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Current Constipation News and Events, Constipation News Articles.
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Despite crisis patients perceive opioids as superior and expect them for postsurgical pain
Even with concerns about addiction, side effects and the other risks of opioids dominating headlines, a study presented at the ANESTHESIOLOGY® 2018 annual meeting found people expect to be prescribed opioids and perceive them to be the most effective form of pain relief after surgery. Interestingly, other research presented at the meeting found opioids led to complications such as increased pain, poorer quality of life and dependence following back surgery. (2018-10-13)

A new generation of pain medications
Researchers from Charité - Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of pain medications. The researchers used computer simulations to develop new opioids that will only work at sites affected by injury or inflammation. These drugs can prevent the occurrence of brain- and gut-related side effects typically associated with conventional opioids and have been shown to be successful in preclinical studies. Results from this research have been published in Pain* and Scientific Reports**. (2018-09-07)

Discovery of long-lived macrophages in the intestine
Macrophages are specialised immune cells that destroy bacteria and other harmful organisms. KU Leuven scientists, Belgium, have come to the surprising conclusion that some macrophages in the intestines of mice can survive for quite some time. Most importantly, these long-lived macrophages are vital for the survival of the nerve cells of the gastrointestinal tract. This sheds new light on neurodegenerative conditions of the intestine, but also of the brain. (2018-08-30)

CU researchers identify potential target for treating pain during surgery
A research team lead by faculty of the University of Colorado School of Medicine have published a study that improves the understanding of the pain-sensing neurons that respond to tissue injury during surgery. (2018-08-28)

How do you assess pain in children who can't express themselves? New research identifies priorities in identifying pain in nonverbal children with medical complexity
Pain is a frequent problem for children with complex medical conditions -- but many of them are unable to communicate their pain verbally. For these children, nurses face a challenging task in assessing and determining the cause of pain, according to a study in the August issue of the American Journal of Nursing. The journal is published in the Lippincott portfolio by Wolters Kluwer. (2018-08-02)

Mayo Clinic discovery is first step toward new bacteria-based constipation treatment
Genetically engineered bacteria are showing promise as a new treatment for constipation, researchers at the Mayo Clinic Center for Individualized Medicine have discovered in a mouse study. The finding is significant in part because there are few approved constipation remedies on the market. The research is published in Cell Host & Microbe. (2018-06-13)

Mangos help promote gut health
Eating mangos found to be more effective in relieving constipation and reducing intestinal inflammation than comparable amount of fiber. (2018-06-06)

Study: Ibuprofen, acetaminophen more effective than opioids in treating dental pain
Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) alone or in combination with acetaminophen are better at easing dental pain than opioids, according to new research conducted with the School of Dental Medicine at Case Western Reserve University. (2018-04-17)

Genetic link to IBS identified in women
New research coordinated by Karolinska Institutet in Sweden links certain DNA variants to increased risk of irritable bowel syndrome (IBS) in women. The findings, published in the scientific journal Gastroenterology, might help explain why IBS is more common in women than in men. (2018-04-05)

A small, daily dose of Viagra may reduce colorectal cancer risk
A small, daily dose of Viagra significantly reduces colorectal cancer risk in an animal model that is genetically predetermined to have the third leading cause of cancer death, scientists report. Viagra cut in half the formation of polyps, an abnormal and often asymptomatic clump of cells on the lining of the intestines that may become cancer, says Dr. Darren D. Browning, cancer researcher at the Georgia Cancer Center and Department of Biochemistry and Molecular Biology at the Medical College of Georgia at Augusta University. (2018-03-19)

Study shows bowel care is top concern for those with spinal cord injury
A study by SFU research Victoria Claydon reveals that bowel care, followed by sexual function, bladder function and pain were of key concern. Surprisingly, one of the lowest-ranked concerns was using a wheelchair for mobility. (2018-03-08)

Magnetically applied MicroRNAs could one day help relieve constipation
Micro metal beads and magnets help deliver a biologic where it's needed to improve constipation or rectoanal incontinence in animal models of the disorders. (2018-01-16)

Safer opioid drugs could treat pain and save lives
Opioid drugs are the most widely prescribed and effective type of pain medication. But they are highly addictive and have some unpleasant and potentially deadly side effects. Now a group of researchers, led by Dr. Laura Bohn at The Scripps Research Institute, may have found a way to make opioids safer by separating the drugs' pain relieving effects from their most dangerous side effect, respiratory suppression, which, in very severe cases, causes patients to stop breathing and to die. (2017-12-05)

