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UCLA study shows how interferon-gamma guides response to cancer immunotherapy
UCLA researchers shed light on how interferon-gamma (IFN-y) guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies -- immune checkpoint blockade. (2020-09-10)

Participants in CPC+ are diverse but not representative of all primary care practices
This study analyzes patterns of participation in the Comprehensive Primary Care Plus initiative which is the largest voluntary primary care payment and delivery reform model tested to date. (2020-07-14)

What encourages--or impedes--primary care team collaboration through case management?
While multiple recent studies have provided evidence of the benefits of case management, primary care teams have struggled to implement and sustain its use in their clinical practices. In this systematic review, researchers examine barriers to case management, as well as factors facilitating its implementation. (2020-07-14)

Scientists reveal comprehensive proteomic map of human lung adenocarcinoma
A team of Chinese scientists from Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, National Center for Protein Sciences (Beijing), National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, and Shanghai Jiao Tong University, recently reported a comprehensive proteomic analysis based on 103 Chinese patients with lung adenocarcinoma (LUAD), a leading cause of death among all types of cancer worldwide. (2020-07-09)

A new biotinylation enzyme for analyzing protein-protein interactions
Proteins play roles by interacting with various other proteins. Therefore, interaction analysis is an indispensable technique for studying the function of proteins. In this research, we have developed a biotinylation enzyme, AirID, using an ancestral enzyme reconstruction algorithm. AirID is a highly active biotinylation enzyme with low toxicity. By using AirID, comprehensive biotinylation of proteins interacting with a target protein in cells was achieved when the target protein was expressed as a fusion protein with AirID. (2020-07-06)

A comprehensive survey reveals bacteria are widespread in human tumors and differ by tumor type
Different human tumor types each harbor their own unique bacterial communities, researchers report in a new study that profiled the microbiomes of more than 1,500 individual tumors across seven types of human cancer - the most comprehensive tumor microbiome study to date. (2020-05-28)

Primary care practice transformation introduces different staff types
The Comprehensive Primary Care initiative was launched in 2012 by the CMS Innovation Center as a four-year multi-payer initiative designed to strengthen primary care. This study examines shifts in staffing patterns, from 2012 to 2016, at 461 primary care practices participating in the CPC transformation initiative with those at 358 non-CPC practices. (2020-05-12)

Young stem cell donors harbor undetectable mutations linked to disease
A pilot study of 25 donor-recipient pairs reveals that healthy young donors of stem cells harbor previously undetected and potentially disease-causing mutations in their blood stem cells, which were transferred to unrelated recipients of the transplants. (2020-01-15)

Poor sight causes people to overstep the mark
People with vision impairment are more cautious when stepping over obstacles when walking - but increase their risk of falls, according to a new study published in the journal Scientific Reports. (2019-12-17)

Study examines Appalachian Kentucky's breast cancer care disparities
Despite the benefits of breast reconstruction, women from Appalachia are less likely to have the surgery than non-Appalachian Kentuckians, according to a new study by the University of Kentucky Markey Cancer Center. (2019-11-20)

A national decline in primary care visits associated with more comprehensive visits and electronic follow-up
The number of primary care visits may be declining nationally, but analysis reveals that in-person visits have become more comprehensive and follow-up care has moved online. (2019-11-12)

Mitochondrial activity in lung tumors predicts response to drug inhibitor
Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new biomarker using a noninvasive imaging method that tracks mitochondrial activity in lung tumors. (2019-10-30)

New survey shows link between comprehensive antibiotic stewardship programs and infection preventionist certification
Nearly half of all nursing homes do not have adequately trained infection prevention staff and their efforts to combat the over prescription of antibiotics are suffering as a result, according to a new study in the American Journal of Infection Control (AJIC), the journal of the Association for Professionals in Infection Control and Epidemiology, published by Elsevier. (2019-10-24)

