survivors
A new study shows that breast cancer survivors may benefit from a combination of exercise and mindfulness training. When used together, the two approaches seem to help reduce fatigue. The preliminary results may help improve intervention techniques used for cancer patients. (2020-12-02)

AI predicts which drug combinations kill cancer cells
A machine learning model developed in Finland can help us treat cancer more effectively. (2020-12-01)

Perspectives of tumor treatment: Researchers investigate combination of carbon ion and immunotherapy
It is still a glance into the future: The combination of carbon ion and immune therapy could become an effective tool in the fight against cancer. Promising results for the potential benefit of this treatment combination have now been published in the journal ''International Journal of Radiation Oncology, Biology, Physics'' of the American Society for Therapeutic Radiation Oncology. The authors are an international team, led by the Biophysics Department at the GSI Helmholtzzentrum für Schwerionenforschung. (2020-11-09)

Immunotherapy combination improves outcomes in advanced kidney cancer
An immunotherapy agent combined with a tyrosine kinase inhibitor drug significantly improved progression-free survival and reduced the risk of death compared to a single agent treatment in advanced kidney cancer patients, according to first results of a phase 3 clinical trial. The pivotal study could lead to a new treatment option for patients with metastatic kidney cancer. (2020-09-19)

Going small for big solutions: sub-nanoparticle catalysts made from coinage elements as effective c
'Sub-nanometer' particles (SNPs) are very popular because of their diverse applications, but technical difficulties in their synthesis has hindered research in this field. Scientists at the Tokyo Institute of Technology (Tokyo tech) used an 'atom-hybridization method' to overcome this barrier they developed to study the reactivity of alloy SNPs made from three coinage metal elements. Their findings are an important step in improving the knowledge about properties of finite elements and help in building a sustainable society. (2020-09-15)

Immunotherapy: Enhancing the therapeutic effectiveness of photothermal cancer treatments
Immune checkpoint blockade is the most promising therapy mode of cancer immunotherapy. But the therapeutic efficiency remains low mainly due to immunosuppression. Near-infrared light can be used to stimulate black phosphorus to produce heat, which can then be a specific immunological stimulator for reversing immunosuppressive tumor microenvironment. The light-induced black phosphorus (BP) nanosystem,combined with anti-CD47 antibody offers significant synergistic antitumor effect and activates local and systemic anti-tumor immunity. (2020-09-15)

Gut microbiota not involved in the incidence of gestational diabetes mellitus
Consuming the combination of fish oil and probiotic food supplements modulate the composition of gut microbiota in overweight and obese pregnant women, reveals a new study conducted at the University of Turku, Finland. The same study shows that gut microbiota composition and function is not related to gestational diabetes. (2020-09-09)

Chemotherapy drug more effective when combined with microbubbles
Hepatocellular carcinoma is usually treated by blocking the flow of blood to the tumor to induce cancer cell death, but the common treatment, transarterial chemoembolization, is invasive and too imprecise to be a local drug delivery method. Aiming to increase the precision, researchers at Tulane University created a treatment that involves vaporizing tiny droplets of perfluorocarbon, a common organic material composed of carbon and fluorine. The method of gas embolization is published in APL Bioengineering. (2020-09-08)

New therapy targets breast cancer metastases in brain
When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targeting breast cancer cells in the brain aren't effective, because they can't cross the blood-brain-barrier. But a new combination therapy targeting breast cancer tumors in the brain dramatically decreased tumor size and increased survival in a preclinical study. (2020-08-26)

New analysis shows hydroxychloroquine does not lower mortality in COVID-19 patients, and is associated with increased mortality when combined with the antibiotic azithromycin
A new meta-analysis of published studies into the drug hydroxychloroquine shows that it does not lower mortality in COVID-19 patients, and using it combined with the antibiotic azithromycin is associated with a 27% increased mortality. The study is published in Clinical Microbiology and Infection. (2020-08-26)

Combination therapy improves survival outcomes for patients with acute myeloid leukemia
A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center. (2020-08-12)

Addition of sintilimab to pemetrexed and platinum improved progression-free survival
The interim analysis of ORIENT-11, a phase III double-blind randomized trial has shown a nearly two-fold increase in progression-free survival with addition of sintilimab to chemotherapy in patients with advanced or metastatic non-squamous non-small cell lung cancer without EGFR or ALK genomic aberrations, according to research data presented today at the International Association for the Study of Lung Cancer Virtual Presidential Symposium. (2020-08-08)

Radboudumc research leads to simplified dosage of HIV medicine for children
Children living with HIV can benefit from an adapted, simpler combination therapy. It is now clear that the use of one, widely available, pill of dolutegravir in children yields equally good treatment results as a combination of several, less readily available pills of that drug. Especially in countries where the number of infections is high and good care is less accessible, this makes it easier to treat children. These results are included in the World Health Organization (WHO) treatment guidelines. (2020-08-04)