Opioid use by patients after rhinoplasty
Rhinoplasty patients used an average of nine of 20 to 30 hydrocodone-acetaminophen tablets prescribed for pain relief, suggesting that over-prescription of opioids after the common procedure could be a source available for diversion and misuse. (2017-11-09)

Standardized ambulatory surgical protocol reduces unplanned postoperative returns
Health system study of patients undergoing open inguinal hernia repair identifies patient education and anesthetic management as key elements of care. (2017-10-23)

Ibuprofen better choice over oral morphine for pain relief in children after minor surgery
Widely available ibuprofen is a better choice for pain relief in children who have undergone minor orthopedic outpatient surgery, as it has fewer adverse effects compared with oral morphine, according to results from a clinical trial published in CMAJ (Canadian Medical Association Journal). (2017-10-10)

1 in 3 older adults take something to help them sleep but many don't talk to their doctors
Sleep doesn't come easily for nearly half of older Americans, and more than a third have resorted to some sort of medication to help them doze off at night, a new national poll finds. But most said they hadn't talked to their doctor about their sleep, even though more than a third said their sleep posed a problem. Half believe -- incorrectly -- that sleep problems just come naturally with age. (2017-09-27)

Pelvic Floor Society statement -- use of mesh surgeries for constipation & rectal prolapse
In light of ongoing concerns by the media and the public surrounding the use of mesh in women with pelvic organ prolapse and urinary incontinence, the Pelvic Floor Society has issued a consensus statement addressing the use of mesh for the treatment of constipation and rectal prolapse (via a surgical procedure called ventral mesh rectopexy, or VMR). (2017-09-21)

Study suggests increase in adverse effects due to use of opioids in hospitalized children
New research to be presented during the American Academy of Pediatrics 2017 National Conference and Exhibition in Chicago suggests an urgent need for safer children's pain medications, with the number of hospitalized infants, children and teens who experienced adverse reactions to opioid painkillers increasing by more than half between 2003 and 2012. (2017-09-15)

Two new studies offer insights into gastrointestinal dysfunction in Parkinson's patients
Constipation is one of the most common non-motor related complaints affecting Parkinson's disease (PD) patients. (2017-07-31)

Study: Diet not connected to GI problems in children with autism
Many children with autism spectrum disorder experience significant gastrointestinal issues, but the cause of these symptoms is unknown. Professionals in the medical community have suggested a potential link between diet and gastrointestinal issues related to autism. Now, researchers from the University of Missouri School of Medicine have found that diet is not a contributing factor in these individuals. The researchers hope the findings could help lead to improved treatment options. (2017-07-12)

Protein associated with Parkinson's disease linked to human upper GI tract infections
Acute and chronic infections in a person's upper gastrointestinal tract appear to be linked to Parkinson's disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions. (2017-06-27)

New study shows for first time link between passive smoking in childhood and rheumatoid arthritis
The results of a study presented today at the Annual European Congress of Rheumatology 2017 press conference confirmed the link between active smoking and the risk of developing rheumatoid arthritis (RA). However, interestingly, it also suggested for the first time that in smokers, exposure to tobacco early in life through passive smoking in childhood significantly increased this risk. (2017-06-16)

First study shows tie between probiotic and improved symptoms of depression
This is the first study showing improved depression scores with a probiotic. It adds to the whole field of microbiota-gut-brain axis, providing evidence that bacteria affect behavior. (2017-05-23)

Understanding the architecture of our 'second brain'
Scientists have made an important step in understanding the organisation of nerve cells embedded within the gut that control its function -- a discovery that could give insight into the origin of common gastrointestinal diseases, including irritable bowel syndrome and chronic constipation. (2017-05-19)

Vaginal estriol gel helps women recover after surgery for pelvic organ prolapse
Pelvic organ prolapse is estimated to affect up to one-half of all women, causing pain and interfering with sexual function. A new study demonstrates how an ultralow dose of vaginal estriol gel used before and after pelvic organ prolapse surgery can improve recovery time and results. The study outcomes are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2017-03-29)

Painkillers without dangerous side effects
Researchers from Charité - Universitätsmedizin Berlin have discovered a new way of developing painkillers. When used in an animal model, their prototype of a morphine-like molecule was able to produce substantial pain relief in inflamed tissues. However, healthy tissues remained unaffected, suggesting that the severe side effects currently associated with these types of painkillers might be avoided. This research has been published in the current issue of the journal Science*. (2017-03-03)

