Current Congenital Heart Defects News and Events

Current Congenital Heart Defects News and Events, Congenital Heart Defects News Articles.
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New features of a gene defect that affects muzzle length and caudal vertebrae in dogs
A recent genetic study at the University of Helsinki provides new information on the occurrence of a DVL2 gene defect associated with a screw tail and its relevance to canine constitution and health. The variant was found in several Bulldog and Pit Bull type breeds, and it was shown to result in caudal vertebral anomalies and shortening of the muzzle. The DLV2 variant may also affect the development of the heart. (2021-02-23)

Fat cells may influence how the body reacts to heart failure, study shows
University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells when in heart failure could help improve outcomes for patients. (2021-02-23)

Improved vectors for ocular gene therapy
Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. (2021-02-22)

Spina bifida can be caused by uninherited genetic mutations
Genetic mutations which occur naturally during the earliest stages of an embryo's development can cause the severe birth defect spina bifida, finds a new experimental study in mice led by UCL scientists. (2021-02-19)

Real world data on hospital readmissions of patients with heart failure
In an analysis of information on 448 patients with heart failure who were discharged from a hospital in Sweden, 20.3% of patients were readmitted to the hospital within 30 days, and 60.9% were readmitted within 1 year. The ESC Heart Failure analysis found that most of the patients who needed to be rehospitalized were readmitted for heart failure. (2021-02-18)

Stents or bypass surgery more effective for stable patients with high-risk cardiac anatomy
A study by University of Alberta cardiologists at the Canadian VIGOUR Centre shows that a particular group of patients with stable ischemic heart disease have better outcomes with percutaneous coronary intervention (also called angioplasty with stent) or coronary artery bypass surgery and medication, versus conservative management with medication alone. (2021-02-18)

A 'twisted elevator' could be key to understanding neurological diseases
For the first time, researchers have found one of the most important molecular machines in our cells uses a 'twisting elevator' mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another. (2021-02-17)

Proton therapy induces biologic response to attack treatment-resistant cancers
Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment. The technique is called LEAP, an acronym for 'biologically enhanced particle therapy.' The findings are published today in Cancer Research, the journal of the American Association for Cancer Research. (2021-02-17)

FSU College of Medicine researcher develops new possibilities to prevent sudden cardiac death
Stephen Chelko, an assistant professor of biomedical sciences at the Florida State University College of Medicine, has developed a better understanding of the pathological characteristics behind arrhythmogenic cardiomyopathy, as well as promising avenues for prevention. (2021-02-17)

Avian insights into human ciliopathies
Ciliopathies are genetic disorders caused by defects in the structure and function of cilia, and present a wide range of clinical symptoms, leading to conditions such as micrognathia (an underdeveloped lower jaw that can impair feeding and breathing). Researchers have now discovered that ciliopathic micrognathia in an animal model results from abnormal skeletal differentiation and remodelling. (2021-02-15)

Drinking, smoking, and drug use linked to premature heart disease in the young
Recreational drinking, smoking, and drug use is linked to premature heart disease in young people, particularly younger women, finds research published online in the journal Heart. (2021-02-15)

Aspirin preferred to prevent blood clots in kids after heart surgery
Aspirin should be favoured over warfarin to prevent blood clotting in children who undergo a surgery that replumbs their hearts, according to a new study. (2021-02-14)

Heart disease deaths rising in young women
A nationwide US study has found increasing death rates from heart disease in women under 65. The research is published in European Heart Journal - Quality of Care and Clinical Outcomes, a journal of the European Society of Cardiology (ESC).1 The study found that while death rates from cancer declined every year between 1999 and 2018, after an initial drop, heart disease death rates have been rising since 2010. (2021-02-10)

Long-term stress linked to increased risk of heart attack
Can long-term stress lead to heart attacks? Most people would probably answer in the affirmative, but the scientific evidence of this is scarce. A new study by researchers from Linköping University in Sweden reveals that the levels of the stress hormone cortisol were increased in the months preceding a heart attack. The results, published in Scientific Reports, suggest that long-term stress is a risk factor for heart attacks. (2021-02-10)