Prescription drug monitoring program mandates
States that require prescribers to register with and use prescription drug monitoring programs in most clinical circumstances saw notably fewer opioid prescriptions and reduced opioid-related hospital use by Medicaid patients compared to states with weak or no drug monitoring program mandates, according to a new study from investigators at Weill Cornell Medicine. The approximate annual reduction of about 12,000 inpatient stays and 39,000 emergency department visits could save an estimated $155 million a year in Medicaid spending. (2019-09-03)

Explaining why TP53 is commonly mutated in human cancer, and the effects of its mutation
A comprehensive functional analysis of TP53 mutations in human leukemia may refute a working hypothesis -- primarily based on mouse studies -- that missense mutations confer new cancer-causing functions to the p53 tumor suppressor protein; the new study instead suggests that these mutations exert a 'dominant-negative' effect that reduces the cancer-suppressing activity of wild-type p53, the authors say. (2019-08-08)

Few US higher education campuses have gone completely smoke and/or tobacco-free
Just one in six accredited US colleges and universities have gone completely smoke and/or tobacco free, reveals the first study of its kind, published in the journal Tobacco Control. (2019-07-02)

Research by the UPNA states that muscle strength training improves cardiovascular health
A paper published recently in the scientific journal Nature Reviews Cardiology shows that regular physical exercise and, specifically, that which is undertaken to increase muscle strength, improves cardiovascular health through non-traditional mechanisms, such as, for example, the release through the skeletal muscles of substances that are healthy for the heart (known as myokines) or the improvement in intestinal microbiota (the microorganisms in the intestines). (2018-09-10)

Study offers strategies to prevent death by suicide in patients with cancer
In addition to focusing on curing or prolonging the life of patients with cancer, it is important to also address mental health aspects of cancer care, especially because there is an elevated incidence of death by suicide in this patient population. A new Psycho-Oncology analysis uncovers opportunities to mitigate the risk of death by suicide among patients with cancer. (2018-07-18)

Experts provide insights on the body's stress response during critical illness
Critical illness causes the body to initiate a stress response, which activates the hypothalamus-pituitary-adrenal axis to increase the availability of the stress hormone cortisol. (2018-01-10)

Insurance vs. out-of-pocket payment not a big factor in weight-loss outcomes
Individuals whose insurance covered the cost of a comprehensive medical weight-loss program had one-year outcomes very similar to those of patients who paid for the treatment out of pocket, according to an observational study conducted at Wake Forest Baptist Medical Center. (2017-05-25)

William Small, Jr., M.D., editor of new edition of classic radiation oncology textbook
William Small, Jr., M.D., chair of Loyola Medicine's radiation oncology department, is editor of a revised third edition of a classic reference in radiation oncology. (2017-03-14)

AAP, Vanderbilt neonatologist urge public health approach for opioid use during pregnancy
The American Academy of Pediatrics (AAP) issued a statement today stating that a public health response, rather than a punitive approach, is needed to address the increasing number of pregnant women using opioids. (2017-02-20)

BMJ launches new platform to help researchers get published, discovered and cited
BMJ, one of the world's leading medical knowledge providers, is pleased to announce the launch of the Author Hub, a new platform to assist researchers in every field, at every stage of the publishing process. (2017-01-23)

Coordinated approach essential to care after ICU and hospital discharge, new research finds
New research published today in the British Journal of General Practice has found inconsistencies in the experiences of patients once they were discharged from hospital, following admission to an intensive care unit (ICU), impacting detrimentally on the continuity of care they received. (2016-11-21)

Handgrip strength provides a new window to health
A simple test of grip strength could provide a quick and inexpensive screening tool for health practitioners, according to a new study from IIASA population researchers. (2016-10-04)

Study tests new breast cancer drug in African-American women
The first clinical trial to test a newly approved breast cancer drug specifically in African-American patients is now enrolling at Georgetown Lombardi Comprehensive Cancer Center and will begin soon at five other institutions in Washington, D.C., Maryland, Alabama and New Jersey. (2016-07-06)

Sylvester to present latest cancer care and research at ASCO annual meeting
Physician-scientists and researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine will present a selection of their latest cancer care and research at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, June 3-7, at McCormick Place in Chicago, Ill. (2016-05-26)