Intestinal bacteria alter gut and brain function: McMaster study
The goal of the study was to explore whether fecal microbiota from human IBS patients with diarrhea has the ability to influence gut and brain function in recipient mice. Using fecal transplants, researchers transferred microbiota from IBS patients with or without anxiety into germ-free mice. The mice went on to develop changes both in intestinal function and behavior reminiscent of the donor IBS patients, compared to mice that were transplanted with microbiota from healthy individuals. (2017-03-01)

Physicians' opioid prescribing patterns linked to patients' risk for long-term drug use
Emergency room patients treated by physicians who prescribe opioids more often are at greater risk for long-term opioid use even after a single prescription than those who see less-frequent prescribers, according to the findings of a study from Harvard Medical School and T.H. Chan School of Public Health. The research, believed to be the first to measure variation in provider prescribing practices and their impact on long-term opioid use, is published Feb. 16 in the New England Journal of Medicine. (2017-02-15)

Spinal cord injury patients face many serious health problems besides paralysis
Spinal cord patients are at higher risk for cardiovascular disease; pneumonia; life-threatening blood clots; bladder, bowel and sexual dysfunction; constipation and other gastrointestinal problems; pressure ulcers; and chronic pain, according to a report published in the journal Current Neurology and Neuroscience Reports. (2017-02-15)

Half of breast cancer patients experience severe side effects
Nearly half of women treated for early stage breast cancer reported at least one side effect from their treatment that was severe or very severe, a new study finds. (2017-01-24)

IBS affects women's quality of life more than men's
Double work and a high embarrassment factor can lead to the quality of life being affected more among women than men by irritable bowel syndrome (IBS), a very common gastrointestinal disease. Even with the same level of physical pain and other symptoms, women's perceived quality of life is worse than the men's, according to new research. (2017-01-09)

Increased reaction to stress linked to gastrointestinal issues in children with autism
One in 45 American children lives with autism spectrum disorder, according to the Centers for Disease Control and Prevention. Many of these children also have significant gastrointestinal issues, but the cause of these symptoms is unknown. Now, researchers from the University of Missouri School of Medicine suggest that the gastrointestinal issues in these individuals with autism may be related to an increased reaction to stress. The researchers hope the finding could lead to better treatments. (2017-01-04)

New research links genetic defects in carbohydrate digestion to irritable bowel syndrome
Irritable bowel syndrome (IBS) affects a large portion of the general population. New research coordinated by Karolinska Institutet now shows a link between defective sucrase-isomaltase gene variants and IBS. (2016-11-21)

Study uncovers link between constipation and kidney disease
Individuals with constipation had a 13 percent higher likelihood of developing chronic kidney disease and a 9 percent higher likelihood of developing kidney failure compared with individuals without constipation. More severe constipation was linked with an incrementally higher risk for both chronic kidney disease and kidney failure. (2016-11-10)

Many back pain patients get limited relief from opioids and worry about taking them
Millions of people take opioids for chronic back pain, but many of them get limited relief while experiencing side effects and worrying about the stigma associated with taking them, suggests research presented at the ANESTHESIOLOGY 2016 annual meeting. (2016-10-23)

Deadly intestinal disease in preemies may be caused by genetic deficiency
A life-threatening condition that causes the intestines in premature infants to become infected and die may be triggered by a disruption in the way the body metabolizes energy, according to Rutgers scientists. A new study indicates that a genetic deficiency might be what stops this critical metabolic development process from occurring in the fetus near the end of gestation, when the intestines should become fully developed (2016-10-18)

BMJ Case Reports: Alternative therapy dangers, rapunzel syndrome, tick-born illness
This week in BMJ Case Reports: Doctors warn of the dangers associated with alternative therapies for children; giant hairballs removed from patient with Rapunzel syndrome; and women develops threatening tick-borne illness. (2016-10-06)

Certain alternative therapies may help patients with bowel disorders
A new review looks at the evidence behind the effectiveness of complementary or alternative therapies -- including probiotics, prebiotics, synbiotics, fiber, and herbal medicinal products -- for the treatment of bowel disorders such as irritable bowel syndrome (IBS), functional constipation, and ulcerative colitis. (2016-10-03)

Criteria to ID those who won't survive cardiac arrest,could be referred for organ donation
Three objective criteria can be used to quickly identify patients with out-of-hospital cardiac arrest who have zero chance of survival and can therefore be considered for organ donation. (2016-09-12)

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