Texas A&M researchers discover energy drinks' harmful effects on heart
A team of researchers, led by a Texas A&M University professor, has found that some energy drinks have adverse effects on the muscle cells of the heart. (2021-02-10)

'Defective' carbon simplifies hydrogen peroxide production
Rice University scientists introduce a new catalyst to reduce oxygen to widely used hydrogen peroxide. The process sidesteps complex and expensive processes that generate toxic organic byproducts and large amounts of wastewater. (2021-02-09)

Ural Federal University scientists developed a new way of synthesis of high-purity zircon
A research group from Ural Federal University synthesized high-purity single-phase zircon (ZrSiO4) and analyzed its structural, thermal, vibrational and optical properties. The results have been published in the Journal of Solid State Chemistry (Q2) (2021-02-05)

Drinking green tea, coffee lowers risk of death for stroke and heart attack survivors
Stroke survivors who drank seven or more cups of green tea each day lowered their risks of multiple causes of death by 62%. Drinking one cup of coffee each day lowered the risks of death for heart attack survivors and for those without a history of stroke or heart attack. (2021-02-04)

Surprising new research: We're more like primitive fishes than once believed
People traditionally think that lungs and limbs are key innovations that came with the vertebrate transition from water to land. But in fact, the genetic basis of air-breathing and limb movement was already established in our fish ancestor 50 million years earlier. This, according to a recent genome mapping of primitive fish conducted by the University of Copenhagen, among others. The new study changes our understanding of a key milestone in our own evolutionary history. (2021-02-04)

Uncovering a link between inflammation and heart disease
Patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present. A new study published in Circulation reveals a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart. (2021-02-04)

In vitro study helps explain how Zika virus passes from mother to fetus during pregnancy
A preclinical study by a University of South Florida Health Morsani College of Medicine team has discovered a new mechanism for how Zika virus can pass from mothers to their children during pregnancy - a process known as vertical transmission. The researchers showed, for the first time, that specialized maternal cells lining the uterus (decidual cells) act as reservoirs for trimester-dependent transmission of the virus through the placenta. (2021-02-03)

Racial disparities: Young, Black adults had significantly worse heart transplant outcomes
Young, Black adults (ages 18-30) are more than twice as likely to die in the first year after a heart transplant compared to non-Black transplant recipients who are the same age. By age 61 and older, there was no significant racial disparity in the health outcomes among heart transplantation recipients. (2021-02-02)

Iron release may contribute to cell death in heart failure
A process that releases iron in response to stress may contribute to heart failure, and blocking this process could be a way of protecting the heart, suggests a study in mice published today in eLife. (2021-02-02)

Mayo Clinic research yields breakthrough in mobile determination of QT prolongation
Researchers from Mayo Clinic and AliveCor Inc. have been using artificial intelligence (AI) to develop a mobile device that can identify certain patients at risk of sudden cardiac death. (2021-02-01)

Stem cell study illuminates the cause of a devastating inherited heart disorder
Penn Medicine scientists have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM)-- one of multiple congenital disorders caused by inherited mutations in a gene called LMNA. The scientists used stem cell techniques to grow human heart muscle cells containing DCM-causing mutations in LMNA. They found that these mutations severely disrupt the structural organization of DNA in the nucleus of heart muscle cells. (2021-02-01)

Researchers demonstrate how defects in mitochondria may lead to autism spectrum disorder
Researchers have demonstrated that autism spectrum disorder (ASD) may be caused by defects in the mitochondria of brain cells. (2021-02-01)

ERAS program expedites recovery for congenital heart surgery patients
Select patients born with heart defects and who undergo congenital heart surgery recover with few complications and reduced opioid use when a comprehensive, evidence-based enhanced recovery after surgery (ERAS) program is used. (2021-01-30)