New Medicare primary care improvement results: U-M expert available to comment
This week, new results emerged from the federal government's largest-ever effort to improve primary care for people who rely on Medicare - the Comprehensive Primary Care Initiative. A primary care physician who has studied Medicare authored the editorial in NEJM addressing the implications of the new results. (2016-04-13)

NCI renews funding for San Diego Universities, community health centers to work together
A collaborative program aimed at reducing the burden of cancer among Hispanic/Latinos in San Diego and Imperial counties through research and community outreach has received a $13 million grant from the National Cancer Institute, part of the National Institutes of Health. The five-year grant renews funding for a partnership started in 2008 between San Diego State University and Moores Cancer Center at UC San Diego Health. (2015-09-28)

Georgetown scientist awarded Alex's Lemonade Stand Foundation Innovation Grant
Alex's Lemonade Stand Foundation, a nonprofit dedicated to finding better treatments and ultimately cures for all children with cancer, has awarded a 2015 Innovation Grant to Todd Waldman, M.D., Ph.D., a professor of oncology at Georgetown Lombardi Comprehensive Cancer Center. (2015-07-20)

Online registry improves clinical research study participation
Research for Her, Cedars-Sinai's groundbreaking online registry that matches women with research studies and clinical trials, enrolled study participants more quickly when compared with traditional paper-based registries, according to new research published in the journal Gynecologic Oncology. (2015-07-13)

Comprehensive stroke centers may improve bleeding stroke survival
People with brain bleeds are more likely to survive if they're treated at a comprehensive stroke center. Comprehensive stroke centers have the equipment and personnel to deal with the most severe strokes, including neurological critical care and 24-hour availability of neurosurgeons. (2015-05-06)

Triple negative breast cancer in African-American women has distinct difference
What makes triple negative breast cancer more lethal in African-American women than white women or women of European descent? A new study reveals specific genetic alterations that appears to impact their prognosis and ultimately survival rates. (2015-04-22)

Finding liver cancer early and reversing its course
Liver cancer is often lethal in humans because it is diagnosed in late stages, but new work in animal models has identified a potential diagnostic biomarker of the disease and a potential way to reverse the damage done. (2015-04-21)

Norris Cotton Cancer Center at Dartmouth redesignated as NCI 'Comprehensive Cancer Center'
The National Cancer Institute has renewed its Cancer Center Support Grant to Norris Cotton Cancer Center at Dartmouth, continuing NCCC's designation as a Comprehensive Cancer Center. (2015-03-26)

When cancer cells stop acting like cancer
Cancer cells crowded tightly together suddenly surrender their desire to spread, and this change of heart is related to a cellular pathway that controls organ size. (2015-03-16)

Study: One-third of Americans do not have access to stroke center within 1 hour
One-third of the US population does not have access to a primary stroke center within one hour by ambulance, and even under optimal conditions, a large proportion of the US would be unable to access a stroke center within this window, according to a new study published in the March 4, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. Stroke is a leading cause of death and disability in the country. (2015-03-04)

Pasture feeding may improve nutritional benefits of red meat
A new review article in Comprehensive Reviews in Food Science and Food Safety published by the Institute of Food Technologists found that pasture-fed lamb meat is high in polyunsaturated fat due to the specific plant species consumed. (2015-01-21)

Orphan receptor proteins deliver 2 knock-out punches to glioblastoma cells
Two related proteins exert a lethal double whammy effect against glioblastoma cells when activated with a small molecule. Scientists say when activated, one protein, called the short form, stops glioblastoma cells from replicating their DNA, and the other, called the long form, prevents cell division if the DNA has already been replicated. (2014-12-17)

Georgetown receives renewal as D.C.'s only federally designated comprehensive cancer center
The National Cancer Institute today awarded a five-year, $11.25 million P30 Cancer Center Support Grant to Georgetown Lombardi Comprehensive Cancer Center, and renewed its designation as a 'comprehensive cancer center.' (2014-09-10)

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