Researchers ID new target in drive to improve immunotherapy for cancer
UCLA researchers have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer. (2020-07-21)

High-end microscopy refined
New details are known about an important cell structure: For the first time, two Würzburg research groups have been able to map the synaptonemal complex three-dimensionally with a resolution of 20 to 30 nanometres. (2020-07-01)

The combination of four drugs at low doses is more effective in the treatment of a lu
The study, published in the Nature Communications journal, and led by the Netherlands Cancer Institute (NKI), has had the collaboration of researchers from IDIBELL/ICO and HUB. This study demonstrates the beneficial effect of treatment with a cocktail drug at low doses to block a single signaling pathway in a lung cancer type. (2020-07-01)

Yale Cancer Center study validates combination therapy for aggressive endometrial cancer
Yale Cancer Center (YCC) scientists have found that combining the targeted drug trastuzumab with chemotherapy significantly improves survival rates for women with a rare, aggressive form of endometrial cancer. These results may help to change the standard of care worldwide for the disease. The findings are published today in the journal Clinical Cancer Research. (2020-06-29)

Chemotherapy/immunotherapy combo shows promise for first-line treatment of mesothelioma
Inoperable malignant pleural mesothelioma, is a rare and aggressive cancer of the protective lining of the lungs, or pleura, often caused by exposure to asbestos. (2020-06-11)

University of Cincinnati research points to potential new treatment for pancreatic cancer
As the next step in finding a potential targeted treatment for pancreatic cancer, researchers at the University of Cincinnati are publishing a new study revealing how a combination therapy may improve outcomes for patients with this disease. (2020-06-08)

Ribociclib in breast cancer: Added benefit for certain women after menopause
After expiry of the G-BA decisions, IQWiG reassessed the drug in two combinations. The new data cut-offs used for this purpose confirm both advantages and disadvantages. (2020-06-05)

NUS-led team develops artificial intelligence platform to combat infectious diseases
A research team led by Professor Dean Ho from the National University of Singapore has developed a ground-breaking artificial intelligence platform known as 'IDentif.AI' which can identify optimal drug combination therapies at unprecedented speeds. (2020-04-27)

Drugs considered for COVID-19 can raise risk for dangerous abnormal heart rhythms
As some consider treating coronavirus patients with a combination of the malaria drug hydroxychloroquine and the antibiotic azithromycin, cardiologists are advising caution because both medications can increase the risk for dangerous abnormal heart rhythms, which can in turn lead to cardiac arrest. (2020-04-02)

Two-pronged attack on DNA repair could kill drug-resistant cancers
Launching a two-pronged attack on cancer's ability to safeguard its DNA could offer an effective new way of treating the disease, a new study reports. (2020-03-11)

Study reveals potential new treatment for patients with metastatic melanoma
Researchers at the University of Cincinnati have uncovered a potentially more beneficial treatment regimen for patients with metastatic melanoma. (2020-02-26)

A potential new weapon against deadly brain and soft tissue cancers
Researchers at the USC Viterbi School of Engineering have designed a new drug cocktail that kills some types of brain and soft tissue cancers by tricking the cancer cells to behave as if they were starving for their favorite food -- glucose. The researchers' findings were recently published in the Journal of Biological Chemistry and may pave the way for targeted cancer treatments with greater efficacy and less harmful side effects. (2020-02-20)

Combination drug therapy for childhood brain tumors shows promise in laboratory models
In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas. (2020-02-17)

Trial shows using two drugs not better than one when treating MRSA blood infections
Researchers attempting to improve the treatment for methicillin-resistant Staphylococcus aureus (MRSA) blood infections have discovered the combination of two antibiotics was no better than one, and led to more adverse effects. In what is the biggest trial of MRSA bloodstream infections to date, (352 participants from Australia, Singapore, New Zealand and Israel), the CAMERA2 clinical trial, researchers were surprised to see the drug combination wasn't as effective as anticipated. (2020-02-11)

Foot-and-mouth-disease virus could help target the deadliest cancer
The foot-and-mouth-disease virus is helping scientists to tackle a common cancer with the worst survival rate -- pancreatic cancer. (2020-02-11)

Combined drug treatment for lung cancer and secondary tumors
Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other. (2020-02-07)

Researchers identify possible new combination treatment for advanced melanoma
Immunotherapy drug in combination with an infusion of anti-tumor immune cells may produce a stronger immune response that could help fight advanced melanoma. (2020-01-31)

Improved brain chip for precision medicine
The Akay Lab biomedical research team at the University of Houston is reporting an improvement on a microfluidic brain cancer chip previously developed in their lab. The new chip allows quick assessment of the effectiveness of cancer drugs on brain tumors. (2020-01-16)

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