Researchers map heart recovery after heart attack with great detail
Researchers from the Hubrecht Institute mapped the recovery of the heart after a heart attack with great detail. They found that cardiomyocytes play an important role in the intracellular communication after a heart attack. The researchers documented their findings in a database that is accessible for scientists around the world. This brings the research field a step closer to the development of therapies for improved recovery after heart injury. (2021-01-29)

Fetal and neonatal therapies improve prognosis of congenital cytomegalovirus infection
A cross-institutional research group has revealed for the first time in the world that infants with symptomatic congenital cytomegalovirus (CMV) infection who were treated with a combination of immunoglobulin fetal therapy and neonatal therapy with antiviral drugs were less likely to experience the severe aftereffects associated with the infection than those who only received the neonatal therapy. (2021-01-28)

Study reveals cause of common Zika virus birth defect
CLEVELAND - Cleveland Clinic researchers have described for the first time how Zika virus (ZIKV) causes one of the most common birth defects associated with prenatal infection, called brain calcification, according to new study findings published in Nature Microbiology. The findings may reveal novel strategies to prevent prenatal ZIKV brain calcification and offer important insights into how calcifications form in other congenital infections. (2021-01-28)

Scientists develop perovskite solar modules with greater size, power and stability
Researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) have created perovskite solar modules with improved stability and efficiency by using a new fabrication technique that reduced defects. Their findings were published on the 25th January in Advanced Energy Materials. (2021-01-27)

Breakthrough design at UBCO vastly improves mechanical heart valve
New research coming out of UBC's Okanagan campus may take the current 'gold standard' for heart valves to a new level of reliability. A team of researchers at UBCO's Heart Valve Performance Lab (HVPL) has developed a way to improve overall blood flow through the valves, so the design of mechanical heart valves will more closely match the real thing. (2021-01-26)

Beauty in imperfection: How crystal defects can help convert waste heat into electricity
Half-Heusler Ni-based alloys are thermoelectric materials with the potential for converting waste heat into electricity. However, the origin of their impressive conversion efficiency is not entirely clear. In a recent study, scientists from Japan and Turkey have attempted to uncover the role that Ni defects have in the crystal structure of these alloys and how their desirable thermoelectric properties are a consequence of small changes in strain around defective sites. (2021-01-26)

Childhood cancer survivors are not more likely to terminate their pregnancies
Study finds they have a reduced likelihood of becoming pregnant, however. (2021-01-25)

Highly efficient perovskite light-emitting diodes for next-generation display technology
Highly efficient perovskite light-emitting diodes for next-generation display technology. (2021-01-24)

Targeted coating improves graphene oxide membranes for nanofiltration
A research group led by Prof. WAN Yinhua from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences developed a stable graphene oxide nanofiltration membrane with uniform pore size to remove organic micropollutants. (2021-01-22)

University of Cincinnati student uses zebrafish to study spinal deformities
Oriana Zinani, a doctoral student in molecular developmental biology at the University of Cincinnati, is part of a team of researchers using zebrafish embryos to study a gene mutation that causes scoliosis, a sideways curvature of the spine that typically occurs in humans just before puberty. (2021-01-22)

Predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.1266, Zhuzhi Wen, Jingying Hou, Zun Mai, Huifen Huang, Yangxin Chen, Dengfeng Geng and Jingfeng Wang from Sun Yat-sen University, Guangzhou, China and Guandong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China consider predictive value of blood pressure, heart rate, and blood pressure/heart rate ratio in a Chinese subpopulation with vasovagal syncope. (2021-01-22)

Electrons caught in the act
Tsukuba University scientists create movies of the ultrafast motion of electrons traveling through an organic semiconductor with atomic-level resolution. This work may lead to more powerful and miniaturized smart devices. (2021-01-21)

Counting patients social determinants of health may help doctors avert fatal heart attacks
Doctors may be able to predict their patients' risks of fatal coronary heart disease more accurately by taking into account the number of adverse social factors affecting them, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. (2021-01-21